Publications by authors named "Philipp Henneke"

89Publications

Protocol for a prospective cohort study: Prevention of Transmissions by Effective Colonisation Tracking in Neonates (PROTECT-Neo).

BMJ Open 2020 09 21;10(9):e034068. Epub 2020 Sep 21.

Institute for Infection Prevention and Hospital Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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September 2020

Mycobacterial immunevasion-spotlight on the enemy within: Discussion on how antibiotic treatment routes Mycobacterium avium to phagolysosomes without eliciting an immune response in human macrophages.

J Leukoc Biol 2020 Aug 6. Epub 2020 Aug 6.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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August 2020

Resident macrophages acquire innate immune memory in staphylococcal skin infection.

Elife 2020 07 8;9. Epub 2020 Jul 8.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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July 2020

Control of myeloid cell density in barrier tissues.

FEBS J 2021 Jan 30;288(2):405-426. Epub 2020 Jun 30.

Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Germany.

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January 2021

Cytomegaloviruses and Macrophages-Friends and Foes From Early on?

Front Immunol 2020 12;11:793. Epub 2020 May 12.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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May 2020

PCR for the detection of pathogens in neonatal early onset sepsis.

PLoS One 2020 24;15(1):e0226817. Epub 2020 Jan 24.

Microbiology, Virology and Infection Control, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.

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April 2020

Origin and Differentiation of Nerve-Associated Macrophages.

J Immunol 2020 01;204(2):271-279

Institute for Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany;

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January 2020

Macrophages Are a Potent Source of -Induced IFN-β.

J Immunol 2019 12 15;203(12):3416-3426. Epub 2019 Nov 15.

Institute for Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; and

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December 2019

Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies.

J Allergy Clin Immunol 2020 01 14;145(1):434-437.e4. Epub 2019 Sep 14.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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January 2020

A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves.

Immunity 2019 06 11;50(6):1482-1497.e7. Epub 2019 Jun 11.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Freiburg, Germany. Electronic address:

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June 2019

The role of CNS macrophages in streptococcal meningoencephalitis.

J Leukoc Biol 2019 07 14;106(1):209-218. Epub 2019 Feb 14.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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July 2019

Codevelopment of Microbiota and Innate Immunity and the Risk for Group B Streptococcal Disease.

Front Immunol 2017 10;8:1497. Epub 2017 Nov 10.

Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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November 2017

Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management.

Pediatr Infect Dis J 2017 12;36(12):1205-1213

From the *Paediatric Infectious Diseases Research Group, St George's University, London, United Kingdom; †Centre for Virology, University College Medical School, London; ‡Kingston Hospital NHS Foundation Trust, London, United Kingdom; §The Hague Medical Center (HMC), Department of Pediatrics and Sophia Children's hospital, Erasmus Medical Center Rotterdam Department of Pediatric Infectious Diseases; ¶Pediatric Infectious Diseases Unit, Hospital Universitario 12 de Octubre, Universidad Complutense, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain; ∥Center for Chronic Immunodeficiency and Center for Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, University of Freiburg, Germany; **Our Lady's Children's Hospital Crumlin, UCD School of Medicine and Health Sciences, Dublin, Ireland; ††Department of Obstetrical, Gynaecological and Paediatric Sciences, Operative Unit of Neonatology, Polyclinic St. Orsola-Malpighi, University of Bologna, Bologna, Italy; ‡‡Pediatric Infectious Diseases, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain; §§Department of Paediatrics, The University of Melbourne & Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, Australia; ¶¶NICU and Neonatal Unit, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy; ∥∥Infectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Thessaloniki, Greece; ***Great Ormond Street Children's Hospital, London, and the Institute of Child Health, UCL, London, United Kingdom; †††NICU and Neonatal Unit, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy; ‡‡‡Imperial College NHS Healthcare, London, United Kingdom; §§Pediatric Infectious Diseases, Children's Hospital, University of Helsinki and Helsinki University Hospital, Finland; ¶¶¶Department of Pediatric Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands; ∥∥∥National and Kapodistrian University of Athens, Greece; ****Children's Hospital of Geneva, University Hospitals of Geneva, Switzerland; ††††Pediatric Infectious Diseases Unit, Gregorio Marañón Hospital, Madrid, Spain; and ‡‡‡‡Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

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December 2017

Symptomatic Cytomegalovirus Infections in the First Year of Life: When Is Antiviral Therapy Conceived to Be Justified?

Pediatr Infect Dis J 2017 02;36(2):224-227

From the *Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Freiburg, Germany; †Department of Neonatology, University Children's Hospital Tuebingen, 72076 Tuebingen, Germany; and ‡Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany.

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February 2017

Dynamic interactions between dermal macrophages and Staphylococcus aureus.

J Leukoc Biol 2017 01 12;101(1):99-106. Epub 2016 Oct 12.

Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg, Germany;

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January 2017

Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.

J Immunol 2016 Mar 12;196(6):2733-41. Epub 2016 Feb 12.

Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, 79106 Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany

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March 2016

Preserved effector functions of human ORAI1- and STIM1-deficient neutrophils.

J Allergy Clin Immunol 2016 05 6;137(5):1587-1591.e7. Epub 2015 Dec 6.

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany. Electronic address:

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May 2016

Osteomyelitis Because of Mycobacterium Xenopi in an Immunocompetent Child.

Pediatr Infect Dis J 2016 Jan;35(1):110-3

From the *Department of General Pediatrics, Adolescent Medicine and Neonatology, University Medical Center Freiburg, Freiburg, Germany; †Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Freiburg, Germany; and ‡Institute for Surgical Pathology, University Medical Center Freiburg, Freiburg, Germany.

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January 2016

Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency.

Blood 2015 Oct 19;126(14):1658-69. Epub 2015 Aug 19.

Center for Chronic Immunodeficiency (CCI), University Medical Center and University of Freiburg, Freiburg, Germany; Center of Pediatric and Adolescent Medicine, University Medical Center and University of Freiburg, Freiburg, Germany;

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October 2015

Enterococcus faecalis Glycolipids Modulate Lipoprotein-Content of the Bacterial Cell Membrane and Host Immune Response.

PLoS One 2015 14;10(7):e0132949. Epub 2015 Jul 14.

Center for Infectious Disease and Travel Medicine, University Medical Center Freiburg, Freiburg, Germany; Division of Pediatric Infectious Diseases, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.

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April 2016

MyD88 in macrophages is critical for abscess resolution in staphylococcal skin infection.

J Immunol 2015 Mar 13;194(6):2735-45. Epub 2015 Feb 13.

Center for Chronic Immunodeficiency, University Medical Center, University of Freiburg, 79106 Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, University Medical Center, University of Freiburg, 79106 Freiburg, Germany

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March 2015

Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease.

Front Immunol 2014 29;5:519. Epub 2014 Oct 29.

Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg , Freiburg , Germany ; Center for Chronic Immunodeficiency, University Medical Center Freiburg , Freiburg , Germany.

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November 2014

The role of multiplex PCR in respiratory tract infections in children.

Dtsch Arztebl Int 2014 Sep;111(38):639-45

Center for Pediatrics, Medical Center - University of Freiburg, Institute of Virology, Medical Center - University of Freiburg.

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September 2014

Structural biology of the membrane attack complex.

Subcell Biochem 2014 ;80:83-116

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Breisacher Straße 117, 79106, Freiburg, Germany,

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August 2014

Synchronous recurrence of group B streptococcal late-onset sepsis in twins.

Pediatrics 2014 May 7;133(5):e1388-91. Epub 2014 Apr 7.

Centers for Pediatrics and Adolescent Medicine and Chronic Immunodeficiency, University Medical Center, Freiburg, Freiburg, Germany;

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May 2014

Prospective virtual screening in a sparse data scenario: design of small-molecule TLR2 antagonists.

ChemMedChem 2014 Apr 27;9(4):813-22. Epub 2014 Jan 27.

Pharmaceutical Chemistry, Institute of Pharmacy, Freie Universität Berlin, Königin-Luise Str. 2-4, 14195 Berlin (Germany).

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April 2014

Deficiency of innate and acquired immunity caused by an IKBKB mutation.

N Engl J Med 2013 Dec;369(26):2504-14

From the Institute for Transfusion Medicine, University Hospital Ulm (U.P., C.L., H.S., K.S.), the Institute of Physiological Chemistry (B.B., T.W.), the Center for Biomedical Research, Genomics Core Facility (K. Holzmann), University of Ulm, and the Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Wuerttemberg-Hessen (E.-M.R., H.S., K.S.), Ulm; the Center of Chronic Immunodeficiency, University Medical Center Freiburg (S.F., P.H., A.R.-E., K. Hese, M.R., A.J., M.S., S.E.), the Faculty of Biology, University of Freiburg (S.F.), the Center for Pediatrics and Adolescent Medicine (P.H., S.E.), and the Department of Rheumatology and Clinical Immunology (M.S.), University Hospital Freiburg, Freiburg; and the Translational Center for Regenerative Medicine, University of Leipzig, Leipzig (S.B.) - all in Germany; the Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm (S.B.); and the Department of Pediatrics, University of Saskatchewan, Saskatoon (A.R.), and the Departments of Biochemistry and Medical Genetics (T.Z.) and Pediatrics and Child Health (T.Z., M.L.S.), University of Manitoba, Winnipeg - both in Canada.

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December 2013

Host defense against common early life-threatening infections.

Clin Dev Immunol 2013 5;2013:350808. Epub 2013 Sep 5.

IWK Health Centre, 5850 University Avenue, Halifax, NS, Canada B3H 1L6.

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February 2014

Dengue fever in children: where are we now?

Pediatr Infect Dis J 2013 Sep;32(9):1020-2

From the *Center of Pediatrics and Adolescent Medicine; †Centre of Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany; and ‡Swiss Tropical and Public Health Institute, Basel, Switzerland.

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September 2013

Role of pore-forming toxins in neonatal sepsis.

Clin Dev Immunol 2013 23;2013:608456. Epub 2013 Apr 23.

Center of Chronic Immunodeficiency, Medical Center, University of Freiburg, Breisacher Straße 117, 79106 Freiburg, Germany.

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December 2013

Klaus Magdorf. 4 July 1942-23 January 2013.

Eur J Pediatr 2013 May 9;172(5):575. Epub 2013 Apr 9.

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May 2013

Mucociliary clearance defects in a murine in vitro model of pneumococcal airway infection.

PLoS One 2013 19;8(3):e59925. Epub 2013 Mar 19.

Centre of Chronic Immunodeficiency, University Medical Centre Freiburg and University of Freiburg, Freiburg, Germany.

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September 2013

IgG4-related disease.

N Engl J Med 2012 04;366(17):1643-4; author reply 1646-7

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April 2012

Spontaneous clearance of hepatitis C virus in vertically infected children.

Eur J Pediatr 2012 Feb 7;171(2):253-8. Epub 2011 Jul 7.

Centre for Paediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.

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February 2012

Macrophages recognize streptococci through bacterial single-stranded RNA.

EMBO Rep 2011 Jan 17;12(1):71-6. Epub 2010 Dec 17.

Centre of Chronic Immunodeficiency, Medical Centre, University Freiburg, Breisacherstrasse 117, Freiburg 79106, Germany.

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January 2011

Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.

EMBO J 2009 Jul 2;28(14):2018-27. Epub 2009 Jul 2.

Center for Pediatrics and Adolescent Medicine and Centre of Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg 79106, Germany.

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July 2009

[Infection with human immunodeficiency virus (HIV) in childhood].

Kinderkrankenschwester 2009 Feb;28(2):59-69

Zentrum für Kinderheilkunde und Jugendmedizin, Universitätsklinik Freiburg, Freiburg.

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February 2009

Induction and termination of inflammatory signaling in group B streptococcal sepsis.

Immunol Rev 2008 Oct;225:114-27

Centre for Pediatrics and Adolescent Medicine, University Medical Centre, Freiburg, Germany.

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October 2008

Secular trends in pediatric bloodstream infections over a 20-year period at a tertiary care hospital in Germany.

Eur J Pediatr 2008 Oct 30;167(10):1149-59. Epub 2008 Jan 30.

Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Mathildenstr. 1, 79106, Freiburg, Germany.

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October 2008

TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia.

J Immunol 2007 Nov;179(9):6134-43

Center for Anatomy, Institute of Cell Biology and Neurobiology, Charité-Universitaetsmedizin Berlin, Berlin, Germany.

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November 2007

Lipopolysaccharide binding protein is a potential marker for invasive bacterial infections in children.

Pediatr Infect Dis J 2007 Feb;26(2):159-62

Centre for Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Freiburg, Germany.

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February 2007

Toll-like receptor-dependent discrimination of streptococci.

J Endotoxin Res 2006 ;12(5):307-12

Division of Infectious Diseases, Children's Hospital, Freiburg University, Freiburg, Germany.

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December 2006

Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in a southwestern region of Germany.

Eur J Pediatr 2006 Oct 30;165(10):688-90. Epub 2006 May 30.

Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany.

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October 2006

Interaction of neonatal phagocytes with group B streptococcus: recognition and response.

Infect Immun 2006 Jun;74(6):3085-95

Zentrum für Kinderheilkunde und Jugendmedizin, Albert-Ludwigs Universität Freiburg, Mathildenstr. 1, 79106 Freiburg, Germany.

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June 2006

SIRS and group-B streptococcal sepsis in newborns: pathogenesis and perspectives in adjunctive therapy.

Semin Fetal Neonatal Med 2006 Oct 11;11(5):333-42. Epub 2006 May 11.

Zentrum für Kinderheilkunde und Jugendmedizin, Albert-Ludwigs Universität Freiburg, Mathildenstr. 1, 79106 Freiburg, Germany.

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October 2006

The innate immune system and its relevance to neonatal sepsis.

Curr Opin Infect Dis 2006 Jun;19(3):264-70

Zentrum für Kinderheilkunde und Jugendmedizin, Albert-Ludwigs Universität Freiburg, Freiburg, Germany.

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June 2006

The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.

J Biol Chem 2003 Sep 14;278(39):37561-8. Epub 2003 Jul 14.

Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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September 2003

Impaired CD14-dependent and independent response of polymorphonuclear leukocytes in preterm infants.

J Perinat Med 2003 ;31(2):176-83

Department of Pediatrics, Benjamin Franklin Medical Center, FU Medical School, Berlin, Germany.

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September 2003

Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.

J Biol Chem 2002 Oct 8;277(42):39320-6. Epub 2002 Aug 8.

Evans Memorial Department of Clinical Research, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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October 2002

Innate immune recognition of lipopolysaccharide by endothelial cells.

Crit Care Med 2002 May;30(5 Suppl):S207-13

Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA, USA.

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May 2002

Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.

J Immunol 2002 Feb;168(4):1533-7

Department of Medicine, Division of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA.

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February 2002