Philippe Pasero

Philippe Pasero

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Philippe Pasero

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MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading.

Mol Cell 2020 Jan 20;77(2):395-410.e3. Epub 2019 Nov 20.

Institut de Génétique Humaine, CNRS, Université de Montpellier, Equipe Labellisée Ligue contre le Cancer, Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.10.029DOI Listing
January 2020

Top1 and Top2 promote replication fork arrest at a programmed pause site.

Genes Dev 2020 01;34(1-2):1-3

Institut de Génétique Humaine, Centre National de la Recherche Scientifique, Université de Montpellier, Montpellier 34396, France.

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http://dx.doi.org/10.1101/gad.335463.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938665PMC
January 2020

qDSB-Seq is a general method for genome-wide quantification of DNA double-strand breaks using sequencing.

Nat Commun 2019 05 24;10(1):2313. Epub 2019 May 24.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, Texas, 77555, USA.

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http://dx.doi.org/10.1038/s41467-019-10332-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534554PMC
May 2019

Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells.

Mol Cell Oncol 2019 7;6(4):1607455. Epub 2019 May 7.

Equipe Labellisée Ligue contre le Cancer, Institut de Génétique Humaine, CNRS, Université de Montpellier, Montpellier, France.

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http://dx.doi.org/10.1080/23723556.2019.1607455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548472PMC
May 2019

DDR Inc., one business, two associates.

Curr Genet 2019 Apr 22;65(2):445-451. Epub 2018 Nov 22.

Equipe Labellisée Ligue contre le Cancer, Institut de Génétique Humaine, CNRS and Université de Montpellier, Montpellier, France.

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http://dx.doi.org/10.1007/s00294-018-0908-7DOI Listing
April 2019

SAMHD1 and the innate immune response to cytosolic DNA during DNA replication.

Curr Opin Immunol 2019 02 5;56:24-30. Epub 2018 Oct 5.

Institut de Génétique Humaine, CNRS, Université de Montpellier, Equipe Labellisée Ligue contre le Cancer, Montpellier France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09527915183005
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http://dx.doi.org/10.1016/j.coi.2018.09.017DOI Listing
February 2019

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage.

EMBO J 2018 11 29;37(21). Epub 2018 Aug 29.

Institut de Génétique Humaine, CNRS, Equipe Labellisée Ligue contre le Cancer, Université de Montpellier, Montpellier, France

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http://emboj.embopress.org/lookup/doi/10.15252/embj.20189931
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http://dx.doi.org/10.15252/embj.201899319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213276PMC
November 2018

DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.

Neoplasia 2018 10 26;20(10):985-995. Epub 2018 Aug 26.

Laboratory of Genome Integrity and Tumorigenesis, Van Andel Research Institute (VARI), Grand Rapids, MI 49503. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586183023
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http://dx.doi.org/10.1016/j.neo.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111017PMC
October 2018

SAMHD1 acts at stalled replication forks to prevent interferon induction.

Nature 2018 05 18;557(7703):57-61. Epub 2018 Apr 18.

Institut de Génétique Humaine, CNRS, Université de Montpellier, Laboratoire Maintien de l'Intégrité du Génome au cours de la Réplication, Ligue Contre le Cancer, Montpellier, France.

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http://www.nature.com/articles/s41586-018-0050-1
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http://dx.doi.org/10.1038/s41586-018-0050-1DOI Listing
May 2018

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.

Nat Commun 2018 02 7;9(1):533. Epub 2018 Feb 7.

LBCMCP, Centre de Biologie Integrative (CBI), CNRS, Université de Toulouse, UT3, 118 Route de Narbonne, 31062, Toulouse, France.

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http://dx.doi.org/10.1038/s41467-018-02894-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803260PMC
February 2018

Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing.

Genes Dev 2017 12 12;31(23-24):2405-2415. Epub 2018 Jan 12.

State Key Laboratory of Agro-Biotechnology, Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.306571.117
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http://dx.doi.org/10.1101/gad.306571.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795786PMC
December 2017

Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts.

Annu Rev Genet 2017 11;51:477-499

Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA; email:

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http://dx.doi.org/10.1146/annurev-genet-120116-024745DOI Listing
November 2017

Transcription-Replication Conflicts: Orientation Matters.

Cell 2017 08;170(4):603-604

Institute of Human Genetics, CNRS UMR9002 and University of Montpellier, Equipe Labéllisée Ligue Contre le Cancer, 34090 Montpellier, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173087
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http://dx.doi.org/10.1016/j.cell.2017.07.040DOI Listing
August 2017

Signaling pathways of replication stress in yeast.

FEMS Yeast Res 2017 03;17(2)

Institute of Human Genetics, CNRS UPR1142, University of Montpellier, Montpellier 34396, France.

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http://dx.doi.org/10.1093/femsyr/fow101DOI Listing
March 2017

Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches.

Crit Rev Microbiol 2017 Mar 14;43(2):156-177. Epub 2016 Dec 14.

a Centro Internacional de Zoonosis, Facultad de Ciencias Químicas, Facultad de Medicina Veterinaria , Universidad Central del Ecuador , Quito , Ecuador.

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http://dx.doi.org/10.1080/1040841X.2016.1188758DOI Listing
March 2017

RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.

Mol Cell 2016 12 23;64(5):951-966. Epub 2016 Nov 23.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; University of Basel, Faculty of Natural Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.10.032DOI Listing
December 2016

Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.

Proc Natl Acad Sci U S A 2016 06 13;113(26):E3639-48. Epub 2016 Jun 13.

Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065; Laboratory of DNA Replication, Rockefeller University, New York, NY 10065

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http://dx.doi.org/10.1073/pnas.1607552113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932992PMC
June 2016

USP1 Regulates Cellular Senescence by Controlling Genomic Integrity.

Cell Rep 2016 05 5;15(7):1401-1411. Epub 2016 May 5.

Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, Department of Cell Biology and Infection, 75015 Paris, France; INSERM, U993, 75015 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer, 14 rue Corvisart, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.04.033DOI Listing
May 2016

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.

Genes Dev 2016 Feb 21;30(3):337-54. Epub 2016 Jan 21.

Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland; Faculty of Natural Sciences, University of Basel, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1101/gad.273813.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743062PMC
February 2016

RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.

Biomark Res 2016 13;4. Epub 2016 Feb 13.

Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, Hôpital Saint-Eloi - CHRU de Montpellier, 80, av. Augustin Fliche, 34295 Montpellier, Cedex 5 France ; Institute of Human Genetics, CNRS-UPR1142, Montpellier, F-34396 France ; University of Montpellier 1, UFR de Médecine, Montpellier, France.

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http://dx.doi.org/10.1186/s40364-016-0057-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752763PMC
February 2016

Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance.

Mol Cell 2015 Dec 19;60(6):835-46. Epub 2015 Nov 19.

IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691243PMC
December 2015

DNA repair in diffuse large B-cell lymphoma: a molecular portrait.

Br J Haematol 2015 Apr 5;169(2):296-9. Epub 2014 Nov 5.

Department of Biological Haematology, CHU Montpellier, Montpellier, France; INSERM U1040, CHU Montpellier, Montpellier, France; UFR de Médecine, University of Montpellier 1, Montpellier, France.

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http://dx.doi.org/10.1111/bjh.13206DOI Listing
April 2015

Closing the MCM cycle at replication termination sites.

EMBO Rep 2014 Dec 12;15(12):1226-7. Epub 2014 Nov 12.

Institute of Human Genetics CNRS, Montpellier, France.

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http://dx.doi.org/10.15252/embr.201439774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264923PMC
December 2014

Caught in the Act: R-loops are cleaved by structure-specific endonucleases to generate DSBs.

Mol Cell 2014 Dec;56(6):721-2

Institute of Human Genetics, CNRS-UPR 1142, Montpellier, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140096
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http://dx.doi.org/10.1016/j.molcel.2014.12.011DOI Listing
December 2014

The replication timing program in the hands of two HDACs.

Microb Cell 2014 Jul 25;1(8):273-275. Epub 2014 Jul 25.

Equipe Labellisée Ligue Contre le Cancer, Institute of Human Genetics, UPR 1142, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France.

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http://dx.doi.org/10.15698/mic2014.08.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349235PMC
July 2014

The causes of replication stress and their consequences on genome stability and cell fate.

Semin Cell Dev Biol 2014 Jun 9;30:154-64. Epub 2014 May 9.

Institut Curie, centre de recherche, CNRS UMR338, Bat 110, centre universitaire, 91405 Orsay, France. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.04.035DOI Listing
June 2014

The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.

Mol Cell 2014 May;54(4):691-7

Institute of Human Genetics, UPR 1142, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France; Equipe Labellisée Ligue Contre le Cancer, 14 rue Corvisart, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.032DOI Listing
May 2014

New histone supply regulates replication fork speed and PCNA unloading.

J Cell Biol 2014 Jan 30;204(1):29-43. Epub 2013 Dec 30.

Biotech Research and Innovation Centre, 2 Centre for Epigenetics, and 3 The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1083/jcb.201305017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882791PMC
January 2014

Time to be versatile: regulation of the replication timing program in budding yeast.

J Mol Biol 2013 Nov 25;425(23):4696-705. Epub 2013 Sep 25.

Institute of Human Genetics, CNRS UPR 1142, 141 rue de la Cardonille, Equipe Labellisée Ligue Contre le Cancer, 34396 Montpellier cedex 5, France; Department of Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.jmb.2013.09.020DOI Listing
November 2013

DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells.

Sci Rep 2013 Nov 20;3:3277. Epub 2013 Nov 20.

1] DNA Damage Response Laboratory, Centre for Chromosome Biology, Biochemistry, School of Natural Sciences, National University of Ireland, Galway, Ireland [2].

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http://dx.doi.org/10.1038/srep03277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505966PMC
November 2013

DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment.

Cell Cycle 2013 Sep 9;12(17):2760-73. Epub 2013 Aug 9.

CHU Montpellier; Institute of Research in Biotherapy; Montpellier, France; INSERM; U1040; Montpellier, France.

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http://dx.doi.org/10.4161/cc.25951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899190PMC
September 2013

Rescuing stalled or damaged replication forks.

Cold Spring Harb Perspect Biol 2013 May 1;5(5):a012815. Epub 2013 May 1.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1101/cshperspect.a012815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632063PMC
May 2013

Genetic and epigenetic determinants of DNA replication origins, position and activation.

Curr Opin Genet Dev 2013 Apr 28;23(2):124-31. Epub 2013 Mar 28.

Institute of Human Genetics, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1016/j.gde.2013.02.010DOI Listing
April 2013

Cohesin association to replication sites depends on rad50 and promotes fork restart.

Mol Cell 2012 Oct 9;48(1):98-108. Epub 2012 Aug 9.

Department of Biochemistry and Molecular Biology, Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB Canada T2N 4N1.

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http://dx.doi.org/10.1016/j.molcel.2012.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904740PMC
October 2012

Transcription and replication: breaking the rules of the road causes genomic instability.

Transcription 2010 Sep-Oct;1(2):99-102

Institute of Human Genetics, CNRS UPR, Montpelier, France.

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http://dx.doi.org/10.4161/trns.1.2.12665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023637PMC
June 2012

Interference between DNA replication and transcription as a cause of genomic instability.

Curr Genomics 2012 Mar;13(1):65-73

Institute of Human Genetics, CNRS-UPR1142, Montpellier, France.

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http://dx.doi.org/10.2174/138920212799034767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269018PMC
March 2012

Histone H3 lysine 56 acetylation and the response to DNA replication fork damage.

Mol Cell Biol 2012 Jan 24;32(1):154-72. Epub 2011 Oct 24.

Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1128/MCB.05415-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255698PMC
January 2012

New Topoisomerase I mutations are associated with resistance to camptothecin.

Mol Cancer 2011 May 27;10:64. Epub 2011 May 27.

Institut de Recherche en Cancérologie de Montpellier, INSERM, Université Montpellier1, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France.

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http://dx.doi.org/10.1186/1476-4598-10-64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120799PMC
May 2011

Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response.

Nat Struct Mol Biol 2010 Nov 24;17(11):1391-7. Epub 2010 Oct 24.

Institute of Human Genetics, Centre National de Recherche Scientifique, Unité Propre de Recherche 1142, Montpellier, France.

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http://dx.doi.org/10.1038/nsmb.1932DOI Listing
November 2010

The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages.

Nucleic Acids Res 2010 Oct 22;38(19):6502-12. Epub 2010 Jun 22.

IRBLLEIDA, Department of Ciències Mèdiques Bàsiques, Facultat de Medicina, Universitat de Lleida, 25008 Lleida, Spain.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkq546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965248PMC
October 2010

Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation.

Mol Cell 2010 Oct;40(1):50-62

Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, 20133, Italy.

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http://dx.doi.org/10.1016/j.molcel.2010.09.004DOI Listing
October 2010

Does interference between replication and transcription contribute to genomic instability in cancer cells?

Cell Cycle 2010 May 15;9(10):1886-92. Epub 2010 May 15.

Institute of Human Genetics CNRS UPR1142, Montpellier, France.

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http://www.tandfonline.com/doi/abs/10.4161/cc.9.10.11539
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http://dx.doi.org/10.4161/cc.9.10.11539DOI Listing
May 2010

Defining replication origin efficiency using DNA fiber assays.

Chromosome Res 2010 Jan;18(1):91-102

Institute of Human Genetics, CNRS UPR 1142, 141 rue de la Cardonille, 34396, Montpellier Cedex 5, France.

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http://dx.doi.org/10.1007/s10577-009-9098-yDOI Listing
January 2010

Involvement of a chromatin remodeling complex in damage tolerance during DNA replication.

Nat Struct Mol Biol 2009 Nov 25;16(11):1167-72. Epub 2009 Oct 25.

Department of Carcinogenesis, Science Park Research Division, MD Anderson Cancer Center, Smithville, Texas, USA.

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http://dx.doi.org/10.1038/nsmb.1686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974178PMC
November 2009

Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.

Proc Natl Acad Sci U S A 2009 May 22;106(18):7525-30. Epub 2009 Apr 22.

Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain.

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http://dx.doi.org/10.1073/pnas.0812000106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678616PMC
May 2009

The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress.

EMBO J 2009 Apr 12;28(8):1142-56. Epub 2009 Mar 12.

Department of Biochemistry and Molecular Biology, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/emboj.2009.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683708PMC
April 2009

Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpoint.

EMBO J 2009 Apr 26;28(8):1131-41. Epub 2009 Mar 26.

Department of Genome Dynamics, Institute of Human Genetics, CNRS UPR 1142, Montpellier, France.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2009.75
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http://dx.doi.org/10.1038/emboj.2009.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683710PMC
April 2009

Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA.

EMBO Rep 2008 Oct 15;9(10):1034-40. Epub 2008 Aug 15.

Institute of Biochemistry, Swiss Federal Institute of Technology Zurich (ETH), ETH Hoenggerberg, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/embor.2008.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572122PMC
October 2008

A journey into the nucleus. Conference on Nuclear Structure and Dynamics.

EMBO Rep 2008 Mar 15;9(3):228-33. Epub 2008 Feb 15.

Department of Biology II, Institute of Human Genetics, Biocenter, Ludwig-Maximilians University of Munich, Grosshadernerstrasse 2, Planegg-Martinsried 82152, Germany.

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http://dx.doi.org/10.1038/embor.2008.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267376PMC
March 2008

Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast.

Mol Cell Biol 2007 Sep 16;27(18):6433-45. Epub 2007 Jul 16.

MRC Protein Phosphorylation Unit, James Black Centre, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00135-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099619PMC
September 2007

Maintenance of fork integrity at damaged DNA and natural pause sites.

DNA Repair (Amst) 2007 Jul 26;6(7):900-13. Epub 2007 Mar 26.

Institute of Human Genetics, CNRS UPR 1142, 141 rue de la Cardonille, F-34396 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1016/j.dnarep.2007.02.004DOI Listing
July 2007

Anaphase onset before complete DNA replication with intact checkpoint responses.

Science 2007 Mar;315(5817):1411-5

Cell Cycle Group, Medical Research Council (MRC) Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1126/science.1134025DOI Listing
March 2007

Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint.

Cell Cycle 2007 Feb 19;6(4):471-7. Epub 2007 Feb 19.

Group Instabilité génétique et cancer équipe labellisée par La ligue contre le cancer, Institut de Pharmacologie et de Biologie Structurale, Toulouse Cedex 4, France.

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http://dx.doi.org/10.4161/cc.6.4.3857DOI Listing
February 2007

The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites.

Curr Biol 2006 Apr;16(8):786-92

Swiss Federal Institute of Technology Zurich (ETH), Institute of Biochemistry, ETH Hoenggerberg HPM G 10.0, Switzerland.

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http://dx.doi.org/10.1016/j.cub.2006.02.071DOI Listing
April 2006

Mitotic remodeling of the replicon and chromosome structure.

Cell 2005 Dec;123(5):787-801

Genome Dynamics and Development, Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France.

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http://dx.doi.org/10.1016/j.cell.2005.08.045DOI Listing
December 2005

Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.

Mol Cell 2005 Sep;19(5):699-706

Institute of Human Genetics, Centre National de la Recherche Scientifique, UPR 1142, 34396 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1016/j.molcel.2005.07.028DOI Listing
September 2005

Multiple roles of replication forks in S phase checkpoints: sensors, effectors and targets.

Cell Cycle 2003 Nov-Dec;2(6):568-72

Institute of Molecular Genetics, CNRS UMR 5535 and Université Montpellier II, 34293 Montpellier cedex 5, France.

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July 2004

The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication.

EMBO J 2003 Apr;22(8):1939-49

Institute of Molecular Genetics, CNRS and Université Montpellier II, 1919 route de Mende, 34293 Montpellier, France.

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http://dx.doi.org/10.1093/emboj/cdg180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154472PMC
April 2003

An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing.

Proc Natl Acad Sci U S A 2002 Dec 19;99(25):16087-92. Epub 2002 Nov 19.

Department of Molecular Biology, University of Geneva, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.

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http://www.pnas.org/cgi/doi/10.1073/pnas.252093999
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http://dx.doi.org/10.1073/pnas.252093999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138569PMC
December 2002

ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.

Genes Dev 2002 Dec;16(24):3236-52

University of Geneva, Department of Molecular Biology, Switzerland.

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http://dx.doi.org/10.1101/gad.239802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187497PMC
December 2002

Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus.

Genes Dev 2002 Oct;16(19):2479-84

Institute of Molecular Genetics, CNRS UMR 5535 and Université Montpellier II, 34293 Montpellier cedex 5, France.

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http://dx.doi.org/10.1101/gad.232902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187456PMC
October 2002

In vitro DNA replication assays in yeast extracts.

Methods Enzymol 2002 ;351:184-99

Institute of Molecular Genetics, National Center for Scientific Research, Mixed Research Unit 5535, F-34293 Montpellier, France.

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http://dx.doi.org/10.1016/s0076-6879(02)51848-6DOI Listing
July 2002