Philip E Empey

Philip E Empey

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Philip E Empey

Philip E Empey

Publications by authors named "Philip E Empey"

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Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children.

Clin Pharmacokinet 2019 Dec;58(12):1567-1576

Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/s40262-019-00773-1DOI Listing
December 2019

Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest.

Nitric Oxide 2019 12 14;93:71-77. Epub 2019 Sep 14.

Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, PA, USA; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2019.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957908PMC
December 2019

Translational Informatics Connects Real-World Information to Knowledge in an Increasingly Data-Driven World.

Clin Pharmacol Ther 2019 Dec 14. Epub 2019 Dec 14.

University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/cpt.1719DOI Listing
December 2019

Affiliate network members as force amplifiers of genomic medicine research.

Per Med 2019 11 11;16(6):431-433. Epub 2019 Nov 11.

University of Pittsburgh Medical Center (UPMC) Institute of Precision Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA.

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http://dx.doi.org/10.2217/pme-2019-0077DOI Listing
November 2019

Engaging and Empowering Stakeholders to Advance Pharmacogenomics.

Clin Pharmacol Ther 2019 Aug 26;106(2):305-308. Epub 2019 Jun 26.

Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1002/cpt.1470DOI Listing
August 2019

Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications.

Exp Neurol 2019 07 21;317:10-21. Epub 2019 Feb 21.

Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA, United States of America; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544476PMC
July 2019

Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy.

SLAS Discov 2019 07 30;24(6):653-668. Epub 2019 Apr 30.

1 Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1177/2472555219844566DOI Listing
July 2019

Therapeutic Hypothermia in Cardiac Arrest.

Ther Hypothermia Temp Manag 2018 12 9;8(4):195-198. Epub 2018 Nov 9.

4 Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.

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https://www.liebertpub.com/doi/10.1089/ther.2018.29051.mjn
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http://dx.doi.org/10.1089/ther.2018.29051.mjnDOI Listing
December 2018

Regionally clustered polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury.

J Neurol Neurosurg Psychiatry 2018 11 19;89(11):1152-1162. Epub 2018 Apr 19.

Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1136/jnnp-2017-317741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181785PMC
November 2018

Clinical Pharmacogenomics: Applications in Nephrology.

Clin J Am Soc Nephrol 2018 10 23;13(10):1561-1571. Epub 2018 May 23.

Department of Pharmacy and Therapeutics, School of Pharmacy, and

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http://dx.doi.org/10.2215/CJN.02730218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218819PMC
October 2018

Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.

Crit Care Med 2018 09;46(9):1471-1479

Clinical and Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1097/CCM.0000000000003203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095742PMC
September 2018

Usefulness of Intravenous Sodium Nitrite During Resuscitation for the Treatment of Out-of-Hospital Cardiac Arrest.

Am J Cardiol 2018 08 20;122(4):554-559. Epub 2018 Jun 20.

Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington; Department of Emergency Medicine, Harborview Medical Center, University of Washington, Seattle, Washington.

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183106
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http://dx.doi.org/10.1016/j.amjcard.2018.04.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515919PMC
August 2018

ABCG2 c.421C>A Is Associated with Outcomes after Severe Traumatic Brain Injury.

J Neurotrauma 2018 01 19;35(1):48-53. Epub 2017 Sep 19.

6 Safar Center for Resuscitation Research, University of Pittsburgh , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2017.5000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757075PMC
January 2018

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.

JACC Cardiovasc Interv 2018 01 1;11(2):181-191. Epub 2017 Nov 1.

Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida; Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.jcin.2017.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775044PMC
January 2018

The pharmacogenomics of severe traumatic brain injury.

Pharmacogenomics 2017 Oct 4;18(15):1413-1425. Epub 2017 Oct 4.

Clinical & Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.2217/pgs-2017-0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694019PMC
October 2017

Design and evaluation of a pharmacogenomics information resource for pharmacists.

J Am Med Inform Assoc 2017 Jul;24(4):822-831

Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1093/jamia/ocx007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080676PMC
July 2017

ABCB1 genotype is associated with fentanyl requirements in critically ill children.

Pediatr Res 2017 07 31;82(1):29-35. Epub 2017 May 31.

Department of Critical Care Medicine and Pediatrics, Safar Center for Resuscitation Research and the Brain Care Institute at the Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1038/pr.2017.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509475PMC
July 2017

Precision Medicine in Critical Care Requires an Understanding of Pharmacokinetic Variability.

Authors:
Philip E Empey

Pediatr Crit Care Med 2017 07;18(7):728-729

Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1097/PCC.0000000000001208DOI Listing
July 2017

Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine.

Xenobiotica 2017 Apr 9;47(4):346-353. Epub 2016 Jun 9.

b Department of Pharmacy and Therapeutics , Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh , PA , USA.

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http://dx.doi.org/10.1080/00498254.2016.1187777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572076PMC
April 2017

Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations.

Ther Hypothermia Temp Manag 2016 Dec 13;6(4):169-179. Epub 2016 Sep 13.

3 Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/ther.2016.0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144886PMC
December 2016

Pharmacogenomics to achieve precision medicine.

Authors:
Philip E Empey

Am J Health Syst Pharm 2016 Dec 26;73(23):1906-1907. Epub 2016 Oct 26.

School of Pharmacy and Institute for Precision MedicineUniversity of PittsburghPittsburgh,

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http://dx.doi.org/10.2146/ajhp160682DOI Listing
December 2016

Educational strategies to enable expansion of pharmacogenomics-based care.

Am J Health Syst Pharm 2016 Dec;73(23):1986-1998

Department of Pharmacy and Therapeutics, School of Pharmacy and Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.2146/ajhp160104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665396PMC
December 2016

Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro.

J Neurotrauma 2016 10 22;33(20):1913-1917. Epub 2016 Mar 22.

1 Department of Critical Care Medicine, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2015.4342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079409PMC
October 2016

Dexmedetomidine Reduces Shivering during Mild Hypothermia in Waking Subjects.

PLoS One 2015 3;10(8):e0129709. Epub 2015 Aug 3.

Applied Physiology Laboratory, Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129709PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523180PMC
May 2016

Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

J Neurotrauma 2016 Mar 20;33(6):567-80. Epub 2016 Jan 20.

1 Brain Trauma Neuroprotection/Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research , Silver Spring, Maryland.

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http://dx.doi.org/10.1089/neu.2015.4130DOI Listing
March 2016

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

J Neurotrauma 2016 Mar;33(6):553-66

10 Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2015.4122DOI Listing
March 2016

Bringing clinical pharmacogenomics information to pharmacists: A qualitative study of information needs and resource requirements.

Int J Med Inform 2016 Feb 30;86:54-61. Epub 2015 Nov 30.

Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Intelligent Systems Program, University of Pittsburgh, Pittsburgh, PA, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S13865056153006
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http://dx.doi.org/10.1016/j.ijmedinf.2015.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720137PMC
February 2016

Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans.

J Neurotrauma 2016 Jan 17;33(2):226-31. Epub 2015 Jun 17.

1 Department of Critical Care Medicine, University of Pittsburgh School of Medicine , the Safar Center for Resuscitation Research and the Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2015.3879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722575PMC
January 2016

Interpatient variability in dexmedetomidine response: a survey of the literature.

ScientificWorldJournal 2014 16;2014:805013. Epub 2014 Jan 16.

Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, 3501 Terrace Street, Pittsburgh, PA 15261, USA.

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http://downloads.hindawi.com/journals/tswj/2014/805013.pdf
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http://www.hindawi.com/journals/tswj/2014/805013/
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http://dx.doi.org/10.1155/2014/805013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914598PMC
October 2014

In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers.

Eur J Pharmacol 2014 Jun 29;732:86-95. Epub 2014 Mar 29.

Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00142999140022
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http://dx.doi.org/10.1016/j.ejphar.2014.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074512PMC
June 2014

Patient predictors of dexmedetomidine effectiveness for sedation in intensive care units.

Am J Crit Care 2014 Mar;23(2):160-5

Pamela L. Smithburger and Philip E. Empey are assistant professors, Randall B. Smith is senior associate dean, and Sandra L. Kane-Gill is an associate professor at University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.4037/ajcc2014678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132632PMC
March 2014

Toward semantic modeling of pharmacogenomic knowledge for clinical and translational decision support.

AMIA Jt Summits Transl Sci Proc 2013 18;2013:28-32. Epub 2013 Mar 18.

University of Pittsburgh, Pittsburgh, PA;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814496PMC
December 2013

Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury.

Neurocrit Care 2013 Oct;19(2):192-8

Department of Emergency Medicine, University of Cincinnati, 231 Albert Sabin Way, PO Box 670769, Cincinnati, OH, 45267-0769, USA,

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http://dx.doi.org/10.1007/s12028-013-9881-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332629PMC
October 2013

Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury.

Crit Care Med 2013 Oct;41(10):2379-87

1Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA. 2Division of Clinical Pharmacology, School of Medicine and Indiana Clinical and Translational Sciences Institute, Indiana University, Indianapolis, IN. 3Department of Critical Care Medicine, School of Medicine, and the Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA. 4Department of Neurological Surgery, School of Medicine, and the Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA. 5Department of Pharmaceutical Sciences, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA. 6Division of Neurosurgery/Children's Neuroscience, Department of Child Health, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ.

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http://dx.doi.org/10.1097/CCM.0b013e318292316cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783553PMC
October 2013

Stereoselective interaction of pantoprazole with ABCG2. II. In vitro flux analysis.

Drug Metab Dispos 2012 May 21;40(5):1024-31. Epub 2012 Feb 21.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1124/dmd.111.041616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336798PMC
May 2012

Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.

Crit Care Med 2012 Apr;40(4):1221-8

Department of Pharmacy and Therapeutics, School of Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1097/CCM.0b013e31823779f9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307845PMC
April 2012

Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism.

Drug Metab Dispos 2011 Dec 25;39(12):2209-18. Epub 2011 Aug 25.

Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1124/dmd.111.040642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226379PMC
December 2011

Genetic predisposition to adverse drug reactions in the intensive care unit.

Authors:
Philip E Empey

Crit Care Med 2010 Jun;38(6 Suppl):S106-16

Department of Pharmacy and Therapeutics and Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1097/CCM.0b013e3181de09f8DOI Listing
June 2010

Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers.

Drug Metab Dispos 2010 May 17;38(5):781-8. Epub 2010 Feb 17.

Department of Emergency Medicine, Emergency Responder Human Performance Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1124/dmd.109.031377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872942PMC
May 2010

Cyclosporin A disposition following acute traumatic brain injury.

J Neurotrauma 2006 Jan;23(1):109-16

Department of Pharmaceutical Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, USA.

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http://dx.doi.org/10.1089/neu.2006.23.109DOI Listing
January 2006