Publications by authors named "Philip Van Damme"

100Publications

Dipeptide repeat protein and TDP-43 pathology along the hypothalamic-pituitary axis in C9orf72 and non-C9orf72 ALS and FTLD-TDP cases.

Acta Neuropathol 2020 Aug 30. Epub 2020 Aug 30.

Laboratory for Neuropathology, Department of Imaging and Pathology, Leuven Brain Institute (LBI), KU Leuven (University of Leuven), O&N IV Herestraat 49-Bus 1032, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00401-020-02216-9DOI Listing
August 2020

Diagnostic yield of testing for repeat expansions in patients with unexplained adult-onset cerebellar ataxia.

J Neurol Neurosurg Psychiatry 2020 Jul 30. Epub 2020 Jul 30.

Department of Neurology, University Hospitals Leuven, Leuven, Flanders, Belgium

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http://dx.doi.org/10.1136/jnnp-2020-323998DOI Listing
July 2020

TRICALS: creating a highway toward a cure.

Amyotroph Lateral Scler Frontotemporal Degener 2020 Jul 9:1-6. Epub 2020 Jul 9.

Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1080/21678421.2020.1788092DOI Listing
July 2020

Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for ALS.

N Engl J Med 2020 07;383(2):109-119

From the Washington University School of Medicine, St. Louis (T.M., R.C.B., A.P.); the Healey Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston (M.C., N.A.), and Biogen, Cambridge (A.S., H.R., D.G., H.H., A.M., I.N., I.C., L.F., S.F., T.A.F.) - both in Massachusetts; the Sheffield Institute for Translational Neuroscience, University of Sheffield, and NIHR Sheffield Biomedical Research Centre and Clinical Research Facility, University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield (P.J.S., C.J.M.), and Biogen, Maidenhead (M.M.) - both in the United Kingdom; the Department of Clinical Science, Neurosciences, Umeå University, Umea, Sweden (P.M.A.); Montreal Neurological Institute and Hospital, Montreal (A.G.), and Sunnybrook Research Institute, Toronto (L.Z.); Emory University, Atlanta (J.G.); Barrow Neurological Institute, Phoenix, AZ (S.L.); the University of Ulm, Ulm, Germany (A.L.L.); Johns Hopkins University School of Medicine, Baltimore (N.J.M.); the University of California San Diego, La Jolla (J.R.), and Ionis Pharmaceuticals, Carlsbad (C.F.B., R.L.) - both in California; Paris ALS Centre, Hôpital de la Salpêtrière, Paris (F.S.); the University of Tennessee Medical Center, Knoxville (R.T.); and KU Leuven, VIB Center for Brain and Disease Research, University Hospitals Leuven, Leuven, Belgium (P.V.D.).

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http://dx.doi.org/10.1056/NEJMoa2003715DOI Listing
July 2020

Combined brain and spinal FDG PET allows differentiation between ALS and ALS mimics.

Eur J Nucl Med Mol Imaging 2020 Apr 20. Epub 2020 Apr 20.

Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00259-020-04786-yDOI Listing
April 2020

Neurofilament light chain and C reactive protein explored as predictors of survival in amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2020 04 6;91(4):436-437. Epub 2020 Feb 6.

Department of Neurosciences, Leuven Brain Institute, Laboratory for Molecular Neurobiomarker Research, KU Leuven, Leuven, Belgium

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http://dx.doi.org/10.1136/jnnp-2019-322309DOI Listing
April 2020

Myositis as a neuromuscular complication of immune checkpoint inhibitors.

Acta Neurol Belg 2020 Apr 29;120(2):355-364. Epub 2020 Jan 29.

Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s13760-020-01282-wDOI Listing
April 2020

Papillary thyroid carcinoma presenting with severe Guillain-Barré syndrome.

Acta Clin Belg 2019 Dec 20:1-3. Epub 2019 Dec 20.

Department of Medical Intensive Care, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1080/17843286.2019.1708124DOI Listing
December 2019

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.

Authors:
Katrina M Moore Jennifer Nicholas Murray Grossman Corey T McMillan David J Irwin Lauren Massimo Vivianna M Van Deerlin Jason D Warren Nick C Fox Martin N Rossor Simon Mead Martina Bocchetta Bradley F Boeve David S Knopman Neill R Graff-Radford Leah K Forsberg Rosa Rademakers Zbigniew K Wszolek John C van Swieten Lize C Jiskoot Lieke H Meeter Elise Gp Dopper Janne M Papma Julie S Snowden Jennifer Saxon Matthew Jones Stuart Pickering-Brown Isabelle Le Ber Agnès Camuzat Alexis Brice Paola Caroppo Roberta Ghidoni Michela Pievani Luisa Benussi Giuliano Binetti Bradford C Dickerson Diane Lucente Samantha Krivensky Caroline Graff Linn Öijerstedt Marie Fallström Håkan Thonberg Nupur Ghoshal John C Morris Barbara Borroni Alberto Benussi Alessandro Padovani Daniela Galimberti Elio Scarpini Giorgio G Fumagalli Ian R Mackenzie Ging-Yuek R Hsiung Pheth Sengdy Adam L Boxer Howie Rosen Joanne B Taylor Matthis Synofzik Carlo Wilke Patricia Sulzer John R Hodges Glenda Halliday John Kwok Raquel Sanchez-Valle Albert Lladó Sergi Borrego-Ecija Isabel Santana Maria Rosário Almeida Miguel Tábuas-Pereira Fermin Moreno Myriam Barandiaran Begoña Indakoetxea Johannes Levin Adrian Danek James B Rowe Thomas E Cope Markus Otto Sarah Anderl-Straub Alexandre de Mendonça Carolina Maruta Mario Masellis Sandra E Black Philippe Couratier Geraldine Lautrette Edward D Huey Sandro Sorbi Benedetta Nacmias Robert Laforce Marie-Pier L Tremblay Rik Vandenberghe Philip Van Damme Emily J Rogalski Sandra Weintraub Alexander Gerhard Chiadi U Onyike Simon Ducharme Sokratis G Papageorgiou Adeline Su Lyn Ng Amy Brodtmann Elizabeth Finger Rita Guerreiro Jose Bras Jonathan D Rohrer

Lancet Neurol 2020 02 3;19(2):145-156. Epub 2019 Dec 3.

Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30394-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007771PMC
February 2020

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy.

Front Neurosci 2019 19;13:1233. Epub 2019 Nov 19.

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3389/fnins.2019.01233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877733PMC
November 2019

Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases.

Acta Neuropathol Commun 2019 12 2;7(1):189. Epub 2019 Dec 2.

Department of Imaging and Pathology, Laboratory for Neuropathology, KU Leuven (University of Leuven), Leuven Brain Institute (LBI), Leuven, Belgium.

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http://dx.doi.org/10.1186/s40478-019-0845-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889626PMC
December 2019

C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport.

Sci Rep 2019 10 31;9(1):15728. Epub 2019 Oct 31.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-019-52035-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823349PMC
October 2019

Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis.

Sci Rep 2019 10 1;9(1):14112. Epub 2019 Oct 1.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-019-50615-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773754PMC
October 2019

TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study.

J Nucl Med 2020 04 27;61(4):604-607. Epub 2019 Sep 27.

Division of Nuclear Medicine, Department of Imaging and Pathology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.2967/jnumed.119.231985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198372PMC
April 2020

Serum neurofilament heavy chains as early marker of motor neuron degeneration.

Ann Clin Transl Neurol 2019 10 13;6(10):1971-1979. Epub 2019 Sep 13.

Laboratory for Molecular Neurobiomarker Research, Department of Neurosciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/acn3.50890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801162PMC
October 2019

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis.

Acta Neuropathol Commun 2019 07 12;7(1):114. Epub 2019 Jul 12.

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s40478-019-0759-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626434PMC
July 2019

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model.

Acta Neuropathol Commun 2019 07 5;7(1):107. Epub 2019 Jul 5.

Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1186/s40478-019-0750-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612190PMC
July 2019

Inflammatory markers in cerebrospinal fluid: independent prognostic biomarkers in amyotrophic lateral sclerosis?

J Neurol Neurosurg Psychiatry 2019 12 7;90(12):1338-1346. Epub 2019 Jun 7.

Department of Neurosciences, Laboratory for Molecular Neurobiomarker Research, KU Leuven, Leuven, Belgium

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http://dx.doi.org/10.1136/jnnp-2018-319586DOI Listing
December 2019

Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis.

Neurology 2019 06 22;92(23):e2661-e2673. Epub 2019 May 22.

From the Department of Neurology (J.F.H.), University of North Carolina, Chapel Hill; Krembil Neuroscience Centre (V.B.), University Health Network, Toronto, Canada; Department of Neurology (T.M.B.), University of Virginia, Charlottesville; Department of Neuroimmunology and Neuromuscular Diseases (R.M.), Fondazione Istituto Neurologico Carlo Besta, Milan, Italy; Department of Neurology (B.M.), Wroclaw Medical University; Department of Neurology (A.S.), Jagiellonian University Medical College, Cracow, Poland; Department of Neurology (S.B.), University of Southern California, Keck School of Medicine, Los Angeles County Medical Center; Department of Neurology (F.J.R.D.R.G.), La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonoma University of Madrid, Spain; Neuroimmunology Unit, Department Clinical Neuroscience (F.P.), Karolinska Institutet, Karolinska University Hospital (Solna), Stockholm, Sweden; USC Neurologia (M.R.), USS Malattie Autoimmuni-Centro Sclerosi Multipla, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy; Neurology Department (P.V.D.), University Hospitals Leuven; Laboratory of Neurobiology (P.V.D.), Department of Neuroscience, KU Leuven and Center for Brain & Disease Research, VIB, Leuven, Belgium; Department of Neurology (T.V.), University of South Florida, Morsani College of Medicine, Tampa; Institute of Neurology (A.E.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy; Neurology Department (M.F.), The Ohio State University, Columbus; Department of Neurology (T.M.), University of California, Irvine; Department of Molecular and Cellular Medicine (E.S.W.), Texas A&M University Health Science Center, College Station; argenx BVBA (T.D., P.U., K.V., A.G., H.d.H., N.L.), Zwijnaarde, Belgium; and Department of Neurology (J.J.G.M.V.), Leiden University Medical Center (LUMC), the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000007600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556100PMC
June 2019

An ALS case with 38 (G4C2)-repeats in the C9orf72 gene shows TDP-43 and sparse dipeptide repeat protein pathology.

Acta Neuropathol 2019 05 27;137(5):855-858. Epub 2019 Mar 27.

Department of Neurosciences, Laboratory for Neuropathology, KU Leuven, Leuven Brain Institute (LBI), Leuven, Belgium.

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http://dx.doi.org/10.1007/s00401-019-01996-zDOI Listing
May 2019

Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits.

J Neuroinflammation 2019 Mar 13;16(1):61. Epub 2019 Mar 13.

Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Cell Metabolism, KU Leuven - University of Leuven, Campus Gasthuisberg O/N2, Herestraat 49, B-3000, Leuven, Belgium.

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http://dx.doi.org/10.1186/s12974-019-1442-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417251PMC
March 2019

Clinical spectrum of the anti-GQ1b antibody syndrome: a case series of eight patients.

Acta Neurol Belg 2019 Mar 12;119(1):29-36. Epub 2019 Feb 12.

Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s13760-019-01093-8DOI Listing
March 2019

Diagnostic and Prognostic Performance of Neurofilaments in ALS.

Front Neurol 2018 18;9:1167. Epub 2019 Jan 18.

Laboratory of Neurobiology, Department of Neurosciences, KU Leuven and Center for Brain & Disease Research VIB Leuven, Leuven, Belgium.

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https://www.frontiersin.org/article/10.3389/fneur.2018.01167
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http://dx.doi.org/10.3389/fneur.2018.01167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345692PMC
January 2019

Analytical performance of a CE-marked immunoassay to quantify phosphorylated neurofilament heavy chains.

Clin Chem Lab Med 2019 07;57(8):e199-e202

Department of Neurosciences, Laboratory for Molecular Neurobiomarker Research, KU Leuven (University of Leuven), Leuven, Belgium.

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http://dx.doi.org/10.1515/cclm-2018-1004DOI Listing
July 2019

Glucose metabolic brain patterns to discriminate amyotrophic lateral sclerosis from Parkinson plus syndromes.

EJNMMI Res 2018 Dec 13;8(1):110. Epub 2018 Dec 13.

Department of Nuclear Medicine and Molecular Imaging, Division of Nuclear Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1186/s13550-018-0458-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292827PMC
December 2018

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins.

Hum Mol Genet 2018 12;27(23):4103-4116

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddy303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240733PMC
December 2018

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice.

Mol Neurodegener 2018 10 16;13(1):55. Epub 2018 Oct 16.

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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https://molecularneurodegeneration.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13024-018-0288-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192075PMC
October 2018

Derivation of norms for the Dutch version of the Edinburgh cognitive and behavioral ALS screen.

Amyotroph Lateral Scler Frontotemporal Degener 2019 02 12;20(1-2):19-27. Epub 2018 Oct 12.

a Department of Neurology , Brain Centre Rudolf Magnus, University Medical Centre Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/21678421.2018.1522352DOI Listing
February 2019

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.

Alzheimers Dement 2018 10 20;14(10):1261-1280. Epub 2018 Jul 20.

Department of Development and Regeneration, Stem Cell Biology and Embryology, KU Leuven Stem Cell Institute, Leuven, Belgium; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.05.007DOI Listing
October 2018

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.

Cell Rep 2018 07;24(3):529-537.e4

Experimental Neurology, Department of Neurosciences, and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, 3000 Leuven, Belgium; Laboratory of Neurobiology, Center for Brain & Disease Research, VIB, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077250PMC
July 2018

Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis.

Neurobiol Dis 2018 11 26;119:26-40. Epub 2018 Jul 26.

KU Leuven - University of Leuven, Department of Neurosciences, Laboratory of Neurobiology and Experimental Neurology, and Leuven Brain Institute (LBI), Herestraat 49, B-3000 Leuven, Belgium; VIB, Center for Brain & Disease Research, Herestraat 49, B-3000 Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Herestraat 49, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.07.012DOI Listing
November 2018

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration.

J Vis Exp 2018 06 15(136). Epub 2018 Jun 15.

Department of Neurosciences, Experimental Neurology, KU Leuven - University of Leuven; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB;

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http://dx.doi.org/10.3791/57741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101751PMC
June 2018

From lexical regularities to axiomatic patterns for the quality assurance of biomedical terminologies and ontologies.

J Biomed Inform 2018 08 14;84:59-74. Epub 2018 Jun 14.

Departamento de Informática y Sistemas, Universidad de Murcia, IMIB-Arrixaca, Murcia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2018.06.008DOI Listing
August 2018

Multicenter validation of [F]-FDG PET and support-vector machine discriminant analysis in automatically classifying patients with amyotrophic lateral sclerosis versus controls.

Amyotroph Lateral Scler Frontotemporal Degener 2018 11 4;19(7-8):570-577. Epub 2018 Jun 4.

a Division of Nuclear Medicine and Department of Imaging and pathology , University Hospitals Leuven and KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1080/21678421.2018.1476548DOI Listing
November 2018

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1 mice.

Neurobiol Aging 2018 08 3;68:1-4. Epub 2018 Apr 3.

Department of Neurosciences, KU Leuven-University of Leuven, Experimental Neurology, Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium; Department of Neurology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183011
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998381PMC
August 2018

How much of the missing heritability of ALS is hidden in known ALS genes?

Authors:
Philip Van Damme

J Neurol Neurosurg Psychiatry 2018 08 12;89(8):794. Epub 2018 Apr 12.

Department of Neuroscience, Experimental Neurology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1136/jnnp-2018-318354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204935PMC
August 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Detection of myositis-specific antibodies.

Ann Rheum Dis 2019 01 25;78(1):e7. Epub 2018 Jan 25.

Department of Microbiology and Immunology, Experimental Laboratory Immunology, KU Leuven, Leuven, Belgium.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2017-21291
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http://dx.doi.org/10.1136/annrheumdis-2017-212915DOI Listing
January 2019

Anterior interosseous mononeuropathy associated with HEV infection.

Neurol Neuroimmunol Neuroinflamm 2018 Mar 22;5(2):e429. Epub 2017 Dec 22.

Department of Neurosciences, Experimental Neurology (B.S., S.B., P.V.D.), KU Leuven-University of Leuven; Laboratory of Neurobiology (B.S., S.B., P.V.D.), Center for Brain & Disease Research, VIB; Departments of Neurology (B.S., M.S., K.G.C., P.V.D.), and Laboratory Medicine (V.S.), University Hospitals Leuven; and Laboratory for Cognitive Neurology (M.S.), Department of Neurosciences, Department of Microbiology and Immunology (V.S.), Laboratory for Muscle Diseases and Neuropathies (K.G.C.), Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Belgium.

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http://dx.doi.org/10.1212/NXI.0000000000000429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745356PMC
March 2018

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

Neurology 2018 01 6;90(1):e22-e30. Epub 2017 Dec 6.

From the Nuffield Department of Clinical Neurosciences (E.F., E.G., M.R.T.), University of Oxford, UK; Department of Neurology (P.O., P.S., F.V., J.H.W., P.W., A.C.L., M.O.), Ulm University Hospital, Germany; Department of Pathophysiology and Transplantation (F.V., V.S.), Università degli Studi di Milano; Department of Neurology-Stroke Unit and Laboratory of Neuroscience (F.V., C.M., V.S.), IRCCS Istituto Auxologico Italiano, Milan, Italy; Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine (C.B., J.K.), University Hospital and University of Basel, Switzerland; Department of Neurology (P.V.D.) and Laboratory of Molecular Neurobiomarker Research and Laboratory Medicine (K.P.), University Hospitals Leuven; KU Leuven-University of Leuven (P.V.D.); Department of Neurosciences (P.V.D.), VIB-Center for Brain & Disease Research, Leuven, Belgium; Department of Neurology (J.G., P.M., B.S.), Jena University Hospital, Germany; Department of Metabolic Biochemistry (C.J., F.L.) and Neurological Diseases Department (M.d.M.A., F.S.), Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France; Department of Neurology (S.K., S.P.), Hannover Medical School; Institute for Epidemiology and Medical Biometry (B.M.) Ulm University, Germany; Donders Institute for Brain, Cognition and Behaviour, Department of Neurology (J.R., M.M.V.), and Radboud Alzheimer Center, Department of Laboratory Medicine (M.M.V.), Radboud University Medical Center, Nijmegen, the Netherlands; and Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology (P.W.), Bonn University Hospital, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004761DOI Listing
January 2018

Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth.

Neurobiol Dis 2018 03 29;111:59-69. Epub 2017 Nov 29.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology, Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.11.011DOI Listing
March 2018

Is there a glucose metabolic signature of spreading TDP-43 pathology in amyotrophic lateral sclerosis?

Q J Nucl Med Mol Imaging 2020 Mar 22;64(1):96-104. Epub 2017 Nov 22.

Division of Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospitals Leuven and KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.23736/S1824-4785.17.03009-6DOI Listing
March 2020

Defining Y-SNP variation among the Flemish population (Western Europe) by full genome sequencing.

Forensic Sci Int Genet 2017 11 28;31:e12-e16. Epub 2017 Oct 28.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.fsigen.2017.10.008DOI Listing
November 2017

Comparison of elevated phosphorylated neurofilament heavy chains in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2018 04 20;89(4):367-373. Epub 2017 Oct 20.

Department of Neurosciences, Laboratory for Molecular Neurobiomarker Research, KU Leuven (University of Leuven), Leuven, Belgium.

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http://dx.doi.org/10.1136/jnnp-2017-316605DOI Listing
April 2018

NEK1 genetic variability in a Belgian cohort of ALS and ALS-FTD patients.

Neurobiol Aging 2018 01 31;61:255.e1-255.e7. Epub 2017 Aug 31.

Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.08.021DOI Listing
January 2018

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access: An Editorial Comment for 'The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C' on page 236.

Authors:
Philip Van Damme

J Neurochem 2017 10 4;143(2):154-157. Epub 2017 Aug 4.

Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/jnc.14125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655790PMC
October 2017

Identification and characterization of Nanobodies targeting the EphA4 receptor.

J Biol Chem 2017 07 19;292(27):11452-11465. Epub 2017 May 19.

From the KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), 3000 Leuven, Belgium,

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http://dx.doi.org/10.1074/jbc.M116.774141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500810PMC
July 2017

Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease.

Neurology 2017 Jun 12;88(24):2302-2309. Epub 2017 May 12.

From the Laboratory for Molecular Neurobiomarker Research (K.P., M.D.S., B.G.), Laboratory for Cognitive Neurology (R.V.) and Laboratory of Neurobiology (Center for Brain & Disease Research, VIB, Leuven) (P.V.D.), Department of Neurosciences, KU Leuven (University of Leuven); Laboratory Medicine (K.P., M.D.S.) and Department of Neurology (O.S., K.G.C., G.C., A.D., N.L., P.T., D.V.R., R.V., P.V.D.), University Hospitals Leuven, Belgium; Hans Berger Department of Neurology (B.S., T.P., T.M.R., N.F., B.H., M.R., A.R., A.G., O.W.W., J.G.) and Institute for Biochemistry (P.M., S.W., H.R.), Jena University Hospital, Germany; INSERM, U942 (S.G., C.P.), Groupe Hospitalier Lariboisière Fernand-Widal Saint-Louis, CMRR Paris Nord AP-HP, Université Paris Diderot, France.

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http://dx.doi.org/10.1212/WNL.0000000000004029DOI Listing
June 2017

Modelling amyotrophic lateral sclerosis: progress and possibilities.

Dis Model Mech 2017 05;10(5):537-549

KU Leuven, University of Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium

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http://dx.doi.org/10.1242/dmm.029058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451175PMC
May 2017

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.

Hum Mol Genet 2017 08;26(15):2850-2863

Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/hmg/ddx162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886064PMC
August 2017

Finger extension weakness and downbeat nystagmus motor neuron disease syndrome: A novel motor neuron disorder?

Muscle Nerve 2017 Dec 15;56(6):1164-1168. Epub 2017 May 15.

Department of Neurology, University Hospitals Leuven, Campus Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1002/mus.25669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656559PMC
December 2017

Randomized cross-over trial of ventilator modes during non-invasive ventilation titration in amyotrophic lateral sclerosis.

Respirology 2017 08 4;22(6):1212-1218. Epub 2017 Apr 4.

Department of Pulmonology and Leuven University Centre for Sleep and Wake Disorders (LUCS), University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/resp.13046DOI Listing
August 2017

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.

Mol Cell 2017 Mar;65(6):1044-1055.e5

Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Department of Neurosciences, KU Leuven - University of Leuven, 3000 Leuven, Belgium; Laboratory of Neurobiology, VIB, Center for Brain and Disease Research, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364369PMC
March 2017

Negative commercial screening test for paraneoplastic antibodies in a case of opsoclonus.

Neurol Neuroimmunol Neuroinflamm 2017 Mar 3;4(2):e329. Epub 2017 Feb 3.

Department of Neurology (N.V., M.S., P.V.D.), Department of Ophthalmology (C.C.), and Laboratory Medicine (X.B., K.P.), University Hospital Leuven; Department of Microbiology and Immunology (X.B.), Experimental Laboratory Immunology, Leuven, Belgium; Department of Immunology (T.V.), St Eloi Hospital, Montpellier University, France; Department of Neurosciences (P.V.D.), Laboratory for Neurobiology; Vesalius Research Center (P.V.D.), Flemish Institute for Biotechnology (VIB); and Department of Neurosciences (B.G., K.P.), Laboratory for Molecular Neurobiomarker Research, Leuven, Belgium.

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http://dx.doi.org/10.1212/NXI.0000000000000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292927PMC
March 2017

Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients.

Neurobiol Aging 2017 03 21;51:177.e9-177.e16. Epub 2016 Dec 21.

Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.008DOI Listing
March 2017

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Hum Mutat 2017 03 19;38(3):297-309. Epub 2017 Jan 19.

Center for Molecular Neurology, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1002/humu.23161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324646PMC
March 2017

IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients.

J Autoimmun 2017 02 10;77:104-115. Epub 2016 Dec 10.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.11.005DOI Listing
February 2017

Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease.

Neurotherapeutics 2017 04;14(2):417-428

KU Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven, B-3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s13311-016-0501-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398982PMC
April 2017

Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.

Eur J Nucl Med Mol Imaging 2017 Mar 8;44(3):533-547. Epub 2016 Dec 8.

Division of Nuclear Medicine, Department of Imaging and Pathology, University Hospitals Leuven and KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00259-016-3587-yDOI Listing
March 2017

Diagnostic Challenges and Clinical Characteristics of Hepatitis E Virus-Associated Guillain-Barré Syndrome.

JAMA Neurol 2017 Jan;74(1):26-33

Department of Neurology, University Hospitals Leuven, Leuven, Belgium2Department of Neurosciences, Experimental Neurology, KU Leuven, University of Leuven, Leuven, Belgium5VIB, Vesalius Research Center, Leuven, Belgium.

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http://dx.doi.org/10.1001/jamaneurol.2016.3541DOI Listing
January 2017

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice.

Hum Mol Genet 2016 08 4;25(16):3491-3499. Epub 2016 Jul 4.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND)

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http://dx.doi.org/10.1093/hmg/ddw190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179944PMC
August 2016

Inside out: the role of nucleocytoplasmic transport in ALS and FTLD.

Acta Neuropathol 2016 08 6;132(2):159-173. Epub 2016 Jun 6.

Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven-University of Leuven, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00401-016-1586-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947127PMC
August 2016

A mapping review of international guidance on the management and care of amyotrophic lateral sclerosis (ALS).

Amyotroph Lateral Scler Frontotemporal Degener 2016 Jul-Aug;17(5-6):325-36. Epub 2016 Apr 14.

m Walter Sermeus, KU Leuven Institute for Healthcare Policy, Department of Public Health and Primary Care , University of Leuven - KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.3109/21678421.2016.1167911DOI Listing
October 2017

Patient-ventilator asynchrony, leaks and sleep in patients with amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Jul-Aug;17(5-6):343-50. Epub 2016 Apr 14.

a Department of Pulmonology and Leuven University Centre for Sleep and Wake disorders (LUCS) - University Hospitals Leuven .

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http://dx.doi.org/10.3109/21678421.2016.1170149DOI Listing
October 2017