Piercarlo Sarzi-Puttini

Piercarlo Sarzi-Puttini

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Piercarlo Sarzi-Puttini

Piercarlo Sarzi-Puttini

Publications by authors named "Piercarlo Sarzi-Puttini"

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Evaluation of salivary and plasma microRNA expression in patients with Sjögren's syndrome, and correlations with clinical and ultrasonographic outcomes.

Clin Exp Rheumatol 2019 May-Jun;37 Suppl 118(3):70-77. Epub 2019 Jan 10.

Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy.

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October 2019

The therapeutic journey of biologic agents: There will be an end?

Pharmacol Res 2019 Sep 2;147:104340. Epub 2019 Jul 2.

Department of Biomedical and Clinical Sciences L.Sacco, Università di Milano, Milano, Italy.

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http://dx.doi.org/10.1016/j.phrs.2019.104340DOI Listing
September 2019

Psoriatic arthritis: From pathogenesis to pharmacologic management.

Pharmacol Res 2019 Sep 7;148:104394. Epub 2019 Sep 7.

Orthopedic Unit, Santissima Trinità Hospital, Cagliari, Italy.

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http://dx.doi.org/10.1016/j.phrs.2019.104394DOI Listing
September 2019

Medical cannabis and cannabinoids in rheumatology: where are we now?

Expert Rev Clin Immunol 2019 Sep 12. Epub 2019 Sep 12.

Department of Internal Medicine 1, Klinikum Saarbrücken , Winterberg 1, D-66119 Saarbrücken , Germany .

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1665997DOI Listing
September 2019

IL-6 INVOLVEMENT IN PAIN, FATIGUE AND MOOD DISORDERS IN RHEUMATOID ARTHRITIS AND THE EFFECTS OF IL-6 INHIBITOR SARILUMAB.

Pharmacol Res 2019 Sep 16:104402. Epub 2019 Sep 16.

Department of Biomedical Science for Health, University of Milan, Istituto Clinico Sant'Ambrogio, Milan, Italy.

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http://dx.doi.org/10.1016/j.phrs.2019.104402DOI Listing
September 2019

The Effect of Neuropathic Pain Symptoms on Remission in Patients with Early Rheumatoid Arthritis.

Curr Rheumatol Rev 2019 ;15(2):154-161

Department of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, Italy.

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http://dx.doi.org/10.2174/1573397114666180806142814DOI Listing
August 2019

AAPT Diagnostic Criteria for Fibromyalgia.

J Pain 2019 Jun 16;20(6):611-628. Epub 2018 Nov 16.

Epidemiology Group and Aberdeen Centre for Arthritis and Musculoskeletal Health, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/j.jpain.2018.10.008DOI Listing
June 2019

Response to Wolfe. Letter to the Editor, "Fibromyalgia Criteria".

J Pain 2019 Jun 26;20(6):741-742. Epub 2019 Feb 26.

Epidemiology Group and Aberdeen Centre for Arthritis and Musculoskeletal Health, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom.

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http://dx.doi.org/10.1016/j.jpain.2019.02.003DOI Listing
June 2019

Systemic rheumatic diseases: From biological agents to small molecules.

Autoimmun Rev 2019 Jun 5;18(6):583-592. Epub 2019 Apr 5.

Rheumatology Unit, University of Messina, Messina, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15689972193008
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http://dx.doi.org/10.1016/j.autrev.2018.12.009DOI Listing
June 2019

Noninvasive imaging methods for evaluating cardiovascular involvement in patients with rheumatoid arthritis before and after anti-TNF drug treatment.

Future Sci OA 2019 Jun 13;5(6):FSO396. Epub 2019 Jun 13.

Department of Biomedical Sciences for Health, IRCCS, Galeazzi Orthopedic Institute, University of Milan, Italy.

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http://dx.doi.org/10.2144/fsoa-2018-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609891PMC
June 2019

Epidemiological, pharmacological and sociodemographic characterisation of a population of 386 fibromyalgic patients referred to a tertiary pain centre in Italy.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):27-38. Epub 2018 Aug 29.

Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy.

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May 2019

Fibromyalgia syndrome: under-, over- and misdiagnosis.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):90-97. Epub 2019 Feb 8.

Division of Rheumatology, McGill University Health Centre, Quebec, Canada and Alan Edwards Pain Management Unit, McGill University Health Centre, Quebec, Canada.

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May 2019

Fibromyalgia and the concept of resilience.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):105-113. Epub 2019 Feb 8.

Clinical and Oncological Psychology, Città della Salute e della Scienza Hospital of Turin, Turin, Italy.

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May 2019

Hyperbaric oxygen treatment of fibromyalgia: a prospective observational clinical study.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):63-69. Epub 2019 Feb 6.

Department of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, Italy.

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May 2019

Neuromuscular efficiency in fibromyalgia is improved by hyperbaric oxygen therapy: looking inside muscles by means of surface electromyography.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):75-80. Epub 2019 Feb 8.

NeuroMuscularFunction/Research Group, School of Exercise & Sport Sciences, Department of Medical Sciences, University of Turin, Italy.

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May 2019

Severe bitter taste associated with apremilast.

Dermatol Ther 2019 05 26;32(3):e12876. Epub 2019 Mar 26.

Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

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http://dx.doi.org/10.1111/dth.12876DOI Listing
May 2019

Rationale underlying the measurement of fractional exhaled nitric oxide in systemic sclerosis patients.

Clin Exp Rheumatol 2019 Jul-Aug;37 Suppl 119(4):125-132. Epub 2019 Feb 27.

L. Sacco Department of Biomedical Sciences, University of Milan, Italy.

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February 2019

Usefulness of six-minute walk test in systemic sclerosis.

Clin Exp Rheumatol 2018 Jul-Aug;36 Suppl 113(4):161-167. Epub 2018 Sep 7.

Rheumatology Unit, University of Messina, Italy.

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January 2019

Ultramicronized Palmitoylethanolamide (um-PEA) as Add-on Treatment in Fibromyalgia Syndrome (FMS): Retrospective Observational Study on 407 Patients.

CNS Neurol Disord Drug Targets 2019 ;18(4):326-333

Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy.

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http://dx.doi.org/10.2174/1871527318666190227205359DOI Listing
January 2019

A Review of Chronic Musculoskeletal Pain: Central and Peripheral Effects of Diclofenac.

Pain Ther 2018 Dec 5;7(2):163-177. Epub 2018 Jun 5.

Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.

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http://dx.doi.org/10.1007/s40122-018-0100-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251833PMC
December 2018

Adverse events, clinical considerations and management recommendations in rheumatoid arthritis patients treated with JAK inhibitors.

Expert Rev Clin Immunol 2018 11 21;14(11):945-956. Epub 2018 Aug 21.

d Rheumatology Unit, Department of Internal Medicine , ASST-Fatebenefratelli L. Sacco University Hospital , Milan , Italy.

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2018.1
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http://dx.doi.org/10.1080/1744666X.2018.1504678DOI Listing
November 2018

The subjective components of the Disease Activity Score 28-joints (DAS28) in rheumatoid arthritis patients and coexisting fibromyalgia.

Rheumatol Int 2018 Oct 28;38(10):1911-1918. Epub 2018 Jun 28.

Department of Rheumatology, ASST-FBF-Sacco, Milan, Italy.

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http://dx.doi.org/10.1007/s00296-018-4096-zDOI Listing
October 2018

From autoinflammation to autoimmunity: old and recent findings.

Clin Rheumatol 2018 Sep 16;37(9):2305-2321. Epub 2018 Jul 16.

Rheumatology Unit, University of Messina, Messina, Italy.

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http://dx.doi.org/10.1007/s10067-018-4209-9DOI Listing
September 2018

Controlled-release pregabalin in the treatment of fibromyalgia.

Expert Rev Neurother 2018 08 23;18(8):617-623. Epub 2018 Aug 23.

g Department of Rheumatology , ASST Fatebenefratelli-Sacco , Milan , Italy.

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http://dx.doi.org/10.1080/14737175.2018.1508344DOI Listing
August 2018

Central nervous system involvement in rheumatoid arthritis patients and the potential implications of using biological agents.

Best Pract Res Clin Rheumatol 2018 08 27;32(4):500-510. Epub 2019 Feb 27.

Department of Rheumatology, University Hospital ASST-Fatebenefratelli-Sacco, Via GB Grassi 74, 20157, Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.berh.2019.02.003DOI Listing
August 2018

Neurobiological similarities between RA and fibromyalgia.

Nat Rev Rheumatol 2018 06;14(6):324-325

Department of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, Italy.

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http://dx.doi.org/10.1038/s41584-018-0011-yDOI Listing
June 2018

Accelerated subcutaneous nodulosis in patients with rheumatoid arthritis treated with tocilizumab: a case series.

J Med Case Rep 2018 Jun 3;12(1):154. Epub 2018 Jun 3.

Department of Rheumatology, ASST Fatebenefratelli-Sacco, via GB Grassi n. 74, 20157, Milan, Italy.

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http://dx.doi.org/10.1186/s13256-018-1687-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985057PMC
June 2018

The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review.

J Immunol Res 2017 1;2017:6836498. Epub 2017 Aug 1.

Department of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, Italy.

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http://dx.doi.org/10.1155/2017/6836498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556609PMC
May 2018

Ankylosing Spondylitis Treatment after First Anti-TNF Drug Failure.

Isr Med Assoc J 2018 Feb;20(2):119-122

Rheumatology Unit, Sacco University Hospital, Milan, Italy.

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February 2018

Cardiovascular Imaging Techniques in Systemic Rheumatic Diseases.

Front Med (Lausanne) 2018 14;5:26. Epub 2018 Feb 14.

Cardiology Unit, IRCCS Galeazzi Orthopedic Institute, Milan, Italy.

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http://dx.doi.org/10.3389/fmed.2018.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819573PMC
February 2018

Features of mood associated with high body weight in females with fibromyalgia.

Compr Psychiatry 2018 01 6;80:57-64. Epub 2017 Sep 6.

Department of Clinical Neurosciences, Villa San Benedetto Menni Hospital, Hermanas Hospitalarias, FoRiPsi, Albese con Cassano, Como, Italy; Research Institute of Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, Netherlands; Department of Psychiatry and Behavioral Sciences, Leonard Miller School of Medicine, University of Miami, Miami, USA.

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http://dx.doi.org/10.1016/j.comppsych.2017.08.006DOI Listing
January 2018

Controversies in Rheumatology and Autoimmunity: Approaching the truth by the discussion.

Autoimmun Rev 2018 01 3;17(1):1-3. Epub 2017 Nov 3.

Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15689972173027
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http://dx.doi.org/10.1016/j.autrev.2017.11.001DOI Listing
January 2018

TNF inhibitors in rheumatoid arthritis and spondyloarthritis: Are they the same?

Autoimmun Rev 2018 Jan 3;17(1):24-28. Epub 2017 Nov 3.

Rheumatology Unit, ASST Fatebenefratelli Sacco, Milan, Italy, Milan, Italy.

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http://dx.doi.org/10.1016/j.autrev.2017.11.005DOI Listing
January 2018

Are the ACR 2010 diagnostic criteria for fibromyalgia better than the 1990 criteria?

Autoimmun Rev 2018 Jan 3;17(1):33-35. Epub 2017 Nov 3.

CREATE Centre, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, UK. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2017.11.007DOI Listing
January 2018

Interstitial lung disease in systemic autoimmune rheumatic diseases: a comprehensive review.

Expert Rev Clin Immunol 2018 01 11;14(1):69-82. Epub 2017 Dec 11.

b Rheumatology Unit, Department of Internal Medicine , ASST-Fatebenefratelli L. Sacco University Hospital , Milan , Italy.

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2018.1
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http://dx.doi.org/10.1080/1744666X.2018.1411190DOI Listing
January 2018

EULAR recommendations for management of fibromyalgia.

Ann Rheum Dis 2017 12 5;76(12):e54. Epub 2017 May 5.

Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211587DOI Listing
December 2017

The influence of fibromyalgia on achieving remission in patients with long-standing rheumatoid arthritis.

Rheumatol Int 2017 Dec 5;37(12):2035-2042. Epub 2017 Sep 5.

Rheumatology Unit, ASST Fatebenefratelli-L. Sacco University Hospital, Milan, Italy.

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http://dx.doi.org/10.1007/s00296-017-3792-4DOI Listing
December 2017

Rheumatic diseases and autoimmune vascular dementia.

Autoimmun Rev 2017 Dec 14;16(12):1265-1269. Epub 2017 Oct 14.

Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.

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http://dx.doi.org/10.1016/j.autrev.2017.10.011DOI Listing
December 2017

An update on emerging drugs for fibromyalgia treatment.

Expert Opin Emerg Drugs 2017 12 19;22(4):357-367. Epub 2017 Dec 19.

b Department of Rheumatology , ASST Fatebenefratelli-Sacco , Milan , Italy.

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http://dx.doi.org/10.1080/14728214.2017.1418323DOI Listing
December 2017

Unresolved and critical issues in autoimmune rheumatic diseases.

Autoimmun Rev 2017 11 12;16(11):1093-1095. Epub 2017 Sep 12.

Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.

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http://dx.doi.org/10.1016/j.autrev.2017.09.001DOI Listing
November 2017

The Immunogenicity of Branded and Biosimilar Infliximab in Rheumatoid Arthritis According to Th9-Related Responses.

Int J Mol Sci 2017 Oct 12;18(10). Epub 2017 Oct 12.

Department of Biomedical and Clinical Sciences, Azienda Ospedaliera-Polo Universitario Luigi Sacco, Milan 20157, Italy.

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http://dx.doi.org/10.3390/ijms18102127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666809PMC
October 2017

Subclinical atherosclerosis and history of cardiovascular events in Italian patients with rheumatoid arthritis: Results from a cross-sectional, multicenter GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study.

Medicine (Baltimore) 2017 Oct;96(42):e8180

aRheumatology Section, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila bClinical Medicine and Rheumatology Department, Campus Bio-Medico University of Rome, Rome cRheumatology Section, Department of Internal Medicine, University of Palermo, Palermo dRheumatology Section, Department of Clinical and Experimental Medicine, Second University of Naples, Naples eRheumatology Section, Department of Medical and Surgical Sciences, University of Foggia Medical School, Foggia fDepartment of Experimental and Clinical Medicine, University of Florence, Florence gRheumatology Section, L. Sacco University Hospital, Milan hSystemic Rheumatic and Autoimmune Diseases Unit, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy.

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http://dx.doi.org/10.1097/MD.0000000000008180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662366PMC
October 2017

International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome and Sjogren's syndrome)?: The unmet needs and the clinical grey zone in autoimmune disease management.

Autoimmun Rev 2017 Sep 11;16(9):911-924. Epub 2017 Jul 11.

Department of Pathophysiology, University of Athens, Athens, Greece.

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http://dx.doi.org/10.1016/j.autrev.2017.07.012DOI Listing
September 2017

Influence of autonomic nervous system dysfunction in the genesis of sleep disorders in fibromyalgia patients.

Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):74-80. Epub 2017 Jun 29.

Rheumatology Unit, ASST-Fatebenefratelli-L. Sacco University Hospital, Milan, Italy.

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August 2017

Current trends in disability claims due to fibromyalgia syndrome.

Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):119-126. Epub 2017 Jun 29.

Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy.

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August 2017

Acute and chronic pain in orthopaedic and rheumatologic diseases: mechanisms and characteristics.

Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):127-131. Epub 2017 Jun 29.

IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.

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August 2017

One year in review 2017: fibromyalgia.

Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):6-12. Epub 2017 Jun 28.

Rheumatology Unit, ASST-Fatebenefratelli-L. Sacco University Hospital, Milan, Italy.

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August 2017

Childhood adversities in patients with fibromyalgia: are they related to comorbid lifetime major depression?

Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):112-118. Epub 2017 Jun 29.

Clinical Neurosciences, Villa S.Benedetto Menni, Hermanas Hospitalarias, Como, Italy; Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Univ. of Maastricht, Netherland; and Psychiatry & Behavioral Sciences, Univ.of Miami, USA.

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August 2017

Earthquake vulnerability of fibromyalgia patients: six-month follow-up after the catastrophic disasters in central Italy.

Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):93-99. Epub 2017 Jun 29.

Rheumatology Unit, ASST-Fatebenefratelli- L. Sacco University Hospital, Milan, Italy.

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August 2017

From Old to New Cardiovascular Complications in Ankylosing Spondylitis.

Isr Med Assoc J 2017 Aug;19(8):506-509

Cardiology Unit, IRCCS Galeazzi Orthopedic Institute, Milan, Italy.

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August 2017

Biomarkers in Rheumatoid Arthritis.

Isr Med Assoc J 2017 Aug;19(8):512-516

Rheumatology Unit, Sacco University Hospital, Milan, Italy.

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August 2017

Infections in rheumatoid arthritis.

Curr Opin Rheumatol 2017 07;29(4):323-330

aIRCCS Galeazzi Orthopedic Institute, Milan bOrthopedic and Trauma Unit, Santissima Trinità Hospital, Cagliari cRheumatology Unit, Department of Internal Medicine and Medical Specialities, La Sapienza University of Rome, Rome dRheumatology Unit, L. Sacco University Hospital, Milan, Italy.

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http://dx.doi.org/10.1097/BOR.0000000000000389DOI Listing
July 2017

The Role of Hyperbaric Oxygen Therapy in Orthopedics and Rheumatological Diseases.

Isr Med Assoc J 2017 Jul;19(7):429-434

IRCCS Galeazzi Orthopedic Institute, Milan, Italy.

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July 2017

Can speckle tracking echocardiography detect subclinical left ventricular dysfunction in patients with primary Sjögren's syndrome?

Clin Exp Rheumatol 2017 Jan-Feb;35(1):173. Epub 2016 Oct 3.

Cardiology Unit, Department of Biomedical Sciences for Health, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.

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June 2017

What are the dangers of biological therapy discontinuation or dose reduction strategies when treating rheumatoid arthritis?

Expert Rev Clin Pharmacol 2016 Nov 20;9(11):1403-1411. Epub 2016 Oct 20.

c Rheumatology Unit , S. Anna Hospital University of Ferrara , Ferrara , Italy.

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http://dx.doi.org/10.1080/17512433.2016.1234374DOI Listing
November 2016

The safety of pregabalin in the treatment of fibromyalgia.

Expert Opin Drug Saf 2016 11;15(11):1541-1548. Epub 2016 Oct 11.

a Rheumatology Unit, ASST-Fatebenefratelli-L , Sacco University Hospital , Milan , Italy.

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http://dx.doi.org/10.1080/14740338.2016.1242575DOI Listing
October 2016

Is panic disorder associated with clinical severity of fibromyalgia? A preliminary study in a tertiary-care centre.

Clin Exp Rheumatol 2016 Mar-Apr;34(2 Suppl 96):S99-105. Epub 2016 Apr 22.

Clinical Neurosciences, Villa S.Benedetto Menni, Hermanas Hospitalarias, Como, Italy; Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Univ. of Maastricht, Netherland; and Psychiatry & Behavioral Sciences, Univ.of Miami, USA.

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July 2016

Impaired lung transfer factor in fibromyalgia syndrome.

Clin Exp Rheumatol 2016 Mar-Apr;34(2 Suppl 96):S114-9. Epub 2016 Apr 22.

Rheumatology Unit, University Hospital L. Sacco, Milan, Italy.

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July 2016

Abnormal resting state functional connectivity of the periaqueductal grey in patients with fibromyalgia.

Clin Exp Rheumatol 2016 Mar-Apr;34(2 Suppl 96):S129-33. Epub 2016 Apr 20.

Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.

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July 2016

One year in review 2016: fibromyalgia.

Clin Exp Rheumatol 2016 Mar-Apr;34(2 Suppl 96):S145-9. Epub 2016 Apr 22.

Rheumatology Unit, L. Sacco University Hospital of Milan, Italy.

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July 2016

Reactivation of occult hepatitis B virus infection under treatment with abatacept: a case report.

BMC Pharmacol Toxicol 2016 Apr 21;17:17. Epub 2016 Apr 21.

Rheumatology Unit, University Hospital "Luigi Sacco", Via GB Grassi 74, 20157, Milan, Italy.

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http://dx.doi.org/10.1186/s40360-016-0060-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839135PMC
April 2016