Publications by authors named "Philip Owens"

54Publications

Loss of Myeloid BMPR1a Alters Differentiation and Reduces Mouse Prostate Cancer Growth.

Front Oncol 2020 7;10:357. Epub 2020 Apr 7.

Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2020.00357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154049PMC
April 2020

Myeloid Cell-Derived TGFβ Signaling Regulates ECM Deposition in Mammary Carcinoma via Adenosine-Dependent Mechanisms.

Cancer Res 2020 06 20;80(12):2628-2638. Epub 2020 Apr 20.

Division of Allergy, Pulmonary, Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-19-3954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299805PMC
June 2020

Integrating the immune microenvironment of prostate cancer induced bone disease.

Mol Carcinog 2020 07 31;59(7):822-829. Epub 2020 Mar 31.

Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mc.23192DOI Listing
July 2020

Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients.

J Immunother Cancer 2019 11 8;7(1):293. Epub 2019 Nov 8.

Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-019-0753-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839115PMC
November 2019

Extreme levels of fallout radionuclides and other contaminants in glacial sediment (cryoconite) and implications for downstream aquatic ecosystems.

Sci Rep 2019 08 29;9(1):12531. Epub 2019 Aug 29.

School of Geography, Earth and Environmental Sciences, University of Plymouth, Plymouth, Devon, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-48873-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715685PMC
August 2019

Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER breast cancer.

FASEB J 2019 02 30;33(2):1644-1657. Epub 2018 Aug 30.

Department of Molecular and Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.

View Article

Download full-text PDF

Source
https://www.fasebj.org/doi/10.1096/fj.201801241R
Publisher Site
http://dx.doi.org/10.1096/fj.201801241RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338642PMC
February 2019

Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment.

Biomicrofluidics 2018 May 7;12(3):034102. Epub 2018 May 7.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1063/1.5016433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938175PMC
May 2018

ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation.

Breast Cancer Res 2017 Sep 8;19(1):105. Epub 2017 Sep 8.

Department of Cancer Biology, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Rm 749 Preston Research Building, Nashville, TN, 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13058-017-0893-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591538PMC
September 2017

Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.

Cancer Immunol Res 2017 09 3;5(9):718-729. Epub 2017 Aug 3.

Department of Cancer Biology and the Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University, Nashville, Tennessee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2326-6066.CIR-16-0311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581681PMC
September 2017

Uncertainties in vegetated buffer strip function in controlling phosphorus export from agricultural land in the Canadian prairies.

Environ Sci Pollut Res Int 2017 Aug 22;24(22):18372-18382. Epub 2017 Jun 22.

University of Northern British Columbia, Prince George, BC,, V2N 4Z9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-017-9406-6DOI Listing
August 2017

TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment.

Cold Spring Harb Perspect Biol 2017 May 1;9(5). Epub 2017 May 1.

Department of Cancer Biology and Vanderbilt-Ingram Comprehensive Cancer Center, Nashville, Tennessee 37232.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a022285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411701PMC
May 2017

Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition.

Biochem Soc Trans 2016 08;44(4):1117-34

Department of Medicine, Pharmacology, and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A. Research Medicine, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, U.S.A.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20160069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483997PMC
August 2016

The Bone Microenvironment: a Fertile Soil for Tumor Growth.

Curr Osteoporos Rep 2016 08;14(4):151-8

Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11914-016-0315-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927340PMC
August 2016

Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma.

Neuro Oncol 2016 07 18;18(7):928-38. Epub 2015 Dec 18.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (L.D.H., T.W.A.); Department of Cancer Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee (P.O., H.L.M.); Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee (A.M.); Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee (J.W., L.C.); Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee (C.H.); Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee (C.C.H.); Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center (C.C.H.); Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee (C.C.H.); Research Medicine, Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee (C.C.H.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/nov310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896540PMC
July 2016

Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis.

Oncotarget 2015 Sep;6(26):22890-904

Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.4413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673207PMC
September 2015

Genomic Analysis of the BMP Family in Glioblastomas.

Transl Oncogenomics 2015 15;7:1-9. Epub 2015 Apr 15.

Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/TOG.S22256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406393PMC
May 2015

TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions.

PLoS One 2015 28;10(1):e0117908. Epub 2015 Jan 28.

Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117908PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309578PMC
February 2016

The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.

Breast Cancer Res Treat 2015 Jan 10;149(1):69-79. Epub 2014 Dec 10.

Department of Pharmacology & Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, One Medical Center Dr., Lebanon, NH, 03756, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-014-3201-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302040PMC
January 2015

Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors.

J Immunol 2014 Sep 15;193(6):3155-64. Epub 2014 Aug 15.

Cancer Biology Department, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1400578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157098PMC
September 2014

Individual and cumulative effects of agriculture, forestry and metal mining activities on the metal and phosphorus content of fluvial fine-grained sediment; Quesnel River Basin, British Columbia, Canada.

Sci Total Environ 2014 Oct 6;496:435-442. Epub 2014 Aug 6.

Environmental Science Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia V2N 4Z9, Canada; Quesnel River Research Centre, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia V2N 4Z9, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2014.07.014DOI Listing
October 2014

Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion.

PLoS One 2013 28;8(6):e67533. Epub 2013 Jun 28.

Department of Cancer Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067533PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695869PMC
April 2014

Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties.

J Leukoc Biol 2012 Sep 8;92(3):641-51. Epub 2012 Jun 8.

Department of Cancer Biology, Vanderbilt University School of Medicine and Vanderbilt-Ingram Comprehensive Cancer Center, Nashville, TN 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.1211639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427612PMC
September 2012

Epidermal Smad4 deletion results in aberrant wound healing.

Am J Pathol 2010 Jan 3;176(1):122-33. Epub 2009 Dec 3.

Department of Otolaryngology, Oregon Health Sciences University, Portland, Oregon, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2353/ajpath.2010.090081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797875PMC
January 2010

Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.

Dev Biol 2008 Oct 26;322(1):156-66. Epub 2008 Jul 26.

Department of Otolaryngology, Oregon Health Sciences University, Portland, OR 97239, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2008.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642977PMC
October 2008

The role of Smads in skin development.

J Invest Dermatol 2008 Apr;128(4):783-90

Department of Otolaryngology, Oregon Health Sciences University, Portland Oregon, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.jid.5700969DOI Listing
April 2008

IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.

Proc Natl Acad Sci U S A 2008 Feb 11;105(7):2487-92. Epub 2008 Feb 11.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0712044105
Publisher Site
http://dx.doi.org/10.1073/pnas.0712044105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268163PMC
February 2008

Controls on catchment-scale patterns of phosphorus in soil, streambed sediment, and stream water.

J Environ Qual 2007 May-Jun;36(3):694-708. Epub 2007 Apr 5.

Dep. of Physical Geography, Utrecht Univ., P.O. Box 80 115, 3508 TC Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2134/jeq2006.0175DOI Listing
July 2007

Role of TGF beta-mediated inflammation in cutaneous wound healing.

J Investig Dermatol Symp Proc 2006 Sep;11(1):112-7

Department of Otolaryngology, Oregon Health & Science University, Portland, Oregon 97239, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.jidsymp.5650004DOI Listing
September 2006

Smad7-induced beta-catenin degradation alters epidermal appendage development.

Dev Cell 2006 Sep;11(3):301-12

Department of Otolaryngology, Oregon Health & Science University, Portland, 97239, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2006.06.014DOI Listing
September 2006

Fingerprinting suspended sediment sources in a large urban river system.

Sci Total Environ 2003 Oct;314-316:513-34

Department of Geography, University of Exeter, Exeter, Devon EX4 4RJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0048-9697(03)00071-8DOI Listing
October 2003

PCB congener dynamics in a heavily industrialized river catchment.

Sci Total Environ 2003 Oct;314-316:439-50

Center for Ecology and Hydrology, Monks Wood, Abbots Ripton, Huntingdon, Cambridgeshire PE17 2LS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0048-9697(03)00067-6DOI Listing
October 2003

The phosphorus content of fluvial sediment in rural and industrialized river basins.

Water Res 2002 Feb;36(3):685-701

Department of Geography, School of Geography & Archaeology, University of Exeter, Devon, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0043-1354(01)00247-0DOI Listing
February 2002