Publications by authors named "Philip C Smith"

68Publications

Differential Detergent Fractionation of Membrane Protein From Small Samples of Hepatocytes and Liver Tissue for Quantitative Proteomic Analysis of Drug Metabolizing Enzymes and Transporters.

J Pharm Sci 2020 Oct 22. Epub 2020 Oct 22.

UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2020.10.037DOI Listing
October 2020

Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR) Rats.

J Pharm Sci 2020 Oct 13. Epub 2020 Oct 13.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2020.10.017DOI Listing
October 2020

Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury.

Toxicol In Vitro 2020 Oct 3;70:105010. Epub 2020 Oct 3.

UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2020.105010DOI Listing
October 2020

Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression.

J Pharm Sci 2020 Sep 12. Epub 2020 Sep 12.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2020.09.013DOI Listing
September 2020

Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.

Drug Metab Dispos 2020 02 26;48(2):93-105. Epub 2019 Nov 26.

Eli Lilly and Company, Indianapolis, Indiana (B.L.M., A.K., L.R.H., A.T.H., L.H.C., R.M.B., G.A.S., K.M.H.); and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.F., P.C.S.).

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http://dx.doi.org/10.1124/dmd.119.088781DOI Listing
February 2020

Evaluation of human primary intestinal monolayers for drug metabolizing capabilities.

J Biol Eng 2019 4;13:82. Epub 2019 Nov 4.

1Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599 USA.

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http://dx.doi.org/10.1186/s13036-019-0212-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829970PMC
November 2019

PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.

Cancer Chemother Pharmacol 2020 01 9;85(1):225-229. Epub 2019 Nov 9.

ProLynx, 455 Mission Bay Blvd. South, Suite 341, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1007/s00280-019-03987-zDOI Listing
January 2020

Neuroendocrine Control of Sleep.

Curr Top Behav Neurosci 2019 ;43:353-378

Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/7854_2019_107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986346PMC
January 2020

Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans.

J Pharmacol Exp Ther 2019 09 24;370(3):360-368. Epub 2019 Jun 24.

Eshelman School of Pharmacy (E.B., J.K.F., N.W., A.P.S., C.S., P.C.S., A.D.M.K.) and School of Medicine (M.K., J.V.G., A.D.M.K.), University of North Carolina, Chapel Hill, North Carolina; School of Medicine, Colorado State University, Fort Collins, Colorado (L.R.-M., R.A.); and School of Medicine, University of California, Davis, California (L.A., P.L.)

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http://dx.doi.org/10.1124/jpet.119.259150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695867PMC
September 2019

Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model.

J Pharmacol Toxicol Methods 2019 Jul - Aug;98:106590. Epub 2019 May 31.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10568719193004
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http://dx.doi.org/10.1016/j.vascn.2019.106590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701468PMC
January 2020

Developmental Expression of the Cytosolic Sulfotransferases in Human Liver.

Drug Metab Dispos 2019 06 18;47(6):592-600. Epub 2019 Mar 18.

Department of Pharmacology (S.D.) and Institute of Environmental Health Sciences (J.A.C., T.A.K., M.R.-M.), Wayne State University, Detroit, Michigan; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri (R.G., C.A.V.); Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina, Chapel Hill, North Carolina (P.C.S.); and Office of Research and Development, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina (R.N.H.)

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http://dx.doi.org/10.1124/dmd.119.086363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505379PMC
June 2019

Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody.

Drug Metab Dispos 2019 05 28;47(5):444-452. Epub 2019 Feb 28.

Centre Hospitalier Universitaire (CHU) de Québec Research Centre and Faculty of Medicine (J.-P.É., S.D., H.H., H.B., L.L., M.P., B.T., E.L.) and CHU de Québec Research Centre and Faculty of Pharmacy, Laval University (A.L., M.R., L.V., P.C., C.G.), and Statistical and Clinical Research Platform, CHU de Québec Research Centre (D.S.), Québec, Canada.); Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S.); and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (K.K., U.M.Z.)

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http://dx.doi.org/10.1124/dmd.119.086330DOI Listing
May 2019

A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies.

Anal Chem 2018 11 30;90(22):13331-13340. Epub 2018 Oct 30.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States and North Carolina State University, Raleigh, North Carolina 27607, United States.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b02845
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http://dx.doi.org/10.1021/acs.analchem.8b02845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339567PMC
November 2018

Quantification of membrane transporter proteins in human lung and immortalized cell lines using targeted quantitative proteomic analysis by isotope dilution nanoLC-MS/MS.

J Pharm Biomed Anal 2018 May 22;154:150-157. Epub 2018 Feb 22.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.02.044DOI Listing
May 2018

Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug-drug interaction profiles.

Xenobiotica 2018 Nov 16;48(11):1173-1183. Epub 2017 Nov 16.

a Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co , 35 Landsdowne Street, Cambridge, MA , USA.

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http://dx.doi.org/10.1080/00498254.2017.1397812DOI Listing
November 2018

Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity.

Drug Metab Dispos 2017 10 2;45(10):1102-1112. Epub 2017 Aug 2.

Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, University of Manchester, Manchester, United Kingdom (B.A., J.B., A.R.-H.); Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.F., P.C.S.); Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut (A.D., M.N., J.J.N., T.C.G.); and Simcyp Limited (a Certara Company), Blades Enterprise Centre, Sheffield, United Kingdom (A.R.-H.)

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http://dx.doi.org/10.1124/dmd.117.076703DOI Listing
October 2017

Multimodal analysis of drug transporter expression in gastrointestinal tissue.

AIDS 2017 07;31(12):1669-1678

aEshelman School of Pharmacy bSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina cSchool of Medicine, Colorado State University, Fort Collins, Colorado dSchool of Medicine, University of California, Davis, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546623PMC
July 2017

Procedural outcomes of fluoroless catheter ablation outside the traditional catheterization lab.

Europace 2017 Aug;19(8):1378-1384

Department of Cardiology, The Heart Center, Akron Children's Hospital, Akron, OH, USA.

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http://dx.doi.org/10.1093/europace/euw207DOI Listing
August 2017

Quantification of Four Efflux Drug Transporters in Liver and Kidney Across Species Using Targeted Quantitative Proteomics by Isotope Dilution NanoLC-MS/MS.

Pharm Res 2016 09 29;33(9):2280-8. Epub 2016 Jun 29.

Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, Massachusetts, 02139, USA.

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http://dx.doi.org/10.1007/s11095-016-1966-5DOI Listing
September 2016

UGT concentrations in human rectal tissue after multidose, oral curcumin.

Pharmacol Res Perspect 2016 Apr 23;4(2):e00222. Epub 2016 Feb 23.

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599.

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http://dx.doi.org/10.1002/prp2.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804320PMC
April 2016

Scaling factors for the in vitro-in vivo extrapolation (IV-IVE) of renal drug and xenobiotic glucuronidation clearance.

Br J Clin Pharmacol 2016 06 14;81(6):1153-64. Epub 2016 Mar 14.

Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide, South Australia, Australia, 5001.

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http://dx.doi.org/10.1111/bcp.12889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876189PMC
June 2016

Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.

Drug Metab Dispos 2015 Sep 15;43(9):1331-5. Epub 2015 Jun 15.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec and Faculty of Pharmacy, Université Laval, Québec, Canada (G.M., M.R., P.C., L.V., C.G.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (K.K., U.M.Z.); Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S.); Canada Research Chair in Pharmacogenomics (C.G.)

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http://dx.doi.org/10.1124/dmd.115.065391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538857PMC
September 2015

Quantitative profiling of human renal UDP-glucuronosyltransferases and glucuronidation activity: a comparison of normal and tumoral kidney tissues.

Drug Metab Dispos 2015 Apr 3;43(4):611-9. Epub 2015 Feb 3.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, and Faculty of Pharmacy, Laval University, Quebec, Canada (G.M., M.R., P.C., L.V., V.T., C.G.); Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.F., P.C.S.); and University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Boulder, Colorado (M.S.J.)

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http://dx.doi.org/10.1124/dmd.114.062877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366751PMC
April 2015

Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.

Drug Metab Dispos 2014 Jan 5;42(1):182-92. Epub 2013 Nov 5.

Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.).

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http://dx.doi.org/10.1124/dmd.113.054783DOI Listing
January 2014

Targeted precise quantification of 12 human recombinant uridine-diphosphate glucuronosyl transferase 1A and 2B isoforms using nano-ultra-high-performance liquid chromatography/tandem mass spectrometry with selected reaction monitoring.

Drug Metab Dispos 2013 Dec 17;41(12):2076-80. Epub 2013 Sep 17.

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.F., P.C.S.); and Department. of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Andover, Massachusetts, (H.N.) and Groton, Connecticut, (T.C.G.).

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http://dx.doi.org/10.1124/dmd.113.053801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834135PMC
December 2013

Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring.

J Proteome Res 2013 Oct 26;12(10):4402-13. Epub 2013 Sep 26.

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/pr4004213DOI Listing
October 2013

Quantification of human uridine-diphosphate glucuronosyl transferase 1A isoforms in liver, intestine, and kidney using nanobore liquid chromatography-tandem mass spectrometry.

Anal Chem 2012 Jan 5;84(1):98-105. Epub 2011 Dec 5.

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina 27599, USA.

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http://pubs.acs.org/doi/10.1021/ac201704a
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http://dx.doi.org/10.1021/ac201704aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259189PMC
January 2012

Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C.

J Clin Pharmacol 2010 Apr 19;50(4):434-49. Epub 2009 Oct 19.

Clinical Assistant Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, CB #7360, Kerr Hall Rm 3310, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1177/0091270009347475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086763PMC
April 2010

Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes.

Drug Metab Dispos 2009 Dec 22;37(12):2314-22. Epub 2009 Sep 22.

Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington, USA.

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http://dx.doi.org/10.1124/dmd.109.028944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784705PMC
December 2009

Influence of clinical and demographic variables on mycophenolic acid pharmacokinetics in antineutrophil cytoplasmic antibody-associated vasculitis.

Ann Pharmacother 2009 Jun 2;43(6):1020-7. Epub 2009 Jun 2.

School of Medicine, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1345/aph.1L699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778272PMC
June 2009

Absolute quantification of human uridine-diphosphate glucuronosyl transferase (UGT) enzyme isoforms 1A1 and 1A6 by tandem LC-MS.

Drug Metab Lett 2008 Aug;2(3):210-22

Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2174/187231208785425764DOI Listing
August 2008

Pharmacokinetics of mycophenolic acid in patients with lupus nephritis.

Pharmacotherapy 2009 Jan;29(1):7-16

University of North Carolina Kidney Center, Chapel Hill, North Carolina 27599-7155, USA.

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http://dx.doi.org/10.1592/phco.29.1.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901907PMC
January 2009

Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).

Drug Metab Dispos 2008 Nov 7;36(11):2219-26. Epub 2008 Aug 7.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.108.021790
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http://dx.doi.org/10.1124/dmd.108.021790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660567PMC
November 2008

The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity.

Drug Metab Dispos 2008 Sep 19;36(9):1909-16. Epub 2008 Jun 19.

Division of Pharmacotherapy and Experimental Therapeutics,School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA.

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http://dx.doi.org/10.1124/dmd.107.019604DOI Listing
September 2008

Androgen regulation of renal uridine diphosphoglucuronosyltransferase 1A1 in rats.

Drug Metab Dispos 2008 Sep 30;36(9):1737-9. Epub 2008 May 30.

School of Pharmacy, CB 7360, University of North Carolina, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1124/dmd.108.020610DOI Listing
September 2008

Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

PLoS One 2007 Nov 28;2(11):e1251. Epub 2007 Nov 28.

Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001251PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080775PMC
November 2007

Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.

Drug Metab Dispos 2008 Jan 3;36(1):65-72. Epub 2007 Oct 3.

School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1124/dmd.107.017566DOI Listing
January 2008

Anti-AIDS agents 66: syntheses and anti-HIV activity of phenolic and aza 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives.

Bioorg Med Chem 2007 Nov 13;15(21):6852-8. Epub 2006 Dec 13.

Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1016/j.bmc.2006.12.013DOI Listing
November 2007

Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers.

Antimicrob Agents Chemother 2007 Sep 18;51(9):3063-6. Epub 2007 Jun 18.

Drug Development, Panacos Pharmaceuticals, 209 Perry Parkway, Suite 7, Gaithersburg, MD 20877, USA.

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http://dx.doi.org/10.1128/AAC.01391-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043192PMC
September 2007

Prenatal diagnosis of obstructed normally connected pulmonary veins by a single orifice to the common atrium in a fetus with right isomerism.

J Ultrasound Med 2007 Apr;26(4):525-8

Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital Medical Center of Akron, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44308-1062, USA.

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http://dx.doi.org/10.7863/jum.2007.26.4.525DOI Listing
April 2007

Gender-related differences in mycophenolate mofetil-induced gastrointestinal toxicity in rats.

Drug Metab Dispos 2007 Mar 15;35(3):449-54. Epub 2006 Dec 15.

School of Pharmacy, CB#7360, 1309 Kerr Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1124/dmd.106.012013DOI Listing
March 2007

Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences.

Drug Metab Dispos 2007 Mar 6;35(3):440-8. Epub 2006 Dec 6.

School of Pharmacy, CB 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1124/dmd.106.012815DOI Listing
March 2007

Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid.

Drug Metab Dispos 2006 Sep 21;34(9):1632-9. Epub 2006 Jun 21.

Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, 1217 Richmond, VA 23298-0613, USA.

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http://dx.doi.org/10.1124/dmd.106.010140DOI Listing
September 2006

Adenovirus-mediated gene therapy to restore expression and functionality of multiple UDP-glucuronosyltransferase 1A enzymes in Gunn rat liver.

J Pharmacol Exp Ther 2006 Sep 8;318(3):1240-7. Epub 2006 Jun 8.

Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1124/jpet.106.104810DOI Listing
September 2006

Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma.

Drug Metab Dispos 2006 Sep 2;34(9):1436-42. Epub 2006 Jun 2.

School of Pharmacy, CB 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1124/dmd.106.009233DOI Listing
September 2006

Predicting the pharmacokinetics of acyl glucuronides and their parent compounds in disease states.

Curr Drug Metab 2006 Feb;7(2):147-63

School of Pharmacy, CB 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.2174/138920006775541589DOI Listing
February 2006

Fetal echocardiographic diagnosis of vascular rings.

J Ultrasound Med 2006 Feb;25(2):251-7

Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital Medical Center of Akron, OH 44308-1062, USA.

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http://dx.doi.org/10.7863/jum.2006.25.2.251DOI Listing
February 2006

Prenatal diagnosis of ventriculocoronary arterial communication in fetuses with hypoplastic left heart syndrome.

J Ultrasound Med 2006 Feb;25(2):245-9

Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital Medical Center of Akron, OH 44308-1062, USA.

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http://dx.doi.org/10.7863/jum.2006.25.2.245DOI Listing
February 2006

Totally anomalous pulmonary venous connection and complex congenital heart disease: prenatal echocardiographic diagnosis and prognosis.

J Ultrasound Med 2005 Sep;24(9):1191-8

Department of Pediatrics, Division of Pediatric Cardiology, The Heart Center, Children's Hospital Medical Center of Akron, 2 Perkins Sq, Akron, OH 44308-1062, USA.

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http://dx.doi.org/10.7863/jum.2005.24.9.1191DOI Listing
September 2005

Anti-AIDS agents 65: investigation of the in vitro oxidative metabolism of 3',4'-Di-O-(-)-camphanoyl-(+)-cis-khellactone derivatives as potent anti-hiv agents.

Drug Metab Dispos 2005 Nov 8;33(11):1588-92. Epub 2005 Aug 8.

Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1124/dmd.105.004218DOI Listing
November 2005

Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo.

Biochem Pharmacol 2005 Sep;70(6):937-48

Department of Pharmacokinetics and Drug Metabolism, Allergan, Inc., Irvine, CA 92623, USA.

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http://dx.doi.org/10.1016/j.bcp.2005.05.026DOI Listing
September 2005

An investigation of human and rat liver microsomal mycophenolic acid glucuronidation: evidence for a principal role of UGT1A enzymes and species differences in UGT1A specificity.

Drug Metab Dispos 2005 Oct 20;33(10):1513-20. Epub 2005 Jul 20.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, 1217 E. Marshall Street, Richmond, VA 23298-0613, USA.

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http://dx.doi.org/10.1124/dmd.105.004663DOI Listing
October 2005

Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms.

Drug Metab Dispos 2005 Jul 15;33(7):977-83. Epub 2005 Apr 15.

Division of Drug Delivery and Disposition, University of North Carolina at Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1124/dmd.104.003491DOI Listing
July 2005

The influence of norfloxacin and metronidazole on the disposition of mycophenolate mofetil.

J Clin Pharmacol 2005 Feb;45(2):219-26

University of North Carolina at Chapel Hill, School of Pharmacy and School of Medicine, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1177/0091270004271555DOI Listing
February 2005

Altered pharmacokinetics of omeprazole in cystic fibrosis knockout mice relative to wild-type mice.

Drug Metab Dispos 2004 Sep;32(9):902-5

Department of Drug Delivery and Disposition, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

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September 2004

Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives.

J Med Chem 2004 Jan;47(3):756-60

Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/jm030416yDOI Listing
January 2004

Pericardial leaflet extension for aortic valve repair: Techniques and late results.

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 1999 ;2:83-94

Heart Institute for Children, Hope Children's Hospital, Chicago, IL.

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http://dx.doi.org/10.1016/s1092-9126(99)70009-8DOI Listing
January 1999