Philippa T Saunders

Philippa T Saunders

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Philippa T Saunders

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Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis.

FASEB J 2019 Oct 10;33(10):11210-11222. Epub 2019 Jul 10.

Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.

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http://dx.doi.org/10.1096/fj.201900797RDOI Listing
October 2019

Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus.

J Endocrinol 2019 Jul 1. Epub 2019 Jul 1.

P Saunders, Centre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1530/JOE-19-0153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690265PMC
July 2019

Repurposing simvastatin as a therapy for preterm labor: evidence from preclinical models.

FASEB J 2019 02 12;33(2):2743-2758. Epub 2018 Oct 12.

Tommy's Centre for Maternal and Fetal Health, Medical Research Council (MRC) Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; and.

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https://www.fasebj.org/doi/10.1096/fj.201801104R
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http://dx.doi.org/10.1096/fj.201801104RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338657PMC
February 2019

Effects of Roxb. and L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2.

Pharmaceuticals (Basel) 2018 Nov 20;11(4). Epub 2018 Nov 20.

Department of Physical Sciences, Hearth and Environment, University of Siena, Via Laterina 8, 53100 Siena, Italy.

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http://dx.doi.org/10.3390/ph11040126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316569PMC
November 2018

Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders.

Int J Mol Sci 2018 Oct 22;19(10). Epub 2018 Oct 22.

Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK.

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http://www.mdpi.com/1422-0067/19/10/3276
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http://dx.doi.org/10.3390/ijms19103276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214123PMC
October 2018

SULFATION PATHWAYS: Contribution of intracrine oestrogens to the aetiology of endometriosis.

J Mol Endocrinol 2018 08;61(2):T253-T270

MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1530/JME-17-0297DOI Listing
August 2018

Animal models of endometriosis: Replicating the aetiology and symptoms of the human disorder.

Best Pract Res Clin Endocrinol Metab 2018 06 6;32(3):257-269. Epub 2018 Apr 6.

Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.beem.2018.03.004DOI Listing
June 2018

Androgens and endometrium: New insights and new targets.

Mol Cell Endocrinol 2018 04 15;465:48-60. Epub 2017 Sep 15.

Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.09.022DOI Listing
April 2018

Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age.

Fertil Steril 2018 04 15;109(4):728-734.e2. Epub 2018 Feb 15.

MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00150282173217
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http://dx.doi.org/10.1016/j.fertnstert.2017.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908781PMC
April 2018

Androgens and androgen receptor: Above and beyond.

Mol Cell Endocrinol 2018 04 24;465:1-3. Epub 2018 Feb 24.

Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2018.02.013DOI Listing
April 2018

Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation.

Nat Commun 2018 01 23;9(1):295. Epub 2018 Jan 23.

MRC Centre for Reproductive Health, The Queen's Medical Research Centre, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland.

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http://www.nature.com/articles/s41467-017-02375-6
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http://dx.doi.org/10.1038/s41467-017-02375-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780386PMC
January 2018

Endometrial apoptosis and neutrophil infiltration during menstruation exhibits spatial and temporal dynamics that are recapitulated in a mouse model.

Sci Rep 2017 12 12;7(1):17416. Epub 2017 Dec 12.

MRC Centre for Reproductive Health (CRH), University of Edinburgh, The Queen's Medical Research Institute (QMRI), 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

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http://dx.doi.org/10.1038/s41598-017-17565-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727295PMC
December 2017

Transcription Analysis of the Myometrium of Labouring and Non-Labouring Women.

PLoS One 2016 13;11(5):e0155413. Epub 2016 May 13.

Tommy's Centre for Maternal and Fetal Health and Medical Research Council (MRC) Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866706PMC
July 2017

Relevant human tissue resources and laboratory models for use in endometriosis research.

Acta Obstet Gynecol Scand 2017 Jun 5;96(6):644-658. Epub 2017 Apr 5.

MRC Centre for Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.

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http://dx.doi.org/10.1111/aogs.13119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485163PMC
June 2017

Steroids Regulate CXCL4 in the Human Endometrium During Menstruation to Enable Efficient Endometrial Repair.

J Clin Endocrinol Metab 2017 06;102(6):1851-1860

MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2016-3604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470763PMC
June 2017

Top ten endometriosis research priorities in the UK and Ireland.

Lancet 2017 Jun 18;389(10085):2191-2192. Epub 2017 May 18.

MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1016/S0140-6736(17)31344-2DOI Listing
June 2017

New concepts for an old problem: the diagnosis of endometrial hyperplasia.

Hum Reprod Update 2017 03;23(2):232-254

MRC Centre for Inflammation Research, The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, EdinburghEH16 4TJ, UK.

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https://academic.oup.com/humupd/article-lookup/doi/10.1093/h
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http://dx.doi.org/10.1093/humupd/dmw042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850217PMC
March 2017

EP receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis.

Sci Rep 2017 03 10;7:44169. Epub 2017 Mar 10.

MRC Centre for Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 UK.

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http://dx.doi.org/10.1038/srep44169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345039PMC
March 2017

Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling.

Sci Rep 2016 11 9;6:36748. Epub 2016 Nov 9.

MRC Centre Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ.

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http://dx.doi.org/10.1038/srep36748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101509PMC
November 2016

Androgens regulate scarless repair of the endometrial "wound" in a mouse model of menstruation.

FASEB J 2016 08 27;30(8):2802-11. Epub 2016 Apr 27.

Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom; and

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http://dx.doi.org/10.1096/fj.201600078RDOI Listing
August 2016

Regulation of androgen action during establishment of pregnancy.

J Mol Endocrinol 2016 07 11;57(1):R35-47. Epub 2016 Apr 11.

Medical Research Council Centre for Inflammation ResearchQueen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1530/JME-16-0027DOI Listing
July 2016

Cortisol regulates the paracrine action of macrophages by inducing vasoactive gene expression in endometrial cells.

J Leukoc Biol 2016 06 23;99(6):1165-71. Epub 2015 Dec 23.

MRC Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom; and

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http://dx.doi.org/10.1189/jlb.5A0215-061RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952012PMC
June 2016

A Role for Androgens in Epithelial Proliferation and Formation of Glands in the Mouse Uterus.

Endocrinology 2016 05 10;157(5):2116-28. Epub 2016 Mar 10.

Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, EH16 4TJ, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1210/en.2015-2032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870887PMC
May 2016

Androgen-Induced Relaxation of Uterine Myocytes Is Mediated by Blockade of Both Ca(2+) Flux and MLC Phosphorylation.

J Clin Endocrinol Metab 2016 Mar 11;101(3):1055-65. Epub 2016 Jan 11.

Medical Research Council (MRC) Centre for Reproductive Health (S.M., L.J.H., S.P.R., S.F.R., P.B., J.E.N.), The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom; Tommy's Centre for Maternal and Fetal Health at the University of Edinburgh (S.M., L.J.H., S.P.R., S.F.R., J.E.N.), The Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom; MRC Centre for Inflammation Research (P.T.K.S.), The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom; School of Physiology and Pharmacology (L.J.H.), University of Bristol, Bristol, BS8 1TD, United Kingdom; and Biomolecular Core Facility at The University of Edinburgh (P.B.), The Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2015-2851DOI Listing
March 2016

Hypoxyprobe™ reveals dynamic spatial and temporal changes in hypoxia in a mouse model of endometrial breakdown and repair.

BMC Res Notes 2016 Jan 19;9:30. Epub 2016 Jan 19.

Medical Research Council Centre for Inflammation Research, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

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http://dx.doi.org/10.1186/s13104-016-1842-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717617PMC
January 2016

Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes.

Sci Rep 2016 Jan 28;6:19970. Epub 2016 Jan 28.

Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ. UK.

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http://dx.doi.org/10.1038/srep19970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730211PMC
January 2016

Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.

Endocrinology 2015 Dec 22;156(12):4522-33. Epub 2015 Sep 22.

Molecular Endocrinology Laboratory (V.D., M.R.L., F.C.), Department of Cellular and Molecular Medicine, Department of Gerontology and Geriatrics (M.R.L.), and Clinical and Experimental Endocrinology (F.J., D.V.), Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; and Medical Research Council Centre for Inflammation Research (I.S., P.T.K.S.), University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2015-1479DOI Listing
December 2015

Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis.

Am J Pathol 2015 Aug 12;185(8):2286-97. Epub 2015 Jun 12.

Medical Research Council Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.ajpath.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530129PMC
August 2015

The peritoneum is both a source and target of TGF-β in women with endometriosis.

PLoS One 2014 10;9(9):e106773. Epub 2014 Sep 10.

MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106773PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160207PMC
May 2015

Pregnancy in obese mice protects selectively against visceral adiposity and is associated with increased adipocyte estrogen signalling.

PLoS One 2014 14;9(4):e94680. Epub 2014 Apr 14.

Tommy's Centre for Maternal and Fetal Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom; MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094680PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986097PMC
January 2015

Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3.

Endocrinology 2014 Oct 22;155(10):4015-26. Epub 2014 Jul 22.

Medical Research Council Centre for Reproductive Health, The University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/en.2014-1086DOI Listing
October 2014

Androgens in pregnancy: roles in parturition.

Hum Reprod Update 2014 Jul-Aug;20(4):542-59. Epub 2014 Mar 18.

Medical Research Council Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom and Tommy's Centre for Maternal and Fetal Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom

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http://dx.doi.org/10.1093/humupd/dmu008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063701PMC
September 2014

Transforming growth factor-β induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis.

J Clin Endocrinol Metab 2014 Sep 5;99(9):3450-9. Epub 2014 May 5.

Medical Research Council Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2014-1026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207934PMC
September 2014

Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis.

J Clin Endocrinol Metab 2014 Sep 16;99(9):E1738-43. Epub 2014 Jul 16.

Medical Research Council Centre for Reproductive Health, The University of Edinburgh, Queens Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2014-2282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207935PMC
September 2014

Evidence of androgen action in endometrial and ovarian cancers.

Endocr Relat Cancer 2014 Aug 12;21(4):T203-18. Epub 2014 Mar 12.

MRC Centre for Reproductive HealthThe University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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http://dx.doi.org/10.1530/ERC-13-0551DOI Listing
August 2014

Intergenerational transmission of postpartum hemorrhage risk: analysis of 2 Scottish birth cohorts.

Am J Obstet Gynecol 2014 Jul 8;211(1):51.e1-7. Epub 2014 Jan 8.

MRC Center for Reproductive Health, University of Edinburgh, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1016/j.ajog.2014.01.012DOI Listing
July 2014

A novel mouse model of endometriosis mimics human phenotype and reveals insights into the inflammatory contribution of shed endometrium.

Am J Pathol 2014 Jul 5;184(7):1930-9. Epub 2014 Jun 5.

Medical Research Council Centre for Reproductive Health, Queens Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440140022
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http://dx.doi.org/10.1016/j.ajpath.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076466PMC
July 2014

The role of the peritoneum in the pathogenesis of endometriosis.

Hum Reprod Update 2013 Sep-Oct;19(5):558-69. Epub 2013 May 29.

MRC Centre for Reproductive Health, Queens Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1093/humupd/dmt024DOI Listing
May 2014

Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: a role for miRNAs?

Semin Cell Dev Biol 2014 May 6;29:76-83. Epub 2014 Apr 6.

MRC Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1016/j.semcdb.2014.04.006DOI Listing
May 2014

A computational model of lipopolysaccharide-induced nuclear factor kappa B activation: a key signalling pathway in infection-induced preterm labour.

PLoS One 2013 30;8(7):e70180. Epub 2013 Jul 30.

Medical Research Council (MRC) Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070180PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736540PMC
April 2014

Endocrine disruption of oestrogen action and female reproductive tract cancers.

Endocr Relat Cancer 2014 Apr 12;21(2):T13-31. Epub 2014 Mar 12.

Queen's Medical Research Institute, MRC Centre for Reproductive Health, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1530/ERC-13-0342DOI Listing
April 2014

ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1.

Hum Reprod 2013 Sep 11;28(9):2490-501. Epub 2013 Jun 11.

The University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1093/humrep/det235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748858PMC
September 2013

The importance of the macrophage within the human endometrium.

J Leukoc Biol 2013 Feb 29;93(2):217-25. Epub 2012 Oct 29.

Medical Research Council Centres for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://doi.wiley.com/10.1189/jlb.0712327
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http://dx.doi.org/10.1189/jlb.0712327DOI Listing
February 2013

A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene.

FASEB J 2012 Oct 13;26(10):4360-72. Epub 2012 Jul 13.

Department of Cellular and Molecular Medicine, Katholieke Univesiteit Leuven, Campus Gasthuisberg O&N1 P.O. Box 901, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1096/fj.11-202283DOI Listing
October 2012

Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis.

Diabetes 2012 May 13;61(5):1072-81. Epub 2012 Mar 13.

Endocrinology Unit, University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, Scotland, UK.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db11
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http://dx.doi.org/10.2337/db11-1136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331763PMC
May 2012

Estrogen dependent signaling in reproductive tissues - a role for estrogen receptors and estrogen related receptors.

Mol Cell Endocrinol 2012 Jan 21;348(2):361-72. Epub 2011 Sep 21.

MRC/UoE Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1016/j.mce.2011.09.026DOI Listing
January 2012

In silico analysis identifies a novel role for androgens in the regulation of human endometrial apoptosis.

J Clin Endocrinol Metab 2011 Nov 24;96(11):E1746-55. Epub 2011 Aug 24.

Medical Research Council Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH164TJ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2011-0272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380091PMC
November 2011

Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad.

PLoS One 2011 3;6(6):e20249. Epub 2011 Jun 3.

Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020249PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108594PMC
September 2011

Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.

Endocrinology 2011 Sep 5;152(9):3541-51. Epub 2011 Jul 5.

Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, Edinburgh, EH16 4TJ, Scotland, United Kingdom.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2011-0282DOI Listing
September 2011

Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary.

J Clin Endocrinol Metab 2011 Jun 23;96(6):1754-62. Epub 2011 Mar 23.

Centre for Reproductive Endocrinology and Medicine, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.

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http://dx.doi.org/10.1210/jc.2010-2618DOI Listing
June 2011

The skeleton: the new controller of male fertility?

Cell 2011 Mar;144(5):642-3

MRC Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1016/j.cell.2011.02.028DOI Listing
March 2011

Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit.

Endocrinology 2011 Feb 22;152(2):718-29. Epub 2010 Dec 22.

MRC Human Reproductive Sciences Unit, The Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1210/en.2010-0928DOI Listing
February 2011

A Role for the orphan nuclear receptor estrogen-related receptor alpha in endometrial stromal cell decidualization and expression of genes implicated in energy metabolism.

J Clin Endocrinol Metab 2010 Oct 28;95(10):E224-8. Epub 2010 Jul 28.

Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, The Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1210/jc.2010-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050102PMC
October 2010

Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation.

Hum Reprod 2010 Oct 3;25(10):2405-14. Epub 2010 Aug 3.

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1093/humrep/deq183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939754PMC
October 2010

Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics.

PLoS One 2010 Oct 26;5(10):e13632. Epub 2010 Oct 26.

Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964321PMC
October 2010

TGFβ1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways.

PLoS One 2010 Sep 24;5(9):e12970. Epub 2010 Sep 24.

Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Queen's Medical Research Institute, Edinburgh, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012970PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945765PMC
September 2010

Inflammatory events in endometrial adenocarcinoma.

J Endocrinol 2010 Aug 20;206(2):141-57. Epub 2010 Apr 20.

MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://joe.endocrinology-journals.org/content/206/2/141.full
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http://joe.endocrinology-journals.org/cgi/doi/10.1677/JOE-10
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http://dx.doi.org/10.1677/JOE-10-0072DOI Listing
August 2010

Identification of androgen receptor phosphorylation in the primate ovary in vivo.

Reproduction 2010 Jul 20;140(1):93-104. Epub 2010 Apr 20.

MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK.

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http://www.reproduction-online.org/content/early/2010/04/20/
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http://www.reproduction-online.org/cgi/doi/10.1530/REP-10-01
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http://dx.doi.org/10.1530/REP-10-0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892820PMC
July 2010

Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol.

Endocrinology 2010 Jul 5;151(7):3374-85. Epub 2010 May 5.

Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/en.2009-1339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033689PMC
July 2010

Establishment of long-term monolayer cultures of somatic cells from human fetal testes and expansion of peritubular myoid cells in the presence of androgen.

Reproduction 2010 Apr 20;139(4):749-57. Epub 2010 Jan 20.

MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1530/REP-09-0532DOI Listing
April 2010

Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.

Mol Cell Endocrinol 2010 Jan 13;314(1):53-61. Epub 2009 Sep 13.

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S030372070900490
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http://dx.doi.org/10.1016/j.mce.2009.09.007DOI Listing
January 2010

Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment.

Biol Reprod 2009 Dec 8;81(6):1083-92. Epub 2009 Jul 8.

Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1095/biolreprod.109.078360DOI Listing
December 2009

Androgen action via testicular peritubular myoid cells is essential for male fertility.

FASEB J 2009 Dec 19;23(12):4218-30. Epub 2009 Aug 19.

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1096/fj.09-138347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812048PMC
December 2009

Attenuated sex steroid receptor expression in fallopian tube of women with ectopic pregnancy.

J Clin Endocrinol Metab 2009 Dec 28;94(12):5146-54. Epub 2009 Oct 28.

Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2009-1476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989877PMC
December 2009

Proliferation of uterine natural killer cells is induced by human chorionic gonadotropin and mediated via the mannose receptor.

Endocrinology 2009 Jun 5;150(6):2882-8. Epub 2009 Feb 5.

Medical Research Council Human Reproductive Sciences Unit, Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1210/en.2008-1309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709965PMC
June 2009

New insights into the role of androgens in wolffian duct stabilization in male and female rodents.

Endocrinology 2009 May 8;150(5):2472-80. Epub 2009 Jan 8.

Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/en.2008-0529DOI Listing
May 2009

Hormone receptor dynamics in a receptive human endometrium.

Reprod Sci 2009 Feb;16(2):191-9

Division of Reproductive and Developmental Sciences, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland.

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http://dx.doi.org/10.1177/1933719108331121DOI Listing
February 2009

Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle.

Hum Reprod 2008 Dec 4;23(12):2782-90. Epub 2008 Sep 4.

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, Edinburgh, UK.

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http://dx.doi.org/10.1093/humrep/den298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583942PMC
December 2008

Clinical importance of estrogen receptor beta isoforms in breast cancer.

J Clin Oncol 2008 Dec 10;26(35):5825; author reply 5825-6. Epub 2008 Nov 10.

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http://dx.doi.org/10.1200/JCO.2008.19.5909DOI Listing
December 2008

Modelling germ cell development in vitro.

Mol Hum Reprod 2008 Sep 1;14(9):501-11. Epub 2008 Aug 1.

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1093/molehr/gan042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547093PMC
September 2008

Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients.

Clin Cancer Res 2008 Aug;14(16):5228-35

YCR and Liz Dawn Pathology and Translational Sciences Centre, Leeds Teaching Hospitals and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4528DOI Listing
August 2008

A single, mild, transient scrotal heat stress causes DNA damage, subfertility and impairs formation of blastocysts in mice.

Reproduction 2008 Jul 4;136(1):73-84. Epub 2008 Apr 4.

MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1530/REP-08-0036DOI Listing
July 2008

Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism.

J Clin Invest 2008 Apr;118(4):1479-90

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1172/JCI34241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267017PMC
April 2008

Transforming growth factor-beta1 attenuates expression of both the progesterone receptor and Dickkopf in differentiated human endometrial stromal cells.

Mol Endocrinol 2008 Mar 21;22(3):716-28. Epub 2007 Nov 21.

Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/me.2007-0316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419609PMC
March 2008

Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility?

Mol Hum Reprod 2008 Jan 5;14(1):1-8. Epub 2008 Jan 5.

MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1093/molehr/gam089DOI Listing
January 2008

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss.

PLoS One 2007 Oct 3;2(10):e989. Epub 2007 Oct 3.

Medical Research Council Human Reproductive Sciences Unit, Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1991594PMC
October 2007

A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells.

Mol Biol Cell 2007 Aug 16;18(8):2795-804. Epub 2007 May 16.

Department of Biological and Biomedical Sciences, University of Durham, Durham, DH1 3LE, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e07-02-0147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949379PMC
August 2007

The critical time window for androgen-dependent development of the Wolffian duct in the rat.

Endocrinology 2007 Jul 12;148(7):3185-95. Epub 2007 Apr 12.

Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom.

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http://dx.doi.org/10.1210/en.2007-0028DOI Listing
July 2007

Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model.

Proc Natl Acad Sci U S A 2007 Mar 12;104(12):4961-6. Epub 2007 Mar 12.

Molecular Endocrinology Laboratory, Department of Molecular Cell Biology, Catholic University of Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1073/pnas.0610814104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829247PMC
March 2007

Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide.

Endocrinology 2006 Oct 29;147(10):4820-30. Epub 2006 Jun 29.

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom.

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http://dx.doi.org/10.1210/en.2006-0149DOI Listing
October 2006

The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice.

Mol Endocrinol 2006 Feb 15;20(2):321-34. Epub 2005 Sep 15.

Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Belgium.

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http://dx.doi.org/10.1210/me.2005-0113DOI Listing
February 2006

Expression of androgen and estrogen receptors in sertoli cells: studies using the mouse SK11 cell line.

Endocrinology 2005 Dec 15;146(12):5304-12. Epub 2005 Sep 15.

Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1210/en.2005-0914DOI Listing
December 2005

Estrogens in testis biology.

Ann N Y Acad Sci 2005 Dec;1061:65-76

MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK.

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http://doi.wiley.com/10.1196/annals.1336.008
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December 2005

Expression of estrogen receptor ESR1 and its 46-kDa variant in the gubernaculum testis.

Biol Reprod 2005 Oct 8;73(4):703-12. Epub 2005 Jun 8.

INSERM, U625, GERHM, IFR 140, Campus de Beaulieu, Univ Rennes I, Bretagne, France.

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http://dx.doi.org/10.1095/biolreprod.105.042796DOI Listing
October 2005

ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.

J Pathol 2005 Sep;207(1):53-60

Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://doi.wiley.com/10.1002/path.1807
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http://dx.doi.org/10.1002/path.1807DOI Listing
September 2005

Does estrogen receptor beta play a significant role in human reproduction?

Trends Endocrinol Metab 2005 Jul;16(5):222-7

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 49 Little France Crescent, Edinburgh, UK, EH16 4SB.

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http://dx.doi.org/10.1016/j.tem.2005.05.006DOI Listing
July 2005