Philip J Webber

Philip J Webber

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Philip J Webber

Philip J Webber

Publications by authors named "Philip J Webber"

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GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.

PLoS Genet 2012 9;8(2):e1002526. Epub 2012 Feb 9.

Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1002526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280333PMC
February 2013

LRRK2 inhibition attenuates microglial inflammatory responses.

J Neurosci 2012 Feb;32(5):1602-11

Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5601-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532034PMC
February 2012

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.

J Mol Biol 2011 Sep 22;412(1):94-110. Epub 2011 Jul 22.

Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158845PMC
September 2011

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.

J Biol Chem 2009 Dec 13;284(52):36346-56. Epub 2009 Oct 13.

Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1074/jbc.M109.025437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794750PMC
December 2009

LRRK2 in Parkinson's disease: function in cells and neurodegeneration.

FEBS J 2009 Nov 5;276(22):6436-44. Epub 2009 Oct 5.

Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama, Birmingham, AL, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2009.07342.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700730PMC
November 2009