Philippe Lefebvre

Philippe Lefebvre

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Philippe Lefebvre

Philippe Lefebvre

Publications by authors named "Philippe Lefebvre"

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100Publications

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Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response.

Cells 2018 Sep 13;7(9). Epub 2018 Sep 13.

Institut Pasteur de Lille, The University of Lille, Inserm, CHU Lille, U1011-EGID, F-59000 Lille, France.

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September 2018

Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle.

PLoS One 2018 15;13(3):e0193882. Epub 2018 Mar 15.

CSGA, AgroSup Dijon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université de Bourgogne Franche-Comté, 9E Boulevard Jeanne d'Arc, Dijon, France.

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June 2018

Tongue Necrosis in Giant-Cell Arteritis.

N Engl J Med 2018 Jun;378(26):2517

Centre Hospitalier Jolimont-Lobbes, La Louvière, Belgium.

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June 2018

Daytime variations in perioperative myocardial injury - Authors' reply.

Lancet 2018 May 24;391(10135):2106. Epub 2018 May 24.

University of Lille, EGID, F-59000 Lille, France; Inserm, U1011, F-Lille, France; University Hospital CHU Lille, Lille, France; Institut Pasteur de Lille, Lille, France.

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May 2018

Organizing combinatorial transcription factor recruitment at cis-regulatory modules.

Transcription 2018 28;9(4):233-239. Epub 2017 Nov 28.

a Université de Lille - Inserm - Chru de Lille, Institut Pasteur de Lille , U1011- EGID, F-59000 Lille , France.

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November 2017

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects.

J Clin Endocrinol Metab 2017 10;102(10):3783-3794

Université Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes, F-59000 Lille, France.

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October 2017

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease.

Gastroenterology 2017 05 15;152(7):1679-1694.e3. Epub 2017 Feb 15.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France. Electronic address:

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May 2017

Feasibility of an implanted microphone for cochlear implant listening.

Eur Arch Otorhinolaryngol 2017 Mar 30;274(3):1383-1390. Epub 2016 Nov 30.

ENT Department, CHU Liège, Liege, Belgium.

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March 2017

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.

Nat Rev Endocrinol 2017 01 16;13(1):36-49. Epub 2016 Sep 16.

Université de Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000 Lille, France.

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January 2017

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.

Mol Metab 2016 Aug 1;5(8):635-645. Epub 2016 Jul 1.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:

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August 2016

Audiometric Results after Stapedotomy Operations in Patients with Otosclerosis and Preoperative Small Air-Bone Gaps.

Audiol Neurootol 2015 28;20(5):330-6. Epub 2015 Aug 28.

Department of Otorhinolaryngology, University of Lix00E8;ge, Lix00E8;ge, Belgium.

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June 2016

The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis.

Atherosclerosis 2016 06 4;249:200-8. Epub 2016 Mar 4.

European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France; Univ. Lille, F-59000 Lille, France; INSERM UMR 1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59000 Lille, France. Electronic address:

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June 2016

Ketone Body Therapy Protects From Lipotoxicity and Acute Liver Failure Upon Pparα Deficiency.

Mol Endocrinol 2015 Aug 18;29(8):1134-43. Epub 2015 Jun 18.

European Genomic Institute for Diabetes, Inserm UMR1011, and University Lille, F-59000 Lille Cédex, France; and Institut Pasteur de Lille, F-59019 Lille Cédex, France.

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August 2015

Nuclear bile acid signaling through the farnesoid X receptor.

Cell Mol Life Sci 2015 May 16;72(9):1631-50. Epub 2014 Dec 16.

European Genomic Institute for Diabetes (EGID), 59000, Lille, France.

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May 2015

SREBF2-embedded mir33 links the nuclear bile acid receptor FXR to cholesterol and lipoprotein metabolism.

Arterioscler Thromb Vasc Biol 2015 Apr;35(4):748-9

From the European Genomic Institute for Diabetes (EGID), Lille, France (P.L., B.S.); INSERM UMR1011, Lille, France (P.L., B.S.); University of Lille, Lille, France (P.L., B.S.); and Institut Pasteur de Lille, Lille, France (P.L., B.S.).

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April 2015

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease.

J Hepatol 2015 Mar 1;62(3):720-33. Epub 2014 Nov 1.

European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France; Université Lille 2, F-59000 Lille, France; Inserm UMR 1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59000 Lille, France. Electronic address:

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March 2015

A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation.

Nucleic Acids Res 2014 2;42(17):10943-59. Epub 2014 Sep 2.

Inserm UMR U1011, F-59000 Lille, France Université Lille 2, F-59000 Lille, France Institut Pasteur de Lille, F-59019 Lille, France European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France

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February 2015

O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing.

Front Endocrinol (Lausanne) 2014 13;5:230. Epub 2015 Jan 13.

U1016, Institut Cochin, INSERM , Paris , France ; UMR 8104, CNRS , Paris , France ; Sorbonne Paris Cité, Université Paris Descartes , Paris , France.

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January 2015

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice.

Hepatology 2014 Nov 1;60(5):1593-606. Epub 2014 Oct 1.

European Genomic Institute for Diabetes, Lille, France; INSERM UMR1011, F-59000, Lille, France; University Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.

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November 2014

Cell-specific dysregulation of microRNA expression in obese white adipose tissue.

J Clin Endocrinol Metab 2014 Aug 23;99(8):2821-33. Epub 2014 Apr 23.

European Genomic Institute for Diabetes (F.O., C.G., D.M., Y.B., O.M.-C., E.B., S.C., D.D., F.P., H.D., J.E., B.S., P.L.), Inserm Unité Mixte de Recherche Unité 1011 (F.O., C.G., D.M., Y.B., O.M.-C., E.B., S.C., D.D., H.D., J.E., B.S., P.L.), Université Lille 2 (F.O., C.G., D.M., Y.B., O.M.-C., E.B., S.C., D.D., F.P., H.D., J.E., B.S., P.L.), and Inserm Unité Mixte de Recherche Unité 859 (F.P.), F-59000 Lille, France; Institut Pasteur de Lille (F.O., C.G., D.M., Y.B., O.M.-C., E.B., S.C., D.D., H.D., J.E., B.S., P.L.), F-59019 Lille, France; and Centre Hospitalier Régional Universitaire de Lille (F.P.), F-59045, Lille, France.

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August 2014

Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.

Circulation 2014 Aug 13;130(7):554-64. Epub 2014 Jun 13.

From the Department of Physiology, Faculty of Medicine Lille, Lille, France (D.M., X.M., A.C., N.D., C.P., S.M., S.P., R.N.); Service d'Explorations Fonctionnelles CardioVasculaires (D.M., A.C., S.M.), Department of Cardiovascular Surgery (T.M., G.F., J.-M.E.A., M.K.), and Biochemistry Division, Pathology and Biology Center (F.Z.), University Hospital of Lille, Lille, France; Université Lille 2, Inserm, U1011, and Institut Pasteur de Lille, Lille, France (D.M., X.M., Y.S., H.D., P.L., B.S.); University Hospital of Lille, Lille, France; INSERM U1096, University of Rouen, Institute for Research and Innovation in Biomedicine, Rouen, France (I.R.-J., V.R.); and EA4483-Département de Médecine du Travail, Faculty of Medicine; University Lille 2, Lille, France (J.-L.E.).

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August 2014

Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR).

Hepatology 2014 May 24;59(5):2022-33. Epub 2014 Mar 24.

European Genomic Institute for Diabetes (EGID), Lille, France; INSERM UMR1011, Lille, France; Univ Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.

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May 2014

Failing FXR expression in the liver links aging to hepatic steatosis.

J Hepatol 2014 Apr 10;60(4):689-90. Epub 2014 Jan 10.

European Genomic Institute for Diabetes, F-59000 Lille, France; INSERM UMR1011, F-59000 Lille, France; Université Lille 2, F-59000 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France. Electronic address:

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April 2014

DCo(H2)ding the metabolic functions of SIRT1 in the intestine.

Gastroenterology 2014 Apr 22;146(4):893-6. Epub 2014 Feb 22.

European Genomic Institute for Diabetes and INSERM UMR1011 and Université Lille 2 and Institut Pasteur de Lille, Lille, France. Electronic address:

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April 2014

Mitochondrial dysfunction as an arrhythmogenic substrate: a translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops.

J Am Coll Cardiol 2013 Oct 1;62(16):1466-73. Epub 2013 May 1.

Equipe d'Accueil 4484, Department of Physiology, Faculty of Medicine Lille, University Lille 2, Lille, France; Service d'Explorations Fonctionnelles CardioVasculaires, University Hospital of Lille, Lille, France. Electronic address:

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October 2013

The hepatic orosomucoid/α1-acid glycoprotein gene cluster is regulated by the nuclear bile acid receptor FXR.

Endocrinology 2013 Oct 16;154(10):3690-701. Epub 2013 Jul 16.

PhD, Director, Institut National de la Santé et de la Recherche Médicale, Atherosclerosis, Boulevard Du Pr Leclerc, Batiment J&K, Faclte De Medecine De Lille, Lille 59000, France.

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October 2013

Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β-cells.

FEBS Lett 2013 Oct 25. Epub 2013 Oct 25.

European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France; UNIV LILLE 2, F-59000 Lille, France; Inserm UMR 1011, F-59000 Lille, France; IPL, F-59000 Lille, France.

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October 2013

Retinoids and nuclear retinoid receptors in white and brown adipose tissues: physiopathologic aspects.

Horm Mol Biol Clin Investig 2013 Aug;14(3):75-86

European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France.

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August 2013

Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways.

J Biol Chem 2013 Jan 20;288(2):1374-84. Epub 2012 Nov 20.

Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Liege University Hospital (Centre Hospitalier Universaitaire-C.H.U.), 4000 Liege, Belgium.

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January 2013

General molecular biology and architecture of nuclear receptors.

Curr Top Med Chem 2012 ;12(6):486-504

University of Lille-Nord de France, F-59000 Lille, France.

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September 2012

Auditory resting-state network connectivity in tinnitus: a functional MRI study.

PLoS One 2012 4;7(5):e36222. Epub 2012 May 4.

Coma Science Group, Cyclotron Research Centre, University of Liège, Liège, Belgium.

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September 2012

Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity.

PPAR Res 2012 6;2012:164140. Epub 2012 Sep 6.

Université Lille Nord de France, 59000 Lille, France ; Inserm, U1011, 59000 Lille, France ; UDSL, 59000 Lille, France ; Institut Pasteur de Lille, 59019 Lille, France.

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September 2012

Intratympanic steroid therapy using the Silverstein Microwick™ for refractory sudden sensorineural hearing loss increases speech intelligibility.

Audiol Neurootol 2012 23;17(2):105-11. Epub 2011 Aug 23.

Department of Otorhinolaryngology, University of Liege, Liege, Belgium.

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May 2012

Naturally improving insulin resistance with amorfrutins.

Proc Natl Acad Sci U S A 2012 May 27;109(19):7136-7. Epub 2012 Apr 27.

Université Lille Nord de France, Institut National de la Santé et de la Recherche Médicale U1011, F-59019 Lille, France.

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May 2012

The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells.

Mol Endocrinol 2012 Mar 2;26(3):399-413. Epub 2012 Feb 2.

Institut Pasteur de Lille, Faculté de Médecine de Lille-Pôle Recherche; Institut National de la Santé et de la Recherche Médicale (INSERM) U1011-Bâtiment J&K; Boulevard du Pr Leclerc, Lille cedex, France.

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March 2012

Control of nuclear receptor activities in metabolism by post-translational modifications.

FEBS Lett 2011 Jun 7;585(11):1640-50. Epub 2011 Apr 7.

Université Lille Nord de France, INSERM, U1011, Lille, France.

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June 2011

Retinoid X receptors: common heterodimerization partners with distinct functions.

Trends Endocrinol Metab 2010 Nov 30;21(11):676-83. Epub 2010 Jul 30.

Université du Droit et de la Santé de Lille - Nord de France.

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November 2010

Implantation of esterified hyaluronic acid in microdissected Reinke's space after vocal fold microsurgery: short- and long-term results.

J Voice 2010 Sep 22;24(5):626-35. Epub 2009 Oct 22.

Department of Otorhinolaryngology, University of Liège, Liège, Belgium.

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September 2010

Hair cell progenitors: identification and regulatory genes.

Acta Otolaryngol 2010 Mar;130(3):312-7

GIGA-Neurosciences, University of Liege, Liege, Belgium.

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March 2010

Hearing preservation in cochlear implantation and drug treatment.

Adv Otorhinolaryngol 2010 25;67:6-13. Epub 2009 Nov 25.

Department of Otorhinolaryngology, University of Liège, CHU Liège, Liège, Belgium.

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March 2010

Molecular modelling insights into DFNA15 mediated enhancement of POU4F3 stability.

Int J Comput Biol Drug Des 2008 ;1(3):295-301

Department of Otolaryngology, University of Liege, CHU de Liege, 4000 Liege, Belgium.

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February 2010

European results with totally implantable carina placed on the round window: 2-year follow-up.

Otol Neurotol 2009 Dec;30(8):1196-203

Service d'Oto-Rhino-Laryngologie, CHU Saint Etienne, CHU Nord, Assistance Publique, Hôpitaux de Marseille and Université de La Méditerranée, Marseille, France.

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December 2009

Pertussis in adulthood: report of two cases and review of the literature.

Laryngoscope 2009 Sep;119(9):1720-2

Department of Otolaryngology, University of Liege, Liege, Belgium.

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September 2009

Role of bile acids and bile acid receptors in metabolic regulation.

Physiol Rev 2009 Jan;89(1):147-91

Institut National de la Sante et de la Recherche Medicale, Lille, France.

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January 2009

The role of parity in medical abortion up to 49 days of amenorrhoea.

Eur J Contracept Reprod Health Care 2008 Dec;13(4):404-11

Service d'Orthogenie, Centre Hospitalier de Roubaix, Roubaix, France.

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December 2008

Strategies to regenerate hair cells: identification of progenitors and critical genes.

Hear Res 2008 Feb 6;236(1-2):1-10. Epub 2007 Sep 6.

Center for Cellular and Molecular Neurosciences, Developmental Neurobiology Unit, University of Liege, 4000 Liege, Belgium.

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February 2008

The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1.

J Neurochem 2008 Feb 6;104(3):777-89. Epub 2007 Nov 6.

Institut Pasteur de Lille, Lille, France.

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February 2008

Topical steroid therapy using the Silverstein Microwick in sudden sensorineural hearing loss after failure of conventional treatment.

Acta Otolaryngol 2007 Oct;127(10):1012-7

Department of Otorhinolaryngology, University of Liege, Liege, Belgium.

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October 2007

The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.

Mol Cell Endocrinol 2007 May 15;270(1-2):23-32. Epub 2007 Feb 15.

Institut Pasteur de Lille, Département d'Athérosclérose, Lille F-59019, France.

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May 2007

Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair cells and neurons after injury.

ORL J Otorhinolaryngol Relat Spec 2007 2;69(1):43-50. Epub 2006 Nov 2.

Department of Otolaryngology, University of Kansas, Kansas City, Kans 66160, USA.

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January 2007

Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1.

Nucleic Acids Res 2006 4;34(19):5515-27. Epub 2006 Oct 4.

INSERM U459, Faculté de Médecine de Lille, 59045 Lille, France.

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December 2006

Down-regulation of the tumor suppressor gene retinoic acid receptor beta2 through the phosphoinositide 3-kinase/Akt signaling pathway.

Mol Endocrinol 2006 Sep 13;20(9):2109-21. Epub 2006 Apr 13.

Institut National de la Santé et de la Recherche Médicale, Unité 545, Faculté de Médecine Henri Warembourg, 1 Place de Verdun, 59045 Lille cedex, France.

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September 2006

Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation.

J Biol Chem 2006 Jul 24;281(29):20338-48. Epub 2006 May 24.

INSERM U459, FacultédeMédecine Henri Warembourg, Lille F-59045, France.

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July 2006

Retinoids interfere with the AP1 signalling pathway in human breast cancer cells.

Cell Signal 2006 Jun 19;18(6):889-98. Epub 2005 Sep 19.

INSERM U459, Equipe labellisée par la Ligue Nationale contre le Cancer, Faculté de Médecine Henri Warembourg, 1 Place de Verdun, F-59045 Lille Cedex, France.

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June 2006

Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis.

J Clin Invest 2006 Mar;116(3):571-80

Département d'Athérosclérose, Institut Pasteur de Lille, INSERM U545, and Université de Lille 2, Lille, France.

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March 2006

Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons.

J Cell Sci 2005 Oct;118(Pt 19):4511-25

Research Centre for Cellular and Molecular Neurobiology, Developmental Neurobiology Unit, University of Liège, Av. de l'Hopital 1 B36, 4000 Liège, Belgium.

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October 2005

Implantation of esterified hyaluronic acid in microdissected Reinke's space after vocal fold microsurgery: first clinical experiences.

Laryngoscope 2005 Oct;115(10):1841-7

Department of Otorhinolaryngology, University of Liège, Belgium.

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October 2005

The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction.

Nucleic Acids Res 2005 29;33(13):4311-21. Epub 2005 Jul 29.

INSERM U459 and Ligue Nationale contre le Cancer, Faculté de Médecine de Lille 1 place de Verdun 59045 Lille cedex, France.

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August 2005

Transcriptional activities of retinoic acid receptors.

Vitam Horm 2005 ;70:199-264

INSERM U459 and Ligue Nationale Contre le Cancer, Faculté de Médecine de Lille, 59045 Lille cedex, France.

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June 2005

Cell cycle regulation of breast cancer cells through estrogen-induced activities of ERK and Akt protein kinases.

Mol Cell Endocrinol 2005 Jun;237(1-2):11-23

INSERM U 459, Faculté de Médecine Henri Warembourg, 1 place de Verdun, 59045 Lille Cedex, France.

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June 2005

The inhibition of cyclin-dependent kinases induces differentiation of supernumerary hair cells and Deiters' cells in the developing organ of Corti.

FASEB J 2003 Nov 4;17(14):2136-8. Epub 2003 Sep 4.

Center for Cellular and Molecular Neurobiology, University of Liège, 17 Place Delcour, B-4020 Liège, Belgium.

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November 2003

Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity.

Nucleic Acids Res 2003 Nov;31(22):6640-50

INSERM U459, Faculté de Médecine Henri Warembourg, 1 Place de Verdun, F-59045 Lille Cedex, France.

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November 2003

PLZF is a negative regulator of retinoic acid receptor transcriptional activity.

Nucl Recept 2003 Sep 6;1(1). Epub 2003 Sep 6.

INSERM U 459 and Ligue Nationale Contre le Cancer, Faculté de Médecine Henri Warembourg, 1 place de Verdun, 59045 Lille cedex, France.

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September 2003

Candida albicans phospholipomannan is sensed through toll-like receptors.

J Infect Dis 2003 Jul 23;188(1):165-72. Epub 2003 Jun 23.

Laboratoire de Mycologie Fondamentale et Appliquée, Inserm EMI0360, Université de Lille II, Lille, France.

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July 2003

Microperfusion of the inner ear.

Acta Otorhinolaryngol Belg 2002 ;56(4):365-8

Dept. of Otorhinolaryngology, University of Liège, Belgium.

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April 2003

Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of conventional therapy: a pilot study.

Acta Otolaryngol 2002 Oct;122(7):698-702

Department of Otorhinolaryngology, University of Liège, Liège, Belgium.

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October 2002