Publications by authors named "Pier Giuseppe Pelicci"

100Publications

The endless frontier? The recent increase of R&D productivity in pharmaceuticals.

J Transl Med 2020 04 9;18(1):162. Epub 2020 Apr 9.

Center for Analysis, Decisions and Society, Human Technopole, Via C. Belgioioso, 20157, Milano, Italy.

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http://dx.doi.org/10.1186/s12967-020-02313-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147016PMC
April 2020

The genomic landscape of 8-oxodG reveals enrichment at specific inherently fragile promoters.

Nucleic Acids Res 2020 05;48(8):4309-4324

Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', Naples, Italy.

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http://dx.doi.org/10.1093/nar/gkaa175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192600PMC
May 2020

On the epigenetic role of guanosine oxidation.

Redox Biol 2020 01 6;29:101398. Epub 2019 Dec 6.

Department of Experimental Oncology, European Institute of Oncology-IRCCS, Via Adamello 16, 20139, Milano, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1016/j.redox.2019.101398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926346PMC
January 2020

Quantification of Self-renewal in Murine Mammosphere Cultures.

J Vis Exp 2019 11 26(153). Epub 2019 Nov 26.

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS; Department of Oncology and Hemato-Oncology, University of Milan;

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http://dx.doi.org/10.3791/60256DOI Listing
November 2019

Cerebro: interactive visualization of scRNA-seq data.

Bioinformatics 2020 04;36(7):2311-2313

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20139 Milan.

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http://dx.doi.org/10.1093/bioinformatics/btz877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141853PMC
April 2020

Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells.

PLoS One 2019 19;14(9):e0217345. Epub 2019 Sep 19.

Department of Experimental Oncology at the IEO, European Institute of Oncology IRCCS, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217345PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752751PMC
March 2020

Emerging roles of HECT-type E3 ubiquitin ligases in autophagy regulation.

Mol Oncol 2019 10 5;13(10):2033-2048. Epub 2019 Sep 5.

Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", Italy.

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http://dx.doi.org/10.1002/1878-0261.12567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763782PMC
October 2019

Tumor mutational burden quantification from targeted gene panels: major advancements and challenges.

J Immunother Cancer 2019 07 15;7(1):183. Epub 2019 Jul 15.

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Via Adamello 16, 20139, Milan, Italy.

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https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0
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http://dx.doi.org/10.1186/s40425-019-0647-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631597PMC
July 2019

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Cancer Cell 2019 05 25;35(5):798-815.e5. Epub 2019 Apr 25.

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, 20139 Milan, Italy; Department of Biosciences, University of Milan, 20100 Milan, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193015
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http://dx.doi.org/10.1016/j.ccell.2019.03.007DOI Listing
May 2019

Modeling cell proliferation in human acute myeloid leukemia xenografts.

Bioinformatics 2019 09;35(18):3378-3386

Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milan, Italy.

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http://dx.doi.org/10.1093/bioinformatics/btz063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748761PMC
September 2019

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value.

Cell Rep 2019 01;26(3):624-638.e8

IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Via Santa Sofia 9, 20142 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334229PMC
January 2019

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology.

Clin Epigenetics 2018 11 16;10(1):143. Epub 2018 Nov 16.

Department of Biomolecular Sciences, Molecular Pathology Laboratory "PaoLa", University of Urbino "Carlo Bo", Via Arco d'Augusto 2, 61032, Fano, PU, Italy.

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-018-0576-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240272PMC
November 2018

Glucose and Lactate Miniaturized Biosensors for SECM-Based High-Spatial Resolution Analysis: A Comparative Study.

ACS Sens 2017 Sep 24;2(9):1310-1318. Epub 2017 Aug 24.

Chemistry Department "Giacomo Ciamician", University of Bologna , Via Selmi 2, 40126 Bologna, Italy.

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http://dx.doi.org/10.1021/acssensors.7b00324DOI Listing
September 2017

Molecular mechanisms of asymmetric divisions in mammary stem cells.

EMBO Rep 2016 12 21;17(12):1700-1720. Epub 2016 Nov 21.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

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http://dx.doi.org/10.15252/embr.201643021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283594PMC
December 2016

P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.

Aging Cell 2016 06 10;15(3):446-54. Epub 2016 Mar 10.

Experimental Oncology Department, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy.

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http://dx.doi.org/10.1111/acel.12448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854904PMC
June 2016

Peak shape clustering reveals biological insights.

BMC Bioinformatics 2015 Oct 28;16:349. Epub 2015 Oct 28.

Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Milan, Italy.

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http://dx.doi.org/10.1186/s12859-015-0787-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625869PMC
October 2015

Maintaining epithelial stemness with p63.

Sci Signal 2015 Jul 28;8(387):re9. Epub 2015 Jul 28.

Biochemistry Laboratory, Istituto Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), c/o Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata," 00133 Rome, Italy. Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

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http://dx.doi.org/10.1126/scisignal.aaa1033DOI Listing
July 2015

Calcite Single Crystals as Hosts for Atomic-Scale Entrapment and Slow Release of Drugs.

Adv Healthc Mater 2015 Jul 1;4(10):1510-6. Epub 2015 Jun 1.

Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.

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http://dx.doi.org/10.1002/adhm.201500170DOI Listing
July 2015

p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling.

Proc Natl Acad Sci U S A 2015 Mar 4;112(11):3499-504. Epub 2015 Mar 4.

Biochemistry Laboratory, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata," 00133 Rome, Italy; Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy;

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http://dx.doi.org/10.1073/pnas.1500762112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372004PMC
March 2015

DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.

Genome Med 2014 10;6(6):44. Epub 2014 Jun 10.

Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia, 20139 Milan, Italy.

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http://dx.doi.org/10.1186/gm563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085541PMC
February 2015

The Combination of the PARP Inhibitor Rucaparib and 5FU Is an Effective Strategy for Treating Acute Leukemias.

Mol Cancer Ther 2015 Apr 9;14(4):889-98. Epub 2015 Feb 9.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0276DOI Listing
April 2015

The genomic and epigenomic landscapes of AML.

Semin Hematol 2014 Oct 26;51(4):259-72. Epub 2014 Aug 26.

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2014.08.007DOI Listing
October 2014

PAT-ChIP coupled with laser microdissection allows the study of chromatin in selected cell populations from paraffin-embedded patient samples.

Epigenetics Chromatin 2014 5;7:18. Epub 2014 Aug 5.

Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Molecular Pathology Lab. 'PaoLa', Via Arco d'Augusto, 2, Fano 61032, Italy.

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http://dx.doi.org/10.1186/1756-8935-7-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124777PMC
August 2014

An intrabody specific for the nucleophosmin carboxy-terminal mutant and fused to a nuclear localization sequence binds its antigen but fails to relocate it in the nucleus.

Biotechnol Rep (Amst) 2014 Sep 27;3:27-33. Epub 2014 May 27.

Department of Biomedical Sciences and Engineering, University of Nova Gorica, Glavni Trg 9, SI-5261 Vipava, Slovenia.

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http://dx.doi.org/10.1016/j.btre.2014.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466097PMC
September 2014

Next-generation sequencing and DNA replication in human cells: the future has arrived.

Future Oncol 2014 Mar;10(4):683-93

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

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http://dx.doi.org/10.2217/fon.13.182DOI Listing
March 2014

DNA damage response in adult stem cells.

Blood Cells Mol Dis 2014 Apr 28;52(4):147-51. Epub 2014 Jan 28.

Department of Experimental Oncology, European Institute of Oncology, IEO, 20141 Milan, Italy; Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, 20122 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2013.12.005DOI Listing
April 2014

A non-redundant function of cyclin E1 in hematopoietic stem cells.

Cell Cycle 2013 Dec 25;12(23):3663-72. Epub 2013 Sep 25.

Center for Genomic Science of IIT@SEMM; Istituto Italiano di Tecnologia (IIT); Milan, Italy.

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http://dx.doi.org/10.4161/cc.26584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903717PMC
December 2013

p66Shc regulates vesicle-mediated secretion in mast cells by affecting F-actin dynamics.

J Leukoc Biol 2014 Feb 27;95(2):285-92. Epub 2013 Sep 27.

1.University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1189/jlb.0313178DOI Listing
February 2014

Maspin expression and melanoma progression: a matter of sub-cellular localization.

Mod Pathol 2014 Mar 13;27(3):412-9. Epub 2013 Sep 13.

Medical Oncology of Melanoma Unit, Division of Medical Oncology, European Institute of Oncology, Milan, Italy.

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http://dx.doi.org/10.1038/modpathol.2013.157DOI Listing
March 2014

Obesity increases the incidence of distant metastases in oestrogen receptor-negative human epidermal growth factor receptor 2-positive breast cancer patients.

Eur J Cancer 2013 Nov 15;49(17):3588-97. Epub 2013 Aug 15.

Division of Medical Oncology, Istituto Europeo di Oncologia, Milan, Italy; Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.07.016DOI Listing
November 2013

Sequence-specific double strand breaks trigger P-TEFb-dependent Rpb1-CTD hyperphosphorylation.

Mutat Res 2013 Sep 29;749(1-2):21-7. Epub 2013 Jul 29.

Department of Biology, University of Naples 'Federico II', Naples, Italy.

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http://dx.doi.org/10.1016/j.mrfmmm.2013.07.005DOI Listing
September 2013

Is PML a Tumor Suppressor?

Front Oncol 2013 9;3:174. Epub 2013 Jul 9.

Department of Experimental Oncology, European Institute of Oncology , Milan , Italy.

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http://dx.doi.org/10.3389/fonc.2013.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705425PMC
July 2013

The other face of ROS: a driver of stem cell expansion in colorectal cancer.

Cell Stem Cell 2013 Jun;12(6):635-6

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S19345909130021
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http://dx.doi.org/10.1016/j.stem.2013.05.023DOI Listing
June 2013

A computational platform for robotized fluorescence microscopy (I): high-content image-based cell-cycle analysis.

Cytometry A 2013 Apr 5;83(4):333-43. Epub 2013 Mar 5.

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus for Oncogenomics, Milano 20139, Italy.

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http://dx.doi.org/10.1002/cyto.a.22266DOI Listing
April 2013

A computational platform for robotized fluorescence microscopy (II): DNA damage, replication, checkpoint activation, and cell cycle progression by high-content high-resolution multiparameter image-cytometry.

Cytometry A 2013 Apr 5;83(4):344-55. Epub 2013 Mar 5.

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus for Oncogenomics, Milan 20139, Italy.

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http://dx.doi.org/10.1002/cyto.a.22265DOI Listing
April 2013

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Blood 2013 Apr 25;121(17):3459-68. Epub 2013 Feb 25.

Department of Experimental Oncology at the IFOM-IEO Campus, European Institute of Oncology, via Adamello 16, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2012-10-461988DOI Listing
April 2013

DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions.

Proc Natl Acad Sci U S A 2013 Mar 15;110(10):3931-6. Epub 2013 Feb 15.

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

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http://dx.doi.org/10.1073/pnas.1213394110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593901PMC
March 2013

Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene.

Aging Cell 2013 Apr 10;12(2):177-83. Epub 2013 Jan 10.

Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, Milan, 20139, Italy.

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http://dx.doi.org/10.1111/acel.12036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141878PMC
April 2013

Sustained hippocampal neurogenesis in females is amplified in P66(Shc-/-) mice: An animal model of healthy aging.

Hippocampus 2012 Dec 18;22(12):2249-59. Epub 2012 Jun 18.

Section of Behavioral Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1002/hipo.22042DOI Listing
December 2012

Genomics of acute myeloid leukemia: the next generation.

Front Oncol 2012 1;2:40. Epub 2012 May 1.

Department of Experimental Oncology, European Institute of Oncology Milan, Italy.

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http://dx.doi.org/10.3389/fonc.2012.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364462PMC
August 2012

TRIM proteins in cancer.

Adv Exp Med Biol 2012 ;770:77-91

Department of Experimental Oncology, European Institute of Oncology, IEO, Milan, Italy.

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http://dx.doi.org/10.1007/978-1-4614-5398-7_6DOI Listing
June 2013

Electrochemical study of hydrogen peroxide formation in isolated mitochondria.

Bioelectrochemistry 2012 Jun 3;85:21-8. Epub 2011 Dec 3.

Experimental Oncology Dept. European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1016/j.bioelechem.2011.11.005DOI Listing
June 2012

The emerging role of p53 in stem cells.

Trends Mol Med 2012 Jan 7;18(1):6-12. Epub 2011 Sep 7.

Istituto Europeo di Oncologia (IEO), Department of Experimental Oncology at the IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1016/j.molmed.2011.08.002DOI Listing
January 2012

Inhibition of epithelial-to-mesenchimal transition: a novel tumor suppressor function of p53?

Cell Cycle 2011 Aug 15;10(16):2616-7. Epub 2011 Aug 15.

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http://dx.doi.org/10.4161/cc.10.16.16543DOI Listing
August 2011