Phillip A Dennis

Phillip A Dennis

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Phillip A Dennis

Phillip A Dennis

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Early Reduction in ctDNA Predicts Survival in Patients with Lung and Bladder Cancer Treated with Durvalumab.

Clin Cancer Res 2018 12 9;24(24):6212-6222. Epub 2018 Aug 9.

Translational Medicine Oncology, MedImmune, Gaithersburg, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0386DOI Listing
December 2018

Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC.

N Engl J Med 2018 12 25;379(24):2342-2350. Epub 2018 Sep 25.

From the H. Lee Moffitt Cancer Center and Research Institute, Tampa (S.J.A., A.C., J.E.G.), Cancer Specialists of North Florida, Jacksonville (A.V.), Florida Cancer Specialists, Fleming Island (A.V.), and Florida Hospital Cancer Institute, Orlando (T.M.) - all in Florida; Tennessee Oncology, Chattanooga (D.D.), and Sarah Cannon Research Institute, Nashville (D.D., D.R.S.) - both in Tennessee; Hospital Universitario Virgen Macarena, Seville (D.V.), and Hospital Universitario 12 de Octubre, CiberOnc, Universidad Complutense and Spanish National Cancer Research Center (L.P.-A.), and Hospital Universitario La Paz (J.C.C.), Madrid - all in Spain; Kanagawa Cancer Center, Yokohama (S.M.), Kansai Medical University Hospital, Hirakata (T.K.), Kurume University Hospital, Kurume (T.T.), and Nippon Medical School Hospital, Tokyo (K.K.) - all in Japan; Westmead Hospital and the University of Sydney, Sydney (R.H.), and Flinders University and Flinders Medical Centre, Adelaide, SA (C.S.K.) - all in Australia; Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju (K.H.L.), Yonsei Cancer Center, Yonsei University College of Medicine, Seoul (B.C.C.), and Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju (Y.-C.K.) - all in South Korea; Vivantes Klinikum Neukoelln, Berlin (M.W.), and the Lung Clinic, Airway Research Center North, German Center for Lung Research, Grosshansdorf (M.R.) - both in Germany; Centre Hospitalier Universitaire de Liège, Liège (M.B.), and University Hospitals KU Leuven, Leuven (J.V.) - both in Belgium; Centre Hospitalier Universitaire de Montpellier and Institut du Cancer de Montpellier Val d'Aurelle, Montpellier (X.Q.), Institut Gustave Roussy, Villejuif (D.P.), and Institut de Cancérologie de l'Ouest-site René Gauducheau, Saint Herblain (S.H.) - all in France; National Koranyi Institute of Pulmonology, Budapest, Hungary (G.O.); the University of Manchester and the Christie NHS Foundation Trust, Manchester (C.F.-F.), AstraZeneca, Alderley Park (C.W.), and AstraZeneca, Cambridge (M.T.) - all in the United Kingdom; AstraZeneca, Gaithersburg, MD (G.M., P.A.D.); and Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, Turkey (M.Ö.).

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http://dx.doi.org/10.1056/NEJMoa1809697DOI Listing
December 2018

Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.

N Engl J Med 2017 11 8;377(20):1919-1929. Epub 2017 Sep 8.

From the H. Lee Moffitt Cancer Center and Research Institute, Tampa (S.J.A., A.C., J.E.G.), Cancer Specialists of North Florida, Jacksonville (A.V.), and Florida Hospital Cancer Institute, Orlando (T.M.) - all in Florida; Tennessee Oncology, Chattanooga, and Sarah Cannon Research Institute, Nashville - both in Tennessee (D.D.); Hospital Universitario Virgen Macarena, Seville (D.V.), and Hospital Universitario 12 de Octubre, Centro de Investigación Biomédica en Red de Cáncer, Universidad Complutense and the Spanish National Cancer Research Center (L.P.-A.), and Hospital Universitario La Paz (J.C.C.), Madrid - all in Spain; Kanagawa Cancer Center, Yokohama (S.M.), Kansai Medical University Hospital, Hirakata (T.Y.), Kurume University Hospital, Kurume (T.T.), and Nippon Medical School Hospital, Tokyo (K.K.) - all in Japan; Westmead Hospital and the University of Sydney, Sydney (R.H.), and Flinders University and Flinders Medical Centre, Bedford Park, SA (C.S.K.) - all in Australia; Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju (K.H.L.), Yonsei Cancer Center, Yonsei University College of Medicine, Seoul (B.C.C.), and Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju (Y.-C.K.) - all in South Korea; Vivantes Klinikum Neukölln, Berlin (M.W.); Centre Hospitalier Universitaire de Liège, Liège, Belgium (M.B.); Centre Hospitalier Universitaire Montpellier and Cancer Institute of Montpellier Val d'Aurelle, Montpellier (X.Q.), Institut Gustave Roussy, Villejuif (D.P.), and Institut de Cancérologie de l'Ouest-Site René Gauducheau, Saint Herblain (S.H.) - all in France; National Koranyi Institute of Pulmonology, Budapest, Hungary (G.O.); AstraZeneca, Alderley Park, United Kingdom (C.W.); AstraZeneca, Gaithersburg, MD (G.M., H.J., Y.H., P.A.D.); and Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey (M.Ö.).

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http://dx.doi.org/10.1056/NEJMoa1709937DOI Listing
November 2017

Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.

Oncotarget 2017 Oct 28;8(50):87044-87053. Epub 2017 Jul 28.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.18632/oncotarget.19667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675614PMC
October 2017

Impact of HIV on lung tumorigenesis in an animal model.

AIDS 2015 Mar;29(5):633-5

aDepartment of Oncology, Johns Hopkins University School of Medicine bInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000588DOI Listing
March 2015

Nelfinavir inhibits maturation and export of herpes simplex virus 1.

J Virol 2014 May 26;88(10):5455-61. Epub 2014 Feb 26.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.03790-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019105PMC
May 2014

Repositioning metformin for cancer prevention and treatment.

Trends Endocrinol Metab 2013 Sep 15;24(9):469-80. Epub 2013 Jun 15.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.tem.2013.05.004DOI Listing
September 2013

Lipid molecules induce p38α activation via a novel molecular switch.

J Mol Biol 2012 Dec 16;424(5):339-53. Epub 2012 Oct 16.

Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences and The Wolfson Centre for Applied Structural Biology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1016/j.jmb.2012.10.007DOI Listing
December 2012

Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.

Cancer Prev Res (Phila) 2011 Nov 25;4(11):1743-51. Epub 2011 Oct 25.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208746PMC
November 2011

Starting with the ABCs: Akt in breast cancer.

Mol Cancer Ther 2011 Nov;10(11):2031

Infinity Pharmaceuticals, Cambridge, Masschusetts, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0712DOI Listing
November 2011

A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.

Carcinogenesis 2011 Aug 30;32(8):1279-84. Epub 2011 May 30.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/carcin/bgr097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149208PMC
August 2011

Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.

Mol Cancer Ther 2011 Jul 6;10(7):1137-48. Epub 2011 May 6.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Dr., Rm. 1118B, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-1028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132820PMC
July 2011

PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

Nat Rev Cancer 2011 Apr;11(4):289-301

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://www.nature.com/articles/nrc3037
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http://dx.doi.org/10.1038/nrc3037DOI Listing
April 2011

Metformin prevents tobacco carcinogen--induced lung tumorigenesis.

Cancer Prev Res (Phila) 2010 Sep 1;3(9):1066-76. Epub 2010 Sep 1.

National Cancer Institute/Navy Medical Oncology, Room 5101, Building 8, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192328PMC
September 2010

The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.

Clin Cancer Res 2010 Jan 22;16(1):4-10. Epub 2009 Dec 22.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805044PMC
January 2010

LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin.

J Clin Oncol 2009 Dec 26;27(34):e226; author reply e227. Epub 2009 Oct 26.

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http://ascopubs.org/doi/10.1200/JCO.2009.25.3963
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http://dx.doi.org/10.1200/JCO.2009.25.3963DOI Listing
December 2009

Akt-dependent and -independent mechanisms of mTOR regulation in cancer.

Cell Signal 2009 May 7;21(5):656-64. Epub 2009 Jan 7.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, M 20889, United States.

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http://dx.doi.org/10.1016/j.cellsig.2009.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650010PMC
May 2009

The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers.

Cancer Prev Res (Phila) 2009 Apr 31;2(4):370-6. Epub 2009 Mar 31.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20889, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-08-0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715041PMC
April 2009

Perifosine: update on a novel Akt inhibitor.

Curr Oncol Rep 2009 Mar;11(2):102-10

Medical Oncology Branch, National Cancer Institute, NNMC Building 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.

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http://dx.doi.org/10.1007/s11912-009-0016-4DOI Listing
March 2009

Rapamycin for chemoprevention of upper aerodigestive tract cancers.

Authors:
Phillip A Dennis

Cancer Prev Res (Phila) 2009 Jan;2(1):7-9

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-08-0215DOI Listing
January 2009

PTEN hamartoma tumor syndromes.

Eur J Hum Genet 2008 Nov 10;16(11):1289-300. Epub 2008 Sep 10.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/ejhg.2008.162DOI Listing
November 2008

Repositioning HIV protease inhibitors as cancer therapeutics.

Curr Opin HIV AIDS 2008 Nov;3(6):666-75

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20899, USA.

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http://dx.doi.org/10.1097/COH.0b013e328313915dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682221PMC
November 2008

Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.

Neoplasia 2008 Aug;10(8):866-72

Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504769PMC
http://dx.doi.org/10.1593/neo.08406DOI Listing
August 2008

Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.

Drug Resist Updat 2008 Feb-Apr;11(1-2):32-50. Epub 2007 Dec 31.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S13687646070007
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http://dx.doi.org/10.1016/j.drup.2007.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442829PMC
July 2008

Germline PTEN mutations as a cause of early-onset endometrial cancer.

J Clin Oncol 2008 May;26(13):2234; author reply 2234

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http://dx.doi.org/10.1200/JCO.2007.15.8949DOI Listing
May 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://www.dwalab.ca/common/pdf/cdd200944a.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654259PMC
http://dx.doi.org/10.4161/auto.5338DOI Listing
February 2008

Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy.

Autophagy 2008 Jan 31;4(1):107-9. Epub 2007 Oct 31.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.4161/auto.5224DOI Listing
January 2008

PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development.

Crit Rev Oncol Hematol 2007 Sep 20;63(3):203-14. Epub 2007 Jul 20.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889, United States.

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http://dx.doi.org/10.1016/j.critrevonc.2007.06.002DOI Listing
September 2007

Targeting Akt in cancer therapy.

Anticancer Drugs 2007 Sep;18(8):861-74

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1097/CAD.0b013e3280cc2c6fDOI Listing
September 2007

PPARgamma agonists follow an unknown TRAIL in lung cancer.

Cancer Biol Ther 2007 Jan;6(1):107-9

Laboratory of Cellular, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland USA.

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http://dx.doi.org/10.4161/cbt.6.1.3751DOI Listing
January 2007

Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.

Clin Cancer Res 2006 Jun;12(11 Pt 1):3502-9

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1837DOI Listing
June 2006

Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.

Mol Cancer Ther 2006 Mar;5(3):713-22

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Building 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-05-0484DOI Listing
March 2006

Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway.

Clin Cancer Res 2006 Feb;12(3 Pt 1):679-89

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1654DOI Listing
February 2006

Using immunotherapy to target EGF in patients with NSCLC.

Cancer Biol Ther 2006 Feb 1;5(2):150-1. Epub 2006 Feb 1.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.4161/cbt.5.2.2557DOI Listing
February 2006

A slow disengagement from platinum-based chemotherapy for patients with advanced non-small cell lung cancer.

Cancer Biol Ther 2005 Dec 9;4(12):1316-7. Epub 2005 Dec 9.

Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.4161/cbt.4.12.2488DOI Listing
December 2005

Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes.

Cancer Res 2005 Aug;65(16):7137-44

Genetics Branch and Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute and the National Naval Medical Center, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1125DOI Listing
August 2005

Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.

Carcinogenesis 2005 Jul 24;26(7):1182-95. Epub 2005 Mar 24.

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889, USA.

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http://dx.doi.org/10.1093/carcin/bgi072DOI Listing
July 2005

The biology of tobacco and nicotine: bench to bedside.

Cancer Epidemiol Biomarkers Prev 2005 Apr;14(4):764-7

Cancer Therapeutics Branch, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20889, USA.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-0
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http://dx.doi.org/10.1158/1055-9965.EPI-04-0652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459058PMC
April 2005

An overview of lung cancer genomics and proteomics.

Am J Respir Cell Mol Biol 2005 Mar;32(3):169-76

National Cancer Institute/NIH, Building 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.

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http://dx.doi.org/10.1165/rcmb.F290DOI Listing
March 2005

Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death.

Cancer Res 2005 Mar;65(6):2070-5

Cell and Molecular Biology Section, Pediatric Oncology Branch and Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3606DOI Listing
March 2005

Re: Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer.

J Natl Cancer Inst 2004 Dec;96(23):1795; author reply 1795-6

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http://dx.doi.org/10.1093/jnci/djh342DOI Listing
December 2004

Disparities in cancer funding.

Authors:
Phillip A Dennis

Science 2004 Sep;305(5689):1401-2

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http://dx.doi.org/10.1126/science.305.5689.1401eDOI Listing
September 2004

The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.

Expert Opin Investig Drugs 2004 Jul;13(7):787-97

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889, USA.

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http://www.tandfonline.com/doi/full/10.1517/13543784.13.7.78
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http://dx.doi.org/10.1517/13543784.13.7.787DOI Listing
July 2004

Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo.

Chest 2004 May;125(5 Suppl):101S-2S

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889-5105, USA.

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http://dx.doi.org/10.1378/chest.125.5_suppl.101sDOI Listing
May 2004

Targeting aberrant signal transduction pathways in lung cancer.

Cancer Biol Ther 2004 Feb 1;3(2):147-55. Epub 2004 Feb 1.

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.4161/cbt.3.2.612DOI Listing
February 2004

Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo.

Cancer Res 2004 Jan;64(2):446-51

Cancer Therapeutics Branch, Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-3241DOI Listing
January 2004

Modulating protein kinase C (PKC) to increase the efficacy of chemotherapy: stepping into darkness.

Drug Resist Updat 2003 Dec;6(6):329-39

Natural Products Program, Cancer Research Center of Hawaii, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1016/j.drup.2003.10.003DOI Listing
December 2003

Immune evasion by murine melanoma mediated through CC chemokine receptor-10.

J Exp Med 2003 Nov 27;198(9):1337-47. Epub 2003 Oct 27.

Dermatology Branch, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20030593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194242PMC
November 2003

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

J Am Chem Soc 2003 Feb;125(5):1144-5

Drug Discovery Program, Department of Neurology, Georgetown University, 3900 Reservoir Road, NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1021/ja0285159DOI Listing
February 2003

Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.

Cancer Res 2003 Feb;63(4):780-6

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA.

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February 2003

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.

J Clin Invest 2003 Jan;111(1):81-90

Cancer Therapeutics Branch, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1172/JCI16147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151834PMC
January 2003

Activation of the PI3K/Akt pathway and chemotherapeutic resistance.

Drug Resist Updat 2002 Dec;5(6):234-48

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Building 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.

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http://dx.doi.org/10.1016/s1368-7646(02)00120-6DOI Listing
December 2002

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

Mol Cancer Ther 2002 Jul;1(9):707-17

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA.

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July 2002