Philipp A Lang

Philipp A Lang

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Philipp A Lang

Philipp A Lang

Publications by authors named "Philipp A Lang"

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Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection.

Pathogens 2020 Feb 4;9(2). Epub 2020 Feb 4.

Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany.

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http://dx.doi.org/10.3390/pathogens9020096DOI Listing
February 2020

A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

J Hepatol 2020 Jan 15. Epub 2020 Jan 15.

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Virology, Technical University of Munich and Helmholtz Zentrum München, Schneckenburgerstrasse 8, 81675 Munich, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.12.019DOI Listing
January 2020

IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy.

Hepatology 2019 Dec 8;70(6):2075-2091. Epub 2019 Jul 8.

Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/hep.30774DOI Listing
December 2019

TLR2 Stimulation Increases Cellular Metabolism in CD8 T Cells and Thereby Enhances CD8 T Cell Activation, Function, and Antiviral Activity.

J Immunol 2019 Dec 21;203(11):2872-2886. Epub 2019 Oct 21.

Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, 45122 Essen, Germany;

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http://dx.doi.org/10.4049/jimmunol.1900065DOI Listing
December 2019

Reply.

Hepatology 2019 Sep;70(3):1074-1075

Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/hep.30600DOI Listing
September 2019

Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis.

Front Immunol 2019 12;10:2191. Epub 2019 Sep 12.

Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.02191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751247PMC
September 2019

Stand by me(mory): Chronic infection diminishes memory pool via IL-6/STAT1.

J Exp Med 2019 03 19;216(3):474-475. Epub 2019 Feb 19.

Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany

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http://dx.doi.org/10.1084/jem.20190066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400542PMC
March 2019

Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function.

Stem Cells 2018 11 11;36(11):1752-1763. Epub 2018 Sep 11.

Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/stem.2892DOI Listing
November 2018

IL-23R Signaling Plays No Role in Myocardial Infarction.

Sci Rep 2018 11 20;8(1):17078. Epub 2018 Nov 20.

Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine University, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/s41598-018-35188-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244091PMC
November 2018

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.

J Virol 2018 10 26;92(20). Epub 2018 Sep 26.

Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

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http://dx.doi.org/10.1128/JVI.00592-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158439PMC
October 2018

Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.

J Biol Chem 2018 10 20;293(40):15359-15369. Epub 2018 Aug 20.

From the Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany,

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http://dx.doi.org/10.1074/jbc.RA118.002243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177596PMC
October 2018

Phospholipase D1 regulation of TNF-alpha protects against responses to LPS.

Sci Rep 2018 07 3;8(1):10006. Epub 2018 Jul 3.

Department of Vascular and Endovascular Surgery, Heinrich-Heine-University University Medical Center, Moorenstraße.5, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/s41598-018-28331-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030188PMC
July 2018

Synthetic cytokine receptors transmit biological signals using artificial ligands.

Nat Commun 2018 05 23;9(1):2034. Epub 2018 May 23.

Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/s41467-018-04454-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964073PMC
May 2018

IRF9 Prevents CD8 T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.

J Virol 2017 11 27;91(22). Epub 2017 Oct 27.

School of Life and Environmental Sciences, the Marie Bashir Institute for Infectious Diseases and Biosecurity, the Charles Perkins Centre, and the Bosch Institute, The University of Sydney, Sydney, Australia

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http://dx.doi.org/10.1128/JVI.01219-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660491PMC
November 2017

Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection.

Cell Rep 2017 Nov;21(9):2528-2540

Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173160
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http://dx.doi.org/10.1016/j.celrep.2017.11.001DOI Listing
November 2017

SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice.

Cell Physiol Biochem 2017 14;42(4):1358-1365. Epub 2017 Jul 14.

Institute of Immunology, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1159/000479197DOI Listing
October 2017

Glutathione Primes T Cell Metabolism for Inflammation.

Immunity 2017 04;46(4):675-689

Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, Esch-sur-Alzette, L-4354, Luxembourg; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, DK-5000, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.03.019DOI Listing
April 2017

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.

Cell Physiol Biochem 2016 5;39(3):1209-28. Epub 2016 Sep 5.

Department of Cardiology, Vascular Medicine and Physiology, University of Tuebingen, Tuebigen, Germany.

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http://dx.doi.org/10.1159/000447827DOI Listing
February 2017

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.

Cell Physiol Biochem 2016 5;39(3):1209-28. Epub 2016 Sep 5.

Department of Cardiology, Vascular Medicine and Physiology, University of Tuebingen, Tuebigen, Germany.

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http://dx.doi.org/10.1159/000447827DOI Listing
February 2017

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.

Cell Physiol Biochem 2016 5;39(3):1209-28. Epub 2016 Sep 5.

Department of Cardiology, Vascular Medicine and Physiology, University of Tuebingen, Tuebigen, Germany.

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http://dx.doi.org/10.1159/000447827DOI Listing
February 2017

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8 T Cells.

Front Immunol 2017 10;8:113. Epub 2017 Feb 10.

Medical Faculty, Institute of Immunology, University of Duisburg-Essen, Essen, Germany; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301005PMC
February 2017

Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation.

J Autoimmun 2016 Feb 7;67:82-89. Epub 2015 Nov 7.

Institute of Immunology, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.10.004DOI Listing
February 2016

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

Sci Signal 2015 Nov 3;8(401):ra109. Epub 2015 Nov 3.

Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1126/scisignal.aac5356DOI Listing
November 2015

IFN-γ licenses CD11b(+) cells to induce progression of systemic lupus erythematosus.

J Autoimmun 2015 Aug 19;62:11-21. Epub 2015 Jun 19.

Institute of Immunology, Medical Faculty, University Duisburg-Essen, Essen, Germany; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.05.007DOI Listing
August 2015

Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.

J Virol 2015 May 11;89(9):4748-59. Epub 2015 Feb 11.

Campell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada Department of Gastroenterology, Hepatology and Infectious Diseases, University of Düsseldorf, Düsseldorf, Germany Department of Molecular Medicine II, Düsseldorf, Germany

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http://dx.doi.org/10.1128/JVI.02976-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403498PMC
May 2015

T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.

Eur J Immunol 2015 Feb 15;45(2):418-27. Epub 2014 Dec 15.

Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1002/eji.201445060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383653PMC
February 2015

B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

Cancer Immunol Res 2015 Feb 19;3(2):184-95. Epub 2014 Dec 19.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Immunology, University of Toronto, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0113DOI Listing
February 2015

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

Nat Commun 2015 Feb 18;6:6217. Epub 2015 Feb 18.

1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.

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http://dx.doi.org/10.1038/ncomms7217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346637PMC
February 2015

Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.

J Immunol 2014 Sep 6;193(6):2952-60. Epub 2014 Aug 6.

Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen 45147, Germany;

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http://dx.doi.org/10.4049/jimmunol.1400649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157120PMC
September 2014

Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

Immunity 2014 Jun 5;40(6):949-60. Epub 2014 Jun 5.

Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.05.004DOI Listing
June 2014

Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.

Proc Natl Acad Sci U S A 2014 Jan 7;111(3):1060-5. Epub 2014 Jan 7.

The Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.1323166111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903229PMC
January 2014

Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection.

Proc Natl Acad Sci U S A 2013 Dec 9;110(52):21089-94. Epub 2013 Dec 9.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02215.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1320999110
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http://dx.doi.org/10.1073/pnas.1320999110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876206PMC
December 2013

Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes.

PLoS Pathog 2013 Oct 24;9(10):e1003650. Epub 2013 Oct 24.

Institute of Immunology, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany ; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1003650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812017PMC
October 2013

Natural killer cells regulate diverse T cell responses.

Trends Immunol 2013 Jul 17;34(7):342-9. Epub 2013 Apr 17.

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.it.2013.03.002DOI Listing
July 2013

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.

Proc Natl Acad Sci U S A 2013 Jul 25;110(28):11433-8. Epub 2013 Jun 25.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.1302553110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710827PMC
July 2013

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.

J Clin Invest 2013 Feb 25;123(2):928-32. Epub 2013 Jan 25.

Arthritis and Tissue Degeneration Program, Autoimmunity and Inflammation Program, Hospital for Special Surgery, Weill Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI66168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561822PMC
February 2013

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.

J Clin Invest 2012 Dec 1;122(12):4698-709. Epub 2012 Nov 1.

The Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI63528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590210PMC
December 2012

The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation.

J Immunol 2012 Sep 18;189(5):2138-50. Epub 2012 Jul 18.

Department of Immunology, University of Toronto, Toronto, Ontario M5S 148, Canada.

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http://dx.doi.org/10.4049/jimmunol.1103184DOI Listing
September 2012

Tunicamycin inhibits diabetes.

Cell Physiol Biochem 2012 3;29(3-4):595-602. Epub 2012 Apr 3.

Department of Gastroenterology, Hepatology and Infectious diseases, University of Düsseldorf, Germany.

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http://dx.doi.org/10.1159/000338513DOI Listing
August 2012

14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.

Proc Natl Acad Sci U S A 2011 Jan 4;108(4):1555-60. Epub 2011 Jan 4.

Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.1017729108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029705PMC
January 2011

Genes determining the course of virus persistence in the liver: lessons from murine infection with lymphocytic choriomeningitis virus.

Cell Physiol Biochem 2010 24;26(3):263-72. Epub 2010 Aug 24.

Ontario Cancer Institute, Toronto, Ontario, Canada.

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https://www.karger.com/Article/FullText/320549
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http://dx.doi.org/10.1159/000320549DOI Listing
December 2010

Oxidized ATP inhibits T-cell-mediated autoimmunity.

Eur J Immunol 2010 Sep;40(9):2401-8

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, UHN, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/eji.200939838DOI Listing
September 2010

Inhibition of Na+/H+ exchanger activity by parvovirus B19 protein NS1.

Cell Physiol Biochem 2009 18;23(1-3):211-20. Epub 2009 Feb 18.

Department of Physiology, University of Tuebingen, Germany.

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http://dx.doi.org/10.1159/000204110DOI Listing
June 2009

Erythrocyte ion channels in regulation of apoptosis.

Adv Exp Med Biol 2004 ;559:211-7

Department of Physiology,Eberhard-Karls-University of Tuebingen, Gmelinstrasse 5, D-72076 Tuebingen, Germany.

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http://link.springer.com/content/pdf/10.1007%2F0-387-23752-6
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http://dx.doi.org/10.1007/0-387-23752-6_20DOI Listing
September 2008