Philippe J Guerin

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK; Infectious Diseases Data Observatory (IDDO), Oxford, UK; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. Electronic address:

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August 2020

Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis.

BMC Med 2020 06 2;18(1):138. Epub 2020 Jun 2.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.

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June 2020

The WorldWide Antimalarial Resistance Network Clinical Trials Publication Library: A Live, Open-Access Database of Treatment Efficacy Trials.

Authors:

Junko Takata Paul Sondo Georgina S Humphreys Rebekah Burrow Brittany Maguire Mohammad S Hossain Debashish Das Robert J Commons Ric N Price Philippe J Guerin

Am J Trop Med Hyg 2020 07 7;103(1):359-368. Epub 2020 May 7.

Infectious Diseases Data Observatory (IDDO), Oxford, United Kingdom.

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July 2020

A living systematic review protocol for COVID-19 clinical trial registrations.

Authors:

Brittany J Maguire Philippe J Guérin

Wellcome Open Res 2020 2;5:60. Epub 2020 Apr 2.

Infectious Diseases Data Observatory (IDDO), Oxford, UK.

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April 2020

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data.

BMC Med 2020 02 25;18(1):47. Epub 2020 Feb 25.

MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

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February 2020

Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting.

Authors:

Prabin Dahal Kasia Stepniewska Philippe J Guerin Umberto D'Alessandro Ric N Price Julie A Simpson

BMC Med Res Methodol 2019 11 27;19(1):215. Epub 2019 Nov 27.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

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November 2019

The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis.

PLoS Med 2019 10 4;16(10):e1002928. Epub 2019 Oct 4.

Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.

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October 2019

Efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a protocol for systematic review and individual patient data (IPD) meta-analysis.

Authors:

Makoto Saito Rashid Mansoor Kalynn Kennon Rose McGready François Nosten Philippe J Guérin Kasia Stepniewska

BMJ Open 2019 08 22;9(8):e027503. Epub 2019 Aug 22.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.

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August 2019

The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis.

BMC Med 2019 08 1;17(1):151. Epub 2019 Aug 1.

Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.

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August 2019

Optimal Duration of Follow-up for Assessing Antimalarial Efficacy in Pregnancy: A Retrospective Analysis of a Cohort Followed Up Until Delivery on the Thailand-Myanmar Border.

Authors:

Makoto Saito Rashid Mansoor Jacher Wiladphaingern Moo Kho Paw Mupawjay Pimanpanarak Stephane Proux Philippe J Guérin Nicholas J White François Nosten Rose McGready

Open Forum Infect Dis 2019 Jul 31;6(7):ofz264. Epub 2019 May 31.

Shoklo Malaria Research Unit (SMRU), Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Tak, Thailand.

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July 2019

Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria.

Authors:

Palang Chotsiri Lise Denoeud-Ndam Elisabeth Baudin Ousmane Guindo Halimatou Diawara Oumar Attaher Michiel Smit Philippe J Guerin Ogobara K Doumbo Lubbe Wiesner Karen I Barnes Richard M Hoglund Alassane Dicko Jean-Francois Etard Joel Tarning

Clin Pharmacol Ther 2019 12 23;106(6):1299-1309. Epub 2019 Jul 23.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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December 2019

Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study.

Authors:

Prabin Dahal Philippe J Guerin Ric N Price Julie A Simpson Kasia Stepniewska

BMC Med Res Methodol 2019 05 17;19(1):107. Epub 2019 May 17.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.

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May 2019

Microbiology Investigation Criteria for Reporting Objectively (MICRO): a framework for the reporting and interpretation of clinical microbiology data.

Authors:

Paul Turner Andrew Fox-Lewis Poojan Shrestha David A B Dance Tri Wangrangsimakul Tomas-Paul Cusack Clare L Ling Jill Hopkins Tamalee Roberts Direk Limmathurotsakul Ben S Cooper Susanna Dunachie Catrin E Moore Christiane Dolecek H Rogier van Doorn Philippe J Guerin Nicholas P J Day Elizabeth A Ashley

BMC Med 2019 03 29;17(1):70. Epub 2019 Mar 29.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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March 2019

Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis.

Authors:

Robert J Commons Julie A Simpson Kamala Thriemer Mohammad S Hossain Nicholas M Douglas Georgina S Humphreys Carol H Sibley Philippe J Guerin Ric N Price

Lancet Infect Dis 2019 01;19(1):91-101

Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; WorldWide Antimalarial Resistance Network, Oxford, UK; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

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January 2019

The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review.

Authors:

Ilsa L Haeusler Xin Hui S Chan Philippe J Guérin Nicholas J White

BMC Med 2018 11 7;16(1):200. Epub 2018 Nov 7.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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November 2018

Enumerating the economic cost of antimicrobial resistance per antibiotic consumed to inform the evaluation of interventions affecting their use.

Authors:

Poojan Shrestha Ben S Cooper Joanna Coast Raymond Oppong Nga Do Thi Thuy Tuangrat Phodha Olivier Celhay Philippe J Guerin Heiman Wertheim Yoel Lubell

Antimicrob Resist Infect Control 2018 9;7:98. Epub 2018 Aug 9.

2Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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September 2019

Secondary analysis and participation of those at the data source.

Authors:

Laura Merson Philippe J Guérin Karen I Barnes Francine Ntoumi Oumar Gaye

Lancet Glob Health 2018 09;6(9):e965

Université Cheikh Anta Diop, Dakar, Senegal.

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September 2018

The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis.

Authors:

Robert J Commons Julie A Simpson Kamala Thriemer Georgina S Humphreys Tesfay Abreha Sisay G Alemu Arletta Añez Nicholas M Anstey Ghulam R Awab J Kevin Baird Bridget E Barber Isabelle Borghini-Fuhrer Cindy S Chu Umberto D'Alessandro Prabin Dahal André Daher Peter J de Vries Annette Erhart Margarete S M Gomes Lilia Gonzalez-Ceron Matthew J Grigg Aliehsan Heidari Jimee Hwang Piet A Kager Tsige Ketema Wasif A Khan Marcus V G Lacerda Toby Leslie Benedikt Ley Kartini Lidia Wuelton M Monteiro Francois Nosten Dhelio B Pereira Giao T Phan Aung P Phyo Mark Rowland Kavitha Saravu Carol H Sibley André M Siqueira Kasia Stepniewska Inge Sutanto Walter R J Taylor Guy Thwaites Binh Q Tran Hien T Tran Neena Valecha José Luiz F Vieira Sonam Wangchuk Timothy William Charles J Woodrow Lina Zuluaga-Idarraga Philippe J Guerin Nicholas J White Ric N Price

Lancet Infect Dis 2018 09 20;18(9):1025-1034. Epub 2018 Jul 20.

Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; WorldWide Antimalarial Resistance Network, Clinical module, Darwin, NT, Australia; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. Electronic address:

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September 2018

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis.

PLoS Med 2018 06 12;15(6):e1002579. Epub 2018 Jun 12.

WorldWide Antimalarial Resistance Network, Bangkok, Thailand.

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June 2018

Malaria and Nutritional Status Among Children With Severe Acute Malnutrition in Niger: A Prospective Cohort Study.

Authors:

Catherine E Oldenburg Philippe J Guerin Fatou Berthé Rebecca F Grais Sheila Isanaka

Clin Infect Dis 2018 09;67(7):1027-1034

Department of Research, Epicentre, Paris, France.

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September 2018

An inventory of supranational antimicrobial resistance surveillance networks involving low- and middle-income countries since 2000.

Authors:

Elizabeth A Ashley Judith Recht Arlene Chua David Dance Mehul Dhorda Nigel V Thomas Nisha Ranganathan Paul Turner Philippe J Guerin Nicholas J White Nicholas P Day

J Antimicrob Chemother 2018 07;73(7):1737-1749

Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.

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July 2018

Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger.

Authors:

Rebecca F Grais Ibrahim M Laminou Lynda Woi-Messe Rockyath Makarimi Seidou H Bouriema Celine Langendorf Alfred Amambua-Ngwa Umberto D'Alessandro Philippe J Guérin Thierry Fandeur Carol H Sibley

Malar J 2018 Feb 27;17(1):98. Epub 2018 Feb 27.

WorldWide Antimalarial Resistance Network, University of Washington, Seattle, USA.

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February 2018

Tools for surveillance of anti-malarial drug resistance: an assessment of the current landscape.

Authors:

Christian Nsanzabana Djibrine Djalle Philippe J Guérin Didier Ménard Iveth J González

Malar J 2018 Feb 8;17(1):75. Epub 2018 Feb 8.

Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland.

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February 2018

Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review.

Authors:

Makoto Saito Mary Ellen Gilder François Nosten Philippe J Guérin Rose McGready

Malar J 2017 Dec 18;16(1):491. Epub 2017 Dec 18.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.

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December 2017

Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges.

Authors:

Makoto Saito Mary Ellen Gilder François Nosten Rose McGready Philippe J Guérin

Malar J 2017 Dec 13;16(1):488. Epub 2017 Dec 13.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.

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December 2017

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges.

Authors:

Prabin Dahal Julie A Simpson Grant Dorsey Philippe J Guérin Ric N Price Kasia Stepniewska

Malar J 2017 10 26;16(1):430. Epub 2017 Oct 26.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.

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October 2017

Systematic review of clinical trials assessing the therapeutic efficacy of visceral leishmaniasis treatments: A first step to assess the feasibility of establishing an individual patient data sharing platform.

Authors:

Jacob T Bush Monique Wasunna Fabiana Alves Jorge Alvar Piero L Olliaro Michael Otieno Carol Hopkins Sibley Nathalie Strub Wourgaft Philippe J Guerin

PLoS Negl Trop Dis 2017 Sep 5;11(9):e0005781. Epub 2017 Sep 5.

Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.

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September 2017

Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Drug Sensitivity-Associated Haplotypes in Uganda.

Authors:

Aimee R Taylor Jennifer A Flegg Chris C Holmes Philippe J Guérin Carol H Sibley Melissa D Conrad Grant Dorsey Philip J Rosenthal

Open Forum Infect Dis 2017 25;4(1):ofw229. Epub 2016 Oct 25.

Department of Medicine, University of California, San Francisco.

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October 2016

Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis.

PLoS Med 2017 01 10;14(1):e1002212. Epub 2017 Jan 10.

WorldWide Antimalarial Resistance Network, Oxford, United Kingdom.

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January 2017

Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger.

BMC Med 2016 10 24;14(1):167. Epub 2016 Oct 24.

Epicentre, Paris, France.

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October 2016

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia.

Int J Health Geogr 2016 10 24;15(1):37. Epub 2016 Oct 24.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.

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October 2016

Beyond open data: realising the health benefits of sharing data.

Authors:

Elizabeth Pisani Peter Aaby J Gabrielle Breugelmans David Carr Trish Groves Michelle Helinski Dorcas Kamuya Steven Kern Katherine Littler Vicki Marsh Souleymane Mboup Laura Merson Osman Sankoh Micaela Serafini Martin Schneider Vreni Schoenenberger Philippe J Guerin

BMJ 2016 Oct 10;355:i5295. Epub 2016 Oct 10.

Infectious Diseases Data Observatory, University of Oxford, Oxford, UK.

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October 2016

Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate-amodiaquine fixed dose combination or artemether-lumefantrine in Liberia.

Authors:

Sabina Dahlström Otienoburu Oumou Maïga-Ascofaré Birgit Schramm Vincent Jullien Joel J Jones Yah M Zolia Pascal Houzé Elizabeth A Ashley Jean-René Kiechel Philippe J Guérin Jacques Le Bras Sandrine Houzé

Malar J 2016 09 5;15:452. Epub 2016 Sep 5.

IRD UMR216, Paris-Descartes University, Paris, France.

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September 2016

The Schistosomiasis Clinical Trials Landscape: A Systematic Review of Antischistosomal Treatment Efficacy Studies and a Case for Sharing Individual Participant-Level Data (IPD).

Authors:

Amélie M Julé Michel Vaillant Trudie A Lang Philippe J Guérin Piero L Olliaro

PLoS Negl Trop Dis 2016 06 27;10(6):e0004784. Epub 2016 Jun 27.

Centre for Global Health and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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June 2016

Combating poor-quality anti-malarial medicines: a call to action.

Authors:

Quique Bassat Marcel Tanner Philippe J Guerin Kirstin Stricker Kamal Hamed

Malar J 2016 06 1;15:302. Epub 2016 Jun 1.

Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.

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June 2016

A link between poor quality antimalarials and malaria drug resistance?

Authors:

Paul N Newton Céline Caillet Philippe J Guerin

Expert Rev Anti Infect Ther 2016 06 23;14(6):531-3. Epub 2016 May 23.

b Centre for Tropical Medicine & Global Health, NDM Research Building , University of Oxford , Oxford , UK.

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June 2016

Avoiding Data Dumpsters--Toward Equitable and Useful Data Sharing.

Authors:

Laura Merson Oumar Gaye Philippe J Guerin

N Engl J Med 2016 Jun 11;374(25):2414-5. Epub 2016 May 11.

From the WorldWide Antimalarial Resistance Network, Infectious Diseases Data Observatory, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK (L.M., P.J.G.); and the Laboratory of Parasitology-Mycology, Faculty of Medicine, University Cheikh Anta Diop, Dakar, Senegal (O.G.).

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June 2016

Ethical challenges in designing and conducting medicine quality surveys.

Authors:

Patricia Tabernero Michael Parker Raffaella Ravinetto Souly Phanouvong Shunmay Yeung Freddy E Kitutu Phaik Yeong Cheah Mayfong Mayxay Philippe J Guerin Paul N Newton

Trop Med Int Health 2016 06 20;21(6):799-806. Epub 2016 May 20.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Mahosot Hospital, Vientiane, Lao PDR.

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June 2016

Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight.

Authors:

Jared Lybbert Justin Gullingsrud Olga Chesnokov Eleanor Turyakira Mehul Dhorda Philippe J Guerin Patrice Piola Atis Muehlenbachs Andrew V Oleinikov

Sci Rep 2016 Apr 13;6:24508. Epub 2016 Apr 13.

Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.

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April 2016

Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations.

BMC Med 2015 Dec 22;13:305. Epub 2015 Dec 22.

Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, 5 Boulevard Monivong, BP 983, Phnom Penh, Cambodia.

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December 2015

Understanding the mechanisms and drivers of antimicrobial resistance.

Authors:

Alison H Holmes Luke S P Moore Arnfinn Sundsfjord Martin Steinbakk Sadie Regmi Abhilasha Karkey Philippe J Guerin Laura J V Piddock

Lancet 2016 Jan 18;387(10014):176-87. Epub 2015 Nov 18.

Antimicrobials Research Group, Institute for Microbiology and Infection, University of Birmingham, Birmingham, UK.

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January 2016

Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis.

Malar J 2015 Sep 22;14:359. Epub 2015 Sep 22.

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September 2015

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data.

Authors:

Prabin Dahal Umberto d'Alessandro Grant Dorsey Philippe J Guerin Christian Nsanzabana Ric N Price Carol H Sibley Kasia Stepniewska Ambrose O Talisuna

BMC Med 2015 Sep 7;13:212. Epub 2015 Sep 7.

WorldWide Antimalarial Resistance Network (WWARN); Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK.

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September 2015

Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions.

Authors:

Philippe Guyant Vincent Corbel Philippe J Guérin Adeline Lautissier François Nosten Sébastien Boyer Marc Coosemans Arjen M Dondorp Véronique Sinou Shunmay Yeung Nicholas White

Malar J 2015 Jul 17;14:279. Epub 2015 Jul 17.

Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, Oxford University, Oxford, UK.

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July 2015

The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data.

Authors:

Martin A Adjuik Richard Allan Anupkumar R Anvikar Elizabeth A Ashley Mamadou S Ba Hubert Barennes Karen I Barnes Quique Bassat Elisabeth Baudin Anders Björkman François Bompart Maryline Bonnet Steffen Borrmann Philippe Brasseur Hasifa Bukirwa Francesco Checchi Michel Cot Prabin Dahal Umberto D'Alessandro Philippe Deloron Meghna Desai Graciela Diap Abdoulaye A Djimde Grant Dorsey Ogobara K Doumbo Emmanuelle Espié Jean-Francois Etard Caterina I Fanello Jean-François Faucher Babacar Faye Jennifer A Flegg Oumar Gaye Peter W Gething Raquel González Francesco Grandesso Philippe J Guerin Jean-Paul Guthmann Sally Hamour Armedy Ronny Hasugian Simon I Hay Georgina S Humphreys Vincent Jullien Elizabeth Juma Moses R Kamya Corine Karema Jean R Kiechel Peter G Kremsner Sanjeev Krishna Valérie Lameyre Laminou M Ibrahim Sue J Lee Bertrand Lell Andreas Mårtensson Achille Massougbodji Hervé Menan Didier Ménard Clara Menéndez Martin Meremikwu Clarissa Moreira Carolyn Nabasumba Michael Nambozi Jean-Louis Ndiaye Frederic Nikiema Christian Nsanzabana Francine Ntoumi Bernhards R Ogutu Piero Olliaro Lyda Osorio Jean-Bosco Ouédraogo Louis K Penali Mbaye Pene Loretxu Pinoges Patrice Piola Ric N Price Cally Roper Philip J Rosenthal Claude Emile Rwagacondo Albert Same-Ekobo Birgit Schramm Amadou Seck Bhawna Sharma Carol Hopkins Sibley Véronique Sinou Sodiomon B Sirima Jeffery J Smith Frank Smithuis Fabrice A Somé Doudou Sow Sarah G Staedke Kasia Stepniewska Todd D Swarthout Khadime Sylla Ambrose O Talisuna Joel Tarning Walter R J Taylor Emmanuel A Temu Julie I Thwing Emiliana Tjitra Roger C K Tine Halidou Tinto Michel T Vaillant Neena Valecha Ingrid Van den Broek Nicholas J White Adoke Yeka Issaka Zongo

BMC Med 2015 Mar 31;13:66. Epub 2015 Mar 31.

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March 2015

Quality assurance of drugs used in clinical trials: proposal for adapting guidelines.

Authors:

Paul N Newton David Schellenberg Elizabeth A Ashley Raffaella Ravinetto Michael D Green Feiko O ter Kuile Patricia Tabernero Nicholas J White Philippe J Guerin

BMJ 2015 Feb 25;350:h602. Epub 2015 Feb 25.

Worldwide Antimalarial Resistance Network, Centre for Tropical Medicine and Global Health, Oxford University, UK.

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February 2015

Artemisinin resistance--modelling the potential human and economic costs.

Authors:

Yoel Lubell Arjen Dondorp Philippe J Guérin Tom Drake Sylvia Meek Elizabeth Ashley Nicholas P J Day Nicholas J White Lisa J White

Malar J 2014 Nov 23;13:452. Epub 2014 Nov 23.

Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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November 2014

Spread of artemisinin resistance in Plasmodium falciparum malaria.

Authors:

Elizabeth A Ashley Mehul Dhorda Rick M Fairhurst Chanaki Amaratunga Parath Lim Seila Suon Sokunthea Sreng Jennifer M Anderson Sivanna Mao Baramey Sam Chantha Sopha Char Meng Chuor Chea Nguon Siv Sovannaroth Sasithon Pukrittayakamee Podjanee Jittamala Kesinee Chotivanich Kitipumi Chutasmit Chaiyaporn Suchatsoonthorn Ratchadaporn Runcharoen Tran Tinh Hien Nguyen Thanh Thuy-Nhien Ngo Viet Thanh Nguyen Hoan Phu Ye Htut Kay-Thwe Han Kyin Hla Aye Olugbenga A Mokuolu Rasaq R Olaosebikan Olaleke O Folaranmi Mayfong Mayxay Maniphone Khanthavong Bouasy Hongvanthong Paul N Newton Marie A Onyamboko Caterina I Fanello Antoinette K Tshefu Neelima Mishra Neena Valecha Aung Pyae Phyo Francois Nosten Poravuth Yi Rupam Tripura Steffen Borrmann Mahfudh Bashraheil Judy Peshu M Abul Faiz Aniruddha Ghose M Amir Hossain Rasheda Samad M Ridwanur Rahman M Mahtabuddin Hasan Akhterul Islam Olivo Miotto Roberto Amato Bronwyn MacInnis Jim Stalker Dominic P Kwiatkowski Zbynek Bozdech Atthanee Jeeyapant Phaik Yeong Cheah Tharisara Sakulthaew Jeremy Chalk Benjamas Intharabut Kamolrat Silamut Sue J Lee Benchawan Vihokhern Chanon Kunasol Mallika Imwong Joel Tarning Walter J Taylor Shunmay Yeung Charles J Woodrow Jennifer A Flegg Debashish Das Jeffery Smith Meera Venkatesan Christopher V Plowe Kasia Stepniewska Philippe J Guerin Arjen M Dondorp Nicholas P Day Nicholas J White

N Engl J Med 2014 Jul;371(5):411-23

The authors' affiliations are listed in the Appendix.

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July 2014

Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.

Authors:

Frank Kloprogge Vincent Jullien Patrice Piola Mehul Dhorda Sulaiman Muwanga François Nosten Nicholas P J Day Nicholas J White Philippe J Guerin Joel Tarning

J Antimicrob Chemother 2014 Nov 25;69(11):3033-40. Epub 2014 Jun 25.

Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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November 2014

Benefits of a pharmacology antimalarial reference standard and proficiency testing program provided by the Worldwide Antimalarial Resistance Network (WWARN).

Authors:

Chris Lourens Niklas Lindegardh Karen I Barnes Philippe J Guerin Carol H Sibley Nicholas J White Joel Tarning

Antimicrob Agents Chemother 2014 Jul 28;58(7):3889-94. Epub 2014 Apr 28.

Worldwide Antimalarial Resistance Network (WWARN) Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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July 2014

Mind the gaps--the epidemiology of poor-quality anti-malarials in the malarious world--analysis of the WorldWide Antimalarial Resistance Network database.

Authors:

Patricia Tabernero Facundo M Fernández Michael Green Philippe J Guerin Paul N Newton

Malar J 2014 Apr 8;13:139. Epub 2014 Apr 8.

Worldwide Antimalarial Resistance Network (WWARN), Churchill Hospital, University of Oxford, Oxford, UK.

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April 2014

Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.

Authors:

Aimee R Taylor Jennifer A Flegg Samuel L Nsobya Adoke Yeka Moses R Kamya Philip J Rosenthal Grant Dorsey Carol H Sibley Philippe J Guerin Chris C Holmes

Malar J 2014 Mar 17;13:102. Epub 2014 Mar 17.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.

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March 2014

International health research monitoring: exploring a scientific and a cooperative approach using participatory action research.

Authors:

Tracey Chantler Phaik Yeong Cheah George Miiro Viriya Hantrakum Annet Nanvubya Elizabeth Ayuo Esther Kivaya Jeremiah Kidola Pontiano Kaleebu Michael Parker Patricia Njuguna Elizabeth Ashley Philippe J Guerin Trudie Lang

BMJ Open 2014 Feb 17;4(2):e004104. Epub 2014 Feb 17.

Nuffield Department of Clinical Medicine, The Global Health Network, Centre for Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, UK.

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February 2014

Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives.

Malar J 2013 Nov 13;12:411. Epub 2013 Nov 13.

WorldWide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, UK.

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November 2013

Surveillance of travellers: an additional tool for tracking antimalarial drug resistance in endemic countries.

Authors:

Myriam Gharbi Jennifer A Flegg Bruno Pradines Ako Berenger Magatte Ndiaye Abdoulaye A Djimdé Cally Roper Véronique Hubert Eric Kendjo Meera Venkatesan Philippe Brasseur Oumar Gaye André T Offianan Louis Penali Jacques Le Bras Philippe J Guérin

PLoS One 2013 30;8(10):e77775. Epub 2013 Oct 30.

Unité Mixte de Recherche 216, Institut de Recherche et de Développement, Paris, France ; PRES Sorbonne Paris Cité, Faculté de Pharmacie, Paris, France ; WorldWide Antimalarial Resistance Network, Oxford, United Kingdom ; Ecole des Hautes Etudes en Santé Publique, Sorbonne Paris Cité, Rennes, France.

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September 2014

Trends in antimalarial drug use in Africa.

Authors:

Jennifer A Flegg Charlotte J E Metcalf Myriam Gharbi Meera Venkatesan Tanya Shewchuk Carol Hopkins Sibley Philippe J Guerin

Am J Trop Med Hyg 2013 Nov 9;89(5):857-865. Epub 2013 Sep 9.

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November 2013

Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine, and quinine in pregnant women with uncomplicated plasmodium falciparum malaria in Uganda.

Authors:

Joel Tarning Frank Kloprogge Mehul Dhorda Vincent Jullien Francois Nosten Nicholas J White Philippe J Guerin Patrice Piola

Antimicrob Agents Chemother 2013 Oct 5;57(10):5096-103. Epub 2013 Aug 5.

Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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October 2013

Infections in children admitted with complicated severe acute malnutrition in Niger.

Authors:

Anne-Laure Page Nathalie de Rekeneire Sani Sayadi Said Aberrane Ann-Carole Janssens Claire Rieux Ali Djibo Jean-Claude Manuguerra Hubert Ducou-le-Pointe Rebecca F Grais Myrto Schaefer Philippe J Guerin Emmanuel Baron

PLoS One 2013 17;8(7):e68699. Epub 2013 Jul 17.

Epidemiology and Population Health, Epicentre, Paris, France.

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March 2014

Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial.

Authors:

Birgit Schramm Parastou Valeh Elisabeth Baudin Charles S Mazinda Richard Smith Loretxu Pinoges Mehul Dhorda Yap Boum Timothy Sundaygar Yah M Zolia Joel J Jones Eric Comte Pascal Houzé Vincent Jullien Gwenaelle Carn Jean-René Kiechel Elizabeth A Ashley Philippe J Guérin

Malar J 2013 Jul 17;12:251. Epub 2013 Jul 17.

Epicentre, 75011 Paris, France.

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July 2013

Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trials in Nimba County, Liberia.

Authors:

Birgit Schramm Parastou Valeh Elisabeth Baudin Charles S Mazinda Richard Smith Loretxu Pinoges Timothy Sundaygar Yah M Zolia Joel J Jones Eric Comte Arnaud Bruneel Michel Branger Vincent Jullien Gwenaelle Carn Jean-René Kiechel Elizabeth A Ashley Philippe J Guérin

Malar J 2013 Jul 17;12:250. Epub 2013 Jul 17.

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July 2013

Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum.

Authors:

Jennifer A Flegg Anand P Patil Meera Venkatesan Cally Roper Inbarani Naidoo Simon I Hay Carol Hopkins Sibley Philippe J Guerin

Malar J 2013 Jul 17;12:249. Epub 2013 Jul 17.

WorldWide Antimalarial Resistance Network-WWARN, University of Oxford, Oxford, UK.

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July 2013

Made in Europe: will artemisinin resistance emerge in French Guiana?

Authors:

Mathieu Nacher Philippe J Guérin Magalie Demar-Pierre Félix Djossou François Nosten Bernard Carme

Malar J 2013 May 4;12:152. Epub 2013 May 4.

Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana.

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May 2013

Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective cohort with intensive malaria screening and prompt treatment.

Authors:

Pierre De Beaudrap Eleanor Turyakira Lisa J White Carolyn Nabasumba Benon Tumwebaze Atis Muehlenbachs Philippe J Guérin Yap Boum Rose McGready Patrice Piola

Malar J 2013 Apr 24;12:139. Epub 2013 Apr 24.

Epicentre, Paris, France.

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April 2013

High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.

Antimicrob Agents Chemother 2013 Jul 22;57(7):3121-30. Epub 2013 Apr 22.

WorldWide Antimalarial Resistance Network (WWARN), Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom.

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July 2013

Early parasitological response following artemisinin-containing regimens: a critical review of the literature.

Authors:

Debashish Das Ric N Price Delia Bethell Philippe J Guerin Kasia Stepniewska

Malar J 2013 Apr 19;12:125. Epub 2013 Apr 19.

WorldWide Antimalarial Resistance Network, Oxford, UK.

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April 2013

Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011.

Authors:

Myriam Gharbi Jennifer A Flegg Véronique Hubert Eric Kendjo Jessica E Metcalf Lionel Bertaux Philippe J Guérin Jacques Le Bras Ahmed Aboubaca Patrice Agnamey Adela Angoulvant Patricia Barbut Didier Basset Ghania Belkadi Anne Pauline Bellanger Dieudonné Bemba Françoise Benoit-Vica Antoine Berry Marie-Laure Bigel Julie Bonhomme Françoise Botterel Olivier Bouchaud Marie-Elisabeth Bougnoux Patrice Bourée Nathalie Bourgeois Catherine Branger Laurent Bret Bernadette Buret Enrique Casalino Sylviane Chevrier Frédérique Conquere de Monbrison Bernadette Cuisenier Martin Danis Marie-Laure Darde Ludovic De Gentile Jean-Marie Delarbre Pascal Delaunay Anne Delaval Guillaume Desoubeaux Michel Develoux Jean Dunand Rémy Durand Odile Eloy Nathalie Fauchet Bernard Faugere Alber Faye Odile Fenneteau Pierre Flori Madeleine Fontrouge Chantal Garabedian Françoise Gayandrieu Nadine Godineau Pascal Houzé Sandrine Houzé Jean-Pierre Hurst Houria Ichou Laurence Lachaud Agathe Lebuisson Magalie Lefevre Anne-Sophie LeGuern Gwenaë Le Moal Daniel Lusina Marie-Claude Machouart Denis Malvy Sophie Matheron Danièle Maubon Denis Mechali Bruno Megarbane Guillaume Menard Laurence Millon Muriel Mimoun Aiach Philippe Minodier Christelle Morelle Gilles Nevez Philippe Parola Daniel Parzy Olivier Patey Pierre Patoz Pascale Penn Alice Perignon Stéphane Picot Jean-Etienne Pilo Isabelle Poilane Denis Pons Marie Poupart Bruno Pradines Didier Raffenot Christophe Rapp Marie-Catherine Receveur Claudine Sarfati Yaye Senghor Fabrice Simon Jean-Yves Siriez Nicolas Taudon Marc Thellier Maxime Thouvenin Dominique Toubas

Malar J 2013 Jan 25;12:35. Epub 2013 Jan 25.

Mère et enfant face aux infections tropicales, IRD unité mixte de recherche 216, Université Paris Descartes-Paris V, 4 avenue de l'Observatoire, Paris Cedex 06 75270, France.

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January 2013

Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems.

Authors:

Ambrose O Talisuna Corine Karema Bernhards Ogutu Elizabeth Juma John Logedi Andrew Nyandigisi Modest Mulenga Wilfred F Mbacham Cally Roper Philippe J Guerin Umberto D'Alessandro Robert W Snow

Lancet Infect Dis 2012 Nov;12(11):888-96

Malaria Public Health and Epidemiology Group, University of Oxford and KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.

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November 2012

Mapping the aetiology of non-malarial febrile illness in Southeast Asia through a systematic review--terra incognita impairing treatment policies.

Authors:

Nathalie Acestor Richard Cooksey Paul N Newton Didier Ménard Philippe J Guerin Jun Nakagawa Eva Christophel Iveth J González David Bell

PLoS One 2012 6;7(9):e44269. Epub 2012 Sep 6.

Malaria/Acute Febrile Syndrome Programme, Foundation for Innovative New Diagnostics, Geneva, Switzerland.

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May 2013

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.

Authors:

Joel Tarning Frank Kloprogge Patrice Piola Mehul Dhorda Sulaiman Muwanga Eleanor Turyakira Nitra Nuengchamnong François Nosten Nicholas P J Day Nicholas J White Philippe J Guerin Niklas Lindegardh

Malar J 2012 Aug 22;11:293. Epub 2012 Aug 22.

Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

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August 2012

Chloroquine-resistant malaria in travelers returning from Haiti after 2010 earthquake.

Authors:

Myriam Gharbi Dylan R Pillai Rachel Lau Véronique Hubert Krishna Khairnar Alexandre Existe Eric Kendjo Sabina Dahlström Philippe J Guérin Jacques Le Bras

Emerg Infect Dis 2012 Aug;18(8):1346-9

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August 2012

Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard.

Authors:

Anne-Laure Page Kathryn P Alberti Vital Mondonge Jean Rauzier Marie-Laure Quilici Philippe J Guerin

PLoS One 2012 30;7(5):e37360. Epub 2012 May 30.

Epicentre, Paris, France.

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October 2012

Efficacy of fixed-dose combination artesunate-amodiaquine versus artemether-lumefantrine for uncomplicated childhood Plasmodium falciparum malaria in Democratic Republic of Congo: a randomized non-inferiority trial.

Authors:

Emmanuelle Espié Angeles Lima Benjamin Atua Mehul Dhorda Laurence Flévaud Eric M Sompwe Pedro Pablo Palma Urrutia Philippe J Guerin

Malar J 2012 May 25;11:174. Epub 2012 May 25.

Division of Malaria and Parasitic Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon-gun 363-951, Republic of Korea.

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May 2012

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial.

Authors:

Atis Muehlenbachs Carolyn Nabasumba Rose McGready Eleanor Turyakira Benon Tumwebaze Mehul Dhorda Dan Nyehangane Aisha Nalusaji Franois Nosten Philippe J Guerin Patrice Piola

Malar J 2012 May 3;11:150. Epub 2012 May 3.

Department of Pathology, University of Washington, Box 357470, 1959 NE Pacific Street, Seattle, WA, USA.

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May 2012

Performance of a histidine-rich protein 2 rapid diagnostic test, Paracheck Pf®, for detection of malaria infections in Ugandan pregnant women.

Authors:

Mehul Dhorda Patrice Piola Dan Nyehangane Benon Tumwebaze Aisha Nalusaji Carolyn Nabasumba Eleanor Turyakira Rose McGready Elizabeth Ashley Philippe J Guerin Georges Snounou

Am J Trop Med Hyg 2012 Jan;86(1):93-5

Epicentre, Mbarara, Uganda.

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January 2012

The primacy of public health considerations in defining poor quality medicines.

Authors:

Paul N Newton Abdinasir A Amin Chris Bird Phillip Passmore Graham Dukes Göran Tomson Bright Simons Roger Bate Philippe J Guerin Nicholas J White

PLoS Med 2011 Dec 6;8(12):e1001139. Epub 2011 Dec 6.

Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.

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December 2011

Poor quality vital anti-malarials in Africa - an urgent neglected public health priority.

Malar J 2011 Dec 13;10:352. Epub 2011 Dec 13.

Wellcome Trust-Mahosot Hospital-Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.

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December 2011

Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator.

Authors:

Jennifer A Flegg Philippe J Guerin Nicholas J White Kasia Stepniewska

Malar J 2011 Nov 10;10:339. Epub 2011 Nov 10.

WorldWide Anti-malarial Resistance Network (WWARN) and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK.

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November 2011