Philip M Hopkins

Philip M Hopkins

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Philip M Hopkins

Philip M Hopkins

Publications by authors named "Philip M Hopkins"

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Investigating the genetic susceptibility to exertional heat illness.

J Med Genet 2020 Feb 13. Epub 2020 Feb 13.

Institute of Medical Research at St James's, University of Leeds Faculty of Medicine and Health, Leeds, UK

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http://dx.doi.org/10.1136/jmedgenet-2019-106461DOI Listing
February 2020

Anaphylaxis to sugammadex: should we be concerned by the Japanese experience?

Br J Anaesth 2020 Jan 22. Epub 2020 Jan 22.

Department of Anaesthesia and; Institute of Medical Research at St James's, University of Leeds, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bja.2020.01.003DOI Listing
January 2020

Mission Impossible or Mission Futile?: Estimating Penetrance for Malignant Hyperthermia.

Anesthesiology 2019 11;131(5):957-959

From the Leeds Institute of Medical Research at St. James's, University of Leeds (M.-A.S., P.M.H.) the Malignant Hyperthermia Unit, St. James's University Hospital (P.M.H.), Leeds, United Kingdom.

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http://dx.doi.org/10.1097/ALN.0000000000002884DOI Listing
November 2019

Special Issue on suspected perioperative allergic reactions.

Br J Anaesth 2019 07 30;123(1):1-3. Epub 2019 Apr 30.

Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bja.2019.04.002DOI Listing
July 2019

Thermoregulation and markers of muscle breakdown in malignant hyperthermia susceptible volunteers during an acute heat tolerance test.

J Sci Med Sport 2019 May 23;22(5):586-590. Epub 2018 Nov 23.

Survival and Thermal Medicine Department, Institute of Naval Medicine, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S14402440183049
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http://dx.doi.org/10.1016/j.jsams.2018.11.012DOI Listing
May 2019

Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals.

Br J Anaesth 2019 May 20;122(5):613-621. Epub 2019 Mar 20.

Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1016/j.bja.2019.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972232PMC
May 2019

Propofol infusion syndrome: a structured literature review and analysis of published case reports.

Br J Anaesth 2019 Apr 6;122(4):448-459. Epub 2019 Feb 6.

Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Department of Anaesthesia, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bja.2018.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435842PMC
April 2019

Malignant hyperthermia.

Handb Clin Neurol 2018 ;157:645-661

Malignant Hyperthermia Investigation Unit, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00038-0DOI Listing
March 2019

Succinylcholine and Dantrolene: Inseparable in the Emergency Cupboard?

Authors:
Philip M Hopkins

Anesthesiology 2019 01;130(1):6-8

From the Malignant Hyperthermia Unit, St. James's University Hospital, Leeds, United Kingdom; and the Institute of Medical Research at St. James's, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1097/ALN.0000000000002507DOI Listing
January 2019

Updated guide for the management of malignant hyperthermia.

Can J Anaesth 2018 06 29;65(6):709-721. Epub 2018 Mar 29.

Department of Anaesthesia, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1007/s12630-018-1108-0DOI Listing
June 2018

Malignant Hyperthermia in the Post-Genomics Era: New Perspectives on an Old Concept.

Anesthesiology 2018 01;128(1):168-180

From the Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada (S.R., N.K.); and the Department of Anaesthesia, University of Leeds, Leeds, United Kingdom (P.M.H.).

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http://Insights.ovid.com/crossref?an=00000542-201801000-0003
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http://dx.doi.org/10.1097/ALN.0000000000001878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726912PMC
January 2018

Aging Effects of Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations.

G3 (Bethesda) 2017 05 5;7(5):1451-1461. Epub 2017 May 5.

School of Biology, Faculty of Biological Sciences, University of Leeds, LS2 9JT, United Kingdom

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http://dx.doi.org/10.1534/g3.117.040535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427508PMC
May 2017

Skeletal Muscle Microalterations in Patients Carrying Malignant Hyperthermia-Related Mutations of the e-c Coupling Machinery.

Eur J Transl Myol 2016 Sep 15;26(4):6105. Epub 2016 Sep 15.

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine , Philadelphia PA, USA.

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http://dx.doi.org/10.4081/ejtm.2016.6105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220216PMC
September 2016

Incidence of suspected perioperative anaphylaxis: A multicenter snapshot study.

J Allergy Clin Immunol Pract 2015 May-Jun;3(3):454-5.e1. Epub 2015 Feb 14.

Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1016/j.jaip.2014.12.016DOI Listing
February 2016

In Reply.

Anesthesiology 2016 Feb;124(2):511

Leeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, Leeds, United Kingdom (P.M.H.).

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http://dx.doi.org/10.1097/ALN.0000000000000980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363266PMC
February 2016

Next-generation Sequencing of RYR1 and CACNA1S in Malignant Hyperthermia and Exertional Heat Illness.

Anesthesiology 2015 May;122(5):1033-46

From the Leeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, Leeds, United Kingdom (D.F., M.-A.S., I.M.C., P.M.H.); Malignant Hyperthermia Investigation Unit, St. James's University Hospital, Leeds, United Kingdom (D.F., M.-A.S., N.A.F., P.K.G., E.J.W., P.M.H.); Environmental Medicine and Science Division, Institute of Naval Medicine, Alverstoke, Hampshire, United Kingdom (D.R.d.S.); and Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington (J.H.K.).

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https://insights.ovid.com/crossref?an=00000542-201505000-000
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http://dx.doi.org/10.1097/ALN.0000000000000610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472733PMC
May 2015

RYR1-related malignant hyperthermia with marked cerebellar involvement - a paradigm of heat-induced CNS injury?

Neuromuscul Disord 2015 Feb 31;25(2):138-40. Epub 2014 Oct 31.

Department of Paediatric Neurology, Neuromuscular Service, Evelina's Children Hospital, Guy's & St. Thomas' Hospital NHS Foundation Trust, London, UK; Randall Division of Cell and Molecular Biophysics, Muscle Signalling Section, King's College, London, UK; Department of Clinical and Basic Neuroscience, IoPPN, King's College, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2014.10.008DOI Listing
February 2015

Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families.

Anesthesiology 2013 Nov;119(5):1054-65

* Assistant Professor, Department of Anesthesiology and Pain Medicine, † Professor, ‡ Associate Professor, § Biostatistician, Department of Medicine, Division of Medical Genetics, ‖ Graduate Student, # Research Professor, ** Research Scientist, †† Professor, Department of Genome Sciences, University of Washington, Seattle, Washington. ‡‡ Research Scientist, §§ Professor, Leeds Institute of Molecular Medicine, Leeds, United Kingdom.

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http://dx.doi.org/10.1097/ALN.0b013e3182a8a998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115638PMC
November 2013

Application of the continual reassessment method to dose-finding studies in regional anesthesia: an estimate of the ED95 dose for 0.5% bupivacaine for ultrasound-guided supraclavicular block.

Anesthesiology 2013 Jul;119(1):29-35

Section of Translational Anaesthetic and Surgical Sciences, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1097/ALN.0b013e31829764cfDOI Listing
July 2013

Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.

Proc Natl Acad Sci U S A 2012 May 30;109(20):7923-8. Epub 2012 Apr 30.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1119207109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356662PMC
May 2012

Store-operated Ca2+ entry in malignant hyperthermia-susceptible human skeletal muscle.

J Biol Chem 2010 Aug 21;285(33):25645-53. Epub 2010 Jun 21.

Institute of Membrane and Systems Biology, University of Leeds, Leeds LS29JT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.104976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919128PMC
August 2010

TNF-alpha and IL-1beta increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes.

Cell Calcium 2010 Apr 12;47(4):378-86. Epub 2010 Mar 12.

Multidisciplinary Cardiovascular Research Centre, Institute of Membrane and Systems Biology, University of Leeds, Leeds LS29JT, UK.

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http://dx.doi.org/10.1016/j.ceca.2010.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877880PMC
April 2010

Core myopathies and risk of malignant hyperthermia.

Anesth Analg 2009 Oct;109(4):1167-73

Department of Anaesthesiology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1213/ANE.0b013e3181b5ae2dDOI Listing
October 2009

The role of CACNA1S in predisposition to malignant hyperthermia.

BMC Med Genet 2009 Oct 13;10:104. Epub 2009 Oct 13.

MH Investigation Unit, Academic Unit of Anaesthesia, St James's University Hospital, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1186/1471-2350-10-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770053PMC
October 2009

Antagonistic actions of halothane and sevoflurane on spontaneous Ca2+ release in rat ventricular myocytes.

Anesthesiology 2006 Jul;105(1):58-64

Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, UK.

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http://dx.doi.org/10.1097/00000542-200607000-00013DOI Listing
July 2006

Nitrous oxide: a unique drug of continuing importance for anaesthesia.

Authors:
Philip M Hopkins

Best Pract Res Clin Anaesthesiol 2005 Sep;19(3):381-9

Academic Unit of Anaesthesia, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1016/j.bpa.2005.03.002DOI Listing
September 2005

The effects of halothane, isoflurane, and sevoflurane on Ca2+ current and transient outward K+ current in subendocardial and subepicardial myocytes from the rat left ventricle.

Anesth Analg 2004 Dec;99(6):1615-22, table of contents

School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1213/01.ANE.0000138422.40560.A9DOI Listing
December 2004

Mutation analysis of two patients with hypokalemic periodic paralysis and suspected malignant hyperthermia.

Muscle Nerve 2004 Jul;30(1):114-7

Malignant Hyperthermia Investigation Unit, Academic Unit of Anesthesia, Level 8 Clinical Sciences Building, St. James University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1002/mus.20068DOI Listing
July 2004

The effects of alfentanil on cytosolic Ca(2+) and contraction in rat ventricular myocytes.

Anesth Analg 2004 Apr;98(4):1013-6, table of contents

School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1213/01.ane.0000104481.20813.35DOI Listing
April 2004

Mg2+ dependence of halothane-induced Ca2+ release from the sarcoplasmic reticulum in rat skeletal muscle.

J Physiol 2003 Sep 8;551(Pt 2):447-54. Epub 2003 Aug 8.

School of Biomedical Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1113/jphysiol.2003.046623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343220PMC
September 2003