Dr Philip Raj Abraham, Ph. D - Vector Control Research Centre - Scientist B

Dr Philip Raj Abraham

Ph. D

Vector Control Research Centre

Scientist B

Puducherry, Pondicherry | India

Main Specialties: Biology, Infectious Disease, Medical Microbiology

Additional Specialties: Microbiology

Dr Philip Raj Abraham, Ph. D - Vector Control Research Centre - Scientist B

Dr Philip Raj Abraham

Ph. D

Introduction

Primary Affiliation: Vector Control Research Centre - Puducherry, Pondicherry , India

Specialties:

Additional Specialties:

Research Interests:


View Dr Philip Raj Abraham’s Resume / CV

Education

Jul 2010
Centre for DNA Fingerprinting and Diagnostics, Hyderabad
Postdoc
Tuberculosis serodiagnosis
Feb 2009
Gulbarga University, Gulbarga
Ph. D
Microbiology (Medical)
Aug 2003
Gulbarga University, Gulbarga
M. Sc
Microbiology
May 2001
Govt. Degree College, Gulbarga University, Gulbarga
B.Sc
Industrial Microbiology, Chemistry and Botany

Experience

Aug 2013
ICMR-Research Associate
Postdoc
CDFD, Hyderabad
Jul 2010
DBT-Research Associate
Postdoc
CDFD, Hyderabad
Jul 2008
Research Scientist/Microbiologist
Research
National AIDS Research Institute, Pune
Mar 2008
Laboratory Coordinator
Research
National AIDS Research Institute, Pune

Publications

8Publications

89Reads

211Profile Views

1PubMed Central Citations

PPE17 (Rv1168c) protein of Mycobacterium tuberculosis detects individuals with latent TB infection

PLOS ONE 13(11): e0207787

PLoS ONE

Latent tuberculosis infection (LTBI) is a clinically distinct category of Mycobacterium tuberculosis (Mtb) infection that needs to be diagnosed at the initial stage. We have reported earlier that one of the Mtb proline-proline-glutamic acid (PPE) proteins, PPE17 (Rv1168c) is associated with stronger B-cell and T-cell responses and could be used to diagnose different clinical categories of active TB patients with higher specificity and sensitivity than PPD and ESAT-6. Based on these observations we further tested the potential of PPE17 for the diagnosis of LTBI. We tested 198 sera samples collected from LTBI individuals (n = 61), QFT-negative (n = 58) and active TB patients (n = 79). Individuals were defined as LTBI by QuantiFERON-TB Gold In-Tube test (QFT–GIT) positive results, while active TB patients were confirmed based on the guidelines of the Revised National TB Control Programme of India. The antibody responses against PPE17, ESAT-6:CFP-10 and PPD were compared in these subjects by enzyme-linked immunosorbent assay. We observed that LTBI individuals show a higher sero-reactivity to PPE17 as compared to currently used latent TB diagnostic antigens like ESAT-6, CFP-10 and PPD. The LTBI and active TB patients display almost similar sensitivity. Interestingly, PPE17 could discriminate LTBI positive subjects from the QFT-negative subjects (P < 0.001). Our study hints that PPE17 may be used as a novel serodiagnostic marker to screen the latently infected subjects and may also be used as a complimentary tool to the QFT–GIT.

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December 2018
1 Read

The N-terminal domain of Mycobacterium tuberculosis PPE17 (Rv1168c) protein plays a dominant role in inducing antibody responses in active TB patients.

PLoS One 2017 26;12(6):e0179965. Epub 2017 Jun 26.

Laboratory of Molecular Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179965PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484515PMC
September 2017
18 Reads
3.234 Impact Factor

The Mycobacterium tuberculosis PPE protein Rv1168c induces stronger B cell response than Rv0256c in active TB patients.

Infect Genet Evol 2016 06 11;40:339-345. Epub 2015 Sep 11.

Laboratory of Molecular Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Gruhakalpa Building, Nampally, Hyderabad 500001, India. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2015.09.005DOI Listing
June 2016
13 Reads
1 Citation
3.020 Impact Factor

Mycobacterium tuberculosis PPE protein Rv0256c induces strong B cell response in tuberculosis patients.

Infect Genet Evol 2014 Mar 2;22:244-9. Epub 2013 Jul 2.

Laboratory of Molecular Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Gruhakalpa Building, Nampally, Hyderabad 500001, India. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2013.06.023DOI Listing
March 2014
16 Reads
3.020 Impact Factor

Prevalence of Mycobacterium tuberculosis with multiple copies of IS6110 elements in Gulbarga, South India.

Int J Mycobacteriol 2013 Dec 12;2(4):237-9. Epub 2013 Oct 12.

Department of Microbiology, Gulbarga University, Gulbarga 585 106, India. Electronic address:

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http://dx.doi.org/10.1016/j.ijmyco.2013.09.003DOI Listing
December 2013
15 Reads

A review on peripheral blood CD4+ T lymphocyte counts in healthy adult Indians.

Indian J Med Res 2010 Dec;132:667-75

National AIDS Research Institute (ICMR), Pune, India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102453PMC
December 2010
7 Reads
1.661 Impact Factor

Top co-authors

Sangita Mukhopadhyay
Sangita Mukhopadhyay

Laboratory of Molecular Cell Biology

3
Gaddam Suman Latha
Gaddam Suman Latha

Bhagwan Mahavir Medical Research Center

2
Channappa T Shivannavar
Channappa T Shivannavar

Gulbarga University

1
Ashwini Shete
Ashwini Shete

National AIDS Research Institute

1
Ramesh Paranjape
Ramesh Paranjape

National AIDS Research Institute

1
Madhuri Thakar
Madhuri Thakar

National AIDS Research Institute

1
Channappa Shivannavar
Channappa Shivannavar

Gulbarga University

1
Atul Udgata
Atul Udgata

Laboratory of Molecular Cell Biology

1