Philip Scheltens

Philip Scheltens

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Philip Scheltens

Publications by authors named "Philip Scheltens"

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Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid.

Neurobiol Aging 2020 Sep 24;93:144.e1-144.e15. Epub 2020 Mar 24.

Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.03.012DOI Listing
September 2020

Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective.

Lancet Neurol 2020 Aug 20;19(8):699-710. Epub 2020 May 20.

Department of Neurology and Alzheimer Center, VU University Medical Center Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/S1474-4422(20)30139-3DOI Listing
August 2020

ATN classification and clinical progression in subjective cognitive decline: The SCIENCe project.

Neurology 2020 Jul 10;95(1):e46-e58. Epub 2020 Jun 10.

From the Alzheimer Center, Department of Neurology (J.L.E., T.T., L.M.P.W., I.M.W.V., R.E.R.S., A.C.v.H., K.A.v.d.B., M.v.L., J.T., A.d.B., P.J.V., N.D.P., S.A.M.S., P.S., B.N.M.v.B., W.M.v.d.F.), and Department of Radiology & Nuclear Medicine (S.C.J.V., F.B., B.N.v.B.), Amsterdam Neuroscience, Neurochemistry Laboratory, Department of Clinical Chemistry (I.M.W.V., C.E.T.), and Department of Epidemiology & Biostatistics (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK; Department of Biological Psychology (A.d.B.), Neuroscience Amsterdam, VU University Amsterdam; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; and Department of Neurobiology, Care Sciences and Society (P.J.V.), Division of Neurogeriatrics, Karolinska Institutet, Stockholm Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000009724DOI Listing
July 2020

Diagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies.

Neurology 2020 Jul 7. Epub 2020 Jul 7.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000009977DOI Listing
July 2020

Associations Between Nutrient Intake and Corresponding Nutritional Biomarker Levels in Blood in a Memory Clinic Cohort: The NUDAD Project.

J Am Med Dir Assoc 2020 Jul 5. Epub 2020 Jul 5.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jamda.2020.04.031DOI Listing
July 2020

Latent atrophy factors related to phenotypical variants of posterior cortical atrophy.

Neurology 2020 Jul 16. Epub 2020 Jul 16.

Colin Groot, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000010362DOI Listing
July 2020

Small vessel disease lesion type and brain atrophy: The role of co-occurring amyloid.

Alzheimers Dement (Amst) 2020 13;12(1):e12060. Epub 2020 Jul 13.

Department of Neurology and Neurosurgery UMC Utrecht Brain Center Utrecht University Utrecht the Netherlands.

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http://dx.doi.org/10.1002/dad2.12060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364862PMC
July 2020

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.

J Alzheimers Dis 2019 ;68(1):311-322

Department of Neurology, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.3233/JAD-180914DOI Listing
June 2020

Reproducibility of EEG functional connectivity in Alzheimer's disease.

Alzheimers Res Ther 2020 Jun 3;12(1):68. Epub 2020 Jun 3.

Department of Clinical Neurophysiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1186/s13195-020-00632-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271479PMC
June 2020

Pre-trained MRI-based Alzheimer's disease classification models to classify memory clinic patients.

Neuroimage Clin 2020 Jun 4;27:102303. Epub 2020 Jun 4.

Institute of Psychology, Leiden University, the Netherlands; Department of Radiology, Leiden University Medical Center, the Netherlands; Leiden Institute for Brain and Cognition, the Netherlands.

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http://dx.doi.org/10.1016/j.nicl.2020.102303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303669PMC
June 2020

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Authors:
Sven J van der Lee Olivia J Conway Iris Jansen Minerva M Carrasquillo Luca Kleineidam Erik van den Akker Isabel Hernández Kristel R van Eijk Najada Stringa Jason A Chen Anna Zettergren Till F M Andlauer Monica Diez-Fairen Javier Simon-Sanchez Alberto Lleó Henrik Zetterberg Marianne Nygaard Cornelis Blauwendraat Jeanne E Savage Jonas Mengel-From Sonia Moreno-Grau Michael Wagner Juan Fortea Michael J Keogh Kaj Blennow Ingmar Skoog Manuel A Friese Olga Pletnikova Miren Zulaica Carmen Lage Itziar de Rojas Steffi Riedel-Heller Ignacio Illán-Gala Wei Wei Bernard Jeune Adelina Orellana Florian Then Bergh Xue Wang Marc Hulsman Nina Beker Niccolo Tesi Christopher M Morris Begoña Indakoetxea Lyduine E Collij Martin Scherer Estrella Morenas-Rodríguez James W Ironside Bart N M van Berckel Daniel Alcolea Heinz Wiendl Samantha L Strickland Pau Pastor Eloy Rodríguez Rodríguez Bradley F Boeve Ronald C Petersen Tanis J Ferman Jay A van Gerpen Marcel J T Reinders Ryan J Uitti Lluís Tárraga Wolfgang Maier Oriol Dols-Icardo Amit Kawalia Maria Carolina Dalmasso Mercè Boada Uwe K Zettl Natasja M van Schoor Marian Beekman Mariet Allen Eliezer Masliah Adolfo López de Munain Alexander Pantelyat Zbigniew K Wszolek Owen A Ross Dennis W Dickson Neill R Graff-Radford David Knopman Rosa Rademakers Afina W Lemstra Yolande A L Pijnenburg Philip Scheltens Thomas Gasser Patrick F Chinnery Bernhard Hemmer Martijn A Huisman Juan Troncoso Fermin Moreno Ellen A Nohr Thorkild I A Sørensen Peter Heutink Pascual Sánchez-Juan Danielle Posthuma Jordi Clarimón Kaare Christensen Nilüfer Ertekin-Taner Sonja W Scholz Alfredo Ramirez Agustín Ruiz Eline Slagboom Wiesje M van der Flier Henne Holstege

Acta Neuropathol 2020 05;139(5):959-962

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-019-02107-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181435PMC
May 2020

Plasma amyloid is associated with the rate of cognitive decline in cognitively normal elderly: the SCIENCe project.

Neurobiol Aging 2020 05 15;89:99-107. Epub 2020 Jan 15.

Alzheimer Center, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.01.007DOI Listing
May 2020

Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2020 May 27. Epub 2020 May 27.

Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00259-020-04831-wDOI Listing
May 2020

A decade of Alzheimer's Research & Therapy: reflections on the past, present, and future.

Alzheimers Res Ther 2020 May 30;12(1):67. Epub 2020 May 30.

Alzheimer Center, Amsterdam UMC, The Netherlands.

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http://dx.doi.org/10.1186/s13195-020-00629-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260791PMC
May 2020

Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease.

Neurobiol Aging 2020 May 21;94:71-80. Epub 2020 May 21.

Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.05.008DOI Listing
May 2020

Fingerprinting Alzheimer's Disease by H Nuclear Magnetic Resonance Spectroscopy of Cerebrospinal Fluid.

J Proteome Res 2020 Apr 12;19(4):1696-1705. Epub 2020 Mar 12.

Laboratory of Clinical Neurochemistry, Department of Medicine, Section of Neurology, University of Perugia, Perugia 06123, Italy.

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http://dx.doi.org/10.1021/acs.jproteome.9b00850DOI Listing
April 2020

Regional [F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2020 Apr 14. Epub 2020 Apr 14.

Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00259-020-04758-2DOI Listing
April 2020

A Suboptimal Diet is Associated with Poorer Cognition: The NUDAD Project.

Nutrients 2020 Mar 6;12(3). Epub 2020 Mar 6.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/nu12030703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146357PMC
March 2020

Diagnostic Impact of CSF Biomarkers in a Local Hospital Memory Clinic Revisited.

Dement Geriatr Cogn Disord 2020 Mar 30:1-6. Epub 2020 Mar 30.

Alzheimer Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000506332DOI Listing
March 2020

Comorbid amyloid-β pathology affects clinical and imaging features in VCD.

Alzheimers Dement 2020 02 4;16(2):354-364. Epub 2020 Jan 4.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2019.08.190DOI Listing
February 2020

Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.

JAMA Netw Open 2020 Feb 5;3(2):e200094. Epub 2020 Feb 5.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1001/jamanetworkopen.2020.0094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137688PMC
February 2020

Modeling grey matter atrophy as a function of time, aging or cognitive decline show different anatomical patterns in Alzheimer's disease.

Neuroimage Clin 2019 19;22:101786. Epub 2019 Mar 19.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439228PMC
January 2020

Why Is Amyloid-β PET Requested After Performing CSF Biomarkers?

J Alzheimers Dis 2020 ;73(2):559-569

Department of Neurology & Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.3233/JAD-190836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081099PMC
January 2020

Methylphenidate and galantamine in patients with vascular cognitive impairment-the proof-of-principle study STREAM-VCI.

Alzheimers Res Ther 2020 01 7;12(1):10. Epub 2020 Jan 7.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0567-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947990PMC
January 2020

Education as Proxy for Cognitive Reserve in a Large Elderly Memory Clinic: 'Window of Benefit'.

J Alzheimers Dis 2020 ;76(2):671-679

Department of Neurology, Tergooi Hospital, Blaricum, The Netherlands.

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http://dx.doi.org/10.3233/JAD-191332DOI Listing
January 2020

Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease?

Alzheimers Dement (Amst) 2019 12 10;11:383-391. Epub 2019 May 10.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517376PMC
December 2019

Cerebrospinal fluid collection: An informative animation video for patients and caregivers.

Alzheimers Dement (Amst) 2019 Dec 12;11:435-438. Epub 2019 Jun 12.

Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562320PMC
December 2019

Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.

Alzheimers Dement (Amst) 2019 12 18;11:463-471. Epub 2019 Jun 18.

Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2019.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584766PMC
December 2019

Added value of amyloid PET in individualized risk predictions for MCI patients.

Alzheimers Dement (Amst) 2019 Dec 29;11:529-537. Epub 2019 Jul 29.

Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667768PMC
December 2019

Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions.

Neurobiol Aging 2019 12 9;84:225-234. Epub 2019 Aug 9.

Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.08.001DOI Listing
December 2019

PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases.

Alzheimers Res Ther 2019 12 7;11(1):100. Epub 2019 Dec 7.

Department of Neurology & Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0561-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898919PMC
December 2019

Hippocampal [F]flortaucipir BP corrected for possible spill-in of the choroid plexus retains strong clinico-pathological relationships.

Neuroimage Clin 2020 2;25:102113. Epub 2019 Dec 2.

Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, location VUmc, PO Box 7057, 1007 MB Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.nicl.2019.102113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920114PMC
December 2019

Cognitive and functional progression of dementia in two longitudinal studies.

Int J Geriatr Psychiatry 2019 11 26;34(11):1623-1632. Epub 2019 Jul 26.

Department of Geriatric Medicine, Radboudumc Alzheimer Center, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/gps.5175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803041PMC
November 2019

Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort: The ABIDE project.

Alzheimers Dement 2019 11 6;15(11):1458-1467. Epub 2019 Oct 6.

Department of Neurology, Amsterdam Neuroscience, Alzheimer Center, VU University, Amsterdam UMC, Amsterdam, the Netherlands; Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, VU University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2019.07.003DOI Listing
November 2019

Applying the ATN scheme in a memory clinic population: The ABIDE project.

Neurology 2019 10 9;93(17):e1635-e1646. Epub 2019 Oct 9.

From the Alzheimer Center Amsterdam, Department of Neurology (D.A., A.d.W., R.O., W.P., F.B., C.G., I.v.M., M.Z., B.N.v.B., P.S., W.M.v.d.F.), Department of Radiology & Nuclear Medicine (R.O., C.G., M.Y., F.B., B.N.v.B.), and Neurochemistry Laboratory, Department of Clinical Chemistry (C.E.T.), Amsterdam Neuroscience, and Department of Epidemiology & Biostatistics (I.v.M., W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; Laboratory of Neuroimaging of Aging (LANVIE) (D.A., G.B.F.), University of Geneva, Switzerland; Memory Clinic (D.A.), University Hospitals of Geneva, Switzerland; Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE) (D.A.), Saint John of God Clinical Research Centre; Department of Molecular and Translational Medicine (D.A.), University of Brescia, Italy; Clinical Memory Research Unit (R.O.), Lund University, Malmö, Sweden; Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK; and Memory Clinic (D.A., G.B.F.), University Hospitals of Geneva, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000008361DOI Listing
October 2019

Amyloid-β peptides in cerebrospinal fluid of patients with dementia with Lewy bodies.

Alzheimers Res Ther 2019 10 10;11(1):83. Epub 2019 Oct 10.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0537-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788069PMC
October 2019

Gray matter T1-w/T2-w ratios are higher in Alzheimer's disease.

Hum Brain Mapp 2019 09 3;40(13):3900-3909. Epub 2019 Jun 3.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hbm.24638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771703PMC
September 2019

Discordant amyloid-β PET and CSF biomarkers and its clinical consequences.

Alzheimers Res Ther 2019 09 12;11(1):78. Epub 2019 Sep 12.

Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0532-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739952PMC
September 2019

Exploring effects of Souvenaid on cerebral glucose metabolism in Alzheimer's disease.

Alzheimers Dement (N Y) 2019 27;5:492-500. Epub 2019 Sep 27.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.trci.2019.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804721PMC
September 2019

High amyloid burden is associated with fewer specific words during spontaneous speech in individuals with subjective cognitive decline.

Neuropsychologia 2019 08 7;131:184-192. Epub 2019 May 7.

Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Department of Epidemiology & Biostatistics, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.05.006DOI Listing
August 2019

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Authors:
Sven J van der Lee Olivia J Conway Iris Jansen Minerva M Carrasquillo Luca Kleineidam Erik van den Akker Isabel Hernández Kristel R van Eijk Najada Stringa Jason A Chen Anna Zettergren Till F M Andlauer Monica Diez-Fairen Javier Simon-Sanchez Alberto Lleó Henrik Zetterberg Marianne Nygaard Cornelis Blauwendraat Jeanne E Savage Jonas Mengel-From Sonia Moreno-Grau Michael Wagner Juan Fortea Michael J Keogh Kaj Blennow Ingmar Skoog Manuel A Friese Olga Pletnikova Miren Zulaica Carmen Lage Itziar de Rojas Steffi Riedel-Heller Ignacio Illán-Gala Wei Wei Bernard Jeune Adelina Orellana Florian Then Bergh Xue Wang Marc Hulsman Nina Beker Niccolo Tesi Christopher M Morris Begoña Indakoetxea Lyduine E Collij Martin Scherer Estrella Morenas-Rodríguez James W Ironside Bart N M van Berckel Daniel Alcolea Heinz Wiendl Samantha L Strickland Pau Pastor Eloy Rodríguez Rodríguez Bradley F Boeve Ronald C Petersen Tanis J Ferman Jay A van Gerpen Marcel J T Reinders Ryan J Uitti Lluís Tárraga Wolfgang Maier Oriol Dols-Icardo Amit Kawalia Maria Carolina Dalmasso Mercè Boada Uwe K Zettl Natasja M van Schoor Marian Beekman Mariet Allen Eliezer Masliah Adolfo López de Munain Alexander Pantelyat Zbigniew K Wszolek Owen A Ross Dennis W Dickson Neill R Graff-Radford David Knopman Rosa Rademakers Afina W Lemstra Yolande A L Pijnenburg Philip Scheltens Thomas Gasser Patrick F Chinnery Bernhard Hemmer Martijn A Huisman Juan Troncoso Fermin Moreno Ellen A Nohr Thorkild I A Sørensen Peter Heutink Pascual Sánchez-Juan Danielle Posthuma Jordi Clarimón Kaare Christensen Nilüfer Ertekin-Taner Sonja W Scholz Alfredo Ramirez Agustín Ruiz Eline Slagboom Wiesje M van der Flier Henne Holstege

Acta Neuropathol 2019 08 27;138(2):237-250. Epub 2019 May 27.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-019-02026-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660501PMC
August 2019

Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years.

J Gerontol A Biol Sci Med Sci 2019 Aug 14. Epub 2019 Aug 14.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/gerona/glz180DOI Listing
August 2019

Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials.

J Neurol 2019 Aug 14. Epub 2019 Aug 14.

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Postbus 85500, 3508 GA, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00415-019-09493-9DOI Listing
August 2019

Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease.

Mol Psychiatry 2019 Aug 20. Epub 2019 Aug 20.

Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/s41380-019-0483-4DOI Listing
August 2019

Use of mild cognitive impairment and prodromal AD/MCI due to AD in clinical care: a European survey.

Alzheimers Res Ther 2019 08 22;11(1):74. Epub 2019 Aug 22.

Alzheimer Centre, Department of Neurology, VU University Medical Centre, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0525-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706888PMC
August 2019

The "rights" of precision drug development for Alzheimer's disease.

Alzheimers Res Ther 2019 08 31;11(1):76. Epub 2019 Aug 31.

Alzheimer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0529-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717388PMC
August 2019

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

J Psychiatry Neurosci 2019 07;44(4):E1-E10

From the Alzheimer Centre Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands (Leeuwis, Hooghiemstra, Prins, Scheltens, van der Flier); the Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, the Netherlands (Weaver, Biesbroek, Exalto, Biessels); the Image Sciences Institute, University Medical Centre Utrecht, Utrecht, the Netherlands (Kuijf); the Department of Medical Humanities, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Hooghiemstra); the Institutes of Neurology and Healthcare Engineering, UCL, London, United Kingdom (Barkhof); the Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Barkhof); and the Department of Epidemiology & Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Flier).

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http://dx.doi.org/10.1503/jpn.180136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606429PMC
July 2019

ApoE and clusterin CSF levels influence associations between APOE genotype and changes in CSF tau, but not CSF Aβ42, levels in non-demented elderly.

Neurobiol Aging 2019 07 1;79:101-109. Epub 2019 Mar 1.

Department of Clinical Chemistry, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Psychiatry, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.017DOI Listing
July 2019

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.

Alzheimers Dement 2019 07 1;15(7):888-898. Epub 2019 Jun 1.

Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646097PMC
July 2019

Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship.

Neurology 2019 07 2;93(4):e334-e346. Epub 2019 Jul 2.

From Alzheimer Center Amsterdam, Department of Neurology (A.C.v.L., W.M.v.d.F., E.D., C.G., P.S., R.O.), and Department of Radiology and Nuclear Medicine (A.M.W., F.B., R.O.), Amsterdam Neuroscience, and Department of Epidemiology and Biostatistics (W.M.v.d.F., J.T.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000007821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669930PMC
July 2019

Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal.

Neurology 2019 06 8;92(23):e2699-e2705. Epub 2019 May 8.

From Alzheimer Center Amsterdam, Department of Neurology (L.V., A.J.L.v.P., P.S., P.J.V., B.M.T.), and Neurochemistry Lab and Biobank, Department of Clinical Chemistry (C.E.T.), Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC; and Department of Psychiatry and Neuropsychology (P.J.V.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000007609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556092PMC
June 2019

Testing Episodic Memory in Elderly Subjects: Not as Simple as It Looks.

Dement Geriatr Cogn Dis Extra 2019 May-Aug;9(2):207-216. Epub 2019 Jun 18.

Department of Geriatric Medicine, NoordWest Hospital, Alkmaar, The Netherlands.

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http://dx.doi.org/10.1159/000499836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600035PMC
June 2019

Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults: a monozygotic twin study.

Neurobiol Aging 2019 05 21;77:58-65. Epub 2019 Jan 21.

Department of Neurology & Alzheimer Center, VU University Medical Center, Neuroscience Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.006DOI Listing
May 2019

Cerebrospinal Fluid Amyloid-β Subtypes in Confirmed Frontotemporal Lobar Degeneration Cases: A Pilot Study.

J Alzheimers Dis 2019 ;71(1):15-20

Departments of Neurology, Amsterdam University Medical Center location VUmc, Alzheimer Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.3233/JAD-190344DOI Listing
January 2019