Publications Authored by Philip L De Jager

Early complement genes are associated with visual system degeneration in multiple sclerosis.

Authors:

Kathryn C Fitzgerald Kicheol Kim Matthew D Smith Sean A Aston Nicholas Fioravante Alissa M Rothman Stephen Krieger Stacey S Cofield Dorlan J Kimbrough Pavan Bhargava Shiv Saidha Katharine A Whartenby Ari J Green Ellen M Mowry Gary R Cutter Fred D Lublin Sergio E Baranzini Philip L De Jager Peter A Calabresi

Brain 2019 Sep;142(9):2722-2736

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/brain/awz188	DOI Listing

September 2019

Using Transcriptomic Hidden Variables to Infer Context-Specific Genotype Effects in the Brain.

Authors:

Bernard Ng William Casazza Ellis Patrick Shinya Tasaki Gherman Novakovsky Daniel Felsky Yiyi Ma David A Bennett Chris Gaiteri Philip L De Jager Sara Mostafavi

Am J Hum Genet 2019 Sep 22;105(3):562-572. Epub 2019 Aug 22.

Department of Statistics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada; Canadian Institute for Advanced Research, Child and Brain Development Program, Toronto M5G 1M1, Canada. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.ajhg.2019.07.016	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731371	PMC

September 2019

Sex differences in the genetic predictors of Alzheimer's pathology.

Brain 2019 Sep;142(9):2581-2589

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/brain/awz206	DOI Listing

September 2019

Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics.

Authors:

Chris Gaiteri Robert Dawe Sara Mostafavi Katherine D Blizinsky Shinya Tasaki Vitalina Komashko Lei Yu Yanling Wang Julie A Schneider Konstantinos Arfanakis Philip L De Jager David A Bennett

Brain Imaging Behav 2019 Aug;13(4):963-972

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

View Article

Download full-text PDF	Source
http://link.springer.com/10.1007/s11682-018-9910-4	Publisher Site
http://dx.doi.org/10.1007/s11682-018-9910-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309607	PMC

August 2019

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.

Authors:

Yiyi Ma Gyungah R Jun Jaeyoon Chung Xiaoling Zhang Brian W Kunkle Adam C Naj Charles C White David A Bennett Philip L De Jager Richard Mayeux Jonathan L Haines Margaret A Pericak-Vance Gerard D Schellenberg Lindsay A Farrer Kathryn L Lunetta

Aging Cell 2019 Aug 29;18(4):e12964. Epub 2019 May 29.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1111/acel.12964	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612647	PMC

August 2019

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits.

Authors:

Sini Nagpal Xiaoran Meng Michael P Epstein Lam C Tsoi Matthew Patrick Greg Gibson Philip L De Jager David A Bennett Aliza P Wingo Thomas S Wingo Jingjing Yang

Am J Hum Genet 2019 Aug 20;105(2):258-266. Epub 2019 Jun 20.

Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.ajhg.2019.05.018	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698804	PMC

August 2019

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.

Authors:

Sven J van der Lee Maria J Knol Ganesh Chauhan Claudia L Satizabal Albert Vernon Smith Edith Hofer Joshua C Bis Derrek P Hibar Saima Hilal Erik B van den Akker Konstantinos Arfanakis Manon Bernard Lisa R Yanek Najaf Amin Fabrice Crivello Josh W Cheung Tamara B Harris Yasaman Saba Oscar L Lopez Shuo Li Jeroen van der Grond Lei Yu Tomas Paus Gennady V Roshchupkin Philippe Amouyel Neda Jahanshad Kent D Taylor Qiong Yang Rasika A Mathias Stefan Boehringer Bernard Mazoyer Ken Rice Ching Yu Cheng Pauline Maillard Diana van Heemst Tien Yin Wong Wiro J Niessen Alexa S Beiser Marian Beekman Wanting Zhao Paul A Nyquist Christopher Chen Lenore J Launer Bruce M Psaty M Kamran Ikram Meike W Vernooij Helena Schmidt Zdenka Pausova Diane M Becker Philip L De Jager Paul M Thompson Cornelia M van Duijn David A Bennett P Eline Slagboom Reinhold Schmidt W T Longstreth M Arfan Ikram Sudha Seshadri Stéphanie Debette Vilmundur Gudnason Hieab H H Adams Charles DeCarli

Commun Biol 2019 2;2:285. Epub 2019 Aug 2.

49Department of Neurology and Center for Neuroscience, University of California at Davis, Davis, CA 95817 USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s42003-019-0537-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677735	PMC

August 2019

Cognition may link cortical IGFBP5 levels with motor function in older adults.

Authors:

Aron S Buchman Lei Yu Vladislav A Petyuk Chris Gaiteri Shinya Tasaki Katherine D Blizinsky Julie A Schneider Philip L De Jager David A Bennett

PLoS One 2019 12;14(8):e0220968. Epub 2019 Aug 12.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.

View Article

Download full-text PDF	Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220968	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690580	PMC

August 2019

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions.

Authors:

Calvin Park Gerald Ponath Maya Levine-Ritterman Edward Bull Eric C Swanson Philip L De Jager Benjamin M Segal David Pitt

Acta Neuropathol Commun 2019 Aug 12;7(1):130. Epub 2019 Aug 12.

Department of Neurology, Yale School of Medicine, 300 George Street, Suite 353I, New Haven, CT, 06511, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1186/s40478-019-0779-2	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689891	PMC

August 2019

cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.

Authors:

Shamsideen A Ojelade Tom V Lee Nikolaos Giagtzoglou Lei Yu Berrak Ugur Yarong Li Lita Duraine Zhongyuan Zuo Vlad Petyuk Philip L De Jager David A Bennett Benjamin R Arenkiel Hugo J Bellen Joshua M Shulman

Cell Rep 2019 Aug;28(7):1799-1813.e5

Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.celrep.2019.07.041	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703184	PMC

August 2019

The Impact of MRI T1 Hypointense Brain Lesions on Cerebral Deep Gray Matter Volume Measures in Multiple Sclerosis.

Authors:

Korhan Buyukturkoglu Enricomaria Mormina Philip L De Jager Claire S Riley Victoria M Leavitt

J Neuroimaging 2019 Jul 20;29(4):458-462. Epub 2019 Mar 20.

Translational Cognitive Neuroscience Laboratory, Department of Neurology, Columbia University Irving Medical Center, New York, NY.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1111/jon.12611	DOI Listing

July 2019

Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease.

Authors:

Lei Yu Vladislav A Petyuk Shinya Tasaki Patricia A Boyle Chris Gaiteri Julie A Schneider Philip L De Jager David A Bennett

JAMA Neurol 2019 Jul;76(7):818-826

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1001/jamaneurol.2019.0834	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583061	PMC

July 2019

Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.

Genes Brain Behav 2019 07 4;18(6):e12579. Epub 2019 Jun 4.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1111/gbb.12579	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612573	PMC

July 2019

Nuclei multiplexing with barcoded antibodies for single-nucleus genomics.

Authors:

Jellert T Gaublomme Bo Li Cristin McCabe Abigail Knecht Yiming Yang Eugene Drokhlyansky Nicholas Van Wittenberghe Julia Waldman Danielle Dionne Lan Nguyen Philip L De Jager Bertrand Yeung Xinfang Zhao Naomi Habib Orit Rozenblatt-Rosen Aviv Regev

Nat Commun 2019 07 2;10(1):2907. Epub 2019 Jul 2.

Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-019-10756-2	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606589	PMC

July 2019

Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer's disease.

Authors:

Emily R Mahoney Logan Dumitrescu Annah M Moore Francis E Cambronero Philip L De Jager Mary Ellen I Koran Vladislav A Petyuk Renã A S Robinson Sandeep Goyal Julie A Schneider David A Bennett Angela L Jefferson Timothy J Hohman

Mol Psychiatry 2019 Jul 22. Epub 2019 Jul 22.

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41380-019-0458-5	DOI Listing

July 2019

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease.

Authors:

Saranya Canchi Balaji Raao Deborah Masliah Sara Brin Rosenthal Roman Sasik Kathleen M Fisch Philip L De Jager David A Bennett Robert A Rissman

Cell Rep 2019 Jul;28(4):1103-1116.e4

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.celrep.2019.06.073	DOI Listing

July 2019

Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline.

Authors:

Namhee Kim Lei Yu Robert Dawe Vladislav A Petyuk Chris Gaiteri Philip L De Jager Julie A Schneider Konstantinos Arfanakis David A Bennett

Neurobiol Aging 2019 Jul 26;84:17-25. Epub 2019 Jul 26.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.neurobiolaging.2019.07.013	DOI Listing

July 2019

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.

JAMA Neurol 2019 Jun 10. Epub 2019 Jun 10.

Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1001/jamaneurol.2019.1456	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563544	PMC

June 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Authors:

Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Simone Reppermund Steffi G Riedel-Heller Richard J Rose Jerome I Rotter Panos Roussos Suvi P Rovio Yasaman Saba Fred W Sabb Perminder S Sachdev Claudia L Satizabal Matthias Schmid Rodney J Scott Matthew A Scult Jeannette Simino P Eline Slagboom Nikolaos Smyrnis Aïcha Soumaré Nikos C Stefanis David J Stott Richard E Straub Kjetil Sundet Adele M Taylor Kent D Taylor Ioanna Tzoulaki Christophe Tzourio André Uitterlinden Veronique Vitart Aristotle N Voineskos Jaakko Kaprio Michael Wagner Holger Wagner Leonie Weinhold K Hoyan Wen Elisabeth Widen Qiong Yang Wei Zhao Hieab H H Adams Dan E Arking Robert M Bilder Panos Bitsios Eric Boerwinkle Ornit Chiba-Falek Aiden Corvin Philip L De Jager Stéphanie Debette Gary Donohoe Paul Elliott Annette L Fitzpatrick Michael Gill David C Glahn Sara Hägg Narelle K Hansell Ahmad R Hariri M Kamran Ikram J Wouter Jukema Eero Vuoksimaa Matthew C Keller William S Kremen Lenore Launer Ulman Lindenberger Aarno Palotie Nancy L Pedersen Neil Pendleton David J Porteous Katri Räikkönen Olli T Raitakari Alfredo Ramirez Ivar Reinvang Igor Rudan Dan Rujescu Reinhold Schmidt Helena Schmidt Peter W Schofield Peter R Schofield John M Starr Vidar M Steen Julian N Trollor Steven T Turner Cornelia M Van Duijn Arno Villringer Daniel R Weinberger David R Weir James F Wilson Anil Malhotra Andrew M McIntosh Catharine R Gale Sudha Seshadri Thomas H Mosley Jan Bressler Todd Lencz Ian J Deary

Nat Commun 2019 May 1;10(1):2068. Epub 2019 May 1.

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-019-10160-w	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494826	PMC

May 2019

Complex Neurological Phenotype in Female Carriers of Mutations.

Authors:

Matthew F Pescosolido Brian C Kavanaugh Nathalie Pochet Michael Schmidt Beth A Jerskey Jeffrey M Rogg Philip L De Jager Tracy L Young-Pearse Judy S Liu Eric M Morrow

Mol Neuropsychiatry 2019 Apr 6;5(2):98-108. Epub 2019 Mar 6.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1159/000496341	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528080	PMC

April 2019

Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis.

Authors:

Sarah E Sullivan Meichen Liao Robert V Smith Charles White Valentina N Lagomarsino Jishu Xu Mariko Taga David A Bennett Philip L De Jager Tracy L Young-Pearse

Hum Mol Genet 2019 Mar;28(5):718-735

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF	Source
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg	Publisher Site
http://dx.doi.org/10.1093/hmg/ddy376	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381320	PMC

March 2019

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.

Alzheimers Dement 2019 01 15;15(1):76-92. Epub 2018 Oct 15.

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.jalz.2018.07.217	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487485	PMC

January 2019

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.

Authors:

Hans-Ulrich Klein Cristin McCabe Elizabeta Gjoneska Sarah E Sullivan Belinda J Kaskow Anna Tang Robert V Smith Jishu Xu Andreas R Pfenning Bradley E Bernstein Alexander Meissner Julie A Schneider Sara Mostafavi Li-Huei Tsai Tracy L Young-Pearse David A Bennett Philip L De Jager

Nat Neurosci 2019 01 17;22(1):37-46. Epub 2018 Dec 17.

Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41593-018-0291-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516529	PMC

January 2019

Correction: Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.

Mol Psychiatry 2019 Jan 15. Epub 2019 Jan 15.

Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41380-019-0348-x	DOI Listing

January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:

Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1212/WNL.0000000000006851	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905	PMC

January 2019

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain.

Authors:

Daniel Felsky Tina Roostaei Kwangsik Nho Shannon L Risacher Elizabeth M Bradshaw Vlad Petyuk Julie A Schneider Andrew Saykin David A Bennett Philip L De Jager

Nat Commun 2019 01 24;10(1):409. Epub 2019 Jan 24.

Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, New York, NY, 10032, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-018-08279-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345810	PMC

January 2019

An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.

J Alzheimers Dis 2019 ;68(3):1161-1170

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

View Article

Download full-text PDF	Source
https://www.medra.org/servlet/aliasResolver?alias=iospress&a	Publisher Site
http://dx.doi.org/10.3233/JAD-180788	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571137	PMC

January 2019

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.

Authors:

Rebecca G Smith Eilis Hannon Philip L De Jager Lori Chibnik Simon J Lott Daniel Condliffe Adam R Smith Vahram Haroutunian Claire Troakes Safa Al-Sarraj David A Bennett John Powell Simon Lovestone Leonard Schalkwyk Jonathan Mill Katie Lunnon

Alzheimers Dement 2018 12 15;14(12):1580-1588. Epub 2018 Mar 15.

Institute of Clinical and Biomedical Science, University of Exeter Medical School, RILD Building, Royal Devon & Exeter Hospital Campus, Exeter, Devon, UK. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.jalz.2018.01.017	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438205	PMC

December 2018

Sex-specific genetic predictors of Alzheimer's disease biomarkers.

Acta Neuropathol 2018 12 2;136(6):857-872. Epub 2018 Jul 2.

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 1207 17th Avenue S, Nashville, TN, 37212, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/s00401-018-1881-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280657	PMC

December 2018

Reproductive period and epigenetic modifications of the oxidative phosphorylation pathway in the human prefrontal cortex.

Authors:

Riley M Bove Ellis Patrick Cristin McCabe Aubin Gyan Srivastava Julie A Schneider David A Bennett Philip L De Jager Lori B Chibnik

PLoS One 2018 27;13(7):e0199073. Epub 2018 Jul 27.

Harvard Medical School, Boston, MA, United States of America.

View Article

Download full-text PDF	Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199073	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063396	PMC

December 2018

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection.

Genome Res 2018 12 16;28(12):1812-1825. Epub 2018 Nov 16.

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.

View Article

Download full-text PDF	Source
http://genome.cshlp.org/lookup/doi/10.1101/gr.240390.118	Publisher Site
http://dx.doi.org/10.1101/gr.240390.118	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280757	PMC

December 2018

Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.

Mol Psychiatry 2018 Dec 4. Epub 2018 Dec 4.

Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41380-018-0298-8	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548676	PMC

December 2018

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.

Authors:

Towfique Raj Yang I Li Garrett Wong Jack Humphrey Minghui Wang Satesh Ramdhani Ying-Chih Wang Bernard Ng Ishaan Gupta Vahram Haroutunian Eric E Schadt Tracy Young-Pearse Sara Mostafavi Bin Zhang Pamela Sklar David A Bennett Philip L De Jager

Nat Genet 2018 11 8;50(11):1584-1592. Epub 2018 Oct 8.

Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41588-018-0238-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354244	PMC

November 2018

Deconstructing and targeting the genomic architecture of human neurodegeneration.

Authors:

Philip L De Jager Hyun-Sik Yang David A Bennett

Nat Neurosci 2018 10 26;21(10):1310-1317. Epub 2018 Sep 26.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41593-018-0240-z	DOI Listing

October 2018

The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia.

Authors:

Shinya Tasaki Chris Gaiteri Sara Mostafavi Philip L De Jager David A Bennett

Front Neurosci 2018 8;12:699. Epub 2018 Oct 8.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.3389/fnins.2018.00699	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187226	PMC

October 2018

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study.

Authors:

Hyun-Sik Yang Lei Yu Charles C White Lori B Chibnik Jasmeer P Chhatwal Reisa A Sperling David A Bennett Julie A Schneider Philip L De Jager

Lancet Neurol 2018 09 6;17(9):773-781. Epub 2018 Aug 6.

The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/S1474-4422(18)30251-5	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154505	PMC

September 2018

Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.

Authors:

Andrew S P Lim Chris Gaiteri Lei Yu Shahmir Sohail Walter Swardfager Shinya Tasaki Julie A Schneider Claire Paquet Donald T Stuss Mario Masellis Sandra E Black Jacques Hugon Aron S Buchman Lisa L Barnes David A Bennett Philip L De Jager

PLoS Med 2018 09 4;15(9):e1002647. Epub 2018 Sep 4.

Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, United States of America.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1371/journal.pmed.1002647	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122787	PMC

September 2018

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.

Authors:

Dina Vojinovic Hieab H Adams Xueqiu Jian Qiong Yang Albert Vernon Smith Joshua C Bis Alexander Teumer Markus Scholz Nicola J Armstrong Edith Hofer Yasaman Saba Michelle Luciano Manon Bernard Stella Trompet Jingyun Yang Nathan A Gillespie Sven J van der Lee Alexander Neumann Shahzad Ahmad Ole A Andreassen David Ames Najaf Amin Konstantinos Arfanakis Mark E Bastin Diane M Becker Alexa S Beiser Frauke Beyer Henry Brodaty R Nick Bryan Robin Bülow Anders M Dale Philip L De Jager Ian J Deary Charles DeCarli Debra A Fleischman Rebecca F Gottesman Jeroen van der Grond Vilmundur Gudnason Tamara B Harris Georg Homuth David S Knopman John B Kwok Cora E Lewis Shuo Li Markus Loeffler Oscar L Lopez Pauline Maillard Hanan El Marroun Karen A Mather Thomas H Mosley Ryan L Muetzel Matthias Nauck Paul A Nyquist Matthew S Panizzon Zdenka Pausova Bruce M Psaty Ken Rice Jerome I Rotter Natalie Royle Claudia L Satizabal Reinhold Schmidt Peter R Schofield Pamela J Schreiner Stephen Sidney David J Stott Anbupalam Thalamuthu Andre G Uitterlinden Maria C Valdés Hernández Meike W Vernooij Wei Wen Tonya White A Veronica Witte Katharina Wittfeld Margaret J Wright Lisa R Yanek Henning Tiemeier William S Kremen David A Bennett J Wouter Jukema Tomas Paus Joanna M Wardlaw Helena Schmidt Perminder S Sachdev Arno Villringer Hans Jörgen Grabe W T Longstreth Cornelia M van Duijn Lenore J Launer Sudha Seshadri M Arfan Ikram Myriam Fornage

Nat Commun 2018 09 26;9(1):3945. Epub 2018 Sep 26.

The University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-018-06234-w	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158214	PMC

September 2018

A scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks.

Authors:

Amar Dhand Charles C White Catherine Johnson Zongqi Xia Philip L De Jager

Nat Commun 2018 09 26;9(1):3930. Epub 2018 Sep 26.

Broad Institute, Program in Medical and Population Genetics, Cambridge, 02142, MA, USA.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-06408-6	Publisher Site
http://dx.doi.org/10.1038/s41467-018-06408-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158181	PMC

September 2018

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.

JAMA Neurol 2018 Aug;75(8):989-998

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1001/jamaneurol.2018.0821	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142927	PMC

August 2018

Genetic determinants of co-accessible chromatin regions in activated T cells across humans.

Nat Genet 2018 08 9;50(8):1140-1150. Epub 2018 Jul 9.

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41588-018-0156-2	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097927	PMC

August 2018

Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis.

Nat Genet 2018 08 16;50(8):1081-1085. Epub 2018 Jul 16.

Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41588-018-0168-y	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513312	PMC

August 2018

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research.

Authors:

Philip L De Jager Yiyi Ma Cristin McCabe Jishu Xu Badri N Vardarajan Daniel Felsky Hans-Ulrich Klein Charles C White Mette A Peters Ben Lodgson Parham Nejad Anna Tang Lara M Mangravite Lei Yu Chris Gaiteri Sara Mostafavi Julie A Schneider David A Bennett

Sci Data 2018 08 7;5:180142. Epub 2018 Aug 7.

Rush Alzehimer Disease Center, RUSH University, 600 South Paulina Street, Chicago IL 60612, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/sdata.2018.142	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080491	PMC

August 2018

Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline.

Authors:

Shinya Tasaki Chris Gaiteri Sara Mostafavi Lei Yu Yanling Wang Philip L De Jager David A Bennett

Front Genet 2018 9;9:294. Epub 2018 Aug 9.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.

View Article

Download full-text PDF	Source
https://www.frontiersin.org/article/10.3389/fgene.2018.00294	Publisher Site
http://dx.doi.org/10.3389/fgene.2018.00294	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095043	PMC

August 2018

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.

Authors:

Lei Yu Vladislav A Petyuk Chris Gaiteri Sara Mostafavi Tracy Young-Pearse Raj C Shah Aron S Buchman Julie A Schneider Paul D Piehowski Ryan L Sontag Thomas L Fillmore Tujin Shi Richard D Smith Philip L De Jager David A Bennett

Ann Neurol 2018 07 3;84(1):78-88. Epub 2018 Jul 3.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/ana.25266	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119500	PMC

July 2018

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.

Authors:

Daniel Felsky Ellis Patrick Julie A Schneider Sara Mostafavi Chris Gaiteri Nikolaos Patsopoulos David A Bennett Philip L De Jager

Mol Neurodegener 2018 07 24;13(1):38. Epub 2018 Jul 24.

Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, PH 19 - 302, New York, NY, 10032, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1186/s13024-018-0272-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057096	PMC

July 2018

ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.

Authors:

Shahram Oveisgharan Aron S Buchman Lei Yu Jose Farfel Vladimir Hachinski Chris Gaiteri Philip L De Jager Julie A Schneider David A Bennett

Neurology 2018 06 11;90(24):e2127-e2134. Epub 2018 May 11.

From Rush Alzheimer's Disease Center (S.O., A.S.B., L.Y., J.F., C.G., J.A.S., D.A.B.) and Departments of Neurological Sciences (A.S.B., L.Y., J.A.S., D.A.B.) and Pathology (J.F., J.A.S.), Rush University Medical Center, Chicago, IL; Shariati Hospital (S.O.), Tehran University of Medical Sciences, Iran; Department of Geriatrics (J.F.), University of Sao Paulo Medical School, Brazil; University Hospital (V.H.), University of Western Ontario, London, Canada; Broad Institute (P.L.D.J.), Cambridge, MA; Center for Translational & Systems Neuroimmunology (P.L.D.J.), Department of Neurology, Columbia University Medical Center, New York, NY.

View Article

Download full-text PDF	Source
http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000	Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000005677	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996834	PMC

June 2018

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.

Nat Neurosci 2018 06 25;21(6):811-819. Epub 2018 May 25.

Broad Institute, Cambridge, MA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41593-018-0154-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599633	PMC

June 2018

Tau Activates Transposable Elements in Alzheimer's Disease.

Authors:

Caiwei Guo Hyun-Hwan Jeong Yi-Chen Hsieh Hans-Ulrich Klein David A Bennett Philip L De Jager Zhandong Liu Joshua M Shulman

Cell Rep 2018 06;23(10):2874-2880

Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.celrep.2018.05.004	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181645	PMC

June 2018

Is the goal of an epigenomic study to determine causality?

Authors:

Philip L De Jager

Mult Scler 2018 06;24(7):908-909

Center for Translational and Computational Neuro-immunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA/Cell Circuits Program, Broad Institute, Cambridge, MA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1177/1352458517750771	DOI Listing

June 2018

Analysis of shared heritability in common disorders of the brain.

Authors:

Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell J Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1126/science.aap8757	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237	PMC

June 2018

A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.

Authors:

Xulong Wang Vivek M Philip Guruprasad Ananda Charles C White Ankit Malhotra Paul J Michalski Krishna R Murthy Karuturi Sumana R Chintalapudi Casey Acklin Michael Sasner David A Bennett Philip L De Jager Gareth R Howell Gregory W Carter

Genetics 2018 05 5;209(1):51-64. Epub 2018 Mar 5.

The Jackson Laboratory for Mammalian Genetics, Bar Harbor, Maine 04609

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1534/genetics.117.300673	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937180	PMC

May 2018

Evaluating the role of genetic variation in the epigenome in health and disease.

Authors:

Tina Roostaei Philip L De Jager

Mult Scler 2018 05;24(6):707-709

Center for Translational and Computational Neuro-immunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA/Cell Circuits Program, Broad Institute, Cambridge, MA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1177/1352458517751651	DOI Listing

May 2018

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Authors:

Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Simone Reppermund Steffi G Riedel-Heller Richard J Rose Jerome I Rotter Panos Roussos Suvi P Rovio Yasaman Saba Fred W Sabb Perminder S Sachdev Claudia L Satizabal Matthias Schmid Rodney J Scott Matthew A Scult Jeannette Simino P Eline Slagboom Nikolaos Smyrnis Aïcha Soumaré Nikos C Stefanis David J Stott Richard E Straub Kjetil Sundet Adele M Taylor Kent D Taylor Ioanna Tzoulaki Christophe Tzourio André Uitterlinden Veronique Vitart Aristotle N Voineskos Jaakko Kaprio Michael Wagner Holger Wagner Leonie Weinhold K Hoyan Wen Elisabeth Widen Qiong Yang Wei Zhao Hieab H H Adams Dan E Arking Robert M Bilder Panos Bitsios Eric Boerwinkle Ornit Chiba-Falek Aiden Corvin Philip L De Jager Stéphanie Debette Gary Donohoe Paul Elliott Annette L Fitzpatrick Michael Gill David C Glahn Sara Hägg Narelle K Hansell Ahmad R Hariri M Kamran Ikram J Wouter Jukema Eero Vuoksimaa Matthew C Keller William S Kremen Lenore Launer Ulman Lindenberger Aarno Palotie Nancy L Pedersen Neil Pendleton David J Porteous Katri Räikkönen Olli T Raitakari Alfredo Ramirez Ivar Reinvang Igor Rudan Dan Rujescu Reinhold Schmidt Helena Schmidt Peter W Schofield Peter R Schofield John M Starr Vidar M Steen Julian N Trollor Steven T Turner Cornelia M Van Duijn Arno Villringer Daniel R Weinberger David R Weir James F Wilson Anil Malhotra Andrew M McIntosh Catharine R Gale Sudha Seshadri Thomas H Mosley Jan Bressler Todd Lencz Ian J Deary

Nat Commun 2018 05 29;9(1):2098. Epub 2018 May 29.

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-018-04362-x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974083	PMC

May 2018

Designing an epigenomic study.

Authors:

Yiyi Ma Philip L De Jager

Mult Scler 2018 04;24(5):604-609

Center for Translational and Computational Neuro-immunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA/Cell Circuits Program, Broad Institute, Cambridge, MA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1177/1352458517750770	DOI Listing

April 2018

How do we measure the epigenome(s)?

Authors:

Hans-Ulrich Klein Philip L De Jager

Mult Scler 2018 04;24(4):446-448

Center for Translational and Computational Neuro-immunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA/Cell Circuits Program, Broad Institute, Cambridge, MA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1177/1352458517750772	DOI Listing

April 2018

The era of GWAS is over - No.

Authors:

Philip L De Jager

Mult Scler 2018 03 18;24(3):258-260. Epub 2017 Dec 18.

Multiple Sclerosis Center, Department of Neurology, Columbia University Medical Center, New York, NY, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1177/1352458517742980	DOI Listing

March 2018

What is the epigenome and is it involved in multiple sclerosis?

Authors:

Ji Y Lee Philip L De Jager

Mult Scler 2018 03;24(3):268-269

Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA/Center for Cell Circuits, Broad Institute, Cambridge, MA, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1177/1352458517750769	DOI Listing

March 2018

Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.

Authors:

Michiko Sekiya Minghui Wang Naoki Fujisaki Yasufumi Sakakibara Xiuming Quan Michelle E Ehrlich Philip L De Jager David A Bennett Eric E Schadt Sam Gandy Kanae Ando Bin Zhang Koichi M Iijima

Genome Med 2018 03 29;10(1):26. Epub 2018 Mar 29.

Department of Alzheimer's Disease Research, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, 474-8511, Japan.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1186/s13073-018-0530-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875009	PMC

March 2018

Genetic influence of plasma homocysteine on Alzheimer's disease.

Authors:

Tina Roostaei Daniel Felsky Arash Nazeri Philip L De Jager Julie A Schneider David A Bennett Aristotle N Voineskos

Neurobiol Aging 2018 02 13;62:243.e7-243.e14. Epub 2017 Oct 13.

Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Underserved Populations Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.033	DOI Listing

February 2018

A transcriptomic atlas of aged human microglia.

Nat Commun 2018 02 7;9(1):539. Epub 2018 Feb 7.

Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, NY, 10032, USA.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-02926-5	Publisher Site
http://dx.doi.org/10.1038/s41467-018-02926-5	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803269	PMC

February 2018

Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex.

Authors:

Turhan Canli Lei Yu Xiaoqing Yu Hongyu Zhao Debra Fleischman Robert S Wilson Philip L De Jager David A Bennett

Transl Psychiatry 2018 01 10;8(1). Epub 2018 Jan 10.

Rush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41398-017-0086-2	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802527	PMC

January 2018

MS genetic risk promotes IFNγ CD4 T cells.

Authors:

Belinda J Kaskow Thomas S Buttrick Hans-Ulrich Klein Charles White Justin R Bourgeois Russell J Ferland Nikolaos Patsopoulos Elizabeth M Bradshaw Philip L De Jager Wassim Elyaman

Neurol Neuroimmunol Neuroinflamm 2018 Jan 8;5(1):e414. Epub 2017 Dec 8.

Ann Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1212/NXI.0000000000000414	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778810	PMC

January 2018

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.

Mol Neurobiol 2017 Dec 23;54(10):8021-8032. Epub 2016 Nov 23.

Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. P.O. Box 12233, Mail drop A3-05, Research Triangle Park, NC, 27709, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/s12035-016-0282-8	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441979	PMC

December 2017

Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.

Authors:

Lei Yu Michael W Lutz Jose M Farfel Robert S Wilson Daniel K Burns Ann M Saunders Philip L De Jager Lisa L Barnes Julie A Schneider David A Bennett

Alzheimers Dement 2017 Dec 15;13(12):1380-1388. Epub 2017 Jun 15.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.jalz.2017.05.002	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723540	PMC

December 2017

Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.

Authors:

Lei Yu Robert J Dawe Patricia A Boyle Chris Gaiteri Jingyun Yang Aron S Buchman Julie A Schneider Konstantinos Arfanakis Philip L De Jager David A Bennett

JAMA Neurol 2017 12;74(12):1473-1480

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

View Article

Download full-text PDF	Source
http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam	Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2017.2807	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729739	PMC

December 2017

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.

Authors:

Katie J Ryan Charles C White Kruti Patel Jishu Xu Marta Olah Joseph M Replogle Michael Frangieh Maria Cimpean Phoebe Winn Allison McHenry Belinda J Kaskow Gail Chan Nicole Cuerdon David A Bennett Justin D Boyd Jaime Imitola Wassim Elyaman Philip L De Jager Elizabeth M Bradshaw

Sci Transl Med 2017 Dec;9(421)

Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1126/scitranslmed.aai7635	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945290	PMC

December 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:

M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-017-01008-2	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783	PMC

November 2017

Genetic epistasis regulates amyloid deposition in resilient aging.

Authors:

Daniel Felsky Jishu Xu Lori B Chibnik Julie A Schneider Jo Knight James L Kennedy David A Bennett Philip L De Jager Aristotle N Voineskos

Alzheimers Dement 2017 Oct 17;13(10):1107-1116. Epub 2017 Mar 17.

Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.jalz.2017.01.027	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601013	PMC

October 2017

APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.

Authors:

Lei Yu Michael W Lutz Robert S Wilson Daniel K Burns Allen D Roses Ann M Saunders Jingyun Yang Chris Gaiteri Philip L De Jager Lisa L Barnes David A Bennett

PLoS One 2017 3;12(7):e0180356. Epub 2017 Jul 3.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.

View Article

Download full-text PDF	Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180356	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495438	PMC

October 2017

Ultra-rare mutations in segregate in Caribbean Hispanic families with Alzheimer disease.

Authors:

Badri N Vardarajan Giuseppe Tosto Roger Lefort Lei Yu David A Bennett Philip L De Jager Sandra Barral Dolly Reyes-Dumeyer Peter L Nagy Joseph H Lee Rong Cheng Martin Medrano Rafael Lantigua Ekaterina Rogaeva Peter St George-Hyslop Richard Mayeux

Neurol Genet 2017 Oct 24;3(5):e178. Epub 2017 Aug 24.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain (B.N.V., G.T., R. Lefort, P.L.D.J., S.B., D.R.-D., J.H.L., R.C., R. Lantigua, R.M.); Gertrude H. Sergievsky Center (B.N.V., G.T., S.B., D.R.-D., J.H.L., R.C., R.M.); Department of Neurology (P.L.D.J., S.B., R.M.), Department of Psychiatry (R.M.), Department of Systems Biology (B.N.V.), Department of Medicine (R. Lantigua), and Department of Pathology and Cell Biology (R. Lefort, P.L.N.), College of Physicians and Surgeons, Columbia University, New York Presbyterian Hospital; Department of Epidemiology (J.H.L., R.M.), School of Public Health, Columbia University, New York; Tanz Centre for Research in Neurodegenerative Diseases (E.R., P.S.G.-H.) and Department of Medicine (E.R., P.S.G.-H.), University of Toronto, Krembil Discovery Tower, ON, Canada; Department of Clinical Neurosciences (P.S.G.-H.), Cambridge Institute for Medical Research, University of Cambridge, UK; Rush Alzheimer's Disease Center (L.Y., D.A.B.), Rush University Medical Center, Chicago, IL; Program in Medical and Population Genetics (P.L.D.J.), Broad Institute, Cambridge, MA; and School of Medicine (M.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1212/NXG.0000000000000178	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570674	PMC

October 2017

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome.

Authors:

Bernard Ng Charles C White Hans-Ulrich Klein Solveig K Sieberts Cristin McCabe Ellis Patrick Jishu Xu Lei Yu Chris Gaiteri David A Bennett Sara Mostafavi Philip L De Jager

Nat Neurosci 2017 Oct 4;20(10):1418-1426. Epub 2017 Sep 4.

Broad Institute, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/nn.4632	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785926	PMC

October 2017

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.

Authors:

Hansruedi Mathys Chinnakkaruppan Adaikkan Fan Gao Jennie Z Young Elodie Manet Martin Hemberg Philip L De Jager Richard M Ransohoff Aviv Regev Li-Huei Tsai

Cell Rep 2017 Oct;21(2):366-380

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.celrep.2017.09.039	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642107	PMC

October 2017

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Authors:

Nese Direk Stephanie Williams Jennifer A Smith Stephan Ripke Tracy Air Azmeraw T Amare Najaf Amin Bernhard T Baune David A Bennett Douglas H R Blackwood Dorret Boomsma Gerome Breen Henriette N Buttenschøn Enda M Byrne Anders D Børglum Enrique Castelao Sven Cichon Toni-Kim Clarke Marilyn C Cornelis Udo Dannlowski Philip L De Jager Ayse Demirkan Enrico Domenici Cornelia M van Duijn Erin C Dunn Johan G Eriksson Tonu Esko Jessica D Faul Luigi Ferrucci Myriam Fornage Eco de Geus Michael Gill Scott D Gordon Hans Jörgen Grabe Gerard van Grootheest Steven P Hamilton Catharina A Hartman Andrew C Heath Karin Hek Albert Hofman Georg Homuth Carsten Horn Jouke Jan Hottenga Sharon L R Kardia Stefan Kloiber Karestan Koenen Zoltán Kutalik Karl-Heinz Ladwig Jari Lahti Douglas F Levinson Cathryn M Lewis Glyn Lewis Qingqin S Li David J Llewellyn Susanne Lucae Kathryn L Lunetta Donald J MacIntyre Pamela Madden Nicholas G Martin Andrew M McIntosh Andres Metspalu Yuri Milaneschi Grant W Montgomery Ole Mors Thomas H Mosley Joanne M Murabito Bertram Müller-Myhsok Markus M Nöthen Dale R Nyholt Michael C O'Donovan Brenda W Penninx Michele L Pergadia Roy Perlis James B Potash Martin Preisig Shaun M Purcell Jorge A Quiroz Katri Räikkönen John P Rice Marcella Rietschel Margarita Rivera Thomas G Schulze Jianxin Shi Stanley Shyn Grant C Sinnamon Johannes H Smit Jordan W Smoller Harold Snieder Toshiko Tanaka Katherine E Tansey Alexander Teumer Rudolf Uher Daniel Umbricht Sandra Van der Auwera Erin B Ware David R Weir Myrna M Weissman Gonneke Willemsen Jingyun Yang Wei Zhao Henning Tiemeier Patrick F Sullivan

Biol Psychiatry 2017 09 8;82(5):322-329. Epub 2016 Dec 8.

Department of Psychiatry, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Psychiatric Genomics, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.biopsych.2016.11.013	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462867	PMC

September 2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:

Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ng.3916	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039	PMC

September 2017

variants are associated with cerebral amyloid angiopathy.

Authors:

Hyun-Sik Yang Charles C White Lori B Chibnik Hans-Ulrich Klein Julie A Schneider David A Bennett Philip L De Jager

Neurol Genet 2017 Aug 18;3(4):e176. Epub 2017 Jul 18.

Departments of Neurology and Psychiatry (H.-S.Y., C.C.W., H.-U.K., P.L.D.J.), Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences; Department of Neurology (H.-S.Y.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital; Harvard Medical School (H.-S.Y., H.-U.K.); Harvard T.H. Chan School of Public Health (L.B.C.), Boston; Program in Medical and Population Genetics (H.-S.Y., C.C.W., L.B.C., H.-U.K., P.L.D.J.), Broad Institute, Cambridge, MA; Rush Alzheimer's Disease Center (J.A.S., D.A.B.) and Department of Neurological Sciences (J.A.S., D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Neurology (P.L.D.J.), Center for Translational & Systems Neuroimmunology, Columbia University Medical Center, New York, NY.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1212/NXG.0000000000000176	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515600	PMC

August 2017

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

Authors:

Ellis Patrick Sathyapriya Rajagopal Hon-Kit Andus Wong Cristin McCabe Jishu Xu Anna Tang Selina H Imboywa Julie A Schneider Nathalie Pochet Anna M Krichevsky Lori B Chibnik David A Bennett Philip L De Jager

Mol Neurodegener 2017 07 1;12(1):51. Epub 2017 Jul 1.

Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA, 02115, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1186/s13024-017-0191-y	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494142	PMC

July 2017

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach.

Authors:

Dan Ben-Avraham David Karasik Joe Verghese Kathryn L Lunetta Jennifer A Smith John D Eicher Rotem Vered Joris Deelen Alice M Arnold Aron S Buchman Toshiko Tanaka Jessica D Faul Maria Nethander Myriam Fornage Hieab H Adams Amy M Matteini Michele L Callisaya Albert V Smith Lei Yu Philip L De Jager Denis A Evans Vilmundur Gudnason Albert Hofman Alison Pattie Janie Corley Lenore J Launer Davis S Knopman Neeta Parimi Stephen T Turner Stefania Bandinelli Marian Beekman Danielle Gutman Lital Sharvit Simon P Mooijaart David C Liewald Jeanine J Houwing-Duistermaat Claes Ohlsson Matthijs Moed Vincent J Verlinden Dan Mellström Jos N van der Geest Magnus Karlsson Dena Hernandez Rebekah McWhirter Yongmei Liu Russell Thomson Gregory J Tranah Andre G Uitterlinden David R Weir Wei Zhao John M Starr Andrew D Johnson M Arfan Ikram David A Bennett Steven R Cummings Ian J Deary Tamara B Harris Sharon L R Kardia Thomas H Mosley Velandai K Srikanth Beverly G Windham Ann B Newman Jeremy D Walston Gail Davies Daniel S Evans Eline P Slagboom Luigi Ferrucci Douglas P Kiel Joanne M Murabito Gil Atzmon

Aging (Albany NY) 2017 07 7;9(7):1844-1846. Epub 2017 Jul 7.

Department of Medicine and Genetics Albert Einstein College of Medicine, Bronx, NY 10461, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.18632/aging.101260	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559176	PMC

July 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:

M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-017-00031-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526	PMC

July 2017

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1.

Authors:

Peter Cronin Michael J McCarthy Andrew S P Lim David P Salmon Douglas Galasko Eliezer Masliah Philip L De Jager David A Bennett Paula Desplats

Alzheimers Dement 2017 Jun 22;13(6):689-700. Epub 2016 Nov 22.

Department of Neurosciences, University of California San Diego, La Jolla, CA, USA; Department of Pathology, University of California San Diego, La Jolla, CA, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.jalz.2016.10.003	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785929	PMC

June 2017

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.

Alzheimers Dement 2017 Jun 8;13(6):663-673. Epub 2016 Dec 8.

Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.jalz.2016.10.005	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462884	PMC

June 2017

A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer's disease.

Authors:

Jinying Zhao Yun Zhu Jingyun Yang Lin Li Hao Wu Philip L De Jager Peng Jin David A Bennett

Alzheimers Dement 2017 Jun 6;13(6):674-688. Epub 2017 Jan 6.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.jalz.2016.10.004	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675576	PMC

June 2017

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.

Acta Neuropathol 2017 05 28;133(5):839-856. Epub 2017 Feb 28.

Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/s00401-017-1685-y	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613285	PMC

May 2017

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types.

Authors:

Sung Chun Alexandra Casparino Nikolaos A Patsopoulos Damien C Croteau-Chonka Benjamin A Raby Philip L De Jager Shamil R Sunyaev Chris Cotsapas

Nat Genet 2017 Apr 20;49(4):600-605. Epub 2017 Feb 20.

Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ng.3795	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374036	PMC

April 2017

Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease.

Authors:

Andrew S P Lim Hans-Ulrich Klein Lei Yu Lori B Chibnik Sanam Ali Jishu Xu David A Bennett Philip L De Jager

Nat Commun 2017 04 3;8:14931. Epub 2017 Apr 3.

Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 168c, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ncomms14931	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382268	PMC

April 2017

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.

Science 2017 04;356(6335)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

View Article

Download full-text PDF	Source
http://www.sciencemag.org/lookup/doi/10.1126/science.aah4573	Publisher Site
http://dx.doi.org/10.1126/science.aah4573	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775029	PMC

April 2017

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.

Authors:

Charles C White Hyun-Sik Yang Lei Yu Lori B Chibnik Robert J Dawe Jingyun Yang Hans-Ulrich Klein Daniel Felsky Alfredo Ramos-Miguel Konstantinos Arfanakis William G Honer Reisa A Sperling Julie A Schneider David A Bennett Philip L De Jager

PLoS Med 2017 04 25;14(4):e1002287. Epub 2017 Apr 25.

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1371/journal.pmed.1002287	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404753	PMC

April 2017

Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members.

Authors:

Zongqi Xia Sonya U Steele Anshika Bakshi Sarah R Clarkson Charles C White Matthew K Schindler Govind Nair Blake E Dewey Lauren R Price Joan Ohayon Lori B Chibnik Irene C M Cortese Philip L De Jager Daniel S Reich

JAMA Neurol 2017 03;74(3):293-300

Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1001/jamaneurol.2016.5056	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348267	PMC

March 2017

Genetic architecture of age-related cognitive decline in African Americans.

Authors:

Towfique Raj Lori B Chibnik Cristin McCabe Andus Wong Joseph M Replogle Lei Yu Sujuan Gao Frederick W Unverzagt Barbara Stranger Jill Murrell Lisa Barnes Hugh C Hendrie Tatiana Foroud Anna Krichevsky David A Bennett Kathleen S Hall Denis A Evans Philip L De Jager

Neurol Genet 2017 Feb 21;3(1):e125. Epub 2016 Dec 21.

Program in Translational NeuroPsychiatric Genomics (T.R., L.B.C., J.M.R., P.L.D.J.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Center for Neurologic Disease (T.R., A.W., A.K., P.L.D.J.), Department of Neurology, and Division of Genetics (T.R., L.B.C., P.L.D.J.), Department of Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School (T.R., L.B.C., P.L.D.J.), Boston, MA; Program in Medical and Population genetics (T.R., L.B.C., C.M., J.M.R., P.L.D.J.), The Broad Institute, Cambridge, MA; Section of Genetic Medicine (B.S.), Department of Medicine, and Institute for Genomics and Systems Biology (B.S.), University of Chicago, IL; Indiana University Center for Aging Research (H.C.H.); Department of Psychiatry (F.W.U., H.C.H., K.S.H.), Department of Biostatistics (S.G.), Indiana University School of Medicine; Department of Medical and Molecular Genetics (J.M., T.F.), Indiana University, Indianapolis; Rush Institute for Healthy Aging (D.A.V.), Department of Internal Medicine, Department of Neurology (L.B., D.A.B.), and Rush Alzheimer's Disease Center (L.Y., L.B., D.A.B.), Rush University Medical Center, Chicago, IL. T.R. is currently affiliated with Ronald M. Loeb Center for Alzheimer's Disease, Departments of Neuroscience, and Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1212/NXG.0000000000000125	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206965	PMC

February 2017

Selection of first-line therapy in multiple sclerosis using risk-benefit decision analysis.

Authors:

David Bargiela Matthew T Bianchi M Brandon Westover Lori B Chibnik Brian C Healy Philip L De Jager Zongqi Xia

Neurology 2017 Feb 13;88(7):677-684. Epub 2017 Jan 13.

From the Ann Romney Center for Neurologic Diseases (D.B., B.C.H., P.L.D.J., Z.X.), Department of Neurology, and Program in Translational Neuropsychiatric Genomics (D.B., P.L.D.J., Z.X.), Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston; Program for Medical and Population Genetics (D.B., L.B.C., P.L.D.J., Z.X.), Broad Institute, Cambridge; Harvard Medical School (D.B., M.T.B., M.B.W., L.B.C., P.L.D.J., Z.X.); Department of Neurology (M.T.B., M.B.W.) and Biostatistics Center (B.C.H.), Massachusetts General Hospital; Harvard T.H. Chan School of Public Health (L.B.C.), Boston, MA; and Department of Neurology (Z.X.), University of Pittsburgh, PA.

View Article

Download full-text PDF	Source
http://www.neurology.org/content/early/2017/01/13/WNL.000000	Web Search
http://dx.doi.org/10.1212/WNL.0000000000003612	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317380	PMC

February 2017

'523 variant and cognitive decline in older persons with ε3/3 genotype.

Authors:

Lei Yu Michael W Lutz Robert S Wilson Daniel K Burns Allen D Roses Ann M Saunders Chris Gaiteri Philip L De Jager Lisa L Barnes David A Bennett

Neurology 2017 Feb 20;88(7):661-668. Epub 2017 Jan 20.

From the Rush Alzheimer's Disease Center (L.Y., R.S.W., C.G., L.L.B., D.A.B.) and Department of Neurological Sciences (L.Y., R.S.W., C.G., L.L.B., D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (M.W.L., A.D.R., A.M.S.), Duke University School of Medicine, Durham; Zinfandel Pharmaceuticals, Inc (D.K.B., A.D.R.), Research Triangle Park, NC; Program in Translational NeuroPsychiatric Genomics (P.L.D.), Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School (P.L.D.), Boston; and Program in Medical and Population Genetics (P.L.D.), Broad Institute, Cambridge, MA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1212/WNL.0000000000003614	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317377	PMC

February 2017

The complex genetics of gait speed: genome-wide meta-analysis approach.

Authors:

Dan Ben-Avraham David Karasik Joe Verghese Kathryn L Lunetta Jennifer A Smith John D Eicher Rotem Vered Joris Deelen Alice M Arnold Aron S Buchman Toshiko Tanaka Jessica D Faul Maria Nethander Myriam Fornage Hieab H Adams Amy M Matteini Michele L Callisaya Albert V Smith Lei Yu Philip L De Jager Denis A Evans Vilmundur Gudnason Albert Hofman Alison Pattie Janie Corley Lenore J Launer Davis S Knopman Neeta Parimi Stephen T Turner Stefania Bandinelli Marian Beekman Danielle Gutman Lital Sharvit Simon P Mooijaart David C Liewald Jeanine J Houwing-Duistermaat Claes Ohlsson Matthijs Moed Vincent J Verlinden Dan Mellström Jos N van der Geest Magnus Karlsson Dena Hernandez Rebekah McWhirter Yongmei Liu Russell Thomson Gregory J Tranah Andre G Uitterlinden David R Weir Wei Zhao John M Starr Andrew D Johnson M Arfan Ikram David A Bennett Steven R Cummings Ian J Deary Tamara B Harris Sharon L R Kardia Thomas H Mosley Velandai K Srikanth Beverly G Windham Ann B Newman Jeremy D Walston Gail Davies Daniel S Evans Eline P Slagboom Luigi Ferrucci Douglas P Kiel Joanne M Murabito Gil Atzmon

Aging (Albany NY) 2017 01;9(1):209-246

Department of Medicine and Genetics Albert Einstein College of Medicine, Bronx, NY 10461, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.18632/aging.101151	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310665	PMC

January 2017

Novel genetic loci associated with hippocampal volume.

Authors:

Derrek P Hibar Hieab H H Adams Neda Jahanshad Ganesh Chauhan Jason L Stein Edith Hofer Miguel E Renteria Joshua C Bis Alejandro Arias-Vasquez M Kamran Ikram Sylvane Desrivières Meike W Vernooij Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Ashley H Beecham Alexa Beiser Manon Bernard Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Qiang Chen Christopher R K Ching Vincent Chouraki Gabriel Cuellar-Partida Fabrice Crivello Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Oliver Grimm Michael E Griswold Tulio Guadalupe Boris A Gutman Johanna Hass Unn K Haukvik David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Kjetil N Jørgensen Nazanin Karbalai Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre F Marquand Mar Matarin Karen A Mather Manuel Mattheisen David R McKay Yuri Milaneschi Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Paul Nyquist Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Lukas Pirpamer Benno Pütz Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Stefan Ropele Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Arvin Saremi Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Stella Trompet Dhananjay Vaidya Jeroen Van der Grond Sven J Van der Lee Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Katharina Wittfeld Girma Woldehawariat Christiane Wolf Thomas Wolfers Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Anton J M De Craen Eco J C De Geus Philip L De Jager Greig I De Zubicaray Ian J Deary Stéphanie Debette Charles DeCarli Norman Delanty Chantal Depondt Anita DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Christian Enzinger Susanne Erk Thomas Espeseth Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Myriam Fornage Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Asta K Håberg Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Matthew Huentelman Hilleke E Hulshoff Pol Masashi Ikeda Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Francis J McMahon Katie L McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Helena Schmidt Peter R Schofield Sigurdur Sigursson Andrew Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Arthur W Toga Bryan J Traynor Juan Troncoso Magda Tsolaki Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad van der Lugt Nic J A van der Wee Neeltje E M Van Haren Dennis van 't Ent Marie-Jose Van Tol Badri N Vardarajan Bruno Vellas Dick J Veltman Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright Ronald H Zielke Alan B Zonderman Nicholas G Martin Cornelia M Van Duijn Margaret J Wright W T Longstreth Gunter Schumann Hans J Grabe Barbara Franke Lenore J Launer Sarah E Medland Sudha Seshadri Paul M Thompson M Arfan Ikram

Nat Commun 2017 01 18;8:13624. Epub 2017 Jan 18.

Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ncomms13624	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253632	PMC

January 2017

HLA-C levels impact natural killer cell subset distribution and function.

Authors:

Magdalena Sips Qingquan Liu Monia Draghi Musie Ghebremichael Christoph T Berger Todd J Suscovich Yongtao Sun Bruce D Walker Mary Carrington Marcus Altfeld Peter Brouckaert Philip L De Jager Galit Alter

Hum Immunol 2016 Dec 10;77(12):1147-1153. Epub 2016 Aug 10.

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.humimm.2016.08.004	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684021	PMC

December 2016

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

Authors:

Hieab H H Adams Derrek P Hibar Vincent Chouraki Jason L Stein Paul A Nyquist Miguel E Rentería Stella Trompet Alejandro Arias-Vasquez Sudha Seshadri Sylvane Desrivières Ashley H Beecham Neda Jahanshad Katharina Wittfeld Sven J Van der Lee Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Alexa Beiser Manon Bernard Joshua C Bis Laura M E Blanken Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Ganesh Chauhan Qiang Chen Christopher R K Ching Gabriel Cuellar-Partida Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Irina Filippi Tian Ge Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Corina U Greven Oliver Grimm Michael E Griswold Tulio Guadalupe Johanna Hass Unn K Haukvik Saima Hilal Edith Hofer David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee Jiemin Liao David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre Marquand Mar Matarin Karen A Mather Manuel Mattheisen Bernard Mazoyer David R McKay Rebekah McWhirter Yuri Milaneschi Nazanin Mirza-Schreiber Ryan L Muetzel Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Irene Pappa Lukas Pirpamer Sara Pudas Benno Pütz Kumar B Rajan Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Russell Thomson Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Dhananjay Vaidya Jeroen Van der Grond Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Girma Woldehawariat Christiane Wolf Thomas Wolfers Bing Xu Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Neelum T Aggarwal Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Christopher Chen Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Eco J C De Geus Philip L De Jager Greig I de Zubicaray Norman Delanty Chantal Depondt Anita L DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Susanne Erk Thomas Espeseth Denis A Evans Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Hans J Grabe Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Hilleke E Hulshoff Pol Masashi Ikeda M Kamran Ikram Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo W T Longstreth Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Katie L McMahon Francis J McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Peter R Schofield Sigurdur Sigurdsson Andy Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Velandai Srikanth Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Henning Tiemeier Arthur W Toga Bryan J Traynor Juan Troncoso Jessica A Turner Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad Van der Lugt Nic J A Van der Wee Cornelia M Van Duijn Neeltje E M Van Haren Dennis Van T Ent Marie-Jose Van Tol Badri N Vardarajan Dick J Veltman Meike W Vernooij Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright H Ronald Zielke Alan B Zonderman Ian J Deary Charles DeCarli Helena Schmidt Nicholas G Martin Anton J M De Craen Margaret J Wright Lenore J Launer Gunter Schumann Myriam Fornage Barbara Franke Stéphanie Debette Sarah E Medland M Arfan Ikram Paul M Thompson

Nat Neurosci 2016 12 3;19(12):1569-1582. Epub 2016 Oct 3.

Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/nn.4398	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227112	PMC

December 2016

Gene expression elucidates functional impact of polygenic risk for schizophrenia.

Authors:

Menachem Fromer Panos Roussos Solveig K Sieberts Jessica S Johnson David H Kavanagh Thanneer M Perumal Douglas M Ruderfer Edwin C Oh Aaron Topol Hardik R Shah Lambertus L Klei Robin Kramer Dalila Pinto Zeynep H Gümüş A Ercument Cicek Kristen K Dang Andrew Browne Cong Lu Lu Xie Ben Readhead Eli A Stahl Jianqiu Xiao Mahsa Parvizi Tymor Hamamsy John F Fullard Ying-Chih Wang Milind C Mahajan Jonathan M J Derry Joel T Dudley Scott E Hemby Benjamin A Logsdon Konrad Talbot Towfique Raj David A Bennett Philip L De Jager Jun Zhu Bin Zhang Patrick F Sullivan Andrew Chess Shaun M Purcell Leslie A Shinobu Lara M Mangravite Hiroyoshi Toyoshiba Raquel E Gur Chang-Gyu Hahn David A Lewis Vahram Haroutunian Mette A Peters Barbara K Lipska Joseph D Buxbaum Eric E Schadt Keisuke Hirai Kathryn Roeder Kristen J Brennand Nicholas Katsanis Enrico Domenici Bernie Devlin Pamela Sklar

Nat Neurosci 2016 11 26;19(11):1442-1453. Epub 2016 Sep 26.

Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

View Article

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083142	PMC
http://dx.doi.org/10.1038/nn.4399	DOI Listing

November 2016

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:

Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G William Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 11;48(12):1591

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ng1216-1587b	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509058	PMC

November 2016

Personality Polygenes, Positive Affect, and Life Satisfaction.

Twin Res Hum Genet 2016 10 22;19(5):407-17. Epub 2016 Aug 22.

Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1017/thg.2016.65	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125297	PMC

October 2016

The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.

Authors:

Hans-Ulrich Klein David A Bennett Philip L De Jager

Acta Neuropathol 2016 10 29;132(4):503-14. Epub 2016 Aug 29.

Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, NRB 168, Boston, MA, 02115, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/s00401-016-1612-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189639	PMC

October 2016

Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies.

Neurol Genet 2016 Aug 4;2(4):e87. Epub 2016 Aug 4.

Author affiliations are listed at the end of the article.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1212/NXG.0000000000000087	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974846	PMC

August 2016

Philip L De Jager

Philip L De Jager

Publications by authors named "Philip L De Jager"

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors: