Philip W Iversen

Philip W Iversen

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Philip W Iversen

Philip W Iversen

Publications by authors named "Philip W Iversen"

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32Publications

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Translational Framework Predicting Tumour Response in Gemcitabine-Treated Patients with Advanced Pancreatic and Ovarian Cancer from Xenograft Studies.

AAPS J 2019 01 31;21(2):23. Epub 2019 Jan 31.

Pharmacometrics & Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra, 31080, Pamplona, Spain.

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http://dx.doi.org/10.1208/s12248-018-0291-9DOI Listing
January 2019

Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts.

J Pharmacol Exp Ther 2018 07 24;366(1):96-104. Epub 2018 Apr 24.

Pharmacometrics and Systems Pharmacology Research Unit, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain (Z.P.P.-G.,V.M.-S.,M.G.-C., I.F.T.); Navarra Institute for Health Research, Pamplona, Spain (Z.P.P.-G.,V.M.-S.,M.G.-C., I.F.T.); Global PK/PD & Pharmacometrics (G.M., C.P., J.E.W.) and Lilly Research Laboratories (P.W.I.), Eli Lilly and Company, Indianapolis, USA Solna, Sweden

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.24
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http://dx.doi.org/10.1124/jpet.118.248286DOI Listing
July 2018

Predicting tumour growth and its impact on survival in gemcitabine-treated patients with advanced pancreatic cancer.

Eur J Pharm Sci 2018 Mar 31;115:296-303. Epub 2018 Jan 31.

Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), University of Navarra, Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2018.01.033DOI Listing
March 2018

Characterizing Gemcitabine Effects Administered as Single Agent or Combined with Carboplatin in Mice Pancreatic and Ovarian Cancer Xenografts: A Semimechanistic Pharmacokinetic/Pharmacodynamics Tumor Growth-Response Model.

J Pharmacol Exp Ther 2017 03 27;360(3):445-456. Epub 2016 Dec 27.

Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, and Navarra Institute for Health Research (IdiSNA), University of Navarra, Pamplona, Spain (M.G.-C., I.F.T.); Global Pharmacokinetic/Pharmacodynamics and Pharmacometrics, Eli Lilly and Company, Windlesham, Surrey, United Kingdom (C.P.); and Lilly Research laboratories, Eli Lilly and Company, Indianapolis, Indiana (P.W.I.)

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http://dx.doi.org/10.1124/jpet.116.237610DOI Listing
March 2017

Selectivity data: assessment, predictions, concordance, and implications.

J Med Chem 2013 Sep 30;56(17):6991-7002. Epub 2013 Aug 30.

Discovery Chemistry, ‡Discovery Statistics, §Advanced Analytics, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States.

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http://dx.doi.org/10.1021/jm400798jDOI Listing
September 2013

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors.

Blood 2013 May 18;121(18):3675-81. Epub 2013 Mar 18.

Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-01-47
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http://dx.doi.org/10.1182/blood-2013-01-477216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643766PMC
May 2013

Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.

Clin Cancer Res 2013 Mar 16;19(5):1159-68. Epub 2013 Jan 16.

Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1184DOI Listing
March 2013

A comparison of assay performance measures in screening assays: signal window, Z' factor, and assay variability ratio.

J Biomol Screen 2006 Apr 20;11(3):247-52. Epub 2006 Feb 20.

Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana; 303 W. Broadway St. Decorah, IA 52101, USA.

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http://dx.doi.org/10.1177/1087057105285610DOI Listing
April 2006

Elevated expression of angiogenin in prostate cancer and its precursors.

Clin Cancer Res 2005 Dec;11(23):8358-63

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0962DOI Listing
December 2005

Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation.

J Mol Cell Cardiol 2004 Sep;37(3):705-15

Cardiovascular Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2004.06.004DOI Listing
September 2004

Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey.

Mol Cancer Ther 2003 Mar;2(3):307-16

Division of Cancer Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

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March 2003

Protein kinase C betaII activation induces angiotensin converting enzyme expression in neonatal rat cardiomyocytes.

Cardiovasc Res 2003 Jan;57(1):139-46

Cardiovascular Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1016/s0008-6363(02)00610-7DOI Listing
January 2003