Philipp Beckhove

Philipp Beckhove

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Philipp Beckhove

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Targeting immune modulatory pathways in cancer.

Authors:
Philipp Beckhove

Clin Immunol 2018 01 15;186:32-33. Epub 2017 Sep 15.

Regensburg Center of Interventional Immunology and Department of Internal Medicine III, University Hospital Regensburg, Am Biopark 1, 93059 Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.09.006DOI Listing
January 2018

Parity improves anti-tumor immunity in breast cancer patients.

Oncotarget 2017 Dec 8;8(62):104981-104991. Epub 2017 Sep 8.

Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.20756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739613PMC
December 2017

Functional T cells targeting tumor-associated antigens are predictive for recurrence-free survival of patients with radically operated non-small cell lung cancer.

Oncoimmunology 2017 8;6(11):e1360458. Epub 2017 Sep 8.

Regensburg Center for Interventional Immunology and Hematology Department University Clinic and University of Regensburg, Am Biopark 9, Regensburg, BY, Germany.

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http://dx.doi.org/10.1080/2162402X.2017.1360458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674973PMC
September 2017

Combined Treatment of ATRA with Epigenetic Drugs Increases Aggressiveness of Glioma Xenografts.

Anticancer Res 2016 Apr;36(4):1489-96

Division of Neurosurgical Research, Department of Neurosurgery, Hamamatsu Tissue Imaging and Analysis Center, University of Heidelberg, Heidelberg, Germany

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April 2016

Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy.

Breast Care (Basel) 2016 Apr 27;11(2):102-7. Epub 2016 Apr 27.

Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany.

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http://dx.doi.org/10.1159/000446061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881254PMC
April 2016

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab.

Clin Cancer Res 2015 Dec 19;21(24):5453-9. Epub 2015 Aug 19.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0676DOI Listing
December 2015

A randomized phase II study of radiation induced immune boost in operable non-small cell lung cancer (RadImmune trial).

BMC Cancer 2015 Dec 19;15:988. Epub 2015 Dec 19.

Departments of Molecular and Radiation Oncology, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12885-015-2006-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684916PMC
December 2015

T cell responses in early-stage melanoma patients occur frequently and are not associated with humoral response.

Cancer Immunol Immunother 2015 Nov 10;64(11):1369-81. Epub 2015 Jul 10.

Division of Translational Immunology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-015-1739-8DOI Listing
November 2015

Identification of NY-BR-1-specific CD4(+) T cell epitopes using HLA-transgenic mice.

Int J Cancer 2015 Jun 26;136(11):2588-97. Epub 2014 Nov 26.

Department of Translational Immunology, German Cancer Research Center Heidelberg (DKFZ), Germany.

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http://dx.doi.org/10.1002/ijc.29322DOI Listing
June 2015

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells.

Nat Immunol 2015 Jun 27;16(6):609-17. Epub 2015 Apr 27.

Division of Molecular Immunology, German Cancer Research Center, Heidelberg, Germany.

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http://www.nature.com/articles/ni.3159
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http://dx.doi.org/10.1038/ni.3159DOI Listing
June 2015

Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients.

Int J Cancer 2015 May 12;136(10):2352-60. Epub 2014 Nov 12.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The First Hospital Affiliated to Anhui Medical University, Hefei, China.

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http://dx.doi.org/10.1002/ijc.29297DOI Listing
May 2015

Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature.

Anticancer Res 2015 May;35(5):2681-90

Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany

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May 2015

Strong T‑cell costimulation can reactivate tumor antigen‑specific T cells in late‑stage metastasized colorectal carcinoma patients: results from a phase Ⅰ clinical study.

Int J Oncol 2015 Jan 6;46(1):71-7. Epub 2014 Oct 6.

German Cancer Research Center, Division of Translational Immunology; Department of Surgical Oncology, Heidelberg University Hospital, Heidelberg, Germany.

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https://www.spandidos-publications.com/10.3892/ijo.2014.2692
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http://dx.doi.org/10.3892/ijo.2014.2692DOI Listing
January 2015

Classification of current anticancer immunotherapies.

Oncotarget 2014 Dec;5(24):12472-508

Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. INSERM, U1138, Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France. Pôle de Biologie, Hôpital Européen Georges Pompidou (HEGP), AP-HP, Paris, France.

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https://lirias.kuleuven.be/bitstream/123456789/502976/1/2998
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http://oncotarget.com/abstract/2998
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350348PMC
http://dx.doi.org/10.18632/oncotarget.2998DOI Listing
December 2014

A vaccine targeting mutant IDH1 induces antitumour immunity.

Nature 2014 Aug 25;512(7514):324-7. Epub 2014 Jun 25.

1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature13387DOI Listing
August 2014

Adoptive immunotherapy of metastatic breast cancer: present and future.

Cancer Metastasis Rev 2014 Mar;33(1):309-20

Department of Gynecology and Obstetrics, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10555-013-9452-6DOI Listing
March 2014

B cell-regulated immune responses in tumor models and cancer patients.

Oncoimmunology 2013 Jul;2(7):e25443

Department of Gynecology and Obstetrics; University Hospital of Heidelberg; Heidelberg, Germany.

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http://dx.doi.org/10.4161/onci.25443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782133PMC
July 2013

Bone marrow microenvironment in cancer patients: immunological aspects and clinical implications.

Cancer Metastasis Rev 2013 Jun;32(1-2):163-78

Department of Gynecology and Obstetrics, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10555-012-9397-1DOI Listing
June 2013

Long-term survival after adoptive bone marrow T cell therapy of advanced metastasized breast cancer: follow-up analysis of a clinical pilot trial.

Cancer Immunol Immunother 2013 Jun 18;62(6):1053-60. Epub 2013 Apr 18.

Division of Translational Immunology, Tumor Immunology Program, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-013-1414-xDOI Listing
June 2013

T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer.

Cancer Immunol Immunother 2013 Jan 23;62(1):27-37. Epub 2012 Jun 23.

Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-012-1303-8DOI Listing
January 2013

Antigen specific T-cell responses against tumor antigens are controlled by regulatory T cells in patients with prostate cancer.

J Urol 2012 Apr 16;187(4):1458-65. Epub 2012 Feb 16.

Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.juro.2011.11.083DOI Listing
April 2012

Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome.

Cancer Immunol Immunother 2012 Mar 14;61(3):353-62. Epub 2011 Sep 14.

Division of Translational Immunology, Tumor Immunology Program, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), INF 460, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-011-1106-3DOI Listing
March 2012

Therapeutic effects of metformin in breast cancer: involvement of the immune system?

Cancer Immunol Immunother 2011 Sep 17;60(9):1221-5. Epub 2011 Jun 17.

Department of Gynecology and Obstetrics, National Center of Tumor Diseases, University Hospital of Heidelberg, Voßstraße 9, 69115 Heidelberg, Germany.

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http://link.springer.com/10.1007/s00262-011-1062-y
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http://dx.doi.org/10.1007/s00262-011-1062-yDOI Listing
September 2011

CD40L co-stimulation from CD8+ to CD4+ effector memory T cells supports CD4+ expansion.

Immunol Cell Biol 2011 Aug 14;89(6):670-80. Epub 2010 Dec 14.

Translational Immunology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://doi.wiley.com/10.1038/icb.2010.153
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http://dx.doi.org/10.1038/icb.2010.153DOI Listing
August 2011

Immunology and immunotherapeutic approaches in multiple myeloma.

Recent Results Cancer Res 2011 ;183:97-109

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http://dx.doi.org/10.1007/978-3-540-85772-3_5DOI Listing
June 2011

Determination of paraneoplastic autoimmune responses by tumor cell biology and intratumoral IFN-alpha/IL-12 in breast cancer patients.

Cancer Immunol Immunother 2011 Mar 14;60(3):401-11. Epub 2010 Dec 14.

Department of Gynecology and Obstetrics, University Hospital of Heidelberg, Voßstraße 9, 69115 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-010-0956-4DOI Listing
March 2011

The significant role of mast cells in cancer.

Cancer Metastasis Rev 2011 Mar;30(1):45-60

Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, 303 East Superior Street, Lurie 3-250, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1007/s10555-011-9286-zDOI Listing
March 2011

Intraoperative bone marrow puncture in breast cancer patients: prospective assessment of adverse side-effects.

Breast 2011 Feb;20(1):62-5

Department of Gynecology and Obstetrics, University Hospital of Heidelberg, Vossstrasse 9, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.breast.2010.06.007DOI Listing
February 2011

In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction.

Proc Natl Acad Sci U S A 2010 Apr 22;107(14):6430-5. Epub 2010 Mar 22.

Division of Gastroenterology and Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1073/pnas.0913683107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851977PMC
April 2010

Effects of distant metastasis and peripheral CA 15-3 on the induction of spontaneous T cell responses in breast cancer patients.

Cancer Immunol Immunother 2010 Mar 2;59(3):479-86. Epub 2009 Dec 2.

Department of Gynecology and Obstetrics, University Hospital of Heidelberg, Germany.

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http://link.springer.com/10.1007/s00262-009-0801-9
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http://dx.doi.org/10.1007/s00262-009-0801-9DOI Listing
March 2010

Current developments with peptide-based human tumor vaccines.

Curr Opin Oncol 2009 Nov;21(6):524-30

Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Robert Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/CCO.0b013e328331a78eDOI Listing
November 2009

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.

Cancer Res 2009 Jul;69(13):5490-7

Division of Gastroenterology and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611-3015, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881579PMC
July 2009

Treatment of advanced metastasized breast cancer with bone marrow-derived tumour-reactive memory T cells: a pilot clinical study.

Cancer Immunol Immunother 2009 Jun 8;58(6):887-900. Epub 2008 Nov 8.

Department of Gynecology and Obstetrics, The University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-008-0605-3DOI Listing
June 2009

Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration.

J Mol Med (Berl) 2009 Jan 18;87(1):99-112. Epub 2008 Oct 18.

Tumor Immunology Programme, D015, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-008-0410-7DOI Listing
January 2009

An effective tumor vaccine optimized for costimulation via bispecific and trispecific fusion proteins.

Int J Oncol 2008 Apr;32(4):777-89

German Cancer Research Center, Division of Cellular Immunology, Heidelberg, Germany.

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April 2008

Pancreatic cancer microenvironment.

Int J Cancer 2007 Aug;121(4):699-705

Department of General Surgery, Division of Pancreatic Surgery and Molecular Pancreatic Research, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.22871DOI Listing
August 2007

Role of tumor endothelium in CD4+ CD25+ regulatory T cell infiltration of human pancreatic carcinoma.

J Natl Cancer Inst 2007 Aug 24;99(15):1188-99. Epub 2007 Jul 24.

T cell Tumor Immunity group, The German Cancer Research Center, INF280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/jnci/djm064DOI Listing
August 2007

The shaping of a polyvalent and highly individual T-cell repertoire in the bone marrow of breast cancer patients.

Cancer Res 2006 Aug;66(16):8258-65

Department of Cellular Immunology, The German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4201DOI Listing
August 2006

Melanoma-reactive T cells in the bone marrow of melanoma patients: association with disease stage and disease duration.

Cancer Res 2006 Jun;66(12):5997-6001

Skin Cancer Unit, German Cancer Research Center Heidelberg and University Hospital Mannheim, Mannheim, Germany and Division of Cellular Immunology, German Cancer Research Center Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0484DOI Listing
June 2006

Tumor-immune memory T cells from the bone marrow exert GvL without GvH reactivity in advanced metastasized cancer.

Int J Oncol 2005 Oct;27(4):1141-9

German Cancer Research Center, Division of Cellular Immunology, D-69120 Heidelberg, Germany.

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October 2005

Dynamic differentiation of activated human peripheral blood CD8+ and CD4+ effector memory T cells.

J Immunol 2005 Aug;175(3):1433-9

Department of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.4049/jimmunol.175.3.1433DOI Listing
August 2005

Maintenance of long-term tumour-specific T-cell memory by residual dormant tumour cells.

Immunology 2005 Jul;115(3):325-36

Division of Cellular Immunology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1365-2567.2005.02163.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782166PMC
July 2005

Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis.

Clin Cancer Res 2005 Apr;11(8):2899-906

Tumor Immunology Program, German Cancer Research Center, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0664DOI Listing
April 2005

Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma.

Blood 2005 Mar 23;105(5):2132-4. Epub 2004 Nov 23.

Tumor Immunology Program, The German Cancer Research Center, INF 280, 69 120 Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2004-01-0366DOI Listing
March 2005