Philippe Roche

Philippe Roche

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Philippe Roche

Philippe Roche

Publications by authors named "Philippe Roche"

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CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy.

J Chem Inf Model 2019 Apr 5;59(4):1472-1485. Epub 2019 Apr 5.

Aix Marseille Univ, CNRS, Inserm, Institut Paoli Calmettes, CRCM , Marseille CEDEX 09 13273 , France.

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http://dx.doi.org/10.1021/acs.jcim.8b00960DOI Listing
April 2019

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors.

Eur J Med Chem 2019 Jan 23;161:323-333. Epub 2018 Oct 23.

Aix-Marseille Univ, CNRS UMR7258, INSERM U1068, Institut Paoli-Calmettes, CRCM, Marseille, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183083
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http://dx.doi.org/10.1016/j.ejmech.2018.09.056DOI Listing
January 2019

Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches.

Mol Inform 2018 09 27;37(9-10):e1800059. Epub 2018 Jul 27.

CNRS, Inserm, Institut Paoli-Calmettes, Aix-Marseille Univ, CRCM, Marseille, France.

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http://dx.doi.org/10.1002/minf.201800059DOI Listing
September 2018

18F-FDOPA PET/CT Imaging of MAX-Related Pheochromocytoma.

J Clin Endocrinol Metab 2018 04;103(4):1574-1582

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1210/jc.2017-02324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276705PMC
April 2018

Pathological and Genetic Characterization of Bilateral Adrenomedullary Hyperplasia in a Patient with Germline MAX Mutation.

Endocr Pathol 2017 Dec;28(4):302-307

Department of Nuclear Medicine, La Timone University Hospital & CERIMED & Inserm UMR1068 Marseille Cancerology Research Center, Institut Paoli-Calmettes, Aix Marseille University, 264 Rue Saint-Pierre, 13385, Marseille, France.

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http://dx.doi.org/10.1007/s12022-016-9460-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287616PMC
December 2017

[How is transcription reinitiation governed in measles virus?]

Med Sci (Paris) 2017 Oct 10;33(10):843-845. Epub 2017 Oct 10.

Aix Marseille Univ, Architecture et Fonction des Macromolécules Biologiques (AFMB) UMR 7257, Marseille, France - CNRS, Architecture et Fonction des Macromolécules Biologiques AFMB, UMR 7257, 163, avenue de Luminy, 13288 Marseille, France.

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http://dx.doi.org/10.1051/medsci/20173310010DOI Listing
October 2017

Implications of SDHB genetic testing in patients with sporadic pheochromocytoma.

Langenbecks Arch Surg 2017 Aug 22;402(5):787-798. Epub 2017 Feb 22.

Department of Nuclear Medicine, La Timone University Hospital, APHM, CERIMED, Aix Marseille Univ, Marseille, France.

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http://dx.doi.org/10.1007/s00423-017-1564-yDOI Listing
August 2017

Paraganglioma of the organ of Zuckerkandl associated with a somatic α mutation: A case report.

Oncol Lett 2017 Mar 12;13(3):1083-1086. Epub 2017 Jan 12.

Department of Nuclear Medicine, La Timone University Hospital, European Center for Research in Medical Imaging, Aix-Marseille University, 13385 Marseille Cedex 5, France.

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http://dx.doi.org/10.3892/ol.2017.5599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403169PMC
March 2017

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.

Database (Oxford) 2016 15;2016. Epub 2016 Mar 15.

Centre de Recherche en Cancérologie de Marseille (CRCM); CNRS, UMR 7258; INSERM U1068; Institut Paoli-Calmettes; Aix-Marseille Université; Marseille 13009, France

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http://dx.doi.org/10.1093/database/baw007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792518PMC
October 2016

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.

J Med Chem 2016 Feb 6;59(4):1634-41. Epub 2016 Jan 6.

Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Marseille (CRCM), UMR 7258; INSERM U1068; Institut Paoli-Calmettes; Aix-Marseille Université, UM105 , 13273 Marseille, France.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01708DOI Listing
February 2016

[Chemical libraries dedicated to protein-protein interactions].

Med Sci (Paris) 2015 Mar 8;31(3):312-9. Epub 2015 Apr 8.

Centre de recherche en cancérologie de Marseille (CRCM), CNRS UMR7258 ; Inserm U1068 ; institut Paoli-Calmettes ; université d'Aix-Marseille UM105, 27, boulevard Lei Roure,13009, Marseille, France.

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http://dx.doi.org/10.1051/medsci/20153103017DOI Listing
March 2015

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.

Future Med Chem 2014 Jul 28;6(11):1291-307. Epub 2014 Apr 28.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yang Qiao Xi Lu, Fuzhou, Fujian 350002, China.

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http://dx.doi.org/10.4155/fmc.14.57DOI Listing
July 2014

2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.

J R Soc Interface 2014 Jan 6;11(90):20130860. Epub 2013 Nov 6.

Laboratory of integrative Structural and Chemical Biology (iSCB), Centre de Recherche en Cancérologie de Marseille (CRCM); CNRS UMR 7258, INSERM U 1068, Institut Paoli-Calmettes; and Aix-Marseille Universités, , Marseille 13009, France.

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http://dx.doi.org/10.1098/rsif.2013.0860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836326PMC
January 2014

Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein.

Proc Natl Acad Sci U S A 2013 Oct 16;110(40):E3743-52. Epub 2013 Sep 16.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People's Republic of China.

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http://dx.doi.org/10.1073/pnas.1308381110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791790PMC
October 2013

Stereoselective synthesis of original spirolactams displaying promising folded structures.

Org Biomol Chem 2013 Jul 13;11(28):4719-26. Epub 2013 Jun 13.

Institut des Biomolécules Max Mousseron, IBMM UMR 5247 CNRS-Université Montpellier I-Université Montpellier II, Pl. E. Bataillon, 34095 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1039/c3ob40643aDOI Listing
July 2013

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

Nucleic Acids Res 2013 Jan 30;41(Database issue):D824-7. Epub 2012 Nov 30.

Laboratory of Integrative Structural and Chemical Biology (iSCB), Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS UMR 7258, INSERM U 1068, Institut Paoli-Calmettes, Marseille, France.

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http://dx.doi.org/10.1093/nar/gks1002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531195PMC
January 2013

Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.

J Biol Chem 2012 Dec 2;287(53):44703-13. Epub 2012 Nov 2.

Laboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS UMR7255, Aix-Marseille Université, 13402 Marseille cedex 20, France.

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http://dx.doi.org/10.1074/jbc.M112.395152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531785PMC
December 2012

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).

Curr Opin Chem Biol 2011 Aug 22;15(4):475-81. Epub 2011 Jun 22.

Interactions et Modulateurs de Réponses (UPR3243), Centre National de la Recherche Scientifique (CNRS) & Université de Provence, 31 Chemin Joseph Aiguier, 13402 Marseille cedex 20, France.

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http://dx.doi.org/10.1016/j.cbpa.2011.05.024DOI Listing
August 2011

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity.

Bioorg Med Chem 2010 Jul 13;18(14):5425-40. Epub 2010 May 13.

Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.bmc.2010.05.010DOI Listing
July 2010

Amplitude of pancreatic lipase lid opening in solution and identification of spin label conformational subensembles by combining continuous wave and pulsed EPR spectroscopy and molecular dynamics.

Biochemistry 2010 Mar;49(10):2140-9

CNRS Laboratoire de Bioénergétique et Ingénierie des Protéines, UPR 9036, Institut de Microbiologie de la Méditerranée, Aix-Marseille Universités, Marseille, France.

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http://dx.doi.org/10.1021/bi901918fDOI Listing
March 2010

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database.

PLoS One 2010 Mar 9;5(3):e9598. Epub 2010 Mar 9.

Laboratoire Interactions et Modulateurs de Réponses (UPR3243), Centre National de la Recherche Scientifique (CNRS) & Aix-Marseille Universités, Institut de Microbiologie de la Méditerranée (IMM), Marseille, France.

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http://2p2idb_archive.cnrs-mrs.fr/archive/2010/journal.pone.
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http://dx.plos.org/10.1371/journal.pone.0009598
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009598PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834754PMC
March 2010

NMR and MD investigations of human galectin-1/oligosaccharide complexes.

Biophys J 2009 Dec;97(12):3168-77

Unité Interactions et Modulateurs de Réponses, Institut de Microbiologie de la Méditerrannée, Centre National de la Recherche Scientifique, Marseille, France.

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http://dx.doi.org/10.1016/j.bpj.2009.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793364PMC
December 2009

Computational studies of human galectin-1: role of conserved tryptophan residue in stacking interaction with carbohydrate ligands.

J Biomol Struct Dyn 2009 Aug;27(1):49-58

Unite Interactions et Modulateurs de Reponses, Institut Mediterranen de Microbiologie, CNRS, 31 chemin Joseph Aiguier, Marseille Cedex 20, France.

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http://dx.doi.org/10.1080/07391102.2009.10507295DOI Listing
August 2009

Computational model for the IGF-II/IGF2r complex that is predictive of mutational and surface plasmon resonance data.

Proteins 2006 Aug;64(3):758-68

Division of Structural Biology, University of Oxford, Henry Wellcome Building for Genomic Medicine, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/prot.21035DOI Listing
August 2006

Initiation of pre-B cell receptor signaling: common and distinctive features in human and mouse.

Semin Immunol 2006 Feb 7;18(1):56-66. Epub 2005 Dec 7.

Centre d'Immunologie de Marseille-Luminy (CIML), CNRS-INSERM-University Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France.

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http://dx.doi.org/10.1016/j.smim.2005.11.002DOI Listing
February 2006

Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression.

J Immunol 2005 Aug;175(4):2459-68

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.175.4.2459DOI Listing
August 2005

Modeling study of human renal chloride channel (hCLC-5) mutations suggests a structural-functional relationship.

Kidney Int 2003 Apr;63(4):1426-32

Molecular Endocrinology Group, Nuffield Department of Clinical Medicine, University of Oxford, Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1046/j.1523-1755.2003.00859.xDOI Listing
April 2003

Missense mutations in the homeodomain of HOXD13 are associated with brachydactyly types D and E.

Am J Hum Genet 2003 Apr 14;72(4):984-97. Epub 2003 Mar 14.

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, and Department of Plastic and Reconstructive Surgery, Radcliffe Infirmary, Oxford, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180360PMC
http://dx.doi.org/10.1086/374721DOI Listing
April 2003

Molecular dynamics of the FixJ receiver domain: movement of the beta4-alpha4 loop correlates with the in and out flip of Phe101.

Protein Sci 2002 Nov;11(11):2622-30

Laboratoire de Biologie Moléculaire des Relations Plantes-Microorganismes, UMR 215, CNRS-INRA, BP26, 31326 Castanet-Tolosan Cedex, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373730PMC
http://dx.doi.org/10.1110/ps.0218802DOI Listing
November 2002

Symbiotic and taxonomic diversity of rhizobia isolated from Acacia tortilis subsp. raddiana in Africa.

Syst Appl Microbiol 2002 Apr;25(1):130-45

Laboratoire des Symbioses Tropicales et Méditerranéennes, IRD-INRA-CIRAD-ENSAM, Baillarguet, Montpellier, France.

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http://dx.doi.org/10.1078/0723-2020-00091DOI Listing
April 2002