Philippa J Talmud

Philippa J Talmud

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Philippa J Talmud

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Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology.

Circ Genom Precis Med 2018 02;11(2):e001813

From the Institute of Cardiovascular Science (R.C.L., V.K.K., R.E.F., N.H.C., R.P.H., P.J.T., P.D.L., P.M.E., L.C.) and Metabolism and Experimental Therapeutics, Division of Medicine (R.B.), University College London, United Kingdom; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, United Kingdom (P.R., D.O.-S.); Gene Ontology Consortium (P.R., T.Z.B., D.O.-S., J.A.B., D.P.H.); The Zebrafish Model Organism Database, University of Oregon, Eugene (D.G.H.); Rat Genome Database, Human Molecular Genetics Center, Medical College of Wisconsin, Milwaukee (S.J.F.L.); Arabidopsis Information Resource, Phoenix Bioinformatics, Fremont, CA (T.Z.B.); FlyBase, University of Cambridge, United Kingdom (S.T.); Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME (J.A.B., D.P.H.); Oxbridge BHF Centre of Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom (P.R.R.); and William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (A.T.).

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http://dx.doi.org/10.1161/CIRCGEN.117.001813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821137PMC
February 2018

Corrigendum to "APOA5 variants predispose hyperlipidemic patients to atherogenic dyslipidemia and subclinical atherosclerosis" [Atherosclerosis 240/1 (2015) 98-104].

Atherosclerosis 2016 Jul 12;250:190. Epub 2016 May 12.

Unitat de Recerca en Lípids i Arteriosclerosi, Hospital Universitari Sant Joan de Reus, Institut d'Investigacions Sanitàries Pere Virgili, Universitat Rovira i Virgili, Reus, Spain; CIBER Diabetes y Enfermedades Metabólicas (CIBERdem), Instituto de Salud Carlos III (ISCIII), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.008DOI Listing
July 2016

Demonstration of the presence of the "deleted" MIR122 gene in HepG2 cells.

PLoS One 2015 26;10(3):e0122471. Epub 2015 Mar 26.

Centre for Cardiovascular Genetics, BHF Laboratories, Institute of Cardiovascular Science, UCL, London, WC1E 6JF, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122471PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374784PMC
March 2016

Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3.

Atherosclerosis 2016 Mar 12;246:193-201. Epub 2015 Dec 12.

Department of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773290PMC
March 2016

Deciphering the Causal Role of sPLA2s and Lp-PLA2 in Coronary Heart Disease.

Arterioscler Thromb Vasc Biol 2015 Nov 3;35(11):2281-9. Epub 2015 Sep 3.

From the Center for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK (P.J.T.); and Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK (M.V.H.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305234DOI Listing
November 2015

APOA5 variants predispose hyperlipidemic patients to atherogenic dyslipidemia and subclinical atherosclerosis.

Atherosclerosis 2015 May 9;240(1):98-104. Epub 2015 Mar 9.

Unitat de Recerca en Lípids i Arteriosclerosi, Hospital Universitari Sant Joan de Reus, Institut d'Investigacions Sanitàries Pere Virgili, Universitat Rovira i Virgili, Reus, Spain; CIBER Diabetes y Enfermedades Metabólicas (CIBERdem), Instituto de Salud Carlos III (ISCIII), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.03.008DOI Listing
May 2015

PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk.

Circ Cardiovasc Genet 2015 Apr 12;8(2):356-62. Epub 2015 Jan 12.

From the Center for Cardiovascular Genetics, Institute of Cardiovascular Science (M.G., H.J.E., J.P., K.W.L., J.A.C., S.E.H., P.J.T.), and Genetic Epidemiology Group, Department of Epidemiology and Public Health (M.V.H.), University College London, London, UK; Unitat de Recerca en Lípids i Arteriosclerosi, Universitat Rovira i Virgili, CIBERDEM, IISPV, Reus, Spain (M.G.); Genomics and Pathophysiology of Cardiovascular Diseases Team, ICAN, Sorbonne Universités, UPMC University Paris 06, INSERM UMR_S 1166, Paris, France (C.P., E.N.); Molecular Genetics Department, Novo Nordisk A/S, Copenhagen, Denmark (L.F.); Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden (L.F., F.v.H., P.E., G.P.-B.); Atherosclerosis Research Unit, Department of Medicine Solna (F.v.H., P.E.), and Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery (A.F.-C.), Karolinska Institutet, Stockholm, Sweden; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge (K.-T.K.); Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, England, UK (Z.M.); Sorbonne Universités, UPMC Univ Paris 06 (S.-A.K.), and Physiopathology of Genetic Diseases With Pediatric Expression, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 933, Paris, France (S.-A.K.); Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands (S.M.B.); and Department of Surgery and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.V.H.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000633DOI Listing
April 2015

Identifying functional noncoding variants from genome-wide association studies for cardiovascular disease and related traits.

Curr Opin Lipidol 2015 Apr;26(2):120-6

British Heart Foundation Laboratories, Institute of Cardiovascular Sciences, Centre for Cardiovascular Genetics, University College London, London, UK.

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http://dx.doi.org/10.1097/MOL.0000000000000158DOI Listing
April 2015

Mendelian randomization of blood lipids for coronary heart disease.

Eur Heart J 2015 Mar 27;36(9):539-50. Epub 2014 Jan 27.

Genetic Epidemiology Group, Institute of Cardiovacular Science, Faculty of Population Healh Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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https://eurheartj.oxfordjournals.org/content/ehj/36/9/539.fu
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http://eurheartj.oxfordjournals.org/cgi/doi/10.1093/eurheart
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http://dx.doi.org/10.1093/eurheartj/eht571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344957PMC
March 2015

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

Authors:
Daniel I Swerdlow David Preiss Karoline B Kuchenbaecker Michael V Holmes Jorgen E L Engmann Tina Shah Reecha Sofat Stefan Stender Paul C D Johnson Robert A Scott Maarten Leusink Niek Verweij Stephen J Sharp Yiran Guo Claudia Giambartolomei Christina Chung Anne Peasey Antoinette Amuzu KaWah Li Jutta Palmen Philip Howard Jackie A Cooper Fotios Drenos Yun R Li Gordon Lowe John Gallacher Marlene C W Stewart Ioanna Tzoulaki Sarah G Buxbaum Daphne L van der A Nita G Forouhi N Charlotte Onland-Moret Yvonne T van der Schouw Renate B Schnabel Jaroslav A Hubacek Ruzena Kubinova Migle Baceviciene Abdonas Tamosiunas Andrzej Pajak Roman Topor-Madry Urszula Stepaniak Sofia Malyutina Damiano Baldassarre Bengt Sennblad Elena Tremoli Ulf de Faire Fabrizio Veglia Ian Ford J Wouter Jukema Rudi G J Westendorp Gert Jan de Borst Pim A de Jong Ale Algra Wilko Spiering Anke H Maitland-van der Zee Olaf H Klungel Anthonius de Boer Pieter A Doevendans Charles B Eaton Jennifer G Robinson David Duggan John Kjekshus John R Downs Antonio M Gotto Anthony C Keech Roberto Marchioli Gianni Tognoni Peter S Sever Neil R Poulter David D Waters Terje R Pedersen Pierre Amarenco Haruo Nakamura John J V McMurray James D Lewsey Daniel I Chasman Paul M Ridker Aldo P Maggioni Luigi Tavazzi Kausik K Ray Sreenivasa Rao Kondapally Seshasai JoAnn E Manson Jackie F Price Peter H Whincup Richard W Morris Debbie A Lawlor George Davey Smith Yoav Ben-Shlomo Pamela J Schreiner Myriam Fornage David S Siscovick Mary Cushman Meena Kumari Nick J Wareham W M Monique Verschuren Susan Redline Sanjay R Patel John C Whittaker Anders Hamsten Joseph A Delaney Caroline Dale Tom R Gaunt Andrew Wong Diana Kuh Rebecca Hardy Sekar Kathiresan Berta A Castillo Pim van der Harst Eric J Brunner Anne Tybjaerg-Hansen Michael G Marmot Ronald M Krauss Michael Tsai Josef Coresh Ronald C Hoogeveen Bruce M Psaty Leslie A Lange Hakon Hakonarson Frank Dudbridge Steve E Humphries Philippa J Talmud Mika Kivimäki Nicholas J Timpson Claudia Langenberg Folkert W Asselbergs Mikhail Voevoda Martin Bobak Hynek Pikhart James G Wilson Alex P Reiner Brendan J Keating Aroon D Hingorani Naveed Sattar

Lancet 2015 Jan 24;385(9965):351-61. Epub 2014 Sep 24.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1016/S0140-6736(14)61183-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322187PMC
January 2015

The genetic architecture of the familial hyperlipidaemia syndromes: rare mutations and common variants in multiple genes.

Curr Opin Lipidol 2014 Aug;25(4):274-81

Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.

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http://dx.doi.org/10.1097/MOL.0000000000000090DOI Listing
August 2014

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Authors:
Michael V Holmes Caroline E Dale Luisa Zuccolo Richard J Silverwood Yiran Guo Zheng Ye David Prieto-Merino Abbas Dehghan Stella Trompet Andrew Wong Alana Cavadino Dagmar Drogan Sandosh Padmanabhan Shanshan Li Ajay Yesupriya Maarten Leusink Johan Sundstrom Jaroslav A Hubacek Hynek Pikhart Daniel I Swerdlow Andrie G Panayiotou Svetlana A Borinskaya Chris Finan Sonia Shah Karoline B Kuchenbaecker Tina Shah Jorgen Engmann Lasse Folkersen Per Eriksson Fulvio Ricceri Olle Melander Carlotta Sacerdote Dale M Gamble Sruti Rayaprolu Owen A Ross Stela McLachlan Olga Vikhireva Ivonne Sluijs Robert A Scott Vera Adamkova Leon Flicker Frank M van Bockxmeer Christine Power Pedro Marques-Vidal Tom Meade Michael G Marmot Jose M Ferro Sofia Paulos-Pinheiro Steve E Humphries Philippa J Talmud Irene Mateo Leach Niek Verweij Allan Linneberg Tea Skaaby Pieter A Doevendans Maarten J Cramer Pim van der Harst Olaf H Klungel Nicole F Dowling Anna F Dominiczak Meena Kumari Andrew N Nicolaides Cornelia Weikert Heiner Boeing Shah Ebrahim Tom R Gaunt Jackie F Price Lars Lannfelt Anne Peasey Ruzena Kubinova Andrzej Pajak Sofia Malyutina Mikhail I Voevoda Abdonas Tamosiunas Anke H Maitland-van der Zee Paul E Norman Graeme J Hankey Manuela M Bergmann Albert Hofman Oscar H Franco Jackie Cooper Jutta Palmen Wilko Spiering Pim A de Jong Diana Kuh Rebecca Hardy Andre G Uitterlinden M Arfan Ikram Ian Ford Elina Hyppönen Osvaldo P Almeida Nicholas J Wareham Kay-Tee Khaw Anders Hamsten Lise Lotte N Husemoen Anne Tjønneland Janne S Tolstrup Eric Rimm Joline W J Beulens W M Monique Verschuren N Charlotte Onland-Moret Marten H Hofker S Goya Wannamethee Peter H Whincup Richard Morris Astrid M Vicente Hugh Watkins Martin Farrall J Wouter Jukema James Meschia L Adrienne Cupples Stephen J Sharp Myriam Fornage Charles Kooperberg Andrea Z LaCroix James Y Dai Matthew B Lanktree David S Siscovick Eric Jorgenson Bonnie Spring Josef Coresh Yun R Li Sarah G Buxbaum Pamela J Schreiner R Curtis Ellison Michael Y Tsai Sanjay R Patel Susan Redline Andrew D Johnson Ron C Hoogeveen Hakon Hakonarson Jerome I Rotter Eric Boerwinkle Paul I W de Bakker Mika Kivimaki Folkert W Asselbergs Naveed Sattar Debbie A Lawlor John Whittaker George Davey Smith Kenneth Mukamal Bruce M Psaty James G Wilson Leslie A Lange Ajna Hamidovic Aroon D Hingorani Børge G Nordestgaard Martin Bobak David A Leon Claudia Langenberg Tom M Palmer Alex P Reiner Brendan J Keating Frank Dudbridge Juan P Casas

BMJ 2014 Jul 10;349:g4164. Epub 2014 Jul 10.

Genetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091648PMC
http://dx.doi.org/10.1136/bmj.g4164DOI Listing
July 2014

From zebrafish heart jogging genes to mouse and human orthologs: using Gene Ontology to investigate mammalian heart development.

F1000Res 2013 13;2:242. Epub 2013 Nov 13.

Cardiovascular GO Annotation Initiative, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, WC1E 6JF, UK.

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http://dx.doi.org/10.12688/f1000research.2-242.v2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931453PMC
March 2014

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study.

Authors:
Michael V Holmes Tabassome Simon Holly J Exeter Lasse Folkersen Folkert W Asselbergs Montse Guardiola Jackie A Cooper Jutta Palmen Jaroslav A Hubacek Kathryn F Carruthers Benjamin D Horne Kimberly D Brunisholz Jessica L Mega Erik P A van Iperen Mingyao Li Maarten Leusink Stella Trompet Jeffrey J W Verschuren G Kees Hovingh Abbas Dehghan Christopher P Nelson Salma Kotti Nicolas Danchin Markus Scholz Christiane L Haase Dietrich Rothenbacher Daniel I Swerdlow Karoline B Kuchenbaecker Eleonora Staines-Urias Anuj Goel Ferdinand van 't Hooft Karl Gertow Ulf de Faire Andrie G Panayiotou Elena Tremoli Damiano Baldassarre Fabrizio Veglia Lesca M Holdt Frank Beutner Ron T Gansevoort Gerjan J Navis Irene Mateo Leach Lutz P Breitling Hermann Brenner Joachim Thiery Dhayana Dallmeier Anders Franco-Cereceda Jolanda M A Boer Jeffrey W Stephens Marten H Hofker Alain Tedgui Albert Hofman André G Uitterlinden Vera Adamkova Jan Pitha N Charlotte Onland-Moret Maarten J Cramer Hendrik M Nathoe Wilko Spiering Olaf H Klungel Meena Kumari Peter H Whincup David A Morrow Peter S Braund Alistair S Hall Anders G Olsson Pieter A Doevendans Mieke D Trip Martin D Tobin Anders Hamsten Hugh Watkins Wolfgang Koenig Andrew N Nicolaides Daniel Teupser Ian N M Day John F Carlquist Tom R Gaunt Ian Ford Naveed Sattar Sotirios Tsimikas Gregory G Schwartz Debbie A Lawlor Richard W Morris Manjinder S Sandhu Rudolf Poledne Anke H Maitland-van der Zee Kay-Tee Khaw Brendan J Keating Pim van der Harst Jackie F Price Shamir R Mehta Salim Yusuf Jaqueline C M Witteman Oscar H Franco J Wouter Jukema Peter de Knijff Anne Tybjaerg-Hansen Daniel J Rader Martin Farrall Nilesh J Samani Mika Kivimaki Keith A A Fox Steve E Humphries Jeffrey L Anderson S Matthijs Boekholdt Tom M Palmer Per Eriksson Guillaume Paré Aroon D Hingorani Marc S Sabatine Ziad Mallat Juan P Casas Philippa J Talmud

J Am Coll Cardiol 2013 Nov 31;62(21):1966-1976. Epub 2013 Jul 31.

Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2013.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826105PMC
November 2013

Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip.

Thromb Haemost 2013 Nov 29;110(5):995-1003. Epub 2013 Aug 29.

MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1160/TH13-02-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067543PMC
November 2013

Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.

Circ Cardiovasc Genet 2013 Apr 16;6(2):163-70. Epub 2013 Mar 16.

Genetic Epidemiology Group, Research Department of Epidemiology and Public Health, UCL Institute of Epidemiology & Health Care, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1161/CIRCGENETICS.112.964254DOI Listing
April 2013

Identification of seven loci affecting mean telomere length and their association with disease.

Authors:
Veryan Codd Christopher P Nelson Eva Albrecht Massimo Mangino Joris Deelen Jessica L Buxton Jouke Jan Hottenga Krista Fischer Tõnu Esko Ida Surakka Linda Broer Dale R Nyholt Irene Mateo Leach Perttu Salo Sara Hägg Mary K Matthews Jutta Palmen Giuseppe D Norata Paul F O'Reilly Danish Saleheen Najaf Amin Anthony J Balmforth Marian Beekman Rudolf A de Boer Stefan Böhringer Peter S Braund Paul R Burton Anton J M de Craen Matthew Denniff Yanbin Dong Konstantinos Douroudis Elena Dubinina Johan G Eriksson Katia Garlaschelli Dehuang Guo Anna-Liisa Hartikainen Anjali K Henders Jeanine J Houwing-Duistermaat Laura Kananen Lennart C Karssen Johannes Kettunen Norman Klopp Vasiliki Lagou Elisabeth M van Leeuwen Pamela A Madden Reedik Mägi Patrik K E Magnusson Satu Männistö Mark I McCarthy Sarah E Medland Evelin Mihailov Grant W Montgomery Ben A Oostra Aarno Palotie Annette Peters Helen Pollard Anneli Pouta Inga Prokopenko Samuli Ripatti Veikko Salomaa H Eka D Suchiman Ana M Valdes Niek Verweij Ana Viñuela Xiaoling Wang H-Erich Wichmann Elisabeth Widen Gonneke Willemsen Margaret J Wright Kai Xia Xiangjun Xiao Dirk J van Veldhuisen Alberico L Catapano Martin D Tobin Alistair S Hall Alexandra I F Blakemore Wiek H van Gilst Haidong Zhu Jeanette Erdmann Muredach P Reilly Sekar Kathiresan Heribert Schunkert Philippa J Talmud Nancy L Pedersen Markus Perola Willem Ouwehand Jaakko Kaprio Nicholas G Martin Cornelia M van Duijn Iiris Hovatta Christian Gieger Andres Metspalu Dorret I Boomsma Marjo-Riitta Jarvelin P Eline Slagboom John R Thompson Tim D Spector Pim van der Harst Nilesh J Samani

Nat Genet 2013 Apr;45(4):422-7, 427e1-2

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

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http://www.nature.com/doifinder/10.1038/ng.2528
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http://dx.doi.org/10.1038/ng.2528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006270PMC
April 2013

Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays.

PLoS Genet 2012 16;8(8):e1002908. Epub 2012 Aug 16.

Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Sciences, University College London, London, United Kingdom.

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https://dx.plos.org/10.1371/journal.pgen.1002908
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http://dx.doi.org/10.1371/journal.pgen.1002908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420950PMC
December 2012

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

Authors:
Folkert W Asselbergs Yiran Guo Erik P A van Iperen Suthesh Sivapalaratnam Vinicius Tragante Matthew B Lanktree Leslie A Lange Berta Almoguera Yolande E Appelman John Barnard Jens Baumert Amber L Beitelshees Tushar R Bhangale Yii-Der Ida Chen Tom R Gaunt Yan Gong Jemma C Hopewell Toby Johnson Marcus E Kleber Taimour Y Langaee Mingyao Li Yun R Li Kiang Liu Caitrin W McDonough Matthijs F L Meijs Rita P S Middelberg Kiran Musunuru Christopher P Nelson Jeffery R O'Connell Sandosh Padmanabhan James S Pankow Nathan Pankratz Suzanne Rafelt Ramakrishnan Rajagopalan Simon P R Romaine Nicholas J Schork Jonathan Shaffer Haiqing Shen Erin N Smith Sam E Tischfield Peter J van der Most Jana V van Vliet-Ostaptchouk Niek Verweij Kelly A Volcik Li Zhang Kent R Bailey Kristian M Bailey Florianne Bauer Jolanda M A Boer Peter S Braund Amber Burt Paul R Burton Sarah G Buxbaum Wei Chen Rhonda M Cooper-Dehoff L Adrienne Cupples Jonas S deJong Christian Delles David Duggan Myriam Fornage Clement E Furlong Nicole Glazer John G Gums Claire Hastie Michael V Holmes Thomas Illig Susan A Kirkland Mika Kivimaki Ronald Klein Barbara E Klein Charles Kooperberg Kandice Kottke-Marchant Meena Kumari Andrea Z LaCroix Laya Mallela Gurunathan Murugesan Jose Ordovas Willem H Ouwehand Wendy S Post Richa Saxena Hubert Scharnagl Pamela J Schreiner Tina Shah Denis C Shields Daichi Shimbo Sathanur R Srinivasan Ronald P Stolk Daniel I Swerdlow Herman A Taylor Eric J Topol Elina Toskala Joost L van Pelt Jessica van Setten Salim Yusuf John C Whittaker A H Zwinderman Sonia S Anand Anthony J Balmforth Gerald S Berenson Connie R Bezzina Bernhard O Boehm Eric Boerwinkle Juan P Casas Mark J Caulfield Robert Clarke John M Connell Karen J Cruickshanks Karina W Davidson Ian N M Day Paul I W de Bakker Pieter A Doevendans Anna F Dominiczak Alistair S Hall Catharina A Hartman Christian Hengstenberg Hans L Hillege Marten H Hofker Steve E Humphries Gail P Jarvik Julie A Johnson Bernhard M Kaess Sekar Kathiresan Wolfgang Koenig Debbie A Lawlor Winfried März Olle Melander Braxton D Mitchell Grant W Montgomery Patricia B Munroe Sarah S Murray Stephen J Newhouse N Charlotte Onland-Moret Neil Poulter Bruce Psaty Susan Redline Stephen S Rich Jerome I Rotter Heribert Schunkert Peter Sever Alan R Shuldiner Roy L Silverstein Alice Stanton Barbara Thorand Mieke D Trip Michael Y Tsai Pim van der Harst Ellen van der Schoot Yvonne T van der Schouw W M Monique Verschuren Hugh Watkins Arthur A M Wilde Bruce H R Wolffenbuttel John B Whitfield G Kees Hovingh Christie M Ballantyne Cisca Wijmenga Muredach P Reilly Nicholas G Martin James G Wilson Daniel J Rader Nilesh J Samani Alex P Reiner Robert A Hegele John J P Kastelein Aroon D Hingorani Philippa J Talmud Hakon Hakonarson Clara C Elbers Brendan J Keating Fotios Drenos

Am J Hum Genet 2012 Nov 11;91(5):823-38. Epub 2012 Oct 11.

Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.ajhg.2012.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487124PMC
November 2012

Genetic susceptibility for coronary heart disease and type 2 diabetes complications.

Clin Chem 2012 May 23;58(5):818-20. Epub 2012 Feb 23.

Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.

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http://dx.doi.org/10.1373/clinchem.2012.182725DOI Listing
May 2012

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.

Authors:
Richa Saxena Clara C Elbers Yiran Guo Inga Peter Tom R Gaunt Jessica L Mega Matthew B Lanktree Archana Tare Berta Almoguera Castillo Yun R Li Toby Johnson Marcel Bruinenberg Diane Gilbert-Diamond Ramakrishnan Rajagopalan Benjamin F Voight Ashok Balasubramanyam John Barnard Florianne Bauer Jens Baumert Tushar Bhangale Bernhard O Böhm Peter S Braund Paul R Burton Hareesh R Chandrupatla Robert Clarke Rhonda M Cooper-DeHoff Errol D Crook George Davey-Smith Ian N Day Anthonius de Boer Mark C H de Groot Fotios Drenos Jane Ferguson Caroline S Fox Clement E Furlong Quince Gibson Christian Gieger Lisa A Gilhuijs-Pederson Joseph T Glessner Anuj Goel Yan Gong Struan F A Grant Diederick E Grobbee Claire Hastie Steve E Humphries Cecilia E Kim Mika Kivimaki Marcus Kleber Christa Meisinger Meena Kumari Taimour Y Langaee Debbie A Lawlor Mingyao Li Maximilian T Lobmeyer Anke-Hilse Maitland-van der Zee Matthijs F L Meijs Cliona M Molony David A Morrow Gurunathan Murugesan Solomon K Musani Christopher P Nelson Stephen J Newhouse Jeffery R O'Connell Sandosh Padmanabhan Jutta Palmen Sanjey R Patel Carl J Pepine Mary Pettinger Thomas S Price Suzanne Rafelt Jane Ranchalis Asif Rasheed Elisabeth Rosenthal Ingo Ruczinski Sonia Shah Haiqing Shen Günther Silbernagel Erin N Smith Annemieke W M Spijkerman Alice Stanton Michael W Steffes Barbara Thorand Mieke Trip Pim van der Harst Daphne L van der A Erik P A van Iperen Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Bruce H R Wolffenbuttel Taylor Young M Hadi Zafarmand Joseph M Zmuda Michael Boehnke David Altshuler Mark McCarthy W H Linda Kao James S Pankow Thomas P Cappola Peter Sever Neil Poulter Mark Caulfield Anna Dominiczak Denis C Shields Deepak L Bhatt Deepak Bhatt Li Zhang Sean P Curtis John Danesh Juan P Casas Yvonne T van der Schouw N Charlotte Onland-Moret Pieter A Doevendans Gerald W Dorn Martin Farrall Garret A FitzGerald Anders Hamsten Robert Hegele Aroon D Hingorani Marten H Hofker Gordon S Huggins Thomas Illig Gail P Jarvik Julie A Johnson Olaf H Klungel William C Knowler Wolfgang Koenig Winfried März James B Meigs Olle Melander Patricia B Munroe Braxton D Mitchell Susan J Bielinski Daniel J Rader Muredach P Reilly Stephen S Rich Jerome I Rotter Danish Saleheen Nilesh J Samani Eric E Schadt Alan R Shuldiner Roy Silverstein Kandice Kottke-Marchant Philippa J Talmud Hugh Watkins Folkert W Asselbergs Folkert Asselbergs Paul I W de Bakker Jeanne McCaffery Cisca Wijmenga Marc S Sabatine James G Wilson Alex Reiner Donald W Bowden Hakon Hakonarson David S Siscovick Brendan J Keating

Am J Hum Genet 2012 Mar 9;90(3):410-25. Epub 2012 Feb 9.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, USA.

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http://dx.doi.org/10.1016/j.ajhg.2011.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309185PMC
March 2012

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

Authors:
Daniel I Swerdlow Michael V Holmes Karoline B Kuchenbaecker Jorgen E L Engmann Tina Shah Reecha Sofat Yiran Guo Christina Chung Anne Peasey Roman Pfister Simon P Mooijaart Helen A Ireland Maarten Leusink Claudia Langenberg Ka Wah Li Jutta Palmen Philip Howard Jackie A Cooper Fotios Drenos John Hardy Michael A Nalls Yun Rose Li Gordon Lowe Marlene Stewart Suzette J Bielinski Julian Peto Nicholas J Timpson John Gallacher Malcolm Dunlop Richard Houlston Ian Tomlinson Ioanna Tzoulaki Jian'an Luan Jolanda M A Boer Nita G Forouhi N Charlotte Onland-Moret Yvonne T van der Schouw Renate B Schnabel Jaroslav A Hubacek Ruzena Kubinova Migle Baceviciene Abdonas Tamosiunas Andrzej Pajak Roman Topor-Madry Sofia Malyutina Damiano Baldassarre Bengt Sennblad Elena Tremoli Ulf de Faire Luigi Ferrucci Stefania Bandenelli Toshiko Tanaka James F Meschia Andrew Singleton Gerjan Navis Irene Mateo Leach Stephan J L Bakker Ron T Gansevoort Ian Ford Stephen E Epstein Mary Susan Burnett Joe M Devaney J Wouter Jukema Rudi G J Westendorp Gert Jan de Borst Yolanda van der Graaf Pim A de Jong Anke-Hilse Mailand-van der Zee Olaf H Klungel Anthonius de Boer Pieter A Doevendans Jeffrey W Stephens Charles B Eaton Jennifer G Robinson JoAnn E Manson F Gerry Fowkes Timonthy M Frayling Jackie F Price Peter H Whincup Richard W Morris Debbie A Lawlor George Davey Smith Yoav Ben-Shlomo Susan Redline Leslie A Lange Meena Kumari Nick J Wareham W M Monique Verschuren Emelia J Benjamin John C Whittaker Anders Hamsten Frank Dudbridge J A Chris Delaney Andrew Wong Diana Kuh Rebecca Hardy Berta Almoguera Castillo John J Connolly Pim van der Harst Eric J Brunner Michael G Marmot Christina L Wassel Steve E Humphries Philippa J Talmud Mika Kivimaki Folkert W Asselbergs Mikhail Voevoda Martin Bobak Hynek Pikhart James G Wilson Hakon Hakonarson Alex P Reiner Brendan J Keating Naveed Sattar Aroon D Hingorani Juan Pablo Casas

Lancet 2012 Mar 14;379(9822):1214-24. Epub 2012 Mar 14.

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http://dx.doi.org/10.1016/S0140-6736(12)60110-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316968PMC
March 2012

Commentary on the paper by Gustavsson et al. entitled 'Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women'.

Atherosclerosis 2012 Feb 3;220(2):323-4. Epub 2011 Nov 3.

Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, 5 University St, London WC1E 6JF, UK.

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http://dx.doi.org/10.1016/j.atherosclerosis.2011.10.024DOI Listing
February 2012

Blood pressure loci identified with a gene-centric array.

Authors:
Toby Johnson Tom R Gaunt Stephen J Newhouse Sandosh Padmanabhan Maciej Tomaszewski Meena Kumari Richard W Morris Ioanna Tzoulaki Eoin T O'Brien Neil R Poulter Peter Sever Denis C Shields Simon Thom Sasiwarang G Wannamethee Peter H Whincup Morris J Brown John M Connell Richard J Dobson Philip J Howard Charles A Mein Abiodun Onipinla Sue Shaw-Hawkins Yun Zhang George Davey Smith Ian N M Day Debbie A Lawlor Alison H Goodall F Gerald Fowkes Gonçalo R Abecasis Paul Elliott Vesela Gateva Peter S Braund Paul R Burton Christopher P Nelson Martin D Tobin Pim van der Harst Nicola Glorioso Hani Neuvrith Erika Salvi Jan A Staessen Andrea Stucchi Nabila Devos Xavier Jeunemaitre Pierre-François Plouin Jean Tichet Peeter Juhanson Elin Org Margus Putku Siim Sõber Gudrun Veldre Margus Viigimaa Anna Levinsson Annika Rosengren Dag S Thelle Claire E Hastie Thomas Hedner Wai K Lee Olle Melander Björn Wahlstrand Rebecca Hardy Andrew Wong Jackie A Cooper Jutta Palmen Li Chen Alexandre F R Stewart George A Wells Harm-Jan Westra Marcel G M Wolfs Robert Clarke Maria Grazia Franzosi Anuj Goel Anders Hamsten Mark Lathrop John F Peden Udo Seedorf Hugh Watkins Willem H Ouwehand Jennifer Sambrook Jonathan Stephens Juan-Pablo Casas Fotios Drenos Michael V Holmes Mika Kivimaki Sonia Shah Tina Shah Philippa J Talmud John Whittaker Chris Wallace Christian Delles Maris Laan Diana Kuh Steve E Humphries Fredrik Nyberg Daniele Cusi Robert Roberts Christopher Newton-Cheh Lude Franke Alice V Stanton Anna F Dominiczak Martin Farrall Aroon D Hingorani Nilesh J Samani Mark J Caulfield Patricia B Munroe

Am J Hum Genet 2011 Dec 17;89(6):688-700. Epub 2011 Nov 17.

Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.1016/j.ajhg.2011.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234370PMC
December 2011

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Authors:
Georg B Ehret Patricia B Munroe Kenneth M Rice Murielle Bochud Andrew D Johnson Daniel I Chasman Albert V Smith Martin D Tobin Germaine C Verwoert Shih-Jen Hwang Vasyl Pihur Peter Vollenweider Paul F O'Reilly Najaf Amin Jennifer L Bragg-Gresham Alexander Teumer Nicole L Glazer Lenore Launer Jing Hua Zhao Yurii Aulchenko Simon Heath Siim Sõber Afshin Parsa Jian'an Luan Pankaj Arora Abbas Dehghan Feng Zhang Gavin Lucas Andrew A Hicks Anne U Jackson John F Peden Toshiko Tanaka Sarah H Wild Igor Rudan Wilmar Igl Yuri Milaneschi Alex N Parker Cristiano Fava John C Chambers Ervin R Fox Meena Kumari Min Jin Go Pim van der Harst Wen Hong Linda Kao Marketa Sjögren D G Vinay Myriam Alexander Yasuharu Tabara Sue Shaw-Hawkins Peter H Whincup Yongmei Liu Gang Shi Johanna Kuusisto Bamidele Tayo Mark Seielstad Xueling Sim Khanh-Dung Hoang Nguyen Terho Lehtimäki Giuseppe Matullo Ying Wu Tom R Gaunt N Charlotte Onland-Moret Matthew N Cooper Carl G P Platou Elin Org Rebecca Hardy Santosh Dahgam Jutta Palmen Veronique Vitart Peter S Braund Tatiana Kuznetsova Cuno S P M Uiterwaal Adebowale Adeyemo Walter Palmas Harry Campbell Barbara Ludwig Maciej Tomaszewski Ioanna Tzoulaki Nicholette D Palmer Thor Aspelund Melissa Garcia Yen-Pei C Chang Jeffrey R O'Connell Nanette I Steinle Diederick E Grobbee Dan E Arking Sharon L Kardia Alanna C Morrison Dena Hernandez Samer Najjar Wendy L McArdle David Hadley Morris J Brown John M Connell Aroon D Hingorani Ian N M Day Debbie A Lawlor John P Beilby Robert W Lawrence Robert Clarke Jemma C Hopewell Halit Ongen Albert W Dreisbach Yali Li J Hunter Young Joshua C Bis Mika Kähönen Jorma Viikari Linda S Adair Nanette R Lee Ming-Huei Chen Matthias Olden Cristian Pattaro Judith A Hoffman Bolton Anna Köttgen Sven Bergmann Vincent Mooser Nish Chaturvedi Timothy M Frayling Muhammad Islam Tazeen H Jafar Jeanette Erdmann Smita R Kulkarni Stefan R Bornstein Jürgen Grässler Leif Groop Benjamin F Voight Johannes Kettunen Philip Howard Andrew Taylor Simonetta Guarrera Fulvio Ricceri Valur Emilsson Andrew Plump Inês Barroso Kay-Tee Khaw Alan B Weder Steven C Hunt Yan V Sun Richard N Bergman Francis S Collins Lori L Bonnycastle Laura J Scott Heather M Stringham Leena Peltonen Markus Perola Erkki Vartiainen Stefan-Martin Brand Jan A Staessen Thomas J Wang Paul R Burton Maria Soler Artigas Yanbin Dong Harold Snieder Xiaoling Wang Haidong Zhu Kurt K Lohman Megan E Rudock Susan R Heckbert Nicholas L Smith Kerri L Wiggins Ayo Doumatey Daniel Shriner Gudrun Veldre Margus Viigimaa Sanjay Kinra Dorairaj Prabhakaran Vikal Tripathy Carl D Langefeld Annika Rosengren Dag S Thelle Anna Maria Corsi Andrew Singleton Terrence Forrester Gina Hilton Colin A McKenzie Tunde Salako Naoharu Iwai Yoshikuni Kita Toshio Ogihara Takayoshi Ohkubo Tomonori Okamura Hirotsugu Ueshima Satoshi Umemura Susana Eyheramendy Thomas Meitinger H-Erich Wichmann Yoon Shin Cho Hyung-Lae Kim Jong-Young Lee James Scott Joban S Sehmi Weihua Zhang Bo Hedblad Peter Nilsson George Davey Smith Andrew Wong Narisu Narisu Alena Stančáková Leslie J Raffel Jie Yao Sekar Kathiresan Christopher J O'Donnell Stephen M Schwartz M Arfan Ikram W T Longstreth Thomas H Mosley Sudha Seshadri Nick R G Shrine Louise V Wain Mario A Morken Amy J Swift Jaana Laitinen Inga Prokopenko Paavo Zitting Jackie A Cooper Steve E Humphries John Danesh Asif Rasheed Anuj Goel Anders Hamsten Hugh Watkins Stephan J L Bakker Wiek H van Gilst Charles S Janipalli K Radha Mani Chittaranjan S Yajnik Albert Hofman Francesco U S Mattace-Raso Ben A Oostra Ayse Demirkan Aaron Isaacs Fernando Rivadeneira Edward G Lakatta Marco Orru Angelo Scuteri Mika Ala-Korpela Antti J Kangas Leo-Pekka Lyytikäinen Pasi Soininen Taru Tukiainen Peter Würtz Rick Twee-Hee Ong Marcus Dörr Heyo K Kroemer Uwe Völker Henry Völzke Pilar Galan Serge Hercberg Mark Lathrop Diana Zelenika Panos Deloukas Massimo Mangino Tim D Spector Guangju Zhai James F Meschia Michael A Nalls Pankaj Sharma Janos Terzic M V Kranthi Kumar Matthew Denniff Ewa Zukowska-Szczechowska Lynne E Wagenknecht F Gerald R Fowkes Fadi J Charchar Peter E H Schwarz Caroline Hayward Xiuqing Guo Charles Rotimi Michiel L Bots Eva Brand Nilesh J Samani Ozren Polasek Philippa J Talmud Fredrik Nyberg Diana Kuh Maris Laan Kristian Hveem Lyle J Palmer Yvonne T van der Schouw Juan P Casas Karen L Mohlke Paolo Vineis Olli Raitakari Santhi K Ganesh Tien Y Wong E Shyong Tai Richard S Cooper Markku Laakso Dabeeru C Rao Tamara B Harris Richard W Morris Anna F Dominiczak Mika Kivimaki Michael G Marmot Tetsuro Miki Danish Saleheen Giriraj R Chandak Josef Coresh Gerjan Navis Veikko Salomaa Bok-Ghee Han Xiaofeng Zhu Jaspal S Kooner Olle Melander Paul M Ridker Stefania Bandinelli Ulf B Gyllensten Alan F Wright James F Wilson Luigi Ferrucci Martin Farrall Jaakko Tuomilehto Peter P Pramstaller Roberto Elosua Nicole Soranzo Eric J G Sijbrands David Altshuler Ruth J F Loos Alan R Shuldiner Christian Gieger Pierre Meneton Andre G Uitterlinden Nicholas J Wareham Vilmundur Gudnason Jerome I Rotter Rainer Rettig Manuela Uda David P Strachan Jacqueline C M Witteman Anna-Liisa Hartikainen Jacques S Beckmann Eric Boerwinkle Ramachandran S Vasan Michael Boehnke Martin G Larson Marjo-Riitta Järvelin Bruce M Psaty Gonçalo R Abecasis Aravinda Chakravarti Paul Elliott Cornelia M van Duijn Christopher Newton-Cheh Daniel Levy Mark J Caulfield Toby Johnson

The representation of heart development in the gene ontology.

Dev Biol 2011 Jun 17;354(1):9-17. Epub 2011 Mar 17.

Cardiovascular GO Annotation Initiative, Centre for Cardiovascular Genetics, Rayne Institute, University College London, London, UK.

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http://dx.doi.org/10.1016/j.ydbio.2011.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302178PMC
June 2011

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Authors:
Tuomas O Kilpeläinen M Carola Zillikens Alena Stančákova Francis M Finucane Janina S Ried Claudia Langenberg Weihua Zhang Jacques S Beckmann Jian'an Luan Liesbeth Vandenput Unnur Styrkarsdottir Yanhua Zhou Albert Vernon Smith Jing-Hua Zhao Najaf Amin Sailaja Vedantam So-Youn Shin Talin Haritunians Mao Fu Mary F Feitosa Meena Kumari Bjarni V Halldorsson Emmi Tikkanen Massimo Mangino Caroline Hayward Ci Song Alice M Arnold Yurii S Aulchenko Ben A Oostra Harry Campbell L Adrienne Cupples Kathryn E Davis Angela Döring Gudny Eiriksdottir Karol Estrada José Manuel Fernández-Real Melissa Garcia Christian Gieger Nicole L Glazer Candace Guiducci Albert Hofman Steve E Humphries Bo Isomaa Leonie C Jacobs Antti Jula David Karasik Magnus K Karlsson Kay-Tee Khaw Lauren J Kim Mika Kivimäki Norman Klopp Brigitte Kühnel Johanna Kuusisto Yongmei Liu Osten Ljunggren Mattias Lorentzon Robert N Luben Barbara McKnight Dan Mellström Braxton D Mitchell Vincent Mooser José Maria Moreno Satu Männistö Jeffery R O'Connell Laura Pascoe Leena Peltonen Belén Peral Markus Perola Bruce M Psaty Veikko Salomaa David B Savage Robert K Semple Tatjana Skaric-Juric Gunnar Sigurdsson Kijoung S Song Timothy D Spector Ann-Christine Syvänen Philippa J Talmud Gudmar Thorleifsson Unnur Thorsteinsdottir André G Uitterlinden Cornelia M van Duijn Antonio Vidal-Puig Sarah H Wild Alan F Wright Deborah J Clegg Eric Schadt James F Wilson Igor Rudan Samuli Ripatti Ingrid B Borecki Alan R Shuldiner Erik Ingelsson John-Olov Jansson Robert C Kaplan Vilmundur Gudnason Tamara B Harris Leif Groop Douglas P Kiel Fernando Rivadeneira Mark Walker Inês Barroso Peter Vollenweider Gérard Waeber John C Chambers Jaspal S Kooner Nicole Soranzo Joel N Hirschhorn Kari Stefansson H-Erich Wichmann Claes Ohlsson Stephen O'Rahilly Nicholas J Wareham Elizabeth K Speliotes Caroline S Fox Markku Laakso Ruth J F Loos

Nat Genet 2011 Jun 26;43(8):753-60. Epub 2011 Jun 26.

Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262230PMC
June 2011

SERPINA1 11478G→A variant, serum α1-antitrypsin, exacerbation frequency and FEV1 decline in COPD.

Thorax 2011 May 18;66(5):418-24. Epub 2011 Feb 18.

Academic Unit of Respiratory Medicine, University College London, London, UK.

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http://dx.doi.org/10.1136/thx.2010.152975DOI Listing
May 2011

Lipoprotein association studies: taking stock and moving forward.

Curr Opin Lipidol 2011 Apr;22(2):106-12

Department of Medicine, Centre for Cardiovascular Genetics, University College London, 5 University St, London, UK.

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http://dx.doi.org/10.1097/MOL.0b013e3283423f81DOI Listing
April 2011

Utility of genetic determinants of lipids and cardiovascular events in assessing risk.

Nat Rev Cardiol 2011 Apr 15;8(4):207-21. Epub 2011 Feb 15.

Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.

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http://www.nature.com/articles/nrcardio.2011.6
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http://dx.doi.org/10.1038/nrcardio.2011.6DOI Listing
April 2011

Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.

Atherosclerosis 2011 Feb 16;214(2):397-403. Epub 2010 Nov 16.

Institute of Cardiology and Center of Excellence on Aging, G d'Annunzio University-Chieti and Fondazione G Monasterio, Pisa, Italy.

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http://dx.doi.org/10.1016/j.atherosclerosis.2010.11.011DOI Listing
February 2011

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.

Authors:
Matthew B Lanktree Yiran Guo Muhammed Murtaza Joseph T Glessner Swneke D Bailey N Charlotte Onland-Moret Guillaume Lettre Halit Ongen Ramakrishnan Rajagopalan Toby Johnson Haiqing Shen Christopher P Nelson Norman Klopp Jens Baumert Sandosh Padmanabhan Nathan Pankratz James S Pankow Sonia Shah Kira Taylor John Barnard Bas J Peters Cliona M Maloney Maximilian T Lobmeyer Alice Stanton M Hadi Zafarmand Simon P R Romaine Amar Mehta Erik P A van Iperen Yan Gong Tom S Price Erin N Smith Cecilia E Kim Yun R Li Folkert W Asselbergs Larry D Atwood Kristian M Bailey Deepak Bhatt Florianne Bauer Elijah R Behr Tushar Bhangale Jolanda M A Boer Bernhard O Boehm Jonathan P Bradfield Morris Brown Peter S Braund Paul R Burton Cara Carty Hareesh R Chandrupatla Wei Chen John Connell Chrysoula Dalgeorgou Anthonius de Boer Fotios Drenos Clara C Elbers James C Fang Caroline S Fox Edward C Frackelton Barry Fuchs Clement E Furlong Quince Gibson Christian Gieger Anuj Goel Diederik E Grobbee Claire Hastie Philip J Howard Guan-Hua Huang W Craig Johnson Qing Li Marcus E Kleber Barbara E K Klein Ronald Klein Charles Kooperberg Bonnie Ky Andrea Lacroix Paul Lanken Mark Lathrop Mingyao Li Vanessa Marshall Olle Melander Frank D Mentch Nuala J Meyer Keri L Monda Alexandre Montpetit Gurunathan Murugesan Karen Nakayama Dave Nondahl Abiodun Onipinla Suzanne Rafelt Stephen J Newhouse F George Otieno Sanjey R Patel Mary E Putt Santiago Rodriguez Radwan N Safa Douglas B Sawyer Pamela J Schreiner Claire Simpson Suthesh Sivapalaratnam Sathanur R Srinivasan Christine Suver Gary Swergold Nancy K Sweitzer Kelly A Thomas Barbara Thorand Nicholas J Timpson Sam Tischfield Martin Tobin Maciej Tomaszewski Maciej Tomaszweski W M Monique Verschuren Chris Wallace Bernhard Winkelmann Haitao Zhang Dongling Zheng Li Zhang Joseph M Zmuda Robert Clarke Anthony J Balmforth John Danesh Ian N Day Nicholas J Schork Paul I W de Bakker Christian Delles David Duggan Aroon D Hingorani Joel N Hirschhorn Marten H Hofker Steve E Humphries Mika Kivimaki Debbie A Lawlor Kandice Kottke-Marchant Jessica L Mega Braxton D Mitchell David A Morrow Jutta Palmen Susan Redline Denis C Shields Alan R Shuldiner Patrick M Sleiman George Davey Smith Martin Farrall Yalda Jamshidi David C Christiani Juan P Casas Alistair S Hall Pieter A Doevendans Jason D Christie Gerald S Berenson Sarah S Murray Thomas Illig Gerald W Dorn Thomas P Cappola Eric Boerwinkle Peter Sever Daniel J Rader Muredach P Reilly Mark Caulfield Philippa J Talmud Eric Topol James C Engert Kai Wang Anna Dominiczak Anders Hamsten Sean P Curtis Roy L Silverstein Leslie A Lange Marc S Sabatine Mieke Trip Danish Saleheen John F Peden Karen J Cruickshanks Winfried März Jeffrey R O'Connell Olaf H Klungel Cisca Wijmenga Anke Hilse Maitland-van der Zee Eric E Schadt Julie A Johnson Gail P Jarvik George J Papanicolaou Struan F A Grant Patricia B Munroe Kari E North Nilesh J Samani Wolfgang Koenig Tom R Gaunt Sonia S Anand Yvonne T van der Schouw Nicole Soranzo Garret A Fitzgerald Alex Reiner Robert A Hegele Hakon Hakonarson Brendan J Keating

Am J Hum Genet 2011 Jan 30;88(1):6-18. Epub 2010 Dec 30.

Department of Medicine and Biochemistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada.

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http://dx.doi.org/10.1016/j.ajhg.2010.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014369PMC
January 2011

APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.

Mol Med 2010 Sep-Oct;16(9-10):389-99. Epub 2010 May 20.

Centre for Cardiovascular Genetics, BHF Laboratories, The Rayne Building, Department of Medicine, Royal Free and University College Medical School, 5 University Street, London, United Kingdom.

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http://dx.doi.org/10.2119/molmed.2010.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935949PMC
December 2010

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.

Atherosclerosis 2010 Nov 29;213(1):184-90. Epub 2010 Jul 29.

Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK.

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http://dx.doi.org/10.1016/j.atherosclerosis.2010.07.021DOI Listing
November 2010

Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds.

Circulation 2010 May;121(20):2235-48

Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, University College London, London WC1E 6JF, United Kingdom.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.9
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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.914192DOI Listing
May 2010

Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation.

Atherosclerosis 2010 Mar 6;209(1):42-50. Epub 2009 Oct 6.

Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University Street, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00219150090082
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http://dx.doi.org/10.1016/j.atherosclerosis.2009.09.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839074PMC
March 2010

Structure and function of the apoA-IV T347S and Q360H common variants.

Biochem Biophys Res Commun 2010 Feb 1;393(1):126-30. Epub 2010 Feb 1.

Center E. Grossi Paoletti, Department of Pharmacological Sciences, Università degli Studi di Milano, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2010.01.099DOI Listing
February 2010

Improvements to cardiovascular gene ontology.

Atherosclerosis 2009 Jul 1;205(1):9-14. Epub 2008 Nov 1.

Department of Medicine, University College London, Rayne Institute, London, UK.

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http://dx.doi.org/10.1016/j.atherosclerosis.2008.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706316PMC
July 2009

Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

Hum Mol Genet 2009 Jun 31;18(12):2305-16. Epub 2009 Mar 31.

Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, 5 University St, London WC1E 6JF, UK.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddp159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685759PMC
June 2009

Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance.

Atherosclerosis 2009 May 29;204(1):105-11. Epub 2008 Aug 29.

Department of Biochemistry and Molecular Biology II: Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.atherosclerosis.2008.07.046DOI Listing
May 2009

C-reactive protein and coronary heart disease: predictive test or therapeutic target?

Clin Chem 2009 Feb 29;55(2):239-55. Epub 2008 Dec 29.

Division of Population Sciences, Department of Epidemiology and Public Health, University College London, London, UK.

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http://dx.doi.org/10.1373/clinchem.2008.115923DOI Listing
February 2009

ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.

Arterioscler Thromb Vasc Biol 2008 Dec 30;28(12):2319-25. Epub 2008 Oct 30.

Division of Cardiovascular Genetics, Department of Medicine, University College London Medical School, 5 University St, London WC1E 6JF, United Kingdom.

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http://dx.doi.org/10.1161/ATVBAHA.108.176917DOI Listing
December 2008

The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels.

Biochim Biophys Acta 2008 Jul-Aug;1782(7-8):447-52. Epub 2008 Mar 18.

Division of Cardiovascular Genetics, Department of Medicine, University College London, 5 University Street, London WC1E 6JF, UK.

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http://dx.doi.org/10.1016/j.bbadis.2008.03.003DOI Listing
August 2008

The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II.

J Mol Med (Berl) 2008 Jul 15;86(7):815-24. Epub 2008 Apr 15.

Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, WC1E 6JF, UK.

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http://link.springer.com/10.1007/s00109-008-0347-x
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http://dx.doi.org/10.1007/s00109-008-0347-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480609PMC
July 2008

Cardiovascular GO annotation initiative year 1 report: why cardiovascular GO?

Proteomics 2008 May;8(10):1950-3

Centre for Cardiovascular Genetics, Department of Medicine, University College London, Rayne Institute, London, UK.

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http://dx.doi.org/10.1002/pmic.200800078DOI Listing
May 2008

Cardiovascular disease risk prediction using genetic information (gene scores): is it really informative?

Curr Opin Lipidol 2008 Apr;19(2):128-32

Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and UCL Medical School, London, UK.

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https://insights.ovid.com/crossref?an=00041433-200804000-000
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http://dx.doi.org/10.1097/MOL.0b013e3282f5283eDOI Listing
April 2008

Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men.

Clin Chem 2008 Mar 4;54(3):467-74. Epub 2008 Feb 4.

Centre for Cardiovascular Genetics, Department of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1373/clinchem.2007.095489DOI Listing
March 2008

Rare APOA5 mutations--clinical consequences, metabolic and functional effects: an ENID review.

Atherosclerosis 2007 Oct 12;194(2):287-92. Epub 2007 Jan 12.

Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free & University College London Medical School, 5 University Street, London WC1E 6JF, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002191500600754
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http://dx.doi.org/10.1016/j.atherosclerosis.2006.12.010DOI Listing
October 2007

The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.

Clin Sci (Lond) 2007 Jun;112(12):617-24

Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Department of Medicine, Royal Free and University College Medical School, London, UK.

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http://dx.doi.org/10.1042/CS20060344DOI Listing
June 2007

The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes.

Biochim Biophys Acta 2007 Mar 5;1772(3):355-63. Epub 2006 Dec 5.

Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London WC1E 6JF, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S092544390600265
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http://dx.doi.org/10.1016/j.bbadis.2006.11.008DOI Listing
March 2007

Gene-environment interaction and its impact on coronary heart disease risk.

Nutr Metab Cardiovasc Dis 2007 Feb 24;17(2):148-52. Epub 2006 Apr 24.

Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, The Rayne Building, 5 University Street, London WC1E 6JF, UK.

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http://dx.doi.org/10.1016/j.numecd.2006.01.008DOI Listing
February 2007

Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training.

Nutr Metab Cardiovasc Dis 2007 Jan 20;17(1):24-31. Epub 2006 Mar 20.

Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College London Medical School, 5 University Street, London WC1E 6JF, UK.

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January 2007

Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.

J Mol Med (Berl) 2006 Dec;84(12):1005-14

Department of Medicine, Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, WC1E 6JF, UK.

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December 2006