Philippe Rondard

Philippe Rondard

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Philippe Rondard

Philippe Rondard

Publications by authors named "Philippe Rondard"

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Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer.

Nat Commun 2019 06 24;10(1):2765. Epub 2019 Jun 24.

Institut de Génomique Fonctionnelle (IGF), CNRS, INSERM, Université de Montpellier, Montpellier, 34094 Montpellier cedex 05, France.

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http://dx.doi.org/10.1038/s41467-019-10834-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591306PMC
June 2019

GPCR interaction as a possible way for allosteric control between receptors.

Mol Cell Endocrinol 2019 04 5;486:89-95. Epub 2019 Mar 5.

Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.

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http://dx.doi.org/10.1016/j.mce.2019.02.019DOI Listing
April 2019

FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABA Receptor.

Cell Chem Biol 2017 Mar 9;24(3):360-370. Epub 2017 Mar 9.

Institut de Génomique Fonctionnelle (IGF), CNRS, INSERM, University of Montpellier, 141 rue de la Cardonille, 34094 Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.02.011DOI Listing
March 2017

GABAB receptor upregulates fragile X mental retardation protein expression in neurons.

Sci Rep 2015 May 28;5:10468. Epub 2015 May 28.

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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http://dx.doi.org/10.1038/srep10468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447080PMC
May 2015

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.

Nat Chem Biol 2015 Feb 15;11(2):134-40. Epub 2014 Dec 15.

1] CNRS, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France. [2] INSERM, U661, Montpellier, France. [3] Université Montpellier 1 &2, Montpellier, France.

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http://www.nature.com/articles/nchembio.1711
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http://dx.doi.org/10.1038/nchembio.1711DOI Listing
February 2015

Dynamics and modulation of metabotropic glutamate receptors.

Curr Opin Pharmacol 2015 Feb 17;20:95-101. Epub 2014 Dec 17.

CNRS, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; INSERM, U661, Montpellier, France; Université Montpellier 1 & 2, Montpellier F-34000, France.

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http://dx.doi.org/10.1016/j.coph.2014.12.001DOI Listing
February 2015

Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy.

Nat Commun 2014 Oct 17;5:5206. Epub 2014 Oct 17.

1] CNRS UMR5048, Centre de Biochimie Structurale, 29 rue de Navacelles, 34090 Montpellier, France [2] INSERM U1054, 34090 Montpellier, France [3] Universités Montpellier I et II, 34090 Montpellier, France.

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http://dx.doi.org/10.1038/ncomms6206DOI Listing
October 2014

Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations.

FASEB J 2014 Aug 15;28(8):3734-44. Epub 2014 May 15.

Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U661, Montpellier, France; Université Montpellier 1 and 2, Montpellier, France;

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http://dx.doi.org/10.1096/fj.13-243402DOI Listing
August 2014

Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor.

Front Pharmacol 2014 11;5:12. Epub 2014 Feb 11.

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan, China.

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http://dx.doi.org/10.3389/fphar.2014.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920572PMC
June 2014

Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors.

Proc Natl Acad Sci U S A 2013 Apr 4;110(15):E1416-25. Epub 2013 Mar 4.

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier, France.

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http://www.pnas.org/content/110/15/E1416/1.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1215615110
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http://dx.doi.org/10.1073/pnas.1215615110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625292PMC
April 2013

PROK2/PROKR2 Signaling and Kallmann Syndrome.

Front Endocrinol (Lausanne) 2013 12;4:19. Epub 2013 Apr 12.

INSERM U1016, Institut Cochin, Université Paris-Descartes Paris, France.

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http://dx.doi.org/10.3389/fendo.2013.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624607PMC
April 2013

Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.

J Clin Endocrinol Metab 2013 Mar 5;98(3):E547-57. Epub 2013 Feb 5.

Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, University College London (UCL)-Institute of Child Health, London WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-3067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612801PMC
March 2013

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.

Proc Natl Acad Sci U S A 2012 Oct 17;109(40):16342-7. Epub 2012 Sep 17.

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier 1 et 2, 34094 Montpellier cedex 05, France.

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http://dx.doi.org/10.1073/pnas.1205838109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479612PMC
October 2012

PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.

J Clin Endocrinol Metab 2012 Jun 30;97(6):E1068-73. Epub 2012 Mar 30.

Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2M), Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7286, Aix-Marseille University, France.

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http://dx.doi.org/10.1210/jc.2011-3056DOI Listing
June 2012

Interdomain movements in metabotropic glutamate receptor activation.

Proc Natl Acad Sci U S A 2011 Sep 6;108(37):15480-5. Epub 2011 Sep 6.

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1107775108
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http://dx.doi.org/10.1073/pnas.1107775108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174654PMC
September 2011

Dimers and beyond: The functional puzzles of class C GPCRs.

Pharmacol Ther 2011 Apr 20;130(1):9-25. Epub 2011 Jan 20.

CNRS UMR 5203, INSERM U661 and Université Montpellier 1, 2, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, F-34094 Montpellier Cedex 05, France.

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http://linkinghub.elsevier.com/retrieve/pii/S016372581100023
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http://dx.doi.org/10.1016/j.pharmthera.2011.01.006DOI Listing
April 2011

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.

FASEB J 2011 Jan 8;25(1):66-77. Epub 2010 Sep 8.

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Montpellier, France.

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http://www.fasebj.org/content/25/1/66.full.pdf
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http://dx.doi.org/10.1096/fj.10-163147DOI Listing
January 2011

Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation.

EMBO J 2011 Jan 9;30(1):32-42. Epub 2010 Nov 9.

CNRS, UMR 5203, Institut de Génomique Fonctionnelle, Département de Pharmacologie Moléculaire, Montpellier, France.

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http://dx.doi.org/10.1038/emboj.2010.270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020105PMC
January 2011

GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.

J Neurosci 2010 Jan;30(2):749-59

Sino-France Laboratory for Drug Screening, Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, Hubei, China.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2343-09.2
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http://dx.doi.org/10.1523/JNEUROSCI.2343-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633015PMC
January 2010

PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity.

Hum Mol Genet 2009 Jan 29;18(1):75-81. Epub 2008 Sep 29.

CNRS UMR5203, Institut de Génomique Fonctionnelle, INSERM U661, Université Montpellier 1,2, Montpellier, France.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddn318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298864PMC
January 2009

Activity-based probe for specific photoaffinity labeling gamma-aminobutyric acid B (GABAB) receptors on living cells: design, synthesis, and biological evaluation.

J Med Chem 2008 Jun 1;51(11):3057-60. Epub 2008 May 1.

Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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http://dx.doi.org/10.1021/jm800140fDOI Listing
June 2008

Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement.

J Biol Chem 2007 Nov 13;282(45):33000-8. Epub 2007 Sep 13.

University of Montpellier 1 and 2, CNRS UMR 5203, Institute of Functional Genomics, 141 rue de la Cardonille, Montpellier, France.

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http://dx.doi.org/10.1074/jbc.M702542200DOI Listing
November 2007

Human G(salpha) mutant causes pseudohypoparathyroidism type Ia/neonatal diarrhea, a potential cell-specific role of the palmitoylation cycle.

Proc Natl Acad Sci U S A 2007 Oct 25;104(44):17424-9. Epub 2007 Oct 25.

Department of Endocrinology and Nephrology, University of Tokyo School of Medicine, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0708561104
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http://dx.doi.org/10.1073/pnas.0708561104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077272PMC
October 2007

Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons.

Cell Signal 2007 Sep 26;19(9):1996-2002. Epub 2007 May 26.

Sino-France Laboratory for Drug Screening, Key Laboratory of Molecular Biophysics, Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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http://linkinghub.elsevier.com/retrieve/pii/S089865680700137
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http://dx.doi.org/10.1016/j.cellsig.2007.05.004DOI Listing
September 2007

Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors.

J Biol Chem 2006 Aug 20;281(34):24653-61. Epub 2006 Jun 20.

CNRS Unité Mixte de Recherche 5203, INSERM U661, Universités Montpellier 1 and 2, France.

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http://dx.doi.org/10.1074/jbc.M602277200DOI Listing
August 2006

Activation mechanism of the heterodimeric GABA(B) receptor.

Biochem Pharmacol 2004 Oct;68(8):1565-72

Laboratory of Functional Genomic, Department of Molecular Pharmacology, CNRS Unité Propre de Recherche 2580, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, France.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520400525
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http://dx.doi.org/10.1016/j.bcp.2004.06.035DOI Listing
October 2004

Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.

J Biol Chem 2004 Apr 21;279(16):15824-30. Epub 2004 Jan 21.

Department of Molecular Pharmacology, Laboratory of Functional Genomics, CNRS UPR2580, 141, rue de la Cardonille, F-34094 Montpellier, Cedex 5, France.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M313639200
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http://dx.doi.org/10.1074/jbc.M313639200DOI Listing
April 2004

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.

Proc Natl Acad Sci U S A 2002 Aug 31;99(17):11097-102. Epub 2002 Jul 31.

Départment de Chimie et Biochimie Pharmacologiques et Toxicologiques, Unité Mixte de Recherche 8601-Centre National de la Recherche Scientifique, Université René Descartes-Paris V, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.162138699
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http://dx.doi.org/10.1073/pnas.162138699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123216PMC
August 2002