Philip M Potter

Philip M Potter

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Philip M Potter

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Inhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition.

Xenobiotica 2019 Apr 30:1-7. Epub 2019 Apr 30.

a Department of Clinical Pharmacy and Translational Science, College of Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA.

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http://dx.doi.org/10.1080/00498254.2019.1612535DOI Listing
April 2019

Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen").

J Nat Prod 2018 11 23;81(11):2410-2418. Epub 2018 Oct 23.

Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00378
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http://dx.doi.org/10.1021/acs.jnatprod.8b00378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263802PMC
November 2018

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping.

RNA 2018 08 29;24(8):1056-1066. Epub 2018 May 29.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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http://dx.doi.org/10.1261/rna.065383.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049506PMC
August 2018

Targeting ALK in pediatric RMS does not induce antitumor activity in vivo.

Cancer Chemother Pharmacol 2018 08 31;82(2):251-263. Epub 2018 May 31.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.

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http://dx.doi.org/10.1007/s00280-018-3615-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054567PMC
August 2018

Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.

Eur J Med Chem 2018 Apr 19;149:79-89. Epub 2018 Feb 19.

Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.02.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863762PMC
April 2018

Selective Inhibitors of Human Liver Carboxylesterase Based on a β-Lapachone Scaffold: Novel Reagents for Reaction Profiling.

J Med Chem 2017 02 7;60(4):1568-1579. Epub 2017 Feb 7.

Department of Chemical Biology and Therapeutics, ‡Department of Structural Biology, St. Jude Children's Research Hospital , Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556379PMC
February 2017

Carboxylesterases: General detoxifying enzymes.

Chem Biol Interact 2016 Nov 15;259(Pt B):327-331. Epub 2016 Feb 15.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985501PMC
November 2016

Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer.

Br J Pharmacol 2016 10 22;173(19):2811-8. Epub 2016 Aug 22.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1111/bph.13553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055134PMC
October 2016

Sudemycin E influences alternative splicing and changes chromatin modifications.

Nucleic Acids Res 2014 Apr 11;42(8):4947-61. Epub 2014 Mar 11.

Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 South Limestone, Lexington, KY 40536, USA, Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA and GenoSplice Technology, Hôpital Saint-Louis, Av Claude Vellefaux, 75010 Paris, France.

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http://dx.doi.org/10.1093/nar/gku151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005683PMC
April 2014

Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs.

Mol Ther Nucleic Acids 2013 Aug 6;2:e113. Epub 2013 Aug 6.

Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital/Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/mtna.2013.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759737PMC
August 2013

Control of RhoA methylation by carboxylesterase I.

J Biol Chem 2013 Jun 8;288(26):19177-83. Epub 2013 May 8.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M113.467407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696689PMC
June 2013

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors.

Chem Biol Interact 2013 Mar 2;203(1):226-30. Epub 2012 Nov 2.

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.cbi.2012.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582710PMC
March 2013

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

Drug Discov Today 2013 Jan 3;18(1-2):43-9. Epub 2012 Aug 3.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.drudis.2012.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596818PMC
January 2013

Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").

J Nat Prod 2013 Jan 3;76(1):36-44. Epub 2013 Jan 3.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/np300628aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556224PMC
January 2013

Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597.

Biochem Pharmacol 2012 Nov 27;84(9):1215-22. Epub 2012 Aug 27.

Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, MS 39762, USA.

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http://dx.doi.org/10.1016/j.bcp.2012.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470872PMC
November 2012

High payload dual therapeutic-imaging nanocarriers for triggered tumor delivery.

Small 2012 Sep 6;8(18):2895-903. Epub 2012 Jul 6.

Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy and Lineberger, Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1002/smll.201200437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817621PMC
September 2012

Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.

J Mol Model 2012 Jun 30;18(6):2869-83. Epub 2011 Nov 30.

Department of Chemistry & Biochemistry, University of Mississippi, University, MS 38677, USA.

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http://dx.doi.org/10.1007/s00894-011-1308-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603365PMC
June 2012

ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.

J Biol Chem 2012 Apr 31;287(16):12679-90. Epub 2012 Jan 31.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1074/jbc.M111.336180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339991PMC
April 2012

Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon.

Toxicol Appl Pharmacol 2012 Jan 4;258(1):145-50. Epub 2011 Nov 4.

Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0041008X1100416
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http://dx.doi.org/10.1016/j.taap.2011.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345137PMC
January 2012

Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles.

Biotechnol Prog 2011 May-Jun;27(3):863-9. Epub 2011 Apr 20.

Dept. of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1002/btpr.604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670151PMC
November 2011

Carboxylesterase inhibitors.

Expert Opin Ther Pat 2011 Aug 24;21(8):1159-71. Epub 2011 May 24.

Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1517/13543776.2011.586339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139797PMC
August 2011

Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.

Bioorg Med Chem 2011 Aug 4;19(15):4635-43. Epub 2011 Jul 4.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1016/j.bmc.2011.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139784PMC
August 2011

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

ACS Chem Biol 2011 Jun 7;6(6):582-9. Epub 2011 Mar 7.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.

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http://dx.doi.org/10.1021/cb100356kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113647PMC
June 2011

Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles.

Biotechnol Prog 2011 May-Jun;27(3):863-9. Epub 2011 Apr 20.

Dept. of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1002/btpr.604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670151PMC
November 2011

Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones.

Biochim Biophys Acta 2011 Jan 29;1811(1):39-45. Epub 2010 Oct 29.

Department of Medicine, University of Toronto, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbalip.2010.10.002DOI Listing
January 2011

Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2.

Chem Res Toxicol 2010 Dec;23(12):1890-904

Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi State, Mississippi 39762, USA.

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http://dx.doi.org/10.1021/tx1002194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065498PMC
December 2010

Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.

J Med Chem 2010 Dec 24;53(24):8709-15. Epub 2010 Nov 24.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm101101qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022373PMC
December 2010

Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme.

Curr Stem Cell Res Ther 2010 Sep;5(3):273-6

Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010-3000, USA.

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September 2010

Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.

Biochim Biophys Acta 2010 Jan 15;1801(1):31-41. Epub 2009 Sep 15.

Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Matthew Ross, P.O. Box 6100, Mississippi State, MS 39762, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S138819810900206
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http://dx.doi.org/10.1016/j.bbalip.2009.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787731PMC
January 2010

In Silico Design and Evaluation of Carboxylesterase Inhibitors.

J Pest Sci (2004) 2010 ;35(3):240-249

Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.

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http://dx.doi.org/10.1584/jpestics.R10-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593733PMC
January 2010

Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants II: role of plasma esterases in drug release.

AAPS J 2009 Mar 19;11(1):120-2. Epub 2009 Feb 19.

Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, North Carolina 27599-3560, USA.

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http://dx.doi.org/10.1208/s12248-009-9086-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664887PMC
March 2009

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.

Bioorg Med Chem 2009 Jan 9;17(1):149-64. Epub 2008 Nov 9.

Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1016/j.bmc.2008.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752023PMC
January 2009

Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.

Biochim Biophys Acta 2008 Oct 5;1781(10):643-54. Epub 2008 Aug 5.

Department of Basic Sciences, Mississippi State University, Mississippi State, MS 39762-6100, USA.

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http://dx.doi.org/10.1016/j.bbalip.2008.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574903PMC
October 2008

Modifications of human carboxylesterase for improved prodrug activation.

Expert Opin Drug Metab Toxicol 2008 Sep;4(9):1153-65

Department of Molecular Pharmacology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1517/17425255.4.9.1153 DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556898PMC
September 2008

Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition.

Biol Chem 2008 Feb;389(2):149-62

Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA.

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http://dx.doi.org/10.1515/BC.2008.017DOI Listing
February 2008

Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.

J Med Chem 2008 Jan 4;51(2):298-304. Epub 2008 Jan 4.

Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.

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http://dx.doi.org/10.1021/jm7011479DOI Listing
January 2008

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Bioorg Med Chem 2007 Jun 12;15(11):3801-17. Epub 2007 Mar 12.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.bmc.2007.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995442PMC
June 2007

Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun.

Biochemistry 2007 May 4;46(17):5063-71. Epub 2007 Apr 4.

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/bi700246nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517171PMC
May 2007

Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases.

Toxicol Appl Pharmacol 2007 May 12;221(1):1-12. Epub 2007 Mar 12.

Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, PO Box 6100 Mississippi State, MS 39762-6100, USA.

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http://dx.doi.org/10.1016/j.taap.2007.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692260PMC
May 2007

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

J Med Chem 2007 Apr 23;50(8):1876-85. Epub 2007 Mar 23.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, and Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi 38677, USA.

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http://dx.doi.org/10.1021/jm061471kDOI Listing
April 2007

Development of a tumor-selective approach to treat metastatic cancer.

PLoS One 2006 Dec 20;1:e23. Epub 2006 Dec 20.

Divisions of Hematology/Hematopoietic Cell Transplantation and Neurosciences, and Department of Professional Education, City of Hope National Medical Center, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762394PMC
December 2006

Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats.

Drug Metab Dispos 2006 Oct 19;34(10):1764-71. Epub 2006 Jul 19.

Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1124/dmd.106.010058DOI Listing
October 2006

Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.

J Mol Biol 2006 Oct 15;363(1):201-14. Epub 2006 Aug 15.

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762004PMC
October 2006

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Mol Cancer Ther 2006 Sep;5(9):2281-8

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105-2794, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-06
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http://dx.doi.org/10.1158/1535-7163.MCT-06-0160DOI Listing
September 2006

Carboxylesterases--detoxifying enzymes and targets for drug therapy.

Curr Med Chem 2006 ;13(9):1045-54

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.2174/092986706776360969DOI Listing
June 2006

Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy.

Mol Cancer Ther 2006 Jun;5(6):1577-84

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-06
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http://dx.doi.org/10.1158/1535-7163.MCT-06-0090DOI Listing
June 2006

Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases.

Biochem Pharmacol 2006 Feb 4;71(5):657-69. Epub 2006 Jan 4.

Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, PO Box 6100 Mississippi State, MS 39762-6100, USA.

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http://dx.doi.org/10.1016/j.bcp.2005.11.020DOI Listing
February 2006

Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice.

Cancer Chemother Pharmacol 2005 Dec 26;56(6):629-36. Epub 2005 May 26.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/s00280-005-1027-yDOI Listing
December 2005

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

Chem Biol Interact 2005 Dec 28;157-158:247-52. Epub 2005 Oct 28.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.cbi.2005.10.033DOI Listing
December 2005

Update on gene therapy approaches for cancer.

Curr Hematol Rep 2005 Jul;4(4):294-9

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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July 2005

Mammalian carboxylesterases: from drug targets to protein therapeutics.

Drug Discov Today 2005 Mar;10(5):313-25

Department of Chemistry, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-3290, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S135964460503383
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http://dx.doi.org/10.1016/S1359-6446(05)03383-0DOI Listing
March 2005

Development of prodrugs for enzyme-mediated, tumor-selective therapy.

Curr Med Chem Anticancer Agents 2005 Mar;5(2):107-13

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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March 2005

Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.

Mol Cancer Ther 2004 Aug;3(8):903-9

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 3810, USA.

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August 2004

Enzyme-prodrug systems: carboxylesterase/CPT-11.

Methods Mol Med 2004 ;90:247-62

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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March 2004

Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.

Biochemistry 2004 Feb;43(7):1874-82

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/bi035586rDOI Listing
February 2004

Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.

Mol Cancer Ther 2003 Nov;2(11):1171-81

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38015, USA.

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November 2003

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.

Mol Pharmacol 2003 Aug;64(2):279-88

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1124/mol.64.2.279DOI Listing
August 2003

Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism.

Bioorg Med Chem 2003 Jul;11(15):3237-44

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1016/s0968-0896(03)00302-xDOI Listing
July 2003

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme.

Nat Struct Biol 2003 May;10(5):349-56

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nsb919DOI Listing
May 2003

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.

Chem Biol 2003 Apr;10(4):341-9

Department of Chemistry, School of Dentistry, University of North Carolina, Chapel Hill, 27599, USA.

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April 2003

p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).

J Pharmacol Exp Ther 2003 Feb;304(2):699-705

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105,USA.

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http://dx.doi.org/10.1124/jpet.102.044149DOI Listing
February 2003

Structural insights into CPT-11 activation by mammalian carboxylesterases.

Nat Struct Biol 2002 May;9(5):337-42

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nsb790DOI Listing
May 2002