Dr. Philippe A Melas, PhD - Columbia University - Postdoctoral fellow

Dr. Philippe A Melas

PhD

Columbia University

Postdoctoral fellow

New York, NY | United States

Main Specialties: Psychiatry

Additional Specialties: Molecular Psychiatry and Epigenetics

ORCID logohttps://orcid.org/0000-0002-7889-9250

Dr. Philippe A Melas, PhD - Columbia University - Postdoctoral fellow

Dr. Philippe A Melas

PhD

Introduction

Primary Affiliation: Columbia University - New York, NY , United States

Specialties:

Additional Specialties:

Research Interests:

Education

Apr 2012
Karolinska Institutet
PhD
Dec 2008
Uppsala University
MSc
Jul 2005
Democritus University
BSc

Publications

22Publications

472Reads

552Profile Views

224PubMed Central Citations

The Class II Histone Deacetylase Hypothesis of Addiction.

Biol Psychiatry 2018 Aug 22;84(3):165-166. Epub 2018 Jun 22.

Department of Psychiatry, Columbia University, New York, New York; Department of Neuroscience, Columbia University, New York, New York; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York; Kavli Institute for Brain Science, Columbia University, New York, New York; Howard Hughes Medical Institute, Chevy Chase, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.06.006DOI Listing
August 2018
4 Reads
10.260 Impact Factor

NR3C1 hypermethylation in depressed and bullied adolescents.

Transl Psychiatry 2018 06 19;8(1):121. Epub 2018 Jun 19.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41398-018-0169-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008402PMC
June 2018
7 Reads
4.360 Impact Factor

Neuropeptide Y, stressful life events and personality trait conscientiousness: Preliminary associations from a Swedish longitudinal study.

Psychiatry Res 2018 05 21;263:48-53. Epub 2018 Feb 21.

Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.psychres.2018.02.041DOI Listing
May 2018
36 Reads
2.470 Impact Factor

Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats.

Cell Rep 2018 03;22(11):2909-2923

Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA; Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Zuckerman Mind Brain Behavior Institute, New York, NY 10027, USA; Kavli Institute for Brain Science, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.065DOI Listing
March 2018
112 Reads
1 Citation
7.210 Impact Factor

The serotonin transporter promoter variant (5-HTTLPR) and childhood adversity are associated with the personality trait openness to experience.

Psychiatry Res 2017 11 31;257:322-326. Epub 2017 Jul 31.

Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2017.07.071DOI Listing
November 2017
32 Reads
2.470 Impact Factor

MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.

Int J Neuropsychopharmacol 2016 12 30;19(12). Epub 2016 Dec 30.

Department of Molecular Medicine and Surgery, Neurogenetics Unit (Drs Wei, Melas, Liu, and Lavebratt), Center for Molecular Medicine (Drs Wei, Melas, Villaescusa, Liu, Xu, and Lavebratt), Department of Clinical Neuroscience (Drs Melas and Mathé), Department of Molecular Biochemistry and Biophysics, Neurogenetics Unit (Dr Villaescusa), and Department of Medicine (Dr Xu), Karolinska Institutet, Stockholm, Sweden; Department of Neuroscience and Pharmacology, Laboratory for Neural Plasticity, University of Copenhagen, Denmark (Drs Christiansen, Elbrønd-Bek, and Woldbye); Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark (Dr Wegener); Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa (Dr Wegener).

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http://dx.doi.org/10.1093/ijnp/pyw069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203758PMC
December 2016
30 Reads
2 Citations
4.010 Impact Factor

Mood Stabilizers and the Influence on Global Leukocyte DNA Methylation in Bipolar Disorder.

Mol Neuropsychiatry 2015 Jul 4;1(2):76-81. Epub 2015 Jun 4.

Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000430867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996001PMC
July 2015
31 Reads

Hypomethylation of MAOA's first exon region in depression: a replication study.

Psychiatry Res 2015 Mar 13;226(1):389-91. Epub 2015 Jan 13.

Department of Public Health Sciences, Public Health Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.psychres.2015.01.003DOI Listing
March 2015
7 Reads
2 Citations
2.470 Impact Factor

Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene.

Int J Neuropsychopharmacol 2014 Oct 31;18(2). Epub 2014 Oct 31.

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden (Drs Wei, Melas, and Lavebratt); Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden (Drs Wei, Melas, and Lavebratt); Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark (Dr Wegener); Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa (Dr Wegener); and Department of Clinical Neuroscience, Section for Psychiatry, Karolinska Institutet, Stockholm, Sweden (Dr Mathé).

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http://dx.doi.org/10.1093/ijnp/pyu032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368891PMC
October 2014
12 Reads
12 Citations
4.010 Impact Factor

Mental health literacy about depression and schizophrenia among adolescents in Sweden.

Eur Psychiatry 2013 Sep 10;28(7):404-11. Epub 2013 Jun 10.

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.eurpsy.2013.02.002DOI Listing
September 2013
5 Reads
3 Citations
3.440 Impact Factor

Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities.

Int J Neuropsychopharmacol 2013 Aug 1;16(7):1513-28. Epub 2013 Mar 1.

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1017/S1461145713000102DOI Listing
August 2013
9 Reads
45 Citations
4.010 Impact Factor

Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres.

Transl Psychiatry 2013 May 21;3:e261. Epub 2013 May 21.

Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Clinic for Affective Disorders, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/tp.2013.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669924PMC
May 2013
4 Reads
22 Citations
4.360 Impact Factor

Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression.

Transl Psychiatry 2013 May 7;3:e255. Epub 2013 May 7.

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/tp.2013.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669918PMC
May 2013
6 Reads
10 Citations
4.360 Impact Factor

Information related to prenatal genetic counseling: interpretation by adolescents, effects on risk perception and ethical implications.

J Genet Couns 2012 Aug 25;21(4):536-46. Epub 2011 Oct 25.

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s10897-011-9418-1DOI Listing
August 2012
31 Reads
3 Citations
1.750 Impact Factor

Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset.

FASEB J 2012 Jun 16;26(6):2712-8. Epub 2012 Mar 16.

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden.

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http://dx.doi.org/10.1096/fj.11-202069DOI Listing
June 2012
25 Reads
48 Citations
5.043 Impact Factor

Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression.

Int J Neuropsychopharmacol 2012 Jun 20;15(5):669-79. Epub 2011 Jun 20.

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1017/S1461145711000940DOI Listing
June 2012
13 Reads
35 Citations
4.010 Impact Factor

Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model.

Peptides 2012 May 3;35(1):49-55. Epub 2012 Mar 3.

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.peptides.2012.02.020DOI Listing
May 2012
24 Reads
9 Citations
2.620 Impact Factor

Examining the public refusal to consent to DNA biobanking: empirical data from a Swedish population-based study.

J Med Ethics 2010 Feb;36(2):93-8

Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/jme.2009.032367DOI Listing
February 2010
9 Reads
18 Citations
1.691 Impact Factor

PreproNPY Pro7 protects against depression despite exposure to environmental risk factors.

J Affect Disord 2009 Nov 4;118(1-3):124-30. Epub 2009 Mar 4.

Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jad.2009.02.009DOI Listing
November 2009
7 Reads
10 Citations
3.383 Impact Factor