Philipp Saiko

Philipp Saiko

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Philipp Saiko

Philipp Saiko

Publications by authors named "Philipp Saiko"

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Thiosemicarbazone derivatives, thiazolyl hydrazones, effectively inhibit leukemic tumor cell growth: Down-regulation of ribonucleotide reductase activity and synergism with arabinofuranosylcytosine.

Food Chem Toxicol 2017 Oct 14;108(Pt A):53-62. Epub 2017 Jul 14.

Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Department of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2017.07.029DOI Listing
October 2017

Effect of substitution at N″-position of N'-hydroxy-N-amino guanidines on tumor cell growth.

Bioorg Med Chem Lett 2012 Aug 21;22(15):4934-8. Epub 2012 Jun 21.

Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, India.

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http://dx.doi.org/10.1016/j.bmcl.2012.06.048DOI Listing
August 2012

Combination effects of digalloylresveratrol with arabinofuranosylcytosine and difluorodeoxycytidine in human leukemia and pancreatic cancer cells.

Nucleosides Nucleotides Nucleic Acids 2011 Dec;30(12):1190-6

Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1080/15257770.2011.596497DOI Listing
December 2011

N-hydroxy-N'-aminoguanidines as anti-cancer lead molecule: QSAR, synthesis and biological evaluation.

Bioorg Med Chem Lett 2011 Jun 9;21(11):3324-8. Epub 2011 Apr 9.

Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India.

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http://dx.doi.org/10.1016/j.bmcl.2011.04.009DOI Listing
June 2011

Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells.

Int J Oncol 2011 May 11;38(5):1427-36. Epub 2011 Feb 11.

Dipartimento di Scienze per Promozione della Salute G. D'Alessandro- Sezione di Farmacologia, Policlinico P. Giaccone, via del Vespro 129, 90127 Palermo, Italy.

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http://dx.doi.org/10.3892/ijo.2011.943DOI Listing
May 2011

A novel N-hydroxy-N'-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C).

Biochem Pharmacol 2011 Jan 16;81(1):50-9. Epub 2010 Sep 16.

Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.bcp.2010.09.006DOI Listing
January 2011

Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro.

Steroids 2011 Jan 23;76(1-2):156-62. Epub 2010 Oct 23.

Department of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.

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http://dx.doi.org/10.1016/j.steroids.2010.10.006DOI Listing
January 2011

Chemopreventive effects of resveratrol and resveratrol derivatives.

Ann N Y Acad Sci 2011 Jan;1215:89-95

Institute for Laboratory Medicine, Department for Medical, Medical University of Vienna, General Hospital of Vienna, Austria.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05864.xDOI Listing
January 2011

Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity.

Bioorg Med Chem Lett 2010 Jul 15;20(13):3906-10. Epub 2010 May 15.

Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.

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http://dx.doi.org/10.1016/j.bmcl.2010.05.020DOI Listing
July 2010

Resveratrol and resveratrol analogues--structure-activity relationship.

Pharm Res 2010 Jun 16;27(6):1042-8. Epub 2010 Mar 16.

Department of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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http://link.springer.com/content/pdf/10.1007/s11095-010-0090
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http://link.springer.com/10.1007/s11095-010-0090-1
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http://dx.doi.org/10.1007/s11095-010-0090-1DOI Listing
June 2010

Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells.

Invest New Drugs 2009 Oct 8;27(5):393-401. Epub 2008 Oct 8.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

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http://link.springer.com/10.1007/s10637-008-9183-7
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http://dx.doi.org/10.1007/s10637-008-9183-7DOI Listing
October 2009

Digalloylresveratrol, a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells.

Cancer Lett 2009 Feb 25;274(2):299-304. Epub 2008 Oct 25.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.canlet.2008.09.020DOI Listing
February 2009

Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells--synergism with Ara-C.

Int J Oncol 2008 Oct;33(4):887-92

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, A-1090 Vienna, Austria.

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October 2008

Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?

Mutat Res 2008 Jan-Feb;658(1-2):68-94. Epub 2007 Aug 17.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S138357420700032
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http://dx.doi.org/10.1016/j.mrrev.2007.08.004DOI Listing
April 2008

Synergistic effects of deuterium oxide and gemcitabine in human pancreatic cancer cell lines.

Cancer Lett 2008 Feb 26;259(2):231-9. Epub 2007 Nov 26.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.canlet.2007.10.010DOI Listing
February 2008

Novel resveratrol derivatives induce apoptosis and cause cell cycle arrest in prostate cancer cell lines.

Anticancer Res 2007 Sep-Oct;27(5A):3459-64

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

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November 2007

Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells.

Cancer Lett 2007 Jun 29;250(2):323-8. Epub 2006 Nov 29.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.canlet.2006.10.018DOI Listing
June 2007

Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells.

Cancer Lett 2007 Jan 20;245(1-2):156-62. Epub 2006 Feb 20.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835060002
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http://dx.doi.org/10.1016/j.canlet.2006.01.001DOI Listing
January 2007

Cytotoxic and biochemical effects of 3,3',4,4',5,5'-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells.

Exp Hematol 2006 Oct;34(10):1377-84

Clinical Institute of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.exphem.2006.05.018DOI Listing
October 2006

Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines.

Oncol Rep 2006 Sep;16(3):617-24

Department of Mutagenesis and Carcinogenesis, Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovak Republic.

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September 2006

Effects of heavy water (D2O) on human pancreatic tumor cells.

Anticancer Res 2005 Sep-Oct;25(5):3407-11

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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October 2005

Heterodinucleoside phosphates of 5-fluorodeoxyuridine and arabinofuranosylcytosine--new drugs in cancer chemotherapy?

In Vivo 2005 Jan-Feb;19(1):205-14

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, A-1090 Vienna, Austria.

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August 2005

Synergistic action of resveratrol, an ingredient of wine, with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.

Exp Hematol 2005 Mar;33(3):329-35

Clinical Institute of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.exphem.2004.11.009DOI Listing
March 2005

Immunologic and biochemical effects of the fermented wheat germ extract Avemar.

Exp Biol Med (Maywood) 2005 Feb;230(2):144-9

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1177/153537020523000209DOI Listing
February 2005

Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship.

Bioorg Med Chem 2004 Nov;12(21):5571-8

Institute of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.bmc.2004.08.008DOI Listing
November 2004

Combination chemotherapy of BCNU and Didox acts synergystically in 9L glioma cells.

Nucleosides Nucleotides Nucleic Acids 2004 Oct;23(8-9):1531-5

Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1081/NCN-200027746DOI Listing
October 2004

Combination effects of Ara-C and 5-fluorodeoxyuridine against leukemia cells in vitro and in mice.

Anticancer Res 2003 Sep-Oct;23(5A):3841-6

Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia.

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February 2004

Biochemical modulation of Ara-C effects by amidox, an inhibitor of ribonucleotide reductase in HL-60 promyelocytic human leukemia cells.

Life Sci 2004 Jan;74(9):1071-80

Clinical Institute for Medical and Chemical Laboratory Diagnostics, School of Medicine, University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.lfs.2003.06.043DOI Listing
January 2004