Philip Beer

Philip Beer

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Philip Beer

Philip Beer

Publications by authors named "Philip Beer"

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Reasons to be testing: the dawn of complex molecular profiling in routine oncology practice.

Ann Oncol 2019 11;30(11):1691-1694

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Bearsden, Glasgow; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK; South Western Sydney Clinical School, Liverpool, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1093/annonc/mdz392DOI Listing
November 2019

Targeting MEK in vemurafenib-resistant hairy cell leukemia.

Leukemia 2019 02 19;33(2):541-545. Epub 2018 Oct 19.

Department of Haematology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41375-018-0270-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365378PMC
February 2019

Assays for functionally defined normal and malignant mammary stem cells.

Adv Cancer Res 2019 17;141:129-174. Epub 2019 Jan 17.

Laboratory of Stem Cell and Cancer Biology, Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2018.12.004DOI Listing
January 2019

Immuno-oncology from the perspective of somatic evolution.

Semin Cancer Biol 2018 10 6;52(Pt 2):75-85. Epub 2017 Dec 6.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.12.001DOI Listing
October 2018

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.

Exp Hematol 2017 04 11;48:41-49. Epub 2017 Jan 11.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926796PMC
April 2017

Guideline for the investigation and management of eosinophilia.

Br J Haematol 2017 02 23;176(4):553-572. Epub 2017 Jan 23.

Imperial College London, St Mary's Hospital, London, UK.

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http://dx.doi.org/10.1111/bjh.14488DOI Listing
February 2017

Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells.

Stem Cell Reports 2017 01;8(1):152-162

Terry Fox Laboratory, British Columbia Cancer Agency, BC Cancer Research Centre, 675 West 10(th) Avenue, Vancouver, BC V5Z 1L3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233451PMC
January 2017

Early production of human neutrophils and platelets posttransplant is severely compromised by growth factor exposure.

Exp Hematol 2016 07 16;44(7):635-40. Epub 2016 Apr 16.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.04.003DOI Listing
July 2016

Modeling Normal and Disordered Human Hematopoiesis.

Trends Cancer 2015 Nov 2;1(3):199-210. Epub 2015 Oct 2.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, V5Z 1L3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2015.09.002DOI Listing
November 2015

Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells.

Exp Hematol 2015 Jul 4;43(7):514-23.e1-2. Epub 2015 May 4.

Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2015.04.004DOI Listing
July 2015

Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13.

Blood 2014 Dec 22;124(24):3608-12. Epub 2014 Oct 22.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1182/blood-2014-04-564666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256911PMC
December 2014

A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells.

Stem Cell Reports 2014 Nov 11;3(5):841-57. Epub 2014 Oct 11.

Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC V5Z 1L3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235152PMC
November 2014

Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia.

Exp Hematol 2013 Oct 11;41(10):837-47. Epub 2013 Jul 11.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Laboratoire d'Hématologie, Hôpital Paul Brousse, Assistance Publique des Hôpitaux de Paris, Villejuif, France.

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http://dx.doi.org/10.1016/j.exphem.2013.07.001DOI Listing
October 2013

Hematopoietic stem cell heterogeneity takes center stage.

Cell Stem Cell 2012 Jun;10(6):690-697

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, V5Z 1L3 BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2012.05.006DOI Listing
June 2012

The frequency of detection of unexpected diabetes mellitus during haemoglobinopathy investigations.

J Clin Pathol 2011 Oct 5;64(10):898-900. Epub 2011 Jul 5.

St Mary's Hospital Campus of Imperial College Faculty of Medicine, London, UK.

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http://dx.doi.org/10.1136/jclinpath-2011-200214DOI Listing
October 2011

The pathogenesis of essential thrombocythemia.

Authors:
Philip A Beer

Curr Opin Hematol 2011 Sep;18(5):323-9

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/MOH.0b013e3283497f54DOI Listing
September 2011

In situ thrombolysis for cerebral venous thrombosis complicating anti-leukemic therapy.

Leuk Res 2011 Aug 27;35(8):1127-9. Epub 2011 Mar 27.

Department of Haematology, Addenbrooke's Hospital, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, UK.

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http://dx.doi.org/10.1016/j.leukres.2011.02.014DOI Listing
August 2011

Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms.

Blood 2011 Aug 8;118(6):1610-21. Epub 2011 Jun 8.

Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK.

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http://dx.doi.org/10.1182/blood-2011-02-335042DOI Listing
August 2011

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms.

Blood 2011 Jul 11;118(1):177-81. Epub 2011 May 11.

Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK.

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http://dx.doi.org/10.1182/blood-2010-12-327593DOI Listing
July 2011

How I treat essential thrombocythemia.

Blood 2011 Feb 24;117(5):1472-82. Epub 2010 Nov 24.

Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2010-08-270033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145107PMC
February 2011

Comparison of different criteria for the diagnosis of primary myelofibrosis reveals limited clinical utility for measurement of serum lactate dehydrogenase.

Haematologica 2010 Nov 9;95(11):1960-3. Epub 2010 Jun 9.

Department of Haematology, University of Cambridge, 1Cambridge Institute for Medical Research, Cambridge, United Kingdom.

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http://dx.doi.org/10.3324/haematol.2010.026708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966920PMC
November 2010

Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling.

Cancer Cell 2010 Nov;18(5):524-35

Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1016/j.ccr.2010.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996868PMC
November 2010

Pathogenesis and management of essential thrombocythemia.

Hematology Am Soc Hematol Educ Program 2009 :621-8

Department of Haematology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/asheducation-2009.1.621DOI Listing
March 2010

Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders.

N Engl J Med 2008 Dec;359(26):2778-89

Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa0804953DOI Listing
December 2008

Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders.

Haematologica 2008 Nov 24;93(11):1635-44. Epub 2008 Sep 24.

Haemato-oncology, Diagnostic Service, Department, of Haematology, Addenbrooke's, Hospital, Hills Road, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.3324/haematol.13043DOI Listing
November 2008

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove.

Blood 2007 Sep 19;110(6):2193-6. Epub 2007 Jun 19.

Department of Haematology, Belfast City Hospital, Belfast, United Kingdom.

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http://dx.doi.org/10.1182/blood-2007-04-084434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976349PMC
September 2007