Publications by authors named "Philippe L Bedard"

100Publications

Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults.

J Neurooncol 2020 Sep 9;149(3):523-532. Epub 2020 Oct 9.

British Columbia Cancer, 600 W. 10th Avenue, Vancouver, BC, V5Z 4E1, Canada.

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http://dx.doi.org/10.1007/s11060-020-03642-1DOI Listing
September 2020

Clinical dilemmas in local and regional testis cancer.

Can Urol Assoc J 2020 Sep 18. Epub 2020 Sep 18.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.5489/cuaj.6913DOI Listing
September 2020

Small molecules, big impact: 20 years of targeted therapy in oncology.

Lancet 2020 03;395(10229):1078-1088

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(20)30164-1DOI Listing
March 2020

Disease modification and biomarker development in Parkinson disease: Revision or reconstruction?

Neurology 2020 03 26;94(11):481-494. Epub 2020 Feb 26.

From the Department of Neurology (A.J.E.), James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, OH; Edmond J. Safra Program in Parkinson's Disease (L.V.K.), Krembil Research Institute, Toronto Western Hospital, Ontario, Canada; Department of Neurology and Neurosurgery (Z.G.-O.), Montreal Neurological Institute, and Department of Human Genetics (Z.G.-O.), McGill University, Montreal, Quebec, Canada; Department of Clinical Neurosciences (C.H.W.-G.), John van Geest Centre for Brain Repair, University of Cambridge, UK; Division of Medical Oncology and Hematology (P.L.B.), Princess Margaret Cancer Centre, University Health Network, and Department of Medicine (P.L.B.), University of Toronto, Ontario, Canada; Departments of Medicine (S.M.R.), Pediatrics (S.M.R.), Cell Developmental and Integrative Biology (S.M.R.), and Neurology (D.G.S.), University of Alabama at Birmingham; Department of Clinical and Experimental Medicine (F.M.), University of Messina, Italy; Institute of Molecular and Clinical Sciences (F.M.), St George's University of London, UK; Edmond J. Safra Program in Parkinson's Disease (A.F., A.P.S., A.E.L.), Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University of Toronto; Krembil Research Institute (A.F., A.P.S., A.E.L.); Tomorrow Edition (B.S.), Toronto, Ontario, Canada; Consultorio y Laboratorio de Neurogenética (M.A.K.), Centro Universitario de Neurología "José María Ramos Mejía" y División Neurología, Hospital JM Ramos Mejía, Facultad de Medicina, UBA; Programa de Medicina de Precision y Genomica Clinica (M.A.K.), Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, Universidad Austral-CONICET, Buenos Aires, Argentina; Clinical Genomics Program (M.J.F.), Norman Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida Clinical and Translational Science Institute, Gainesville; Clinical Trials Statistical & Data Management Center (C.S.C.), University of Iowa College of Public Health, Iowa City; Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston; Michael J. Fox Foundation for Parkinson's Research (T.S.), New York City, NY; Department of Neurology (R.B.P.), Montreal General Hospital, Quebec; Research Imaging Centre (A.P.S.), Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada; Laboratory of Neurogenetics (A.B.S.), National Institute on Aging, NIH, Bethesda, MD; Department of Clinical Neurosciences (R.A.B.), John van Geest Centre for Brain Repair, WT-MRC Cambridge Stem Cell Institute, University of Cambridge, UK; Clinical Trials Coordination Center (K.K.), University of Rochester Medical Center, NY; Department of Neurology and Neuroscience (C.W.O.), Mount Sinai School of Medicine, New York, NY; Clintrex LLC (C.W.O.), Sarasota, FL; Division of Neurosurgery (A.L.), Krembil Neuroscience Institute, Toronto Western Hospital, Ontario, Canada; Department of Neurological Sciences (J.H.K.), Rush University Medical Center, Chicago, IL; Coeruleus Clinical Sciences (J.M.C.), Woodbridge, CT; and Center for Neurodegenerative Science (P.B.), Van Andel Institute, Grand Rapids, MI.

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http://dx.doi.org/10.1212/WNL.0000000000009107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220234PMC
March 2020

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer.

N Engl J Med 2020 02 11;382(7):597-609. Epub 2019 Dec 11.

From M.D. Anderson Cancer Center, Houston (R.K.M., G.H.); Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (S. Loi); the Royal Marsden NHS Foundation Trust, London (A.O.), and Edinburgh Cancer Research Centre, Edinburgh (D.C.) - both in the United Kingdom; Winship Cancer Institute, Atlanta (E.P.); Sarah Cannon Research Institute/Tennessee Oncology-Nashville (E.H.) and Vanderbilt University Medical Center (V.A.), Nashville; University of California, Los Angeles, Medical Center-Jonsson Comprehensive Cancer Center, Los Angeles (S.A.H., D.S.), and Stanford Comprehensive Cancer Institute, Palo Alto (M.P.) - both in California; Dana-Farber Cancer Institute, Boston (N.U.L., I.K., E.P.W.); University of Colorado Cancer Center, Aurora (V.B.); Duke Cancer Institute, Durham (C.A.), and University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill (L.A.C.) - both in North Carolina; University Health Network, Princess Margaret Cancer Centre, Toronto (P.L.B.), and British Columbia Cancer, Vancouver (K.G.) - both in Canada; Hospital Universitario Vall D'Hebron, Barcelona (M.O.); Sygehus Lillebaelt-Vejle Sygehus, Vejle, Denmark (E.J.); Centre Léon Bérard, Lyon, France (T.B.); Rambam Health Care Campus, Haifa, Israel (S.S.S.); Universitaetsklinikum Hamburg-Eppendorf, Hamburg (V.M.), and German Breast Group, Neu-Isenburg (S. Loibl) - both in Germany; Hospital Cuf Descobertas R. Mário Botas, Lisbon, Portugal (S.B.); Cliniques Universitaires Saint-Luc, Brussels (F.P.D.); Third Medical Department, Paracelsus Medical University Salzburg, Salzburg Cancer Research Institute-Center for Clinical Cancer and Immunology Trials, and Cancer Cluster Salzburg, Salzburg, Austria (R.G.); Istituto Europeo di Oncologia, IRCCS, University of Milan, Milan (G.C.); and Seattle Genetics, Bothell, WA (M.C.P.-W., L.W., W.F.).

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http://dx.doi.org/10.1056/NEJMoa1914609DOI Listing
February 2020

Intracranial Germ Cell Tumors in Adolescents and Young Adults: A 40-Year Multi-Institutional Review of Outcomes.

Int J Radiat Oncol Biol Phys 2020 02 22;106(2):269-278. Epub 2019 Oct 22.

Princess Margaret Cancer Centre, Toronto, Ontario; University of Toronto, Toronto, Ontario; The Hospital for Sick Children, Toronto, Ontario.

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http://dx.doi.org/10.1016/j.ijrobp.2019.10.020DOI Listing
February 2020

Detection of Relapse by Low-dose Computed Tomography During Surveillance in Stage I Testicular Germ Cell Tumours.

Eur Urol Oncol 2019 07 2;2(4):437-442. Epub 2018 Oct 2.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.euo.2018.08.031DOI Listing
July 2019

Referrals to a Phase I Clinic and Trial Enrollment in the Molecular Screening Era.

Oncologist 2019 07 4;24(7):e518-e525. Epub 2019 Mar 4.

Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656436PMC
July 2019

Treatment of Relapse of Clinical Stage I Nonseminomatous Germ Cell Tumors on Surveillance.

J Clin Oncol 2019 08 25;37(22):1919-1926. Epub 2019 Feb 25.

1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.18.01250DOI Listing
August 2019

Applying Radiomics to Predict Pathology of Postchemotherapy Retroperitoneal Nodal Masses in Germ Cell Tumors.

JCO Clin Cancer Inform 2018 12;2:1-12

Jeremy Lewin, Padraig Warde, Peter Chung, Lynn Anson Cartwright, Joan Sweet, Aaron R. Hansen, and Philippe L. Bedard, Princess Margaret Cancer Centre; Michael A.S. Jewett, Robert J. Hamilton, Madhur Nayan, Ricardo Leão, Aaron R. Hansen, and Philippe L. Bedard, University of Toronto; Paul Dufort, Jaydeep Halankar, Martin O'Malley, and Ur Metser, University Health Network; and Abha Gupta, Armando Lorenzo, and Jeffrey Traubici, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/CCI.18.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874033PMC
December 2018

American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives.

JCO Clin Cancer Inform 2018 12;2:1-14

Christine M. Micheel, Michele L. LeNoue-Newton, and Mia A. Levy, Vanderbilt University Medical Center, Nashville, TN; Shawn M. Sweeney, American Association for Cancer Research, Philadelphia, PA; Fabrice André, Institut Gustave Roussy, Villejuif, France; Philippe L. Bedard, University of Toronto, Toronto, Ontario, Canada; Justin Guinney, Sage Bionetworks, Seattle, WA; Gerrit A. Meijer, Netherlands Cancer Institute, Amsterdam, the Netherlands; Barrett J. Rollins, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA; Charles L. Sawyers and Nikolaus Schultz, Memorial Sloan Kettering Cancer Center, New York, NY; Charles L. Sawyers, Howard Hughes Medical Institute, Chevy Chase, MD; Victor E. Velculescu, Johns Hopkins University School of Medicine, Baltimore, MD; and Kenna R. Mills Shaw, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/CCI.17.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873906PMC
December 2018

Somatic Tumor Variant Filtration Strategies to Optimize Tumor-Only Molecular Profiling Using Targeted Next-Generation Sequencing Panels.

J Mol Diagn 2019 03 19;21(2):261-273. Epub 2018 Dec 19.

Advanced Molecular Diagnostics Laboratory, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Clinical Laboratory Genetics, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.09.008DOI Listing
March 2019

Delivery of chemotherapy for testicular cancer in routine practice: A population-based study.

Urol Oncol 2019 03 23;37(3):183.e17-183.e24. Epub 2018 Nov 23.

Division of Cancer Care and Epidemiology, Queen's Cancer Research Institute, Kingston, Canada; Department of Oncology, Queen's University, Kingston, Canada; Department of Public Health Sciences, Queen's University, Kingston, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183043
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http://dx.doi.org/10.1016/j.urolonc.2018.10.025DOI Listing
March 2019

Incorporating Genomics Into the Care of Patients With Advanced Breast Cancer.

Am Soc Clin Oncol Educ Book 2018 May;38:56-64

From the University of Wisconsin Carbone Cancer Center, Madison, WI; Department of Medicine, Division of Hematology/Oncology, University of Wisconsin, Madison, WI; Yale Cancer Center, New Haven, CT; Princess Margaret Hospital, Calgary, ON, Canada; Princess Margaret Cancer Center, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/EDBK_200731DOI Listing
May 2018

Serum miRNA Predicts Viable Disease after Chemotherapy in Patients with Testicular Nonseminoma Germ Cell Tumor.

J Urol 2018 07 21;200(1):126-135. Epub 2018 Feb 21.

Department of Surgery (Urology) and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2018.02.068DOI Listing
July 2018

Utility of molecular tools for extended adjuvant endocrine therapy decisions in early breast cancer.

Future Oncol 2017 12 23;13(30):2733-2736. Epub 2017 Nov 23.

Division of Medical Oncology & Hematology, Department of Medicine, University of Toronto & Princess Margaret Cancer Centre, Toronto, ON,  M5G 1Z9, Canada.

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http://dx.doi.org/10.2217/fon-2017-0427DOI Listing
December 2017

Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.

Clin Colorectal Cancer 2018 03 23;17(1):73-79. Epub 2017 Oct 23.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2017.10.010DOI Listing
March 2018

Impact of Granulocyte-colony Stimulating Factor on Bleomycin-induced Pneumonitis in Chemotherapy-treated Germ Cell Tumors.

Clin Genitourin Cancer 2017 Sep 4. Epub 2017 Sep 4.

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.08.012DOI Listing
September 2017

Shrinking Hepatic Hemangiomas in a Patient Treated for Metastatic Germ Cell Tumor.

Clin Genitourin Cancer 2017 Aug 31. Epub 2017 Aug 31.

Department of Medicine, University of Toronto, Toronto, ON, Canada; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15587673173024
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http://dx.doi.org/10.1016/j.clgc.2017.08.008DOI Listing
August 2017

Standard and Genomic Tools for Decision Support in Breast Cancer Treatment.

Am Soc Clin Oncol Educ Book 2017 ;37:106-115

From the University of Utah, Salt Lake City, UT; Department of Medicine, Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1200/EDBK_175617DOI Listing
December 2017

AKT Inhibition in Solid Tumors With AKT1 Mutations.

J Clin Oncol 2017 Jul 10;35(20):2251-2259. Epub 2017 May 10.

David M. Hyman, Lillian M. Smyth, Mark T.A. Donoghue, Matthew T. Chang, Jonathan B. Reichel, Nancy Bouvier, S. Duygu Selcuklu, Tara E. Soumerai, Jean Torrisi, Joseph P. Erinjeri, Michael F. Berger, Sarat Chandarlapaty, David B. Solit, José Baselga, and Barry S. Taylor, Memorial Sloan Kettering Cancer Center; David B. Solit, Weill Cornell Medical College, Cornell University, New York, NY; J. Carl Barrett and Brian Dougherty, AstraZeneca, Waltham, MA; Helen Ambrose, Andrew Foxley, Justin P.O. Lindemann, Robert McEwen, Martin Pass, and Gaia Schiavon, AstraZeneca, Cambridge; Emma J. Dean, The Christie National Health Service Foundation, Manchester; Udai Banerji, Royal Marsden Hospital, London, United Kingdom; Shannon N. Westin, The University of Texas MD Anderson Cancer Center, Houston, TX; Philippe L. Bedard, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Hideaki Bando, National Cancer Center East Hospital, Kashiwa, Japan; Anthony B. El-Khoueiry, University of Southern California Norris Comprehensive Cancer Center; Alain Mita, Cedars-Sinai Medical Center, Los Angeles, CA; José A. Pérez-Fidalgo, Hospital Clinico de Valencia, Valencia, Spain; and Jan H.M. Schellens, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2017.73.0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501365PMC
July 2017

The association between institution at orchiectomy and outcomes on active surveillance for clinical stage I germ cell tumours.

Can Urol Assoc J 2016 May-Jun;10(5-6):204-209

Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.5489/cuaj.3513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045349PMC
October 2016

A Matched Cohort Study of Patients With End-Stage Heart Failure from Anthracycline-Induced Cardiomyopathy Requiring Advanced Cardiac Support.

Am J Cardiol 2016 Nov 23;118(10):1539-1544. Epub 2016 Aug 23.

Ted Rogers Program in Cardiotoxicity Prevention, Peter Munk Cardiac Center, University Health Network, University of Toronto, Toronto, Ontario, Canada; Ted Rogers Center of Excellence in Heart Function, Peter Munk Cardiac Center, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029149163138
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http://dx.doi.org/10.1016/j.amjcard.2016.08.020DOI Listing
November 2016

Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer.

Cold Spring Harb Mol Case Stud 2016 Sep;2(5):a001016

Drug Development Program, Division of Medical Oncology and Hematology; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5S 1A8, Canada;; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1101/mcs.a001016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002925PMC
September 2016

Conditional Risk of Relapse in Surveillance for Clinical Stage I Testicular Cancer.

Eur Urol 2017 01 12;71(1):120-127. Epub 2016 Aug 12.

Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.07.013DOI Listing
January 2017

Beta-Testing of Next-Generation DNA Sequencing for Patients With Advanced Cancers Treated at Community Hospitals.

J Oncol Pract 2016 Apr 8;12(4):279-81. Epub 2016 Mar 8.

Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada

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http://ascopubs.org/doi/10.1200/JOP.2015.010165
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http://dx.doi.org/10.1200/JOP.2015.010165DOI Listing
April 2016

Conditional Survival of Patients With Metastatic Testicular Germ Cell Tumors Treated With First-Line Curative Therapy.

J Clin Oncol 2016 Mar 19;34(7):714-20. Epub 2016 Jan 19.

Jenny J. Ko, Abbotsford Cancer Agency, Abbotsford, British Columbia; Haocheng Li, University of Calgary; Igor Stukalin, Nimira Alimohamed, and Daniel Y.C. Heng, Tom Baker Cancer Center, Calgary, Alberta; Tehmina Asif, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan; Daphne Day and Philippe L. Bedard, Princess Margaret Cancer Center, Toronto, Ontario, Canada; Brandon Bernard and Christopher J. Sweeney, Dana Farber Cancer Institute, Boston, MA; and Ben Tran and Margaret Lee, Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1200/JCO.2015.64.7909DOI Listing
March 2016

Prospective Evaluation of the 21-Gene Recurrence Score Assay for Breast Cancer Decision-Making in Ontario.

J Clin Oncol 2016 Apr 23;34(10):1065-71. Epub 2015 Nov 23.

Mark N. Levine, Jim A. Julian, and Louise Bordeleau, McMaster University, Hamilton; Mark N. Levine and Louise Bordeleau, Hamilton Health Sciences Juravinski Cancer Centre, Hamilton; Mark N. Levine and Jim A. Julian, Ontario Clinical Oncology Group and Escarpment Cancer Research Institute, Hamilton; Philippe L. Bedard, Andrea Eisen, Maureen E. Trudeau, and Kathleen I. Pritchard, University of Toronto, Toronto; Phillipe L. Bedard, Princess Margaret Hospital, Toronto; Andrea Eisen, Maureen E. Trudeau, and Kathleen I. Pritchard, Odette Sunnybrook Regional Cancer Centre; Toronto; and Brian Higgins, Peel Regional Cancer Centre, Mississauga, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2015.62.8503DOI Listing
April 2016

Randomized controlled trials in testicular cancer: A demographic and quality assessment.

Urol Oncol 2016 Feb 20;34(2):60.e7-13. Epub 2015 Oct 20.

Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Surgery, University Health Network and University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2015.09.007DOI Listing
February 2016

Right Ventricular Dysfunction in Patients Experiencing Cardiotoxicity during Breast Cancer Therapy.

J Oncol 2015 3;2015:609194. Epub 2015 Aug 3.

Division of Cardiology, Peter Munk Cardiac Center, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4 ; Division of Medical Imaging, Peter Munk Cardiac Center, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4.

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http://dx.doi.org/10.1155/2015/609194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539180PMC
September 2015

Elucidating the genomic landscape of breast cancer: how will this affect treatment?

Pharmacogenomics 2015 20;16(6):569-72. Epub 2015 Apr 20.

Bras Drug Development Program, Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, 5-125, 610 University Avenue, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.2217/pgs.15.27DOI Listing
February 2016

Lymph Node Yield in Primary Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumors.

J Urol 2015 Aug 28;194(2):386-91. Epub 2015 Mar 28.

Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2015.03.100DOI Listing
August 2015

Large retroperitoneal lymphadenopathy as a predictor of venous thromboembolism in patients with disseminated germ cell tumors treated with chemotherapy.

J Clin Oncol 2015 Feb 20;33(6):582-7. Epub 2015 Jan 20.

Amirrtha Srikanthan, Ben Tran, Michael A.S. Jewett, Robert J. Hamilton, Lynn Anson-Cartwright, Peter W.M. Chung, Padraig R. Warde, Martin O'Malley, Malcolm J. Moore, Eitan Amir, and Philippe L. Bedard, Princess Margaret Cancer Centre, University of Toronto, Toronto; Michel Beausoleil and Eric Winquist, Western University and London Health Sciences Centre, London, Ontario; Jeremy F.G. Sturgeon, McGill University, Montreal, Quebec, Canada; and Ben Tran, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

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http://jco.ascopubs.org/content/early/2015/01/20/JCO.2014.58
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.58.6537
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http://dx.doi.org/10.1200/JCO.2014.58.6537DOI Listing
February 2015

PIK3CA genotype and treatment decisions in human epidermal growth factor receptor 2-positive breast cancer.

J Clin Oncol 2015 Apr 5;33(12):1318-21. Epub 2015 Jan 5.

Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1200/JCO.2014.59.3160DOI Listing
April 2015

Author financial conflicts of interest, industry funding, and clinical practice guidelines for anticancer drugs.

J Clin Oncol 2015 Jan 10;33(1):100-6. Epub 2014 Nov 10.

Ariadna Tibau and Agustí Barnadas, Hospital de la Santa Creu i Sant Pau and Universitat Autònoma de Barcelona, Barcelona; Alberto Ocaña, Albacete University Hospital, Albacete, Spain; Philippe L. Bedard, Amirrtha Srikanthan, Josee-Lyne Ethier, Francisco E. Vera-Badillo, and Eitan Amir, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada; Arnoud J. Templeton, Kantonsspital St Gallen, St Gallen, Switzerland; and Bostjan Seruga, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

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http://jco.ascopubs.org/content/33/1/100.full.pdf
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.57.8898
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http://dx.doi.org/10.1200/JCO.2014.57.8898DOI Listing
January 2015

A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin.

Invest New Drugs 2014 Dec 12;32(6):1269-77. Epub 2014 Sep 12.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Avenue, M5G 2 M9, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10637-014-0159-5DOI Listing
December 2014

Patterns of relapse in patients with clinical stage I testicular cancer managed with active surveillance.

J Clin Oncol 2015 Jan 18;33(1):51-7. Epub 2014 Aug 18.

Peter C. Black and Alan I. So, University of British Columbia, The Vancouver Prostate Centre; Christian Kollmannsberger, Kim Chi, and Scott Tyldesley, British Columbia Cancer Agency Vancouver Cancer Center, University of British Columbia, Vancouver, British Columbia; Philippe L. Bedard, Michael A. Jewett, Malcom J. Moore, and Peter W. Chung, University Health Network-Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Gabriella Cohn-Cedermark and Padraig R. Warde, Radiumhemmet, Karolinska Institute and University Hospital, Stockholm, Sweden; Tom Powles, Bart's Cancer Institute, St Bartholomew's Hospital, London; Andrew Protheroe, University of Oxford, the Churchill Hospital, Oxford, UK; Siamak Daneshmand, Institute of Urology, USC/Norris Comprehensive Cancer Center, Los Angeles, CA; and Craig R. Nichols, Virginia Mason Medical Center, Section of Hematology/Oncology, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.2014.56.2116DOI Listing
January 2015

Enhancing reproducibility in cancer drug screening: how do we move forward?

Cancer Res 2014 Aug 11;74(15):4016-23. Epub 2014 Jul 11.

Princess Margaret Cancer Centre, University Health Network; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119520PMC
August 2014

Genomic testing in cancer: patient knowledge, attitudes, and expectations.

Cancer 2014 Oct 24;120(19):3066-73. Epub 2014 Jun 24.

Division of Medical Oncology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.28807DOI Listing
October 2014

Promising SINEs for embargoing nuclear-cytoplasmic export as an anticancer strategy.

Cancer Discov 2014 May 17;4(5):527-37. Epub 2014 Apr 17.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/2159-8290.CD-13-1005DOI Listing
May 2014

Tilting the balance of dose modification for oral anticancer drugs?

J Clin Oncol 2014 May 7;32(15):1537-9. Epub 2014 Apr 7.

Princess Margaret Cancer Centre, University Health Network; University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.1200/JCO.2014.55.2372DOI Listing
May 2014

Androgen receptor expression and outcomes in early breast cancer: a systematic review and meta-analysis.

J Natl Cancer Inst 2014 Jan 22;106(1):djt319. Epub 2013 Nov 22.

Affiliations of authors: Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, Canada (FEV-B, AJT, PdG, ID-P, PLB, MA-M, IFT, AO, EA); Sector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia (BS); Medical Oncology Department and Translational Research Unit, Albacete University Hospital, Albacete, Spain (AO).

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http://dx.doi.org/10.1093/jnci/djt319DOI Listing
January 2014

Evolution of clinical trial design in early drug development: systematic review of expansion cohort use in single-agent phase I cancer trials.

J Clin Oncol 2013 Nov 14;31(33):4260-7. Epub 2013 Oct 14.

Arif Manji, Irene Brana, Eitan Amir, Ian F. Tannock, Philippe L. Bedard, Amit Oza, Lillian L. Siu, and Albiruni R. Abdul Razak, Princess Margaret Cancer Centre, University Health Network; George Tomlinson, University of Toronto; and Arif Manji, Hospital for Sick Children, Toronto, and Southlake Regional Health Centre, Newmarket, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2012.47.4957DOI Listing
November 2013

Personalized medicine for metastatic breast cancer.

Curr Opin Oncol 2013 Nov;25(6):615-24

aDrug Development Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre bDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/CCO.0000000000000015DOI Listing
November 2013

Tumour heterogeneity in the clinic.

Nature 2013 Sep;501(7467):355-64

Princess Margaret Cancer Centre, University Health Network, Division of Medical Oncology and Hematology, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nature12627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224525PMC
September 2013

Cost-effectiveness of the 21-gene assay for guiding adjuvant chemotherapy decisions in early breast cancer.

Value Health 2013 Jul-Aug;16(5):729-39. Epub 2013 Jul 1.

Toronto Health Economics and Technology Assessment (THETA) Collaborative, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jval.2013.03.1625DOI Listing
November 2013

A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors.

Invest New Drugs 2013 Oct 17;31(5):1182-91. Epub 2013 Jul 17.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Avenue, 5-125, M5G 2M9, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s10637-013-0001-5
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http://dx.doi.org/10.1007/s10637-013-0001-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771370PMC
October 2013

Anterior transpericardial approach for postchemotherapy residual midvisceral mediastinal mass in metastatic germ cell tumors.

J Thorac Cardiovasc Surg 2013 Apr 9;145(4):1136-1138. Epub 2013 Jan 9.

Division of Urology, Toronto General Hospital and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00225223120153
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http://dx.doi.org/10.1016/j.jtcvs.2012.12.009DOI Listing
April 2013