Publications by authors named "Phillip K Darcy"

100Publications

Chimeric antigen receptor T cell therapies for thoracic cancers-challenges and opportunities.

J Thorac Dis 2020 Aug;12(8):4510-4515

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.21037/jtd.2020.03.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475559PMC
August 2020

Tissue-specific tumour microenvironments are an emerging determinant of immunotherapy responses.

J Thorac Dis 2020 Aug;12(8):4504-4509

Cancer Immunology Program, Peter MacCallum Cancer Center, Melbourne, VIC, Australia.

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http://dx.doi.org/10.21037/jtd.2020.03.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475570PMC
August 2020

Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer.

Curr Opin Pharmacol 2020 Aug 24;53:91-97. Epub 2020 Aug 24.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2020.07.002DOI Listing
August 2020

IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors.

Mol Ther 2020 Nov 21;28(11):2379-2393. Epub 2020 Jul 21.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2020.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647667PMC
November 2020

A New Safety Approach Allowing Reversible Control of CAR T Cell Responses.

Mol Ther 2020 07 18;28(7):1563-1566. Epub 2020 Jun 18.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Pathology, The University of Melbourne, Parkville, VIC, Australia; Department of Immunology, Monash University, Clayton, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2020.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335754PMC
July 2020

p38 Kinase: A Key Target for Driving Potent T Cells for Adoptive Immunotherapy.

Cancer Cell 2020 06;37(6):756-758

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Pathology, University of Melbourne, Parkville, VIC, Australia; Department of Immunology, Monash University, Clayton, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.05.012DOI Listing
June 2020

Cross-talk between tumors at anatomically distinct sites.

FEBS J 2020 Apr 4. Epub 2020 Apr 4.

Cancer Immunology Program, Peter MacCallum Cancer Center, Melbourne, Australia.

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http://dx.doi.org/10.1111/febs.15316DOI Listing
April 2020

Enterotoxins can support CAR T cells against solid tumors.

Proc Natl Acad Sci U S A 2019 12 25;116(50):25229-25235. Epub 2019 Nov 25.

Cancer Immunology Program, Peter MacCallum Cancer Center, Melbourne, VIC 3000, Australia;

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http://dx.doi.org/10.1073/pnas.1904618116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911243PMC
December 2019

CAR T cells take centre stage.

Clin Transl Immunology 2019 25;8(7):e01068. Epub 2019 Jul 25.

Cancer Immunology Program Peter MacCallum Cancer Centre East Melbourne VIC Australia.

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http://dx.doi.org/10.1002/cti2.1068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656936PMC
July 2019

Supercharging adoptive T cell therapy to overcome solid tumor-induced immunosuppression.

Sci Transl Med 2019 06;11(495)

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

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http://dx.doi.org/10.1126/scitranslmed.aaw2293DOI Listing
June 2019

Antagonism of IAPs Enhances CAR T-cell Efficacy.

Cancer Immunol Res 2019 02 16;7(2):183-192. Epub 2019 Jan 16.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0428DOI Listing
February 2019

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy.

Int J Mol Sci 2018 Dec 2;19(12). Epub 2018 Dec 2.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3000, Australia.

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http://dx.doi.org/10.3390/ijms19123837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321150PMC
December 2018

CARs versus BiTEs: A Comparison between T Cell-Redirection Strategies for Cancer Treatment.

Cancer Discov 2018 08 16;8(8):924-934. Epub 2018 Jul 16.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0297DOI Listing
August 2018

Natural killer cells and their therapeutic role in pancreatic cancer: A systematic review.

Pharmacol Ther 2018 09 13;189:31-44. Epub 2018 Apr 13.

Center for Oncological Research, University of Antwerp, Antwerp, Belgium; Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S01637258183006
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http://dx.doi.org/10.1016/j.pharmthera.2018.04.003DOI Listing
September 2018

Tissue-Dependent Tumor Microenvironments and Their Impact on Immunotherapy Responses.

Front Immunol 2018 31;9:70. Epub 2018 Jan 31.

Cancer Immunology Program, Peter MacCallum Cancer Center, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3389/fimmu.2018.00070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797771PMC
February 2019

Neoadjuvant Interferons: Critical for Effective PD-1-Based Immunotherapy in TNBC.

Cancer Immunol Res 2017 10 28;5(10):871-884. Epub 2017 Aug 28.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0150DOI Listing
October 2017

A Novel Target Antigen for the Treatment of Acute Myeloid Leukemia by CAR T Cells.

Mol Ther 2017 09 14;25(9):1997-1998. Epub 2017 Jul 14.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Immunology, Monash University, Clayton, VIC 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589151PMC
September 2017

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape.

Eur J Cancer 2017 08 15;81:116-129. Epub 2017 Jun 15.

Research Branch, Sidra Medical and Research Centre, Doha, Qatar. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.01.035DOI Listing
August 2017

A novel combination strategy for effectively targeting cancer stem-like cells.

Immunol Cell Biol 2017 08 6;95(7):573-574. Epub 2017 Jun 6.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2017.39DOI Listing
August 2017

Immunotherapy of cancer.

Aust Fam Physician 2017 ;46(4):194-199

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September 2017

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2 Tumors.

Cancer Res 2017 05 1;77(10):2594-2606. Epub 2017 Mar 1.

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre (VCCC), Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2247DOI Listing
May 2017

CAR T-cell therapy of solid tumors.

Immunol Cell Biol 2017 04 22;95(4):356-363. Epub 2016 Dec 22.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1038/icb.2016.128DOI Listing
April 2017

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing.

Oncoimmunology 2016 Aug 27;5(8):e1196308. Epub 2016 Jun 27.

Immune Defense Laboratory, Cancer Immunology Division, The Peter MacCallum Cancer Center, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2016.1
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http://dx.doi.org/10.1080/2162402X.2016.1196308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007960PMC
August 2016

Immunosuppressive activities of adenosine in cancer.

Curr Opin Pharmacol 2016 08 19;29:7-16. Epub 2016 May 19.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Institut du Cancer de Montréal, 900 Rue Saint-Denis, H2X0A9 Montréal, QC, Canada; Faculté de Pharmacie, Université de Montréal, Pavillon Jean-Coutu, 2940 chemin de Polytechnique, Montréal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2016.04.001DOI Listing
August 2016

The double-edged sword of IFN-γ-dependent immune-based therapies.

Immunol Cell Biol 2016 07 10;94(6):527-8. Epub 2016 May 10.

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2016.37DOI Listing
July 2016

The Role of the immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor immunity.

Crit Rev Immunol 2015 ;35(4):325-47

Immune Defence Laboratory, Cancer Immunology Division, The Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1615/critrevimmunol.2015014417DOI Listing
September 2016

Clinical relevance of host immunity in breast cancer: from TILs to the clinic.

Nat Rev Clin Oncol 2016 Apr 15;13(4):228-41. Epub 2015 Dec 15.

Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, East Melbourne, Victoria 8006, Australia.

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http://dx.doi.org/10.1038/nrclinonc.2015.215DOI Listing
April 2016

Reprogramming the tumor microenvironment to enhance adoptive cellular therapy.

Semin Immunol 2016 02 25;28(1):64-72. Epub 2015 Nov 25.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville 3010, Australia; Department of Pathology, University of Melbourne, Parkville, Australia; Department of Immunology, Monash University, Clayton, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2015.11.003DOI Listing
February 2016

CAR-T cells are serial killers.

Oncoimmunology 2015 Dec 1;4(12):e1053684. Epub 2015 Jun 1.

Cancer Immunology Research; Peter MacCallum Cancer Center , East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne , Parkville, VIC Australia.

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http://dx.doi.org/10.1080/2162402X.2015.1053684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635863PMC
December 2015

Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.

PLoS One 2015 27;10(10):e0140543. Epub 2015 Oct 27.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Immunology, Monash University, Prahran Victoria 3181 Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140543PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624721PMC
June 2016

CD73: A potential biomarker for anti-PD-1 therapy.

Oncoimmunology 2015 Nov 5;4(11):e1046675. Epub 2015 May 5.

Cancer Immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Clayton, Australia ; Department of Pathology; University of Melbourne ; Parkville, Australia.

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http://dx.doi.org/10.1080/2162402X.2015.1046675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589050PMC
November 2015

Releasing the Brake on Oncolytic Viral Therapy.

Clin Cancer Res 2015 Dec 16;21(24):5417-9. Epub 2015 Sep 16.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia. Department of Pathology, University of Melbourne, Parkville, Australia. Department of Immunology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1769DOI Listing
December 2015

Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene.

PLoS One 2015 3;10(9):e0136817. Epub 2015 Sep 3.

Cancer Immunology Research Program, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, 3010, Australia; Department of Immunology, Monash University, Prahran Victoria, 3181, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559457PMC
May 2016

Relevance of tumor-infiltrating lymphocytes in breast cancer.

BMC Med 2015 Aug 24;13:202. Epub 2015 Aug 24.

Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.

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http://dx.doi.org/10.1186/s12916-015-0431-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547422PMC
August 2015

Cross-talk between tumors can affect responses to therapy.

Oncoimmunology 2015 Jul 17;4(7):e975572. Epub 2015 Jun 17.

Cancer Immunology Research Program; Sir Peter MacCallum Department of Oncology; University of Melbourne ; Parkville, Australia ; ; Department of Immunology; Monash University ; Prahran, Victoria, Australia.

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http://dx.doi.org/10.4161/2162402X.2014.975572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485781PMC
July 2015

Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression.

Immunotherapy 2015 ;7(5):499-512

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2217/imt.15.16DOI Listing
March 2016

Adoptive immunotherapy: a new era for the treatment of cancer.

Immunotherapy 2015 ;7(5):469-71

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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https://www.futuremedicine.com/doi/10.2217/imt.15.37
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http://dx.doi.org/10.2217/imt.15.37DOI Listing
March 2016

Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.

Oncoimmunology 2014 Nov 21;3(11):e963395. Epub 2014 Dec 21.

Cancer Immunology Research Program; Sir Peter MacCallum Department of Oncology; University of Melbourne ; Parkville, Victoria, Australia ; Department of Immunology; Monash University ; Prahran, Victoria, Australia.

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http://dx.doi.org/10.4161/21624011.2014.963395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368122PMC
November 2014

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells.

Cancer Immunol Res 2015 May 24;3(5):483-94. Epub 2015 Feb 24.

Cancer Immunology Research, Peter MacCallum Cancer Center, East Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0048DOI Listing
May 2015

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses.

Cancer Immunol Res 2015 May 11;3(5):506-17. Epub 2015 Feb 11.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia. Department of Pathology, University of Melbourne, Parkville, Victoria, Australia. Department of Immunology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0211DOI Listing
May 2015

Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein.

Clin Transl Immunology 2015 Jan 9;4(1):e30. Epub 2015 Jan 9.

Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department, University Of Melbourne , Melbourne, Victoria, Australia ; Department of Pathology, University Of Melbourne , Melbourne, Victoria, Australia.

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http://doi.wiley.com/10.1038/cti.2014.29
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http://dx.doi.org/10.1038/cti.2014.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318491PMC
January 2015

The potential impact of mouse model selection in preclinical evaluation of cancer immunotherapy.

Oncoimmunology 2014;3(7):e946361. Epub 2014 Jul 3.

Division of Cancer Research; Peter MacCallum Cancer Center ; East Melbourne, Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Prahran, Australia.

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http://dx.doi.org/10.4161/21624011.2014.946361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292559PMC
July 2014

Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic.

Mol Immunol 2015 Oct 13;67(2 Pt A):46-57. Epub 2015 Jan 13.

Cancer Immunology Research Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Immunology, Monash University, Clayton, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2014.12.009DOI Listing
October 2015

Clinical application of genetically modified T cells in cancer therapy.

Clin Transl Immunology 2014 May 16;3(5):e16. Epub 2014 May 16.

Sir Peter MacCallum Cancer Centre, Department of Oncology, University of Melbourne , Melbourne, Victoria, Australia ; Department of Immunology, Monash University , Prahran, Victoria, Australia.

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http://dx.doi.org/10.1038/cti.2014.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232070PMC
May 2014

Trafficking of T cells into tumors.

Cancer Res 2014 Dec 4;74(24):7168-74. Epub 2014 Dec 4.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Department of Pathology, University of Melbourne, Parkville, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia. Department of Immunology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2458DOI Listing
December 2014

Foxp3 expression in macrophages associated with RENCA tumors in mice.

PLoS One 2014 29;9(9):e108670. Epub 2014 Sep 29.

Cancer Immunology Research Program, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia; Department of Immunology, Monash University, Prahran, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108670PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180934PMC
November 2015

Foxp3 expression in T regulatory cells and other cell lineages.

Cancer Immunol Immunother 2014 Sep 26;63(9):869-76. Epub 2014 Jul 26.

Cancer Immunology Research Program, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, 3010, Australia,

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http://dx.doi.org/10.1007/s00262-014-1581-4DOI Listing
September 2014

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers.

Leuk Res 2014 Aug 2;38(8):948-54. Epub 2014 Jun 2.

Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 3010, Australia; Department of Immunology, Monash University, Prahran 3181, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.05.010DOI Listing
August 2014

Routes of delivery for CpG and anti-CD137 for the treatment of orthotopic kidney tumors in mice.

PLoS One 2014 2;9(5):e95847. Epub 2014 May 2.

Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia; Department of Immunology, Monash University, Prahran, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095847PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008493PMC
December 2014

Editorial overview: Tumour immunology: New frontiers in cancer immunotherapy.

Curr Opin Immunol 2014 Apr 11;27:vii-x. Epub 2014 Mar 11.

Royal Melbourne Hospital, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia; Department of Medicine, University of Melbourne, Parkville, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09527915140003
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http://dx.doi.org/10.1016/j.coi.2014.02.007DOI Listing
April 2014

Genetic modification of mouse effector and helper T lymphocytes expressing a chimeric antigen receptor.

Methods Mol Biol 2014 ;1139:177-87

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-0345-0_16DOI Listing
November 2014

A blockade enhances anti-metastatic immune responses.

Oncoimmunology 2013 Dec 22;2(12):e26705. Epub 2013 Oct 22.

Cancer Immunology Program; Peter MacCallum Cancer Centre; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne; Parkville, VIC Australia.

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http://dx.doi.org/10.4161/onci.26705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926871PMC
December 2013

Environmental enrichment does not impact on tumor growth in mice.

F1000Res 2013 12;2:140. Epub 2013 Jun 12.

Sir Peter MacCallum, Department of Oncology, University of Melbourne, Parkville, 3010, Australia ; Department of Immunology, Monash University, Prahran, 3181, Australia.

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https://f1000research.com/articles/2-140/v1
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http://dx.doi.org/10.12688/f1000research.2-140.v1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892918PMC
February 2014

Manipulating immune cells for adoptive immunotherapy of cancer.

Curr Opin Immunol 2014 Apr 15;27:46-52. Epub 2014 Feb 15.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Department of Pathology, University of Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia; Department of Immunology, Monash University, Clayton, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2014.01.008DOI Listing
April 2014

Blockade of PD-1 immunosuppression boosts CAR T-cell therapy.

Oncoimmunology 2013 Oct 10;2(10):e26286. Epub 2013 Oct 10.

Cancer Immunology Program; Peter MacCallum Cancer Centre; East Melbourne, VIC Australia ; Department of Pathology; University of Melbourne; Parkville, VIC Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia ; Department of Immunology; Monash University; Clayton, VIC Australia.

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http://www.tandfonline.com/doi/abs/10.4161/onci.26286
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http://dx.doi.org/10.4161/onci.26286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862687PMC
October 2013

Enhancing immunotherapy using chemotherapy and radiation to modify the tumor microenvironment.

Oncoimmunology 2013 Sep 2;2(9):e25962. Epub 2013 Aug 2.

Cancer Immunology Research Program; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia ; Department of Immunology; Monash University; Prahran, VIC Australia.

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http://www.tandfonline.com/doi/abs/10.4161/onci.25962
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http://dx.doi.org/10.4161/onci.25962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850060PMC
September 2013

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy.

Oncoimmunology 2013 Aug 22;2(8):e25961. Epub 2013 Aug 22.

Cancer Immunology Research Program; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia.

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http://dx.doi.org/10.4161/onci.25961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782527PMC
August 2013

Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy.

Mol Ther 2014 Jan 19;22(1):18-27. Epub 2013 Sep 19.

1] Cancer Immunology Research Program, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia [2] Department of Immunology, Monash University, Prahran, Victoria, Australia.

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http://dx.doi.org/10.1038/mt.2013.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978809PMC
January 2014

Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors.

Proc Natl Acad Sci U S A 2013 Sep 20;110(36):14711-6. Epub 2013 Aug 20.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.

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http://dx.doi.org/10.1073/pnas.1308209110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767556PMC
September 2013

Gene-engineered T cells for cancer therapy.

Nat Rev Cancer 2013 Aug;13(8):525-41

Cancer Immunology Research Program, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia. michael.kershaw@ petermac.org

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http://www.nature.com/articles/nrc3565
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http://dx.doi.org/10.1038/nrc3565DOI Listing
August 2013

Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells.

Clin Cancer Res 2013 Oct 19;19(20):5636-46. Epub 2013 Jul 19.

Authors' Affiliations: Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria; Department of Pathology, University of Melbourne; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville; Department of Immunology, Monash University, Clayton; Immunology in Cancer and Infection Laboratory, Queensland Institute of Medical Research; and School of Medicine, University of Queensland, Herston, Queensland, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0458DOI Listing
October 2013

Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia.

Mol Ther 2013 Nov 8;21(11):2122-9. Epub 2013 Jul 8.

1] Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia [2] Hematology Immunology Translational Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia [3] Cancer Immunology Research Program, Peter MacCallum Cancer Centre, East Melbourne, Australia [4] Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Australia [5] Centre for Blood Cell Therapies, Peter MacCallum Cancer Centre, East Melbourne, Australia.

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http://dx.doi.org/10.1038/mt.2013.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831035PMC
November 2013

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer.

Proc Natl Acad Sci U S A 2013 Jul 17;110(27):11091-6. Epub 2013 Jun 17.

Division of Cancer Medicine and Research, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.

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http://dx.doi.org/10.1073/pnas.1222251110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704029PMC
July 2013

Engineering T cell function using chimeric antigen receptors identified using a DNA library approach.

PLoS One 2013 7;8(5):e63037. Epub 2013 May 7.

Cancer Immunology Research Program, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063037PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646939PMC
December 2013

Virotherapy, gene transfer and immunostimulatory monoclonal antibodies.

Oncoimmunology 2012 Nov;1(8):1344-1354

Division of Hepatology and Gene Therapy; Center for Applied Medical Research; University of Navarra; Pamplona, Spain.

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http://dx.doi.org/10.4161/onci.21679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518506PMC
November 2012

CD73: a potent suppressor of antitumor immune responses.

Trends Immunol 2012 May 7;33(5):231-7. Epub 2012 Apr 7.

Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1016/j.it.2012.02.009DOI Listing
May 2012

CD73-deficient mice are resistant to carcinogenesis.

Cancer Res 2012 May 6;72(9):2190-6. Epub 2012 Mar 6.

Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0420DOI Listing
May 2012

Stable IL-10: a new therapeutic that promotes tumor immunity.

Cancer Cell 2011 Dec;20(6):691-3

Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.ccr.2011.11.020DOI Listing
December 2011

Autoimmunity associated with immunotherapy of cancer.

Blood 2011 Jul 29;118(3):499-509. Epub 2011 Apr 29.

Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.1182/blood-2011-01-325266DOI Listing
July 2011

Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice.

Cancer Immunol Immunother 2011 May 16;60(5):671-83. Epub 2011 Feb 16.

Cancer Immunology Research Program, Peter MacCallum Cancer Centre, 14 St. Andrews Place, Melbourne, VIC 3002, Australia.

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http://link.springer.com/10.1007/s00262-011-0984-8
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http://dx.doi.org/10.1007/s00262-011-0984-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499620PMC
May 2011

CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis.

Cancer Res 2011 Apr 3;71(8):2892-900. Epub 2011 Feb 3.

Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4246DOI Listing
April 2011

Enhancing the specificity of T-cell cultures for adoptive immunotherapy of cancer.

Immunotherapy 2011 Jan;3(1):33-48

Cancer Immunology Research Program, Peter MacCallum Cancer Center, St Andrews Place, Melbourne, Victoria 3002, Australia.

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https://www.futuremedicine.com/doi/10.2217/imt.10.81
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http://dx.doi.org/10.2217/imt.10.81DOI Listing
January 2011

Tumor ablation by gene-modified T cells in the absence of autoimmunity.

Cancer Res 2010 Dec 23;70(23):9591-8. Epub 2010 Nov 23.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2884DOI Listing
December 2010