Pier Paolo Pandolfi

Pier Paolo Pandolfi

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Pier Paolo Pandolfi

Publications by authors named "Pier Paolo Pandolfi"

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Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival.

Theranostics 2018 30;8(16):4359-4371. Epub 2018 Jul 30.

State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.7150/thno.26900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134928PMC
September 2019

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.

Cancer Discov 2019 Sep 19;9(9):1306-1323. Epub 2019 Jun 19.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726527PMC
September 2019

PTEN Mouse Models of Cancer Initiation and Progression.

Cold Spring Harb Perspect Med 2019 Sep 30. Epub 2019 Sep 30.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1101/cshperspect.a037283DOI Listing
September 2019

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis.

Nat Commun 2019 Aug 16;10(1):3716. Epub 2019 Aug 16.

Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.

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http://dx.doi.org/10.1038/s41467-019-11618-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697746PMC
August 2019

Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy.

Cell Res 2019 Jun 25;29(6):446-459. Epub 2019 Apr 25.

Cancer Research Institute, Beth Israel Deaconess Cancer Center; Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41422-019-0162-7
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http://dx.doi.org/10.1038/s41422-019-0162-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796925PMC
June 2019

The PTEN⁻PI3K Axis in Cancer.

Biomolecules 2019 04 17;9(4). Epub 2019 Apr 17.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, MA 02215, USA.

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https://www.mdpi.com/2218-273X/9/4/153
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http://dx.doi.org/10.3390/biom9040153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523724PMC
April 2019

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.

Nat Cell Biol 2019 02 28;21(2):226-237. Epub 2019 Jan 28.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-018-0261-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377565PMC
February 2019

Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.

J Clin Invest 2019 01 26;129(1):215-222. Epub 2018 Nov 26.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI99699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307955PMC
January 2019

The functions and regulation of the PTEN tumour suppressor: new modes and prospects.

Nat Rev Mol Cell Biol 2018 09;19(9):547-562

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41580-018-0015-0DOI Listing
September 2018

The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care.

Front Oncol 2018 28;8:340. Epub 2018 Aug 28.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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https://www.frontiersin.org/article/10.3389/fonc.2018.00340/
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http://dx.doi.org/10.3389/fonc.2018.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122291PMC
August 2018

ZBTB7A governs estrogen receptor alpha expression in breast cancer.

J Mol Cell Biol 2018 08;10(4):273-284

Department of Environmental Health, John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1093/jmcb/mjy020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161408PMC
August 2018

Preclinical and Coclinical Studies in Prostate Cancer.

Cold Spring Harb Perspect Med 2018 04 2;8(4). Epub 2018 Apr 2.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a030544DOI Listing
April 2018

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.

Cell 2018 04;173(3):649-664.e20

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061940PMC
April 2018

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth.

Sci Signal 2018 03 27;11(523). Epub 2018 Mar 27.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aao1052DOI Listing
March 2018

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.

Nat Med 2018 02 8;24(2):165-175. Epub 2018 Jan 8.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4463DOI Listing
February 2018

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.

Nat Commun 2018 01 4;9(1):66. Epub 2018 Jan 4.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://www.nature.com/articles/s41467-017-02427-x
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http://dx.doi.org/10.1038/s41467-017-02427-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754357PMC
January 2018

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.

Nat Commun 2018 01 15;9(1):159. Epub 2018 Jan 15.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41467-017-02272-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768788PMC
January 2018

A circular twist on microRNA regulation.

Cell Res 2017 12 31;27(12):1401-1402. Epub 2017 Oct 31.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/cr.2017.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717405PMC
December 2017

Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure.

Cancer Cell 2017 11;32(5):552-560

Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.

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http://dx.doi.org/10.1016/j.ccell.2017.10.002DOI Listing
November 2017

Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach.

Sci Rep 2017 08 10;7(1):7755. Epub 2017 Aug 10.

Department of Physics, University of Massachusetts Boston, Boston, MA, 02125, USA.

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http://dx.doi.org/10.1038/s41598-017-08209-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552881PMC
August 2017

SPAR, a lncRNA encoded mTORC1 inhibitor.

Cell Cycle 2017 05 20;16(9):815-816. Epub 2017 Mar 20.

a Cancer Research Institute, Beth Israel Deaconess Cancer Center , Department of Medicine and Pathology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15384101.2017.1304735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444354PMC
May 2017

The Epitranscriptome of Noncoding RNAs in Cancer.

Cancer Discov 2017 04 20;7(4):359-368. Epub 2017 Mar 20.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-1292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997407PMC
April 2017

Regulation of NF-κB by PML and PML-RARα.

Sci Rep 2017 03 20;7:44539. Epub 2017 Mar 20.

Centre for Immunobiology, Institute of Infection, Immunity &Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1038/srep44539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357907PMC
March 2017

MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer.

Carcinogenesis 2017 01 17;38(1):64-75. Epub 2016 Oct 17.

Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, via G. Campi 287, 41100 Modena, Italy.

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http://dx.doi.org/10.1093/carcin/bgw110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276925PMC
January 2017

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Nature 2017 01 26;541(7636):228-232. Epub 2016 Dec 26.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.nature.com/articles/nature21034
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http://dx.doi.org/10.1038/nature21034DOI Listing
January 2017

Posttranscriptional Regulation of PTEN by Competing Endogenous RNAs.

Methods Mol Biol 2016 ;1388:139-54

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/978-1-4939-3299-3_10DOI Listing
December 2016

Modeling Cancer-Associated Mutations of PTEN in Mice.

Methods Mol Biol 2016 ;1388:289-306

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/978-1-4939-3299-3_16DOI Listing
December 2016

The pleiotropic role of non-coding genes in development and cancer.

Curr Opin Cell Biol 2016 12 16;43:104-113. Epub 2016 Nov 16.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010204PMC
December 2016

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.

Cell Rep 2016 12;17(10):2776-2788

Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, QC H2W 1R7, Canada; Department of Medicine, University of Montréal, Montréal, QC H3C 3J7, Canada; Department of Medicine, McGill University, Montréal, QC H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656005PMC
December 2016

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.

Cell Rep 2016 08 18;16(9):2415-27. Epub 2016 Aug 18.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA Center, University of Ferrara, Ferrara 44121, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011426PMC
August 2016

Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.

Thromb Haemost 2016 05 21;115(5):969-78. Epub 2016 Jan 21.

Steven R. Lentz, MD, PhD, Department of Internal Medicine, University of Iowa, C21 GH, 200 Hawkins Drive, Iowa City, IA 52242, USA, Tel.: +1 319 356 4048, Fax: +1 319 353 8383, E-mail:

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http://dx.doi.org/10.1160/TH15-05-0373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854776PMC
May 2016

Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells.

J Immunol 2016 05 18;196(10):4110-21. Epub 2016 Apr 18.

INSERM, U1068, Centre de Recherche en Cancérologie de Marseille, 13009 Marseille, France; Institut Paoli-Calmettes, 13009 Marseille, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7258, Centre de Recherche en Cancérologie de Marseille, 13009 Marseille, France; Université d'Aix-Marseille, UM105, 13009 Marseille, France;

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http://dx.doi.org/10.4049/jimmunol.1501037DOI Listing
May 2016

The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis.

Int J Biol Sci 2015 11;11(6):629-32. Epub 2015 Apr 11.

1. Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.7150/ijbs.11615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440252PMC
April 2016

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations.

Cell 2016 Apr 31;165(2):289-302. Epub 2016 Mar 31.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30276-8.pdf
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http://www.cell.com/cms/attachment/2052247247/2059675509/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741630276
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http://dx.doi.org/10.1016/j.cell.2016.03.020DOI Listing
April 2016

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Mol Cell 2016 Apr;62(1):34-46

Howard Hughes Medical Institute, Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836061PMC
April 2016

Endosome and INPP4B.

Oncotarget 2016 Jan;7(1):5-6

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.6663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807978PMC
January 2016

BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation.

Cell Cycle 2015 ;14(7):973-9

a Department of Clinical and Biological Sciences; San Luigi Hospital ; Orbassano - Turin University ; Turin , Italy.

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http://dx.doi.org/10.1080/15384101.2015.1006970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615112PMC
December 2015

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.

Cell 2015 Dec 19;163(6):1400-12. Epub 2015 Nov 19.

Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Howard Hughes Medical Institute and David H. Koch Institute of Integrative Cancer Biology, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671824PMC
December 2015

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Oncotarget 2015 Dec;6(40):42445-67

Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.6442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767444PMC
December 2015

The PTEN Tumor Suppressor Forms Homodimers in Solution.

Structure 2015 Oct 20;23(10):1952-1957. Epub 2015 Aug 20.

Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598300PMC
October 2015

Pseudogenes in Human Cancer.

Front Med (Lausanne) 2015 25;2:68. Epub 2015 Sep 25.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA , USA.

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http://dx.doi.org/10.3389/fmed.2015.00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585173PMC
October 2015

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

Nat Commun 2015 Oct 8;6:8325. Epub 2015 Oct 8.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.nature.com/articles/ncomms9325
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http://dx.doi.org/10.1038/ncomms9325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633636PMC
October 2015

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

Mol Cell 2015 Sep 3;59(6):917-30. Epub 2015 Sep 3.

Department of Pathology, Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575912PMC
September 2015

Mouse hospital and co-clinical trial project--from bench to bedside.

Nat Rev Clin Oncol 2015 Aug 21;12(8):491-8. Epub 2015 Apr 21.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/nrclinonc.2015.62DOI Listing
August 2015

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.

Mol Cancer Res 2015 Aug 20;13(8):1206-17. Epub 2015 May 20.

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543565PMC
August 2015

Establishment of a humanized APL model via the transplantation of PML-RARA-transduced human common myeloid progenitors into immunodeficient mice.

PLoS One 2014 4;9(11):e111082. Epub 2014 Nov 4.

Research Center for Cancer Stem Cell, Tokai University School of Medicine, Isehara, Kanagawa, Japan; Medical Research Institute, Tokai University, Isehara, Kanagawa, Japan; Division of Hematology and Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111082PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219701PMC
July 2015

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.

Cancer Discov 2015 Jul 16;5(7):740-51. Epub 2015 Apr 16.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497843PMC
July 2015

Causality and Chance in the Development of Cancer.

N Engl J Med 2015 Jul;373(1):84-8

From the Istituto Toscano Tumori and University of Firenze, Florence, Italy (L.L.); and the Cancer Research Institute and Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston (P.P.P.).

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http://www.nejm.org/doi/10.1056/NEJMsb1502456
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http://dx.doi.org/10.1056/NEJMsb1502456DOI Listing
July 2015

PTEN ceRNA networks in human cancer.

Methods 2015 May 30;77-78:41-50. Epub 2015 Jan 30.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.01.013DOI Listing
May 2015

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.

Nat Med 2015 May 13;21(5):457-66. Epub 2015 Apr 13.

1] Division of Translational Therapeutics, Department of Medicine, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Medicine, BIDMC, Harvard Medical School, Boston, Massachusetts, USA.. [3] Cancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425616PMC
May 2015

Loss of Wave1 gene defines a subtype of lethal prostate cancer.

Oncotarget 2015 May;6(14):12383-91

Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

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http://www.oncotarget.com/fulltext/3564
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494945PMC
http://dx.doi.org/10.18632/oncotarget.3564DOI Listing
May 2015

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.

Cancer Discov 2015 Apr 22;5(4):396-409. Epub 2015 Jan 22.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418175PMC
April 2015

Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling.

EMBO Rep 2015 Apr 19;16(4):467-80. Epub 2015 Feb 19.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.15252/embr.201439379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388613PMC
April 2015

The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.

Cell 2015 Apr 2;161(2):319-32. Epub 2015 Apr 2.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.02.043DOI Listing
April 2015

PTEN is a negative regulator of NK cell cytolytic function.

J Immunol 2015 Feb 16;194(4):1832-40. Epub 2015 Jan 16.

Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210; The Comprehensive Cancer Center and Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210; Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210; and Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210.

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http://dx.doi.org/10.4049/jimmunol.1401224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319309PMC
February 2015

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner.

Proc Natl Acad Sci U S A 2015 Feb 26;112(6):1779-84. Epub 2015 Jan 26.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara 44121, Italy;

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http://dx.doi.org/10.1073/pnas.1410723112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330769PMC
February 2015

Pseudogenes as competitive endogenous RNAs: target prediction and validation.

Methods Mol Biol 2014 ;1167:199-212

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS-401, Boston, MA, 02215, USA.

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http://link.springer.com/10.1007/978-1-4939-0835-6_13
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http://dx.doi.org/10.1007/978-1-4939-0835-6_13DOI Listing
January 2015

A co-clinical platform to accelerate cancer treatment optimization.

Trends Mol Med 2015 Jan 17;21(1):1-5. Epub 2014 Nov 17.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2014.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005181PMC
January 2015

Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity.

Blood 2015 Jan 4;125(5):852-5. Epub 2014 Dec 4.

Department of Surgery and Center for Transplantation Sciences, Massachusetts General Hospital.

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http://dx.doi.org/10.1182/blood-2014-04-571372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729535PMC
January 2015

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling.

Oncotarget 2015 Jan;6(3):1435-45

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy.

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http://www.oncotarget.com/fulltext/2935
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359305PMC
http://dx.doi.org/10.18632/oncotarget.2935DOI Listing
January 2015

Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.

Cell Rep 2014 Oct 25;9(1):75-89. Epub 2014 Sep 25.

Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland (IOSI), Bellinzona 6500, Switzerland; Faculty of Biology and Medicine, University of Lausanne, UNIL, Rue du Bugnon 21, Lausanne 1011, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.044DOI Listing
October 2014

Dok1 and Dok2 proteins regulate natural killer cell development and function.

EMBO J 2014 Sep 24;33(17):1928-40. Epub 2014 Jun 24.

INSERM U1068 Centre de Recherche en Cancérologie de Marseille, Marseille, France Institut Paoli-Calmettes, Marseille, France CNRS UMR7258 Centre de Recherche en Cancérologie de Marseille, Marseille, France Aix-Marseille Université, Marseille, France

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http://emboj.embopress.org/lookup/doi/10.15252/embj.20138740
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http://dx.doi.org/10.15252/embj.201387404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195787PMC
September 2014

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

Cancer Discov 2014 Aug 27;4(8):896-904. Epub 2014 May 27.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School; Department of Medicine; Divisions of

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http://dx.doi.org/10.1158/2159-8290.CD-13-0230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125493PMC
August 2014

Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment.

J Natl Cancer Inst 2014 Aug 25;106(8). Epub 2014 Jul 25.

Department of Pathology, Massachusetts General Hospital (PMS) and Department of Medicine, Brigham and Women's Hospital (CP, EPH), Harvard Medical School, Boston, MA; Unit of Endocrinology, Department of Medicine, A. Gemelli, Catholic University, Roma, Italy (SN, AP); Division of Cancer Genetics, Department of Medicine (FAK, JC, PPP) and Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Department of Pathology, Center for Vascular Biology Research (MD, CN), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine (RM, CVC) and Department of Pathology (AH, HD, JL), Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA; Dermatopathologische Gemeinschaftspraxis, Siemensstrasse, Friedri chshafen, Germany (HK, TM); National Research Council (CNR-IBCN) and Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy (AF); Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (EP, LEM); MIT/Broad Institute, Cambridge, MA (EP, LEM); Department of Plastic and Reconstructive Surgery, National Health Insurance Service Ilsan Hospital, Ilsan, Korea (SC); Department of Pathology (GF) and Department of Surgery (CPL), A. Gemelli, Catholic University, Roma, Italy; Department of Experimental and Clinical Medicine (AMDA) and Unit of Radiotherapy (OD), University of Catanzaro, Italy; Department of Nuclear Medicine, Beth Israel Deaconess Medical Center (JAP); Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (CF).

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http://dx.doi.org/10.1093/jnci/dju182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155429PMC
August 2014

Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus.

Cell Rep 2014 Aug 31;8(3):714-22. Epub 2014 Jul 31.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128194PMC
August 2014

MicroRNAs in the pathogenesis of myelodysplastic syndromes and myeloid leukaemia.

Curr Opin Hematol 2014 Jul;21(4):276-82

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113208PMC
July 2014

Bone marrow endosteal mesenchymal progenitors depend on HIF factors for maintenance and regulation of hematopoiesis.

Stem Cell Reports 2014 Jun 15;2(6):794-809. Epub 2014 May 15.

Division of Molecular Oncology, Leukemia Unit, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1016/j.stemcr.2014.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050345PMC
June 2014

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

Cell Metab 2014 May 10;19(5):795-809. Epub 2014 Apr 10.

Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096909PMC
May 2014

Tumor microenvironment revisited.

EMBO Rep 2014 May 14;15(5):458-9. Epub 2014 Apr 14.

Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/embr.201438794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210104PMC
May 2014

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.

Cell 2014 Apr;157(3):595-610

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098792PMC
April 2014