Philippe Moreau

Philippe Moreau

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Philippe Moreau

Philippe Moreau

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The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma.

Leukemia 2020 Jan 10;34(1):167-179. Epub 2019 Jun 10.

Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-019-0498-5DOI Listing
January 2020

Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.

Int J Comput Assist Radiol Surg 2020 Jan 29;15(1):129-139. Epub 2019 Jun 29.

Ecole Centrale de Nantes, Laboratoire des Sciences Numériques de Nantes (LS2N), CNRS UMR 6004, Nantes, France.

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http://dx.doi.org/10.1007/s11548-019-02015-yDOI Listing
January 2020

Isatuximab plus carfilzomib/dexamethasone versus carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma: IKEMA Phase III study design.

Future Oncol 2020 Jan 13;16(2):4347-4358. Epub 2019 Dec 13.

Department of Hematology, University of California at San Francisco, San Francisco, CA, CA 94143, USA.

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http://dx.doi.org/10.2217/fon-2019-0431DOI Listing
January 2020

New insights in the treatment of patients with solitary bone plasmacytoma.

Leuk Lymphoma 2019 Nov 25;60(11):2810-2813. Epub 2019 Apr 25.

Department of Hematology, Centre Hospitalier Le Mans, Le Mans, France.

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http://dx.doi.org/10.1080/10428194.2019.1605067DOI Listing
November 2019

The Autoimmune Regulator (Aire) transactivates HLA-G gene expression in thymic epithelial cells.

Immunology 2019 10 19;158(2):121-135. Epub 2019 Aug 19.

Direction de la Recherche Fondamentale, Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.

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http://dx.doi.org/10.1111/imm.13099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742766PMC
October 2019

Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.

Leukemia 2019 Sep 9;33(9):2324-2330. Epub 2019 Apr 9.

ProfilExpert, Lyon, France.

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http://dx.doi.org/10.1038/s41375-019-0452-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756025PMC
September 2019

Carfilzomib-Dexamethasone Versus Bortezomib-Dexamethasone in Relapsed or Refractory Multiple Myeloma: Updated Overall Survival, Safety, and Subgroups.

Clin Lymphoma Myeloma Leuk 2019 Aug 2;19(8):522-530.e1. Epub 2019 May 2.

Department of Clinical Therapeutics, University Athens School of Medicine, Athens, Greece.

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http://dx.doi.org/10.1016/j.clml.2019.04.018DOI Listing
August 2019

Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma.

N Engl J Med 2019 08;381(8):727-738

From the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai (A.C., S.P., S.J.), and New York University Langone Medical Center (D.K.) - both in New York; the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.T.V.); the School of Medicine, National and Kapodistrian University of Athens, Athens (M.G., M. Dimopoulos); the Winship Cancer Institute, Emory University, Atlanta (A.K.N., S.L.); Massachusetts General Hospital Cancer Center (A.J.Y.), Tufts Medical Center (R.L.C.), and the Dana-Farber Cancer Institute (P.G.R.), Boston, and Karyopharm Therapeutics, Newton (M.G.K., S.S., L.L., S. Tang, C.P., J.-R.S.-M., M.C., H.C., Y.L., J.S.) - all in Massachusetts; Johns Hopkins University, Baltimore (C.A.H.); the University of Nantes, Nantes (P.M.), Hôpital Necker (L.F.), Hôpital Saint-Antoine (M.M.), and La Pitié-Salpêtrière Hospital (S.C.), Paris, University Hospital, Lille (T.F.), Centre Hospitalier Lyon Sud, Pierre-Benite (L.K.), and Centre Hospitalo-Universitaire Vandoeuvre-lès-Nancy, Nancy (A.P.) - all in France; the Mayo Clinic, Rochester, MN (D.D.); the University of Michigan, Ann Arbor (C.C.); the Mayo Clinic of Arizona, Phoenix (A.K.S.); Hackensack University Medical Center, Hackensack, NJ (J.R.); Washington University School of Medicine, St. Louis (R.V.); Lineberger Comprehensive Cancer Center at University of North Carolina-Chapel Hill, Chapel Hill (S. Tuchman); the University of Heidelberg, Heidelberg (M.S.R.), University Medical Center Hamburg-Eppendorf, Hamburg (K.C.W.), the University of Tübingen, Tübingen (K.C.W.), University Hospital Würzburg, Würzburg (M.S.), the University of Freiburg, Freiburg (M.E.), and Gemeinschaftspraxis Hämatologie-Onkologie, Dresden (T.I.) - all in Germany; the University of Leuven, Leuven (M. Delforge), Institut Jules Bordet, Université Libre de Bruxelles, Brussels (N.M.), University Hospital Ghent, Ghent (P.V.), and Centre Hospitalier Universitaire Université Catholique de Louvain Namur, Yvoir (C.D.) - all in Belgium; Vanderbilt University Medical Center, Nashville (R.F.C.); Sylvester Cancer Center, University of Miami, Miami (J.E.H.); the University of Alabama at Birmingham, Birmingham (L.J.C.); Yale School of Medicine, New Haven, CT (T.L.P.); Baylor University Medical Center, Dallas (M.L.); the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (G.S.); and University Hospital Krems, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria (K.P.).

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http://www.nejm.org/doi/10.1056/NEJMoa1903455
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http://dx.doi.org/10.1056/NEJMoa1903455DOI Listing
August 2019

Update on elotuzumab for the treatment of relapsed/refractory multiple myeloma: patients' selection and perspective.

Onco Targets Ther 2019 18;12:5813-5822. Epub 2019 Jul 18.

Hematology Department, University Hospital, Nantes, France.

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http://dx.doi.org/10.2147/OTT.S174640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645600PMC
July 2019

F-FDG PET/CT in multiple myeloma: critical insights and future directions.

Eur J Nucl Med Mol Imaging 2019 May 15;46(5):1048-1050. Epub 2019 Feb 15.

CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1007/s00259-019-04279-7DOI Listing
May 2019

Comparison of Sebia Free Light Chain Assay With Freelite Assay for the Clinical Management of Diagnosis, Response, and Relapse Assessment in Multiple Myeloma.

Clin Lymphoma Myeloma Leuk 2019 May 29;19(5):e228-e237. Epub 2019 Jan 29.

Department of Biochemistry, University Hospital of Nantes, Nantes, France.

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http://dx.doi.org/10.1016/j.clml.2019.01.007DOI Listing
May 2019

Carfilzomib or bortezomib with melphalan-prednisone for transplant-ineligible patients with newly diagnosed multiple myeloma.

Blood 2019 05 28;133(18):1953-1963. Epub 2019 Feb 28.

Clinica Universidad de Navarra-Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra, Centro de Investigación Biomédica en Red de Cáncer, Pamplona, Spain.

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http://dx.doi.org/10.1182/blood-2018-09-874396DOI Listing
May 2019

Thermomechanical Polymer Binder Reactivity with Positive Active Materials for Li Metal Polymer and Li-Ion Batteries: An XPS and XPS Imaging Study.

ACS Appl Mater Interfaces 2019 May 8;11(20):18368-18376. Epub 2019 May 8.

Institut des Matériaux Jean Rouxel (IMN), Université de Nantes, CNRS , 2 rue de la Houssinière , BP 32229, 44322 Nantes Cedex 3 , France.

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http://pubs.acs.org/doi/10.1021/acsami.9b01761
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http://dx.doi.org/10.1021/acsami.9b01761DOI Listing
May 2019

Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma.

N Engl J Med 2019 05;380(22):2104-2115

From University of Lille, Centre Hospitalier Universitaire (CHU) Lille, Service des Maladies du Sang, Lille (T.F.), Hematology Department, University Hospital Hôtel-Dieu, Nantes (P.M.), Department of Hematology, Hospital Haut Leveque, University Hospital, Pessac (C.H.), Hematology Department, University Hospital, Vandoeuvre lès Nancy (A.P.), Service d'Hématologie, CHU de Toulouse-Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse (M.A.), Department of Hematology, Vendée Hospital, La Roche sur Yon (M.T.), CHU de Caen, Caen (M.M.), Department of Clinical Hematology, Assistance Publique-Hôpitaux de Paris, Necker Hospital, Paris (L.F.), and Department of Hematology, CHU la Miletrie and INSERM CIC 1402, Poitiers (X.L.) - all in France; the Department of Hematology, Mayo Clinic Rochester, Rochester, MN (S.K.); Vejle Hospital and University of Southern Denmark, Vejle (T.P.); Department of Lymphoma-Myeloma, University of Texas M.D. Anderson Cancer Center, Houston (R.Z.O.); University of Calgary, Arnie Charbonneau Cancer Research Institute, Calgary, AB (N.B.), and the Division of Medical Oncology, University of Alberta, Edmonton (C.P.V.) - both in Canada; Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, United Kingdom (S.B.); Karolinska Institute, Department of Medicine, Division of Hematology, Karolinska University Hospital at Huddinge, Stockholm (H.N.); University of Melbourne, St. Vincent's Hospital, Melbourne, VIC, Australia (H.Q.); University Hospital Heidelberg and National Center of Tumor Diseases (NCT), Heidelberg (H.G.), and the Department of Oncology, Hematology and Bone Marrow Transplantation, Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg (K.W.) - both in Germany; Department of Medicine-Haematology, National University of Ireland, Galway (M.O.); Florida Cancer Specialists and Research Institute, St. Petersburg (J.R.M.); the Department of Hematology-Oncology, Massachusetts General Hospital, Boston (N.R.); Genmab US, Princeton (T.A.), and Janssen Research and Development, Raritan (J.W., R.K.) - both in New Jersey; Janssen Research and Development, Spring House, PA (C.C., C.M.U., M.Q.); Janssen Research and Development, Beerse, Belgium (R.V.R.); and Levine Cancer Institute-Atrium Health, Charlotte, NC (S.Z.U.).

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http://www.nejm.org/doi/10.1056/NEJMoa1817249
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http://dx.doi.org/10.1056/NEJMoa1817249DOI Listing
May 2019

Responses in multiple myeloma should be assigned according to serum, not urine, free light chain measurements.

Leukemia 2019 02 20;33(2):313-318. Epub 2018 Dec 20.

Institut Universitaire du Cancer, CHU, Centre de Recherche en Cancérologie de Toulouse, INSERM, 1037, Toulouse, France.

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http://dx.doi.org/10.1038/s41375-018-0339-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365491PMC
February 2019

Added prognostic value of FDG-PET/CT in relapsing multiple myeloma patients.

Leuk Lymphoma 2019 01 2;60(1):222-225. Epub 2018 May 2.

a Nuclear Medicine Unit, University Hospital , Nantes , France.

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http://dx.doi.org/10.1080/10428194.2018.1459602DOI Listing
January 2019

Cellular tension encodes local Src-dependent differential β and β integrin mobility.

Mol Biol Cell 2019 01 21;30(2):181-190. Epub 2018 Nov 21.

Institut Albert Bonniot, Université Joseph Fourier, INSERM U823, CNRS ERL 5284, Grenoble Alpessite Santé, F38042 Grenoble Cedex 09, France.

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http://dx.doi.org/10.1091/mbc.E18-04-0253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589565PMC
January 2019

Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity.

Nat Commun 2019 01 3;10(1):52. Epub 2019 Jan 3.

Laboratoire interdisciplinaire de Physique, Université Joseph Fourier (Grenoble 1), Domaine universitaire, Bat. E45 140, Rue de la physique, BP 87, 38402, Saint Martin d'Hères, Cedex 9, France.

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http://dx.doi.org/10.1038/s41467-018-07965-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318293PMC
January 2019

HLA-G, -E and -F regulatory and coding region variability and haplotypes in the Beninese Toffin population sample.

Mol Immunol 2018 12;104:108-127

Laboratório de Biologia Molecular, Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto (FMRP-USP), Estado de São Paulo, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2018.08.016DOI Listing
December 2018

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.

N Engl J Med 2018 11;379(19):1811-1822

From the National and Kapodistrian University of Athens, Athens (M.A.D.); Karol Marcinkowski University of Medical Sciences, Poznań (D.D.), and Silesian Medical University, Katowice (S.G.) - both in Poland; University Hospital, Nantes (P.M.), and Centre Hospitalier Universitaire de Poitiers-La Milétrie, Poitiers (X.L.) - both in France; National Hospital Organization Disaster Medical Center (N.T.) and the Japanese Red Cross Medical Center (K.S.), Tokyo, and Ibaraki Prefectural Central Hospital, Kasama (M.H.) - all in Japan; Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal (R.L.); Heidelberg University Hospital, Heidelberg, Germany (M.S.R.); Dana-Farber Cancer Institute, Boston (P.G.R.); Bristol-Myers Squibb, Princeton, NJ (M.P.M., Y.-M.J., S.G.S., M.R., B.R.); and Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra (IDISNA), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Pamplona, Spain (J.S.-M.).

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http://www.nejm.org/doi/10.1056/NEJMoa1805762
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http://dx.doi.org/10.1056/NEJMoa1805762DOI Listing
November 2018

Targeting Bcl-2 for the treatment of multiple myeloma.

Leukemia 2018 09 3;32(9):1899-1907. Epub 2018 Aug 3.

Department of Hematology, Centre Hospitalier Universitaire, Nantes, France.

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http://dx.doi.org/10.1038/s41375-018-0223-9DOI Listing
September 2018

Ixazomib in the management of relapsed multiple myeloma.

Future Oncol 2018 Aug 22;14(20):2013-2020. Epub 2018 Feb 22.

Department of Hematology, University hospital, Nantes, France.

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http://dx.doi.org/10.2217/fon-2017-0710DOI Listing
August 2018

New airtight transfer box for SEM experiments: Application to lithium and sodium metals observation and analyses.

Micron 2018 07 18;110:10-17. Epub 2018 Apr 18.

Institut des Matériaux Jean Rouxel (IMN), Université de Nantes, CNRS, 2 rue de la Houssinière, BP 33229, 44322 Nantes cedex 3, France. Electronic address:

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http://dx.doi.org/10.1016/j.micron.2018.04.003DOI Listing
July 2018

Global Approaches in Myeloma: Critical Trials That May Change Practice.

Am Soc Clin Oncol Educ Book 2018 May;38:656-661

From the University Hospital Hôtel-Dieu, Nantes, France.

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http://dx.doi.org/10.1200/EDBK_200841DOI Listing
May 2018

The genetic diversity within the 1.4 kb HLA-G 5' upstream regulatory region moderately impacts on cellular microenvironment responses.

Sci Rep 2018 04 4;8(1):5652. Epub 2018 Apr 4.

Commissariat à l'Energie Atomique et aux Energies Alternatives, Direction de la Recherche Fondamentale, Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, ZIP code 75010, France.

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http://dx.doi.org/10.1038/s41598-018-24009-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884815PMC
April 2018

A novel multisite confocal system for rapid Ca imaging from submicron structures in brain slices.

J Biophotonics 2018 03 18;11(3). Epub 2017 Dec 18.

Laboratory for Interdisciplinary Physics, UMR 5588 CNRS and Université Grenoble Alpes, Saint Martin d'Hères Cedex, France.

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http://dx.doi.org/10.1002/jbio.201700197DOI Listing
March 2018

A question of class: Treatment options for patients with relapsed and/or refractory multiple myeloma.

Crit Rev Oncol Hematol 2018 Jan 5;121:74-89. Epub 2017 Dec 5.

Department of Hematology, University of Nantes Health Centre, France.

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http://dx.doi.org/10.1016/j.critrevonc.2017.11.016DOI Listing
January 2018

MRD in multiple myeloma: more questions than answers?

Blood Cancer J 2017 12 5;7(12):639. Epub 2017 Dec 5.

Istituto di Ematologia Seragnoli, Bologna, Italy.

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http://dx.doi.org/10.1038/s41408-017-0028-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802510PMC
December 2017