Publications by authors named "Philipp J Kahle"

80Publications

Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.

J Biol Chem 2020 01 28;295(3):673-689. Epub 2019 Nov 28.

German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany

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January 2020

Ubiquitin-specific protease USP36 knockdown impairs Parkin-dependent mitophagy via downregulation of Beclin-1-associated autophagy-related ATG14L.

Exp Cell Res 2019 11 21;384(2):111641. Epub 2019 Sep 21.

Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany; German Center for Neurodegenerative Diseases, 72076, Tübingen, Germany.

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November 2019

Monitoring α-synuclein multimerization in vivo.

FASEB J 2019 02 25;33(2):2116-2131. Epub 2018 Sep 25.

Department of Neurology, University Medical Center, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Aachen, Germany.

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February 2019

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).

J Biol Chem 2018 10 17;293(41):16083-16099. Epub 2018 Aug 17.

From the German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen and

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October 2018

In vivo models of alpha-synuclein transmission and propagation.

Cell Tissue Res 2018 Jul 29;373(1):183-193. Epub 2017 Nov 29.

Institut des Maladies Neurodégénératives, UMR 5293, Université de Bordeaux, 33076, Bordeaux, France.

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July 2018

LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death.

Biochim Biophys Acta Mol Cell Res 2017 Dec 6;1864(12):2356-2368. Epub 2017 Sep 6.

Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea. Electronic address:

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December 2017

Enhanced motivation to alcohol in transgenic mice expressing human α-synuclein.

J Neurochem 2017 11 12;143(3):294-305. Epub 2017 Sep 12.

Laboratory of Functional Neurogenetics, Department of Neurodegeneration, German Center of Neurodegenerative Diseases, Tübingen, Germany.

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November 2017

Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein.

Cell Mol Neurobiol 2017 Oct 27;37(7):1217-1226. Epub 2016 Dec 27.

Department of Public Health and Caring Sciences/Molecular Geriatrics, Uppsala University, Uppsala, Sweden.

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October 2017

Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy.

Nucleic Acids Res 2017 03;45(5):2797-2808

Interfaculty Institute of Biochemistry, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany.

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March 2017

α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.

Sci Rep 2016 11 3;6:36328. Epub 2016 Nov 3.

Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Faculty of Medicine, University of Tübingen, 72076 Tübingen, Germany.

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November 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Neuron 2016 07 9;91(1):56-66. Epub 2016 Jun 9.

German Center for Neurodegenerative Diseases (DZNE), Tuebingen, D-72076 Tuebingen, Germany; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D-72076 Tuebingen, Germany. Electronic address:

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July 2016

α-Synuclein oligomers pump it up!

EMBO J 2015 Oct 15;34(19):2385-7. Epub 2015 Sep 15.

German Center for Neurodegenerative Diseases, Tübingen, Germany Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany.

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October 2015

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes.

BMC Neurosci 2015 Sep 7;16:57. Epub 2015 Sep 7.

Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Faculty of Medicine, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried Müller Str. 27, 72076, Tübingen, Germany.

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September 2015

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.

Neurobiol Dis 2015 Feb 8;74:76-88. Epub 2014 Nov 8.

German Center for Neurodegenerative Diseases (DZNE) Tübingen, Germany; Hertie Institute for Clinical Brain Research, Laboratory of Functional Neurogenetics, Tübingen, Germany. Electronic address:

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February 2015