Publications by authors named "Philip Hieter"

64Publications

A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in .

Genetics 2020 Jul 15;215(3):609-621. Epub 2020 May 15.

Michael Smith Laboratories, University of British Columbia, Vancouver, V6T 1Z4, Canada

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http://dx.doi.org/10.1534/genetics.120.303169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337070PMC
July 2020

Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins.

Genetics 2020 03 14;214(3):735-747. Epub 2020 Jan 14.

Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada

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http://dx.doi.org/10.1534/genetics.119.302971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054014PMC
March 2020

MinION-based long-read sequencing and assembly extends the reference genome.

Genome Res 2018 02 22;28(2):266-274. Epub 2017 Dec 22.

Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4.

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http://dx.doi.org/10.1101/gr.221184.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793790PMC
February 2018

The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast.

Methods Mol Biol 2018 ;1672:11-19

Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_2DOI Listing
June 2018

Synthetic lethality and cancer.

Nat Rev Genet 2017 10 26;18(10):613-623. Epub 2017 Jun 26.

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada.

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http://dx.doi.org/10.1038/nrg.2017.47DOI Listing
October 2017

Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase.

Genetics 2016 11 31;204(3):975-986. Epub 2016 Aug 31.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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http://dx.doi.org/10.1534/genetics.116.192211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105872PMC
November 2016

Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.

Proc Natl Acad Sci U S A 2016 09 22;113(36):9967-76. Epub 2016 Aug 22.

Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3;

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http://dx.doi.org/10.1073/pnas.1611839113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018746PMC
September 2016

Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability.

J Mol Biol 2017 10 22;429(21):3132-3138. Epub 2016 Jul 22.

Department of Medical Genetics, University of British Columbia, Vancouver, V6H3N1, Canada; Michael Smith Laboratories, University of British Columbia, Vancouver, V6T1Z4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253333PMC
October 2017

Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.

Genetics 2015 Nov 8;201(3):885-95. Epub 2015 Sep 8.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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http://dx.doi.org/10.1534/genetics.115.180653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649658PMC
November 2015

An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.

G3 (Bethesda) 2015 Jul 14;5(9):1879-87. Epub 2015 Jul 14.

Terry Fox Laboratory, BC Cancer Research Centre, Vancouver, Canada Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, Canada

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http://dx.doi.org/10.1534/g3.115.019174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555224PMC
July 2015

Understanding rare disease pathogenesis: a grand challenge for model organisms.

Genetics 2014 Oct;198(2):443-5

Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8L1.

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http://dx.doi.org/10.1534/genetics.114.170217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196600PMC
October 2014

Mechanisms of genome instability induced by RNA-processing defects.

Trends Genet 2014 Jun 1;30(6):245-53. Epub 2014 May 1.

Department of Medical Genetics, University of British Columbia, Vancouver, V6T 1Z3, Canada; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, V5Z 1L3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039741PMC
June 2014

Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip.

PLoS Genet 2014 Apr 17;10(4):e1004288. Epub 2014 Apr 17.

Michael Smith Laboratories, University of British Columbia, Vancouver, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1004288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990523PMC
April 2014

Synthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecin.

Genetics 2014 Jun 20;197(2):611-23. Epub 2014 Mar 20.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

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http://www.genetics.org/lookup/doi/10.1534/genetics.114.1613
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http://dx.doi.org/10.1534/genetics.114.161307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063919PMC
June 2014

An E4 ligase facilitates polyubiquitination of plant immune receptor resistance proteins in Arabidopsis.

Plant Cell 2014 Jan 21;26(1):485-96. Epub 2014 Jan 21.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

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http://www.plantcell.org/cgi/doi/10.1105/tpc.113.119057
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http://dx.doi.org/10.1105/tpc.113.119057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963591PMC
January 2014

Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition.

Mol Cancer Ther 2014 Mar 19;13(3):724-32. Epub 2013 Dec 19.

Corresponding Author: Philip Hieter, Michael Smith Laboratories, 2185 East Mall, Room 323, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z4.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130349PMC
March 2014

Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae.

Genetics 2014 Feb 13;196(2):403-12. Epub 2013 Dec 13.

Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.

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http://dx.doi.org/10.1534/genetics.113.159806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914614PMC
February 2014

Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.

Genetics 2013 Nov 3;195(3):757-67. Epub 2013 Sep 3.

Manitoba Institute of Cell Biology and Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.

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http://dx.doi.org/10.1534/genetics.113.156836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813862PMC
November 2013

Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.

G3 (Bethesda) 2013 Feb 1;3(2):273-82. Epub 2013 Feb 1.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1534/g3.112.004754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564987PMC
February 2013

Synthetic lethality and cancer: cohesin and PARP at the replication fork.

Trends Genet 2013 May 18;29(5):290-7. Epub 2013 Jan 18.

Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01689525120020
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http://dx.doi.org/10.1016/j.tig.2012.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868440PMC
May 2013

Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.

Genetics 2013 Mar 24;193(3):853-64. Epub 2012 Dec 24.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.genetics.org/cgi/doi/10.1534/genetics.112.148726
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http://dx.doi.org/10.1534/genetics.112.148726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584002PMC
March 2013

Mutability and mutational spectrum of chromosome transmission fidelity genes.

Chromosoma 2012 Jun 24;121(3):263-75. Epub 2011 Dec 24.

Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada, V6T1Z4.

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http://dx.doi.org/10.1007/s00412-011-0356-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350768PMC
June 2012

Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair.

PLoS Biol 2010 Oct 12;8(10):e1000507. Epub 2010 Oct 12.

Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er Sheva, Israel.

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https://dx.plos.org/10.1371/journal.pbio.1000507
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http://dx.doi.org/10.1371/journal.pbio.1000507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953525PMC
October 2010

Making temperature-sensitive mutants.

Methods Enzymol 2010 1;470:181-204. Epub 2010 Mar 1.

Michael Smith Laboratories, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S007668791070008
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http://dx.doi.org/10.1016/S0076-6879(10)70008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957654PMC
January 2011

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.

Proc Natl Acad Sci U S A 2009 Mar 13;106(9):3276-81. Epub 2009 Feb 13.

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, Canada, V6T 1Z4.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0813414106
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http://dx.doi.org/10.1073/pnas.0813414106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651317PMC
March 2009

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

Proc Natl Acad Sci U S A 2008 Mar 25;105(9):3443-8. Epub 2008 Feb 25.

The Ludwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.0712384105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265152PMC
March 2008

The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.

Mol Cell Biol 2006 Nov 21;26(21):7871-9. Epub 2006 Aug 21.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00573-06
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http://dx.doi.org/10.1128/MCB.00573-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636756PMC
November 2006

Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation.

J Cell Biol 2006 Aug 21;174(5):653-63. Epub 2006 Aug 21.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

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http://dx.doi.org/10.1083/jcb.200605019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064309PMC
August 2006

The kinetochore and cancer: what's the connection?

Curr Opin Cell Biol 2005 Dec 17;17(6):576-82. Epub 2005 Oct 17.

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, British Columbia, Canada V6T 1Z4.

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http://dx.doi.org/10.1016/j.ceb.2005.09.012DOI Listing
December 2005

Spindle checkpoint maintenance requires Ame1 and Okp1.

Cell Cycle 2005 Oct 17;4(10):1448-56. Epub 2005 Oct 17.

Department of Biochemistry & Molecular Biology and Centre for Molecular Medicine and Therapeutics, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4161/cc.4.10.2106DOI Listing
October 2005

The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the nucleus and regulates passenger protein localization.

Mol Biol Cell 2005 Dec 21;16(12):5465-79. Epub 2005 Sep 21.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1091/mbc.e05-04-0337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1289394PMC
December 2005

In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p.

Genetics 2005 Jul 23;170(3):1045-62. Epub 2005 May 23.

Program in Biochemistry, Cellular, and Molecular Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://www.genetics.org/cgi/doi/10.1534/genetics.104.040105
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http://dx.doi.org/10.1534/genetics.104.040105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1451159PMC
July 2005

A robust toolkit for functional profiling of the yeast genome.

Mol Cell 2004 Nov;16(3):487-96

Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.09.035DOI Listing
November 2004

Kinetochore sub-structure comes to MIND.

Nat Cell Biol 2004 Feb;6(2):94-5

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http://dx.doi.org/10.1038/ncb0204-94DOI Listing
February 2004

Identification of protein complexes required for efficient sister chromatid cohesion.

Mol Biol Cell 2004 Apr 23;15(4):1736-45. Epub 2004 Jan 23.

Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.

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http://dx.doi.org/10.1091/mbc.e03-08-0619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379271PMC
April 2004

The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion.

Mol Cell Biol 2004 Feb;24(3):1232-44

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321452PMC
http://dx.doi.org/10.1128/mcb.24.3.1232-1244.2003DOI Listing
February 2004

Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint.

Mol Cell 2003 May;11(5):1201-13

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00145-xDOI Listing
May 2003

Chl4p and iml3p are two new members of the budding yeast outer kinetochore.

Mol Biol Cell 2003 Feb;14(2):460-76

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada V5Z 4H4.

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http://dx.doi.org/10.1091/mbc.e02-08-0517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149985PMC
February 2003

From genetics and genomics to drug discovery: yeast rises to the challenge.

Trends Pharmacol Sci 2002 Dec;23(12):544-7

University of California, San Francisco, Comprehensive Cancer Center, 2340 Sutter Street, San Francisco 94143, USA.

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http://dx.doi.org/10.1016/s0165-6147(02)02097-7DOI Listing
December 2002

The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis.

Cell Cycle 2002 Jul-Aug;1(4):282-92

Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA.

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December 2002

Transcriptome analysis of Saccharomyces cerevisiae using serial analysis of gene expression.

Methods Enzymol 2002 ;350:414-44

Genetics Branch, National Cancer Institute, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)50977-0DOI Listing
August 2002

Synthetic dosage lethality.

Methods Enzymol 2002 ;350:316-26

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/s0076-6879(02)50971-xDOI Listing
August 2002

Overexpression of B-type cyclins alters chromosomal segregation.

Oncogene 2002 Mar;21(13):2051-7

INSERM EMI 9906, Faculté de Médecine et de Pharmacie, IFRMP, 22 boulevard Gambetta, 76183 Rouen Cedex, France.

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http://dx.doi.org/10.1038/sj.onc.1205257DOI Listing
March 2002