Philip L Cohen

Philip L Cohen

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Philip L Cohen

Philip L Cohen

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Gas6/TAM Receptors in Systemic Lupus Erythematosus.

Dis Markers 2019 9;2019:7838195. Epub 2019 Jul 9.

Division of Immunology, Allergy and Rheumatology, Department of Internal Medicine, College of Medicine, University of Cincinnati, OH 45267, USA.

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http://dx.doi.org/10.1155/2019/7838195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652053PMC
January 2020

Antibody Cross-Linking of CD14 Activates MerTK and Promotes Human Macrophage Clearance of Apoptotic Neutrophils: the Dual Role of CD14 at the Crossroads Between M1 and M2c Polarization.

Inflammation 2018 Dec;41(6):2206-2221

Temple Autoimmunity Center, Temple University, 3500 N. Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s10753-018-0864-xDOI Listing
December 2018

Stat1 Regulates Lupus-like Chronic Graft-versus-Host Disease Severity via Interactions with Stat3.

J Immunol 2015 Nov 21;195(9):4136-43. Epub 2015 Sep 21.

Section of Rheumatology, Department of Medicine, Temple University, Philadelphia, PA 19140; and.

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http://dx.doi.org/10.4049/jimmunol.1501353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610853PMC
November 2015

Comment on "Aminoacyl tRNA Synthetase-Interacting Multifunctional Protein 1 Acts as a Novel B Cell-Activating Factor In Vitro and In Vivo".

Authors:
Philip L Cohen

J Immunol 2015 Aug;195(4):1339

Section of Rheumatology, Temple University School of Medicine, Philadelphia, PA 19140

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http://dx.doi.org/10.4049/jimmunol.1501167DOI Listing
August 2015

Monocyte and plasma expression of TAM ligand and receptor in renal failure: Links to unregulated immunity and chronic inflammation.

Clin Immunol 2015 Jun 24;158(2):231-41. Epub 2015 Mar 24.

Section of Rheumatology, Department of Medicine, Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.clim.2015.01.012DOI Listing
June 2015

The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization.

J Inflamm (Lond) 2015 3;12:36. Epub 2015 May 3.

Temple Autoimmunity Center, Temple University, 3500 N. Broad Street, 19140 Philadelphia, PA USA ; Department of Medicine, Section of Rheumatology, Temple University, 3322 N. Broad Street, 19140 Philadelphia, PA USA.

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http://dx.doi.org/10.1186/s12950-015-0081-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429687PMC
May 2015

The Mertk receptor tyrosine kinase promotes T-B interaction stimulated by IgD B-cell receptor cross-linking.

J Autoimmun 2014 Sep 24;53:78-84. Epub 2014 Apr 24.

Section of Rheumatology, Department of Medicine, Temple University, 3322 N. Broad St., Philadelphia, PA 19140, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411140006
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http://dx.doi.org/10.1016/j.jaut.2014.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162827PMC
September 2014

Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis.

Ann Rheum Dis 2014 May 3;73(5):928-36. Epub 2013 May 3.

Department of Rheumatology and Immunology, Peking University People's Hospital, , Beijing, China.

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http://dx.doi.org/10.1136/annrheumdis-2012-202444DOI Listing
May 2014

The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.

Expert Rev Clin Immunol 2014 May 29;10(5):573-82. Epub 2014 Mar 29.

Department of Medicine and Temple Autoimmunity Center, Section of Rheumatology, Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1586/1744666X.2014.893827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249585PMC
May 2014

IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.

J Immunol 2013 May 17;190(10):5237-46. Epub 2013 Apr 17.

Section of Rheumatology, Department of Medicine, Temple University, Philadelphia, PA 19140, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1203017
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http://dx.doi.org/10.4049/jimmunol.1203017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677729PMC
May 2013

Tuberous sclerosis and fulminant lupus in a young woman.

J Clin Rheumatol 2013 Apr;19(3):134-7

Temple University School of Medicine, Division of Rheumatology, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/RHU.0b013e318289c033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034128PMC
April 2013

Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure.

Nephrol Dial Transplant 2012 Nov 20;27(11):4166-72. Epub 2012 Aug 20.

Section of Nephrology, Hypertension and Kidney Transplantation, Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/ndt/gfs337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494842PMC
November 2012

Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.

J Immunol 2012 Oct 31;189(7):3508-20. Epub 2012 Aug 31.

Section of Rheumatology, Department of Medicine, Temple University, Philadelphia, PA 19140, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1200662
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http://dx.doi.org/10.4049/jimmunol.1200662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465703PMC
October 2012

The T cell in Sjogren's syndrome: force majeure, not spectateur.

J Autoimmun 2012 Sep 17;39(3):229-33. Epub 2012 Jun 17.

Temple University School of Medicine, Section of Rheumatology, 3322 North Broad Street, Suite 205, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.jaut.2012.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428488PMC
September 2012

B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren's syndrome.

J Clin Immunol 2012 Jun 17;32(3):551-64. Epub 2012 Feb 17.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s10875-012-9663-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351565PMC
June 2012

Living life without B cells: is repeated B-cell depletion a safe and effective long-term treatment plan for rheumatoid arthritis?

Int J Clin Rheumtol 2012 Apr;7(2):159-166

Section of Rheumatology, Department of Medicine, Temple University School of Medicine, 3322 North Broad St., Room 205, Philadelphia, PA 19140, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392126PMC
http://dx.doi.org/10.2217/ijr.12.7DOI Listing
April 2012

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.

J Clin Invest 2012 Jan 12;122(1):337-47. Epub 2011 Dec 12.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

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http://dx.doi.org/10.1172/JCI58393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248291PMC
January 2012

Selection of individual VH genes occurs at the pro-B to pre-B cell transition.

J Immunol 2011 Aug 11;187(4):1835-44. Epub 2011 Jul 11.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.1100207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150439PMC
August 2011

Disturbances of apoptotic cell clearance in systemic lupus erythematosus.

Arthritis Res Ther 2011 Feb 28;13(1):202. Epub 2011 Feb 28.

Department of Medicine, Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1186/ar3206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157636PMC
February 2011

TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus.

Arthritis Res Ther 2010 16;12(4):R146. Epub 2010 Jul 16.

Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1186/ar3088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945040PMC
January 2011

Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses.

J Immunol 2010 Nov 15;185(10):5859-68. Epub 2010 Oct 15.

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107-5541, USA.

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http://dx.doi.org/10.4049/jimmunol.1001187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563244PMC
November 2010

A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis.

Clin Immunol 2010 Aug 4;136(2):236-44. Epub 2010 May 4.

Department of Medicine, Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.clim.2010.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902650PMC
August 2010

B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus.

Clin Immunol 2010 Jul 8;136(1):105-15. Epub 2010 Apr 8.

Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.clim.2010.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891082PMC
July 2010

The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells.

Clin Immunol 2009 Oct 24;133(1):138-44. Epub 2009 Jul 24.

Department of Medicine, Division of Rheumatology, Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.clim.2009.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746995PMC
October 2009

Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement.

J Immunol 2009 Jul;183(1):452-61

Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.0804060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700953PMC
July 2009

T cell-independent spontaneous loss of tolerance by anti-double-stranded DNA B cells in C57BL/6 mice.

J Immunol 2008 Dec;181(11):7770-7

Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104-6100, USA.

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http://dx.doi.org/10.4049/jimmunol.181.11.7770DOI Listing
December 2008

B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice.

J Immunol 2008 Sep;181(5):2961-72

Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865432PMC
http://dx.doi.org/10.4049/jimmunol.181.5.2961DOI Listing
September 2008

The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus.

J Immunol 2008 Jun;180(11):7728-35

Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.180.11.7728DOI Listing
June 2008

Accelerated atherosclerosis in ApoE deficient lupus mouse models.

Clin Immunol 2008 May 5;127(2):168-75. Epub 2008 Mar 5.

Divisions of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.clim.2008.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464279PMC
May 2008

Mature B cells preferentially lose tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus.

J Immunol 2007 Oct;179(8):5564-70

Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.179.8.5564DOI Listing
October 2007

Modulation of autoimmunity by TLR9 in the chronic graft-vs-host model of systemic lupus erythematosus.

J Immunol 2006 Nov;177(10):7444-50

Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.4049/jimmunol.177.10.7444DOI Listing
November 2006

Apoptotic cell death and lupus.

Authors:
Philip L Cohen

Springer Semin Immunopathol 2006 Oct 29;28(2):145-52. Epub 2006 Aug 29.

University of Pennsylvania, 421 Curie Boulevard, Suite 757, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00281-006-0038-zDOI Listing
October 2006

Stopping traffic in Sjögren's syndrome.

Authors:
Philip L Cohen

Arthritis Rheum 2006 Apr;54(4):1061-2

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http://dx.doi.org/10.1002/art.21746DOI Listing
April 2006

Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity.

Arthritis Res Ther 2005 6;7(6):R1360-74. Epub 2005 Oct 6.

Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1186/ar1832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297582PMC
January 2006

The role of host CD4 T cells in the pathogenesis of the chronic graft-versus-host model of systemic lupus erythematosus.

J Immunol 2005 Jun;174(12):7600-9

Department of Medicine, Division of Rheumatology, University of Pennsylvania, and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.174.12.7600DOI Listing
June 2005

p53 is required for spontaneous autoantibody production in B6/lpr lupus mice.

Eur J Immunol 2005 May;35(5):1653-60

Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1002/eji.200525982DOI Listing
May 2005

Genetic models for the clearance of apoptotic cells.

Rheum Dis Clin North Am 2004 Aug;30(3):473-86, viii

University of Pennsylvania School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Suite 757, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.rdc.2004.04.003DOI Listing
August 2004

Studies of murine systemic autoimmunity.

Authors:
Philip L Cohen

Immunol Res 2003 ;27(2-3):179-84

University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1385/IR:27:2-3:179DOI Listing
March 2004

Self-arthrocentesis in a man with joint pain.

Authors:
Philip L Cohen

Arthritis Rheum 2004 Feb;50(2):680

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http://dx.doi.org/10.1002/art.20031DOI Listing
February 2004

Ultraviolet B radiation-induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution.

J Immunol 2003 Dec;171(11):5778-86

Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.171.11.5778DOI Listing
December 2003

The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity.

Eur J Immunol 2003 Aug;33(8):2160-7

University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1002/eji.200324076DOI Listing
August 2003

T cell reactivity to MHC class II-bound self peptides in systemic lupus erythematosus-prone MRL/lpr mice.

J Immunol 2003 Feb;170(4):2229-35

Division of Rheumatology, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://www.jimmunol.org/content/170/4/2229.full.pdf
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http://dx.doi.org/10.4049/jimmunol.170.4.2229DOI Listing
February 2003

Animal models for SLE.

Curr Protoc Immunol 2003 Feb;Chapter 15:Unit 15.20

University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/0471142735.im1520s52DOI Listing
February 2003

Autoimmunity and lymphoproliferation: two genes are worse than one.

Authors:
Philip L Cohen

Mol Interv 2002 Nov;2(7):427-30

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1124/mi.2.7.427DOI Listing
November 2002

Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase.

J Exp Med 2002 Jul;196(1):135-40

Department of Medicine, Division of Rheumatology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194017PMC
http://dx.doi.org/10.1084/jem.20012094DOI Listing
July 2002