Philippe Merle

Philippe Merle

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Philippe Merle

Philippe Merle

Publications by authors named "Philippe Merle"

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In vitro transformation of primary human hepatocytes: Epigenetic changes and stemness properties.

Exp Cell Res 2019 Nov 23;384(2):111643. Epub 2019 Sep 23.

INSERM U1052, CNRS 5286, Univ Lyon, Université Claude Bernard Lyon 1, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, F-69000, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.111643DOI Listing
November 2019

Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis.

J Hepatol 2019 Oct 18;71(4):763-772. Epub 2019 Jun 18.

INSERM, U1052, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France; Hospices Civils de Lyon, Laboratoire d'Anatomie et Cytologie Pathologiques, Centre Hospitalier Lyon Sud, Pierre Bénite, France. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.05.031DOI Listing
October 2019

Neoadjuvant conformal radiotherapy before liver transplantation for hepatocellular carcinoma: a propensity score matched analysis of postoperative morbidity and oncological results.

Future Oncol 2019 Jul 10;15(21):2517-2530. Epub 2019 Jun 10.

Department of General Surgery & Liver Transplantation, Hospices Civils de Lyon, Croix-Rousse University Hospital, Claude-Bernard Lyon 1 University, Lyon, France.

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https://www.futuremedicine.com/doi/10.2217/fon-2019-0127
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http://dx.doi.org/10.2217/fon-2019-0127DOI Listing
July 2019

Management of adverse events associated with tyrosine kinase inhibitors: Improving outcomes for patients with hepatocellular carcinoma.

Cancer Treat Rev 2019 Jul 15;77:20-28. Epub 2019 May 15.

Department of Hepatology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Lyon 1, 103 Grande rue de la Croix Rousse, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2019.05.004DOI Listing
July 2019

Idarubicin-loaded Beads for Chemoembolization of Hepatocellular Carcinoma: The IDASPHERE II Single-Arm Phase II Trial.

Radiology 2019 Jun 30;291(3):801-808. Epub 2019 Apr 30.

From the Saint-Eloi University Hospital, 80 avenue Augustin Fliche, 34295 Montpellier, France (B.G., E.A.); Archet University Hospital, Nice, France (P.C., J.G.); Biostatistics, Fédération Francophone de Cancérologie Digestive, EPICAD INSERM LNC-UMR 1231, Burgundy & Franche-Comté University Dijon, France (E.B.); Croix Rousse University Hospital, Lyon, France (P.M., A.R.); Hôtel Dieu University Hospital, Angers, France (A.B., F.O.); Edouard Herriot University Hospital, Lyon, France (J.D., P.J.V.); University Hospital, Amiens, France (E.N.K., T.Y., J.C.B.); and Dijon University Hospital, EPICAD INSERM LNC-UMR1231, Burgundy & Franche-Comté University, Dijon, France (O.C., M.L., M.B.).

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http://dx.doi.org/10.1148/radiol.2019182399DOI Listing
June 2019

Hepatic venous pressure gradient after portal vein embolization: An accurate predictor of future liver remnant hypertrophy.

Surgery 2018 08 10;164(2):227-232. Epub 2018 May 10.

Department of General Surgery and Liver Transplantation, Hospices Civils de Lyon, Croix-Rousse University Hospital, Lyon, France; Ecole Doctorale EDISS 205, EMR 3738, Claude Bernard Lyon 1 University, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2018.03.014DOI Listing
August 2018

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma.

N Engl J Med 2018 Jul;379(1):54-63

From Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York (G.K.A.-A.); Royal Free Hospital and University College London, London (T.M.); National Taiwan University Hospital, Taipei (A.-L.C.), and the Department of Medical Oncology, Liouying Chi Mei Hospital, Tainan (Y.C.) - both in Taiwan; USC Norris Comprehensive Cancer Center, Los Angeles (A.B.E.-K.), UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco (A.P.V., R.K.K.), and Exelixis, Alameda (C.H., A.E.B.-H., G.S.) - all in California; Humanitas Cancer Center, Humanitas Clinical and Research Center, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano (L.R., T.P.), the Department of Medical and Surgical Sciences, University of Bologna, Bologna (L.B.), and Medical Oncology Unit 1, Istituto Oncologico Veneto, IRCCS, Padua (V.Z.) - all in Italy; Asan Medical Center, University of Ulsan College of Medicine, Seoul (B.-Y.R., M.-H.R.), and the National Cancer Center, Goyang (J.-W.P.) - both in South Korea; Trakya University School of Medicine, Edirne, Turkey (I.C.); Groupement Hospitalier Nord, Lyon (P.M.), and Hôpital Haut-Lévêque, Centre Hospitalier Universitaire Bordeaux, Bordeaux (J.-F.B.) - both in France; the Department of Medical Oncology, Academic Medical Center, Amsterdam (H.-J.K.); and the Chinese University of Hong Kong, State Key Laboratory in Oncology in South China, Hong Kong (S.L.C.).

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http://dx.doi.org/10.1056/NEJMoa1717002DOI Listing
July 2018

No-touch multibipolar radiofrequency ablation vs. surgical resection for solitary hepatocellular carcinoma ranging from 2 to 5 cm.

J Hepatol 2018 06 2;68(6):1172-1180. Epub 2018 Feb 2.

Department of General Surgery and Liver Transplantation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, EMR3738, Université Lyon 1, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.01.014DOI Listing
June 2018

Recommendations for the use of electroencephalography and evoked potentials in comatose patients.

Neurophysiol Clin 2018 Jun 18;48(3):143-169. Epub 2018 May 18.

Service de neurophysiologie clinique, CHRU de Lille, 59037 Lille cedex, France; Université de Lille, Inserm U 1171, Troubles cognitifs dégénératifs et vasculaires, centre d'excellence des maladies neurodégénératives de Lille (LiCEND), 59000 Lille cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.neucli.2018.05.038DOI Listing
June 2018

Liver Transplantation After Neoadjuvant Sorafenib Therapy: Preliminary Experience and Literature Review.

Exp Clin Transplant 2018 Apr 17;16(2):227-236. Epub 2016 May 17.

From the Croix-Rousse University Hospital, Digestive Surgery and Liver Transplant Department, Lyon, France.

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http://dx.doi.org/10.6002/ect.2015.0299DOI Listing
April 2018

Down-regulation of the Wnt/β-catenin signaling pathway by Cacnb4.

Mol Biol Cell 2017 Dec 11;28(25):3699-3708. Epub 2017 Oct 11.

L'institut du thorax, INSER, CNRS, Université de Nantes, 44000 Nantes, France

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http://dx.doi.org/10.1091/mbc.E17-01-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706996PMC
December 2017

Asleep Robot-Assisted Surgery for the Implantation of Subthalamic Electrodes Provides the Same Clinical Improvement and Therapeutic Window as Awake Surgery.

World Neurosurg 2017 Oct 19;106:602-608. Epub 2017 Jul 19.

Department of Neurosurgery, Amiens University Hospital, Amiens, France; Medical Imaging Unit, Amiens University Hospital, Amiens, France; BioFlowImage Research Group, Jules Verne University of Picardie, Amiens, France.

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http://dx.doi.org/10.1016/j.wneu.2017.07.047DOI Listing
October 2017

Tolerance and outcomes of sorafenib in elderly patients treated for advanced hepatocellular carcinoma.

Dig Liver Dis 2017 Sep 23;49(9):1043-1049. Epub 2017 Jun 23.

Hepato-Gastroenterology Department, University Hospital of Saint-Etienne, Saint Priest en Jarez, France; University Jean Monnet, LINA EA 4624, France.

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http://dx.doi.org/10.1016/j.dld.2017.06.008DOI Listing
September 2017

mRECIST for systemic therapies: More evidence is required before recommendations can be made.

J Hepatol 2017 07 16;67(1):195. Epub 2017 Mar 16.

Royal Free Hospital, London, United Kingdom; UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jhep.2017.02.033DOI Listing
July 2017

Cardiac Abnormalities in Type 1 Facioscapulohumeral Muscular Dystrophy.

J Clin Neuromuscul Dis 2017 Jun;18(4):199-206

Departments of *Cardiology and †Neurology, CHU de Caen, Caen, France; ‡Department of Neurology, CHU Charles Nicolle, Rouen, France; §Department of Neurology, CHU d'Amiens, Amiens, France; and ¶Department of Neurology, Rehabilitation Neuromuscular Disease Center, CHU de Caen, Caen, France.

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http://dx.doi.org/10.1097/CND.0000000000000144DOI Listing
June 2017

Comparison of no-touch multi-bipolar vs. monopolar radiofrequency ablation for small HCC.

J Hepatol 2017 01 13;66(1):67-74. Epub 2016 Jul 13.

Service de Radiologie de l'Hôpital Jean Verdier, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance Publique Hôpitaux de Paris, Bondy, France; Unité de Formation et de Recherche Santé Médecine et Biologie Humaine, Université Paris 13, Communauté d'Universités et Etablissements Sorbonne Paris Cité, Paris, France; Unité mixte de Recherche 1162, Génomique Fonctionnelle des Tumeurs Solides, Institut National de la Santé et de la Recherche Médicale, Paris, France.

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http://dx.doi.org/10.1016/j.jhep.2016.07.010DOI Listing
January 2017

EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes.

J Hepatol 2016 11 26;65(5):888-898. Epub 2016 May 26.

Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907, United States; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289705PMC
November 2016

Neurofascin-155 as a putative antigen in combined central and peripheral demyelination.

Neurol Neuroimmunol Neuroinflamm 2016 Aug 7;3(4):e238. Epub 2016 Jun 7.

IRCCS (A.C., E.Z., C.O., S.R., N.V., E.A., A.M., E.M., D.F.), C. Mondino National Neurological Institute, Pavia, Italy; CNRS (J.J.D., C.M.), CRN2M-UMR 7286, Aix-Marseille Université; Gui de Chauliac Hospital (G.T., C.C.D.), Montpellier University Hospital Center; CHU Amiens-Picardie (P.M.), France; IRCCS Foundation (G.P., E.S., D.P.), C. Besta Neurological Institute, Milan; and University of Pavia (E.Z., A.M.), Italy.

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http://dx.doi.org/10.1212/NXI.0000000000000238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897982PMC
August 2016

Conformal radiotherapy as a bridge to liver transplantation for hepatocellular carcinoma: is it safe?

Future Oncol 2016 Jul 20;12(13):1577-86. Epub 2016 Apr 20.

Department of General Surgery & Liver Transplant, Hospices Civils de Lyon, Croix-Rousse University Hospital, Lyon, France.

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http://dx.doi.org/10.2217/fon-2016-0083DOI Listing
July 2016

Targeted deep DNA methylation analysis of circulating cell-free DNA in plasma using massively parallel semiconductor sequencing.

Epigenomics 2015 ;7(3):353-62

International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France.

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http://dx.doi.org/10.2217/epi.14.94DOI Listing
September 2015

High-resolution 3-dimensional T2*-weighted angiography (HR 3-D SWAN): an optimized 3-T magnetic resonance imaging sequence for targeting the subthalamic nucleus.

Neurosurgery 2014 Jun;74(6):615-26; discussion 627

Departments of *Neurosurgery, ‡Functional Exploration of the Central Nervous System, §Neurology, ¶Neuroradiology, ‖Anesthesiology, Amiens University Medical Center, Amiens, France; #Department of Neurosurgery, Rouen University Medical Center, Rouen, France.

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http://dx.doi.org/10.1227/NEU.0000000000000319DOI Listing
June 2014

Comprehensive profiling and marker identification in non-volatile citrus oil residues by mass spectrometry and nuclear magnetic resonance.

Food Chem 2014 May 1;150:235-45. Epub 2013 Nov 1.

School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, 30 Quai Ernest-Ansermet, 1211 Geneva 4, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03088146130155
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http://dx.doi.org/10.1016/j.foodchem.2013.10.103DOI Listing
May 2014

Update on hepatocellular carcinoma breakthroughs: poly(ADP-ribose) polymerase inhibitors as a promising therapeutic strategy.

Clin Res Hepatol Gastroenterol 2014 Apr 13;38(2):137-42. Epub 2013 Aug 13.

UMR INSERM U1052 CNRS5286, CRCL, 151, cours Albert-Thomas, 69008 Lyon, France; Université Lyon-1, 69622 Villeurbanne, France. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2013.07.006DOI Listing
April 2014

Differentiation of lemon essential oil based on volatile and non-volatile fractions with various analytical techniques: a metabolomic approach.

Food Chem 2014 Jan 3;143:325-35. Epub 2013 Aug 3.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30, Quai Ernest-Ansermet, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.foodchem.2013.07.125DOI Listing
January 2014

Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs.

J Hepatol 2013 Nov 5;59(5):1107-17. Epub 2013 Jul 5.

INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69008 Lyon, France; Université Lyon-1, F-69622 Villeurbanne, France; Centre Léon Bérard, F-69008 Lyon, France.

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http://dx.doi.org/10.1016/j.jhep.2013.07.001DOI Listing
November 2013

Cause-specific telomere factors deregulation in hepatocellular carcinoma.

J Exp Clin Cancer Res 2013 Sep 11;32:64. Epub 2013 Sep 11.

UMR5239 Oncovirologie et Biothérapies, Faculté de Médecine Lyon Sud, ENS - HCL, Université Lyon 1, CNRS, Pierre Bénite, France.

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http://dx.doi.org/10.1186/1756-9966-32-64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850108PMC
September 2013

Proinflammatory cytokine TNF-α increases the stability of hepatitis B virus X protein through NF-κB signaling.

Carcinogenesis 2011 Jul 31;32(7):978-85. Epub 2011 Mar 31.

Infections and Cancer Biology Group, International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France.

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http://dx.doi.org/10.1093/carcin/bgr057DOI Listing
July 2011

Gene signatures in hepatocellular carcinoma (HCC).

Semin Cancer Biol 2011 Feb 17;21(1):4-9. Epub 2010 Sep 17.

Basic Medical Sciences Department and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.

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http://dx.doi.org/10.1016/j.semcancer.2010.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030925PMC
February 2011

Quantification in gas chromatography: prediction of flame ionization detector response factors from combustion enthalpies and molecular structures.

Anal Chem 2010 Aug;82(15):6457-62

Firmenich SA, Corporate R&D Division, PO Box 239, 1211 Geneva 8, Switzerland.

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August 2010

Molecular mechanisms underlying hepatocellular carcinoma.

Viruses 2009 12 9;1(3):852-72. Epub 2009 Nov 9.

INSERM, U871, 69003 Lyon; Université Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France.

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http://www.mdpi.com/1999-4915/1/3/852
Publisher Site
http://dx.doi.org/10.3390/v1030852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185529PMC
December 2009

Synthesis and structures of crystalline Li, Al and Sn(II) 1-azaallyls and beta-diketiminates derived from [Li{mu,eta3-N(SiMe3)C(Ad)C(H)SiMe3}]2 (Ad = 1-adamantyl).

Dalton Trans 2008 Jul 11(26):3493-501. Epub 2008 Mar 11.

Department of Chemistry, University of Sussex, Brighton, United Kingdom.

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http://xlink.rsc.org/?DOI=b718728a
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http://dx.doi.org/10.1039/b718728aDOI Listing
July 2008

Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells.

J Hepatol 2008 May 7;48(5):780-91. Epub 2008 Feb 7.

Liver Research Center, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Providence, RI 02903, USA.

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http://dx.doi.org/10.1016/j.jhep.2007.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390890PMC
May 2008

Synthesis and structures of selected benzamidinates of Li, Na, Al, Zr and Sn(II) using the C1-symmetric ligands [N(SiMe3)C(C6H4Me-4 or Ph)NPh]-.

Dalton Trans 2007 Feb 4(5):585-94. Epub 2007 Jan 4.

Chemistry Department, University of Sussex, Brighton BN1 9QJ, UK.

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http://dx.doi.org/10.1039/b614351bDOI Listing
February 2007

Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma.

J Hepatol 2005 Nov 21;43(5):854-62. Epub 2005 Jun 21.

Department of Medicine and Pathology, Brown Medical School, The Liver Research Center, Providence, 55 Claverick St., 4th Floor, Providence, RI 02903, Rhode Island 02903, USA.

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http://dx.doi.org/10.1016/j.jhep.2005.05.018DOI Listing
November 2005

Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma.

Gastroenterology 2004 Oct;127(4):1110-22

The Liver Research Center, Department of Medicine and Pathology, Brown Medical School, Providence, Rhode Island 02903, USA.

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http://dx.doi.org/10.1053/j.gastro.2004.07.009DOI Listing
October 2004

Analysis of B-lymphocyte differentiation in patients infected with hepatitis C virus.

J Med Virol 2004 Apr;72(4):566-74

Unité mixte CNRS/bioMérieux 2142, Lyon Cédex, France.

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http://dx.doi.org/10.1002/jmv.20039DOI Listing
April 2004

[Glucagonoma revealed by necrolytic migratory erythema].

Gastroenterol Clin Biol 2003 Feb;27(2):230-2

Service d'Hépato-Gastroentérologie, Hôpital de l'Hôtel-Dieu, Lyon.

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February 2003