Philip Lazarus

Philip Lazarus

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Philip Lazarus

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Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.

Oral Oncol 2019 Jul 17;94:47-57. Epub 2019 May 17.

Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

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http://dx.doi.org/10.1016/j.oraloncology.2019.05.006DOI Listing
July 2019

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.

Cancer Epidemiol Biomarkers Prev 2019 May 30;28(5):935-942. Epub 2019 Jan 30.

Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0356DOI Listing
May 2019

Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors.

Drug Metab Dispos 2019 May 25;47(5):535-544. Epub 2019 Feb 25.

Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana (S.N.L., J.B.L.L., Z.D., B.T.G.) and Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (C.J.W.W., P.L.).

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http://dx.doi.org/10.1124/dmd.118.085035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474910PMC
May 2019

Regulation of UGT2A1 by miR-196a-5p and miR-196b-5p.

J Pharmacol Exp Ther 2019 May 8;369(2):234-243. Epub 2019 Mar 8.

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.25
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http://dx.doi.org/10.1124/jpet.118.255935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439457PMC
May 2019

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget 2019 Mar 5;10(19):1760-1774. Epub 2019 Mar 5.

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.18632/oncotarget.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442994PMC
March 2019

Nicotine-'-Oxidation by Flavin Monooxygenase Enzymes.

Cancer Epidemiol Biomarkers Prev 2019 Feb 31;28(2):311-320. Epub 2018 Oct 31.

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363832PMC
February 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane.

Drug Metab Dispos 2018 12 26;46(12):1867-1878. Epub 2018 Sep 26.

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.L., G.C., Z.X., P.L.); Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania (C.I.T., C.C.B.); and Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin, Heilongjiang, China (S.L.)

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http://dx.doi.org/10.1124/dmd.118.081166DOI Listing
December 2018

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity.

Nat Commun 2018 09 25;9(1):3927. Epub 2018 Sep 25.

International Agency for Research on Cancer, World Health Organization, Lyon, 69372 cedex 08, France.

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http://dx.doi.org/10.1038/s41467-018-05890-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156406PMC
September 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

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http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

Carbonyl Reduction of NNK by Recombinant Human Lung Enzymes. Identification of HSD17β12 as the Reductase important in (R)-NNAL formation in Human Lung.

Carcinogenesis 2018 May 17. Epub 2018 May 17.

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington, United States of America.

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http://dx.doi.org/10.1093/carcin/bgy065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067128PMC
May 2018

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.

Carcinogenesis 2018 03;39(3):336-346

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.1093/carcin/bgx113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248554PMC
March 2018

On meta- and mega-analyses for gene-environment interactions.

Genet Epidemiol 2017 12 7;41(8):876-886. Epub 2017 Nov 7.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1002/gepi.22085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775907PMC
December 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

Exemestane potency is unchanged by common nonsynonymous polymorphisms in CYP19A1: results of a novel anti-aromatase activity assay examining exemestane and its derivatives.

Pharmacol Res Perspect 2017 06 27;5(3):e00313. Epub 2017 Apr 27.

Laboratory of Philip Lazarus Department of Pharmaceutical Sciences Washington State University Spokane Washington.

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http://dx.doi.org/10.1002/prp2.313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464342PMC
June 2017

In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17-dihydroexemestane.

Pharmacol Res Perspect 2017 06 27;5(3):e00314. Epub 2017 Apr 27.

Department of Pharmaceutical Sciences Washington State University Spokane Washington.

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http://dx.doi.org/10.1002/prp2.314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464343PMC
June 2017

Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines.

J Pharmacol Exp Ther 2016 10 29;359(1):182-93. Epub 2016 Jul 29.

National Institute on Aging, National Institutes of Health, Baltimore, Maryland (D.F.D.); Department of Pulmonary Medicine, Penn State University College of Medicine, Hershey, Pennsylvania (F.T.I.); and Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington (A.K.S., G.C., C.W., P.L.)

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034702PMC
http://dx.doi.org/10.1124/jpet.116.235044DOI Listing
October 2016

Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases.

Pharmacogenet Genomics 2016 08;26(8):370-80

aDepartment of Pharmaceutical Sciences, Washington State University, Spokane, Washington bPennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088049PMC
http://dx.doi.org/10.1097/FPC.0000000000000226DOI Listing
August 2016

Association between Glucuronidation Genotypes and Urinary NNAL Metabolic Phenotypes in Smokers.

Cancer Epidemiol Biomarkers Prev 2016 07 9;25(7):1175-1184. Epub 2016 May 9.

Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane WA 99210.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087993PMC
http://dx.doi.org/10.1158/1055-9965.EPI-15-1245DOI Listing
July 2016

Adult Behavior in Male Mice Exposed to E-Cigarette Nicotine Vapors during Late Prenatal and Early Postnatal Life.

PLoS One 2015 15;10(9):e0137953. Epub 2015 Sep 15.

Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Julius B. Richmond Center of Excellence, American Academy of Pediatrics, Elk Grove Village, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137953PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570802PMC
May 2016

Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks.

Cancers (Basel) 2015 Dec 9;7(4):2386-96. Epub 2015 Dec 9.

Department of Public Health Sciences, Penn State University College of Medicine, 500 University Drive, CH69, Hershey, PA 17033, USA.

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http://dx.doi.org/10.3390/cancers7040898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695898PMC
December 2015

Stereospecific Metabolism of the Tobacco-Specific Nitrosamine, NNAL.

Chem Res Toxicol 2015 Nov 28;28(11):2112-9. Epub 2015 Oct 28.

Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University , Spokane, Washington 99202, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.5b00278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281438PMC
November 2015

No Association Between Vitamin D Intake, VDR Polymorphisms, and Colorectal Cancer in a Population-Based Case-Control Study.

Cancer Epidemiol Biomarkers Prev 2015 Oct 29;24(10):1635-7. Epub 2015 Jul 29.

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-0284DOI Listing
October 2015

Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction.

Drug Metab Dispos 2015 Sep 12;43(9):1353-9. Epub 2015 Jun 12.

Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., A.G.V., P.L.), College of Pharmacy, Washington State University, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina (N.H.O.)

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http://dx.doi.org/10.1124/dmd.115.065086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855PMC
September 2015

MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors.

Drug Metab Rev 2015 08 20;47(3):320-34. Epub 2015 Aug 20.

b Department of Pharmaceutical Sciences , Washington State University , Spokane , WA , USA.

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http://dx.doi.org/10.3109/03602532.2015.1076438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309899PMC
August 2015

NNK reduction pathway gene polymorphisms and risk of lung cancer.

Mol Carcinog 2015 Jun 29;54 Suppl 1:E94-E102. Epub 2014 Jun 29.

Molecular Epidemiology and Cancer Control Program, Penn State Cancer Institute, Hershey, Pennsylvania.

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http://dx.doi.org/10.1002/mc.22187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296469PMC
June 2015

CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.

J Natl Cancer Inst 2015 May 14;107(5). Epub 2015 Apr 14.

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital

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http://dx.doi.org/10.1093/jnci/djv100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822525PMC
May 2015

Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries.

Int J Cancer 2015 Mar 23;136(5):1125-39. Epub 2014 Aug 23.

Glasgow Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1002/ijc.29063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531373PMC
March 2015

Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium.

Int J Epidemiol 2015 Feb 22;44(1):169-85. Epub 2015 Jan 22.

Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre

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http://dx.doi.org/10.1093/ije/dyu255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339764PMC
February 2015

Education and lung cancer among never smokers.

Epidemiology 2014 Nov;25(6):934-5

INSERM, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health, Paris, France Inserm U1018, Center for Epidemiology and Population Health, Villejuif, France Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany The University of Liverpool Cancer Research Centre, Institute of Translational Medicine, Liverpool, United Kingdom Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain Karmanos Cancer Institute, Wayne State University, Detroit, MI Saw Swee Hock School of Public Health, National University of Singapore, Singapore Dan L. Duncan Cancer Center, Houston, TX Departamento de Medicina, University of Oviedo, Campus del Cristo s/n, Oviedo, Asturias, Spain Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA Inserm U1085, Irset, 97110 Pointe-à-Pitre, Guadeloupe, French West Indies,

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http://dx.doi.org/10.1097/EDE.0000000000000183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246199PMC
November 2014

Identification of diet-derived constituents as potent inhibitors of intestinal glucuronidation.

Drug Metab Dispos 2014 Oct 9;42(10):1675-83. Epub 2014 Jul 9.

Section of Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., P.L.), Washington State University College of Pharmacy, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)

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http://dx.doi.org/10.1124/dmd.114.059451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164973PMC
October 2014

UGT2B gene expression analysis in multiple tobacco carcinogen-targeted tissues.

Drug Metab Dispos 2014 Apr 23;42(4):529-36. Epub 2014 Jan 23.

Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania (N.R.J.); and Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington (P.L.).

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http://dx.doi.org/10.1124/dmd.113.054718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965906PMC
April 2014

Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p.

J Pharmacol Exp Ther 2014 Mar 7;348(3):465-77. Epub 2014 Jan 7.

Departments of Pharmacology (D.F.D., D.S., N.J., R.T.B., G.P.R., P.L.) and Public Health Sciences (A.C.S.), Penn State University College of Medicine, Hershey, Pennsylvania; and Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington (P.L.).

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http://dx.doi.org/10.1124/jpet.113.210658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935146PMC
March 2014

Association of marijuana smoking with oropharyngeal and oral tongue cancers: pooled analysis from the INHANCE consortium.

Cancer Epidemiol Biomarkers Prev 2014 Jan 18;23(1):160-71. Epub 2013 Dec 18.

Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville; Johns Hopkins School of Medicine; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Department of Community Health, School of Medicine, Brown University, Providence, Rhode Island; International Agency of Research on Cancer; Hospices Civils de Lyon, Pole Information Medicale Evaluation Recherche; Universite Lyon 1, Equipe d'Accueil 4129; International Prevention Research Institute, Lyon, France; Fred Hutchinson Cancer Research Cancer, Seattle, Washington; University of Iowa College of Public Health, Iowa City, Iowa; School of Public Health, University of North Carolina, Chapel Hill, North Carolina; Department of Head and Neck Surgery and Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas; UCLA School of Public Health, Los Angeles, California; Departments of Epidemiology and Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan; Penn State College of Medicine, Hershey, Pennsylvania; Boston University School of Public Health, Boston, Massachusetts; Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo; Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro; Universidade Federal de Pelotas, Pelotas; Hospital de Clinicas de Porto Alegre, Port Alegre, Brazil; Institute Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina; Institute of Oncology and Radiobiology, Havana, Cuba; The Tisch Cancer Institute Mount Sinai School of Medicine, New York, New York; and University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947141PMC
January 2014

Meat-related compounds and colorectal cancer risk by anatomical subsite.

Nutr Cancer 2013 ;65(2):202-26

Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1080/01635581.2013.756534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584417PMC
December 2013

Association of dietary and supplemental iron and colorectal cancer in a population-based study.

Eur J Cancer Prev 2013 Nov;22(6):506-11

aDepartment of Nutritional Sciences, Pennsylvania State University, University Park bNortheast Regional Cancer Institute, Scranton Departments of cPublic Health Sciences dPharmacology, Pennsylvania State College of Medicine, Hershey eDepartment of Medicine, Lehigh Valley Hospital, Allentown, Pennsylvania fDepartment of Health Sciences, Exponent Inc., Chicago, Illinois gDepartment of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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November 2013

A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers.

Mol Carcinog 2013 Oct 18;52(10):791-9. Epub 2012 May 18.

Department of Public Health Sciences, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1002/mc.21923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595361PMC
October 2013

Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study.

Genes Chromosomes Cancer 2013 Oct 26;52(10):945-53. Epub 2013 Jul 26.

Department of Nutritional Sciences, Pennsylvania State University, College of Health and Human Development, State College, PA, USA.

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http://doi.wiley.com/10.1002/gcc.22089
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October 2013

The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk.

Cancer 2013 Jul 10;119(13):2477-85. Epub 2013 Apr 10.

Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1002/cncr.28009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686841PMC
July 2013

Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo.

Cancer Prev Res (Phila) 2013 Jul 16;6(7):719-30. Epub 2013 May 16.

Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057281PMC
July 2013

Importance of UDP-glucuronosyltransferases 2A2 and 2A3 in tobacco carcinogen metabolism.

Drug Metab Dispos 2013 Jan 18;41(1):170-9. Epub 2012 Oct 18.

Department of Pharmacology, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1124/dmd.112.049171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533432PMC
January 2013

Identification and functional characterization of a novel UDP-glucuronosyltransferase 2A1 splice variant: potential importance in tobacco-related cancer susceptibility.

J Pharmacol Exp Ther 2012 Dec 13;343(3):712-24. Epub 2012 Sep 13.

Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1124/jpet.112.198770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500542PMC
December 2012

Quantification of Hepatic UDP glucuronosyltransferase 1A splice variant expression and correlation of UDP glucuronosyltransferase 1A1 variant expression with glucuronidation activity.

J Pharmacol Exp Ther 2012 Sep 1;342(3):720-9. Epub 2012 Jun 1.

Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1124/jpet.112.192658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422519PMC
September 2012

Glucuronidation of trans-3'-hydroxycotinine by UGT2B17 and UGT2B10.

Pharmacogenet Genomics 2012 Mar;22(3):183-90

Departments of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32834ff3a5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275669PMC
March 2012

Phenylbutyl isoselenocyanate modulates phase I and II enzymes and inhibits 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induced DNA adducts in mice.

Cancer Prev Res (Phila) 2011 Nov 27;4(11):1884-94. Epub 2011 Jul 27.

Penn State Milton S. Hershey Medical Center, Department of Pharmacology, Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, CH72, 500 University Drive, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208061PMC
November 2011

Olanzapine metabolism and the significance of UGT1A448V and UGT2B1067Y variants.

Pharmacogenet Genomics 2011 Sep;21(9):539-51

Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1097/FPC.0b013e328348c76bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281394PMC
September 2011

Characterization of dibenzo[a,l]pyrene-trans-11,12-diol (dibenzo[def,p]chrysene) glucuronidation by UDP-glucuronosyltransferases.

Chem Res Toxicol 2011 Sep 5;24(9):1549-59. Epub 2011 Aug 5.

Molecular Epidemiology and Cancer Control Program, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1021/tx200178vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177992PMC
September 2011

A GAG trinucleotide-repeat polymorphism in the gene for glutathione biosynthetic enzyme, GCLC, affects gene expression through translation.

FASEB J 2011 Jul 28;25(7):2180-7. Epub 2011 Mar 28.

Penn State Cancer Institute, Penn State University College of Medicine, 500 University Dr., Hershey, PA 17033, USA.

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http://dx.doi.org/10.1096/fj.10-174011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114536PMC
July 2011

Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population.

Cancer Epidemiol 2011 Apr 21;35(2):175-81. Epub 2010 Sep 21.

Molecular Epidemiology and Cancer Control Programs, Penn State Hershey Cancer Institute, Penn State College of Medicine, 500 University Drive, Hershey, PA, USA.

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http://dx.doi.org/10.1016/j.canep.2010.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081042PMC
April 2011

A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.

Cancer Epidemiol Biomarkers Prev 2011 Apr 18;20(4):658-64. Epub 2011 Feb 18.

International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France.

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http://dx.doi.org/10.1158/1055-9965.EPI-10-1008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070066PMC
April 2011

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

Authors:
James D McKay Therese Truong Valerie Gaborieau Amelie Chabrier Shu-Chun Chuang Graham Byrnes David Zaridze Oxana Shangina Neonila Szeszenia-Dabrowska Jolanta Lissowska Peter Rudnai Eleonora Fabianova Alexandru Bucur Vladimir Bencko Ivana Holcatova Vladimir Janout Lenka Foretova Pagona Lagiou Dimitrios Trichopoulos Simone Benhamou Christine Bouchardy Wolfgang Ahrens Franco Merletti Lorenzo Richiardi Renato Talamini Luigi Barzan Kristina Kjaerheim Gary J Macfarlane Tatiana V Macfarlane Lorenzo Simonato Cristina Canova Antonio Agudo Xavier Castellsagué Ray Lowry David I Conway Patricia A McKinney Claire M Healy Mary E Toner Ariana Znaor Maria Paula Curado Sergio Koifman Ana Menezes Victor Wünsch-Filho José Eluf Neto Leticia Fernández Garrote Stefania Boccia Gabriella Cadoni Dario Arzani Andrew F Olshan Mark C Weissler William K Funkhouser Jingchun Luo Jan Lubiński Joanna Trubicka Marcin Lener Dorota Oszutowska Stephen M Schwartz Chu Chen Sherianne Fish David R Doody Joshua E Muscat Philip Lazarus Carla J Gallagher Shen-Chih Chang Zuo-Feng Zhang Qingyi Wei Erich M Sturgis Li-E Wang Silvia Franceschi Rolando Herrero Karl T Kelsey Michael D McClean Carmen J Marsit Heather H Nelson Marjorie Romkes Shama Buch Tomoko Nukui Shilong Zhong Martin Lacko Johannes J Manni Wilbert H M Peters Rayjean J Hung John McLaughlin Lars Vatten Inger Njølstad Gary E Goodman John K Field Triantafillos Liloglou Paolo Vineis Francoise Clavel-Chapelon Domenico Palli Rosario Tumino Vittorio Krogh Salvatore Panico Carlos A González J Ramón Quirós Carmen Martínez Carmen Navarro Eva Ardanaz Nerea Larrañaga Kay-Tee Khaw Timothy Key H Bas Bueno-de-Mesquita Petra H M Peeters Antonia Trichopoulou Jakob Linseisen Heiner Boeing Göran Hallmans Kim Overvad Anne Tjønneland Merethe Kumle Elio Riboli Kristjan Välk Tõnu Vooder Tõnu Voodern Andres Metspalu Diana Zelenika Anne Boland Marc Delepine Mario Foglio Doris Lechner Hélène Blanché Ivo G Gut Pilar Galan Simon Heath Mia Hashibe Richard B Hayes Paolo Boffetta Mark Lathrop Paul Brennan

PLoS Genet 2011 Mar 17;7(3):e1001333. Epub 2011 Mar 17.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.plos.org/10.1371/journal.pgen.1001333
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http://dx.doi.org/10.1371/journal.pgen.1001333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060072PMC
March 2011

Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis.

Pharmacogenet Genomics 2011 Feb;21(2):55-65

Molecular Epidemiology and Cancer Control Program, Penn State Cancer Institute, Department of Pharmacology, Penn State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1097/FPC.0b013e328341db05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019304PMC
February 2011

Sex differences in UDP-glucuronosyltransferase 2B17 expression and activity.

Drug Metab Dispos 2010 Dec 1;38(12):2204-9. Epub 2010 Sep 1.

Department of Pharmacology, Penn State College of Medicine, 500 University Drive, CH69, Hershey, PA 17033, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.110.035345
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http://dx.doi.org/10.1124/dmd.110.035345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993461PMC
December 2010

Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics.

Pharmacogenet Genomics 2010 Oct;20(10):575-85

Molecular Epidemiology and Cancer Control, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32833b04afDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076703PMC
October 2010

Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms.

Cancer Res 2010 Oct 28;70(19):7543-52. Epub 2010 Sep 28.

Molecular Epidemiology and Cancer Control Program, Penn State Cancer Institute, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998997PMC
October 2010

Differential repair of polycyclic aromatic hydrocarbon DNA adducts from an actively transcribed gene.

DNA Repair (Amst) 2010 Sep 14;9(9):1011-6. Epub 2010 Jul 14.

Department of Biochemistry & Molecular Biology, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1016/j.dnarep.2010.06.004DOI Listing
September 2010

Dietary patterns and colorectal adenoma and cancer risk: a review of the epidemiological evidence.

Nutr Cancer 2010 ;62(4):413-24

The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

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http://dx.doi.org/10.1080/01635580903407114DOI Listing
August 2010

A disequilibrium model for detecting genetic mutations for cancer.

J Theor Biol 2010 Aug 5;265(3):218-24. Epub 2010 May 5.

Center for Statistical Genetics, Pennsylvania State University, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1016/j.jtbi.2010.04.019DOI Listing
August 2010

FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma.

Cancer Res 2010 Aug 14;70(15):6205-15. Epub 2010 Jul 14.

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4008DOI Listing
August 2010

Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.

J Natl Cancer Inst 2010 Jul 14;102(13):959-71. Epub 2010 Jun 14.

Genetic Epidemiology Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon Cedex 08, France.

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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djq178
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897877PMC
July 2010

Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors.

Drug Metab Rev 2010 Feb;42(1):182-94

Departments of Pharmacology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.3109/03602530903208652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072888PMC
February 2010