Philip Awadalla

Philip Awadalla

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Philip Awadalla

Philip Awadalla

Publications by authors named "Philip Awadalla"

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Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing.

Clin Epigenetics 2019 Jul 31;11(1):110. Epub 2019 Jul 31.

Department of Medicine, McGill University, 5252 Boul. de Maisonneuve Ouest, Rm 3F.51, Montréal, H4A 3S5, Canada.

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http://dx.doi.org/10.1186/s13148-019-0699-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668183PMC
July 2019

Aberrant expression impacts the pan-cancer genomic landscape.

Genome Res 2018 11 19;28(11):1611-1620. Epub 2018 Oct 19.

Ontario Institute for Cancer Research, Department of Computational Biology, Toronto, Ontario M5G 0A3, Canada.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.231696.117
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http://dx.doi.org/10.1101/gr.231696.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211651PMC
November 2018

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention.

CMAJ 2018 06;190(23):E710-E717

School of Population and Public Health (Dummer), University of British Columbia, Vancouver, BC; Ontario Institute for Cancer Research (Awadalla); CARTaGENE (Boileau), Montréal, Que.; Research Institute of the McGill University Health Centre (Craig, Fortier); Research and Innovation, University of Toronto (Goel); Ontario Agency for Health Protection and Promotion (Goel); Atlantic PATH, Dalhousie University (Hicks), Halifax, NS; Centre hospitalier universitaire Sainte-Justine (Jacquemont); Centre of Genomics and Policy, McGill University (Knoppers, Zawati), Montréal, Que.; BC Cancer Research Centre (Le, McDonald), Vancouver, BC; Public Health Ontario (McLaughlin), Toronto, Ont.; Institut du cancer de Montréal, Université de Montréal (Mes-Masson); Pediatrics, CHU Sainte-Justine Research Center (Nuyt), Montréal, Que.; School of Public Health, University of Adelaide (Palmer), Adelaide, Australia; Department of Medicine, Dalhousie University (Parker); Division of Cancer Epidemiology and Genetics, National Cancer Institute (Purdue), Bethesda, Md.; CancerControl Alberta, Alberta Health Services (Robson, Vena), Edmonton, Alta.; Population Oncology, BC Cancer (Spinelli), Vancouver, BC; Atlantic PATH, Dalhousie University (Thompson), Halifax, NS.

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http://dx.doi.org/10.1503/cmaj.170292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995593PMC
June 2018

Relaxed Selection During a Recent Human Expansion.

Genetics 2018 02 29;208(2):763-777. Epub 2017 Nov 29.

Computational and Molecular Population Genetics Laboratory, Institute of Ecology and Evolution, University of Berne, 3012, Switzerland

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http://dx.doi.org/10.1534/genetics.117.300551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788536PMC
February 2018

The impact of recombination on human mutation load and disease.

Philos Trans R Soc Lond B Biol Sci 2017 Dec;372(1736)

Ontario Institute of Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3.

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http://dx.doi.org/10.1098/rstb.2016.0465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698626PMC
December 2017

A haplotype-based normalization technique for the analysis and detection of allele specific expression.

BMC Bioinformatics 2016 Sep 13;17(1):364. Epub 2016 Sep 13.

CHU Sainte Justine Research Centre, Department of Pediatrics, Faculty of Medicine, Universite de Montreal, 3175 Chemin de la Cote Sainte Catherine, Montreal, QC, Canada.

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http://dx.doi.org/10.1186/s12859-016-1238-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020486PMC
September 2016

Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia.

J Psychiatr Res 2016 Jun 27;77:22-6. Epub 2016 Feb 27.

Department of Neurosurgery and Pediatrics, Interdepartmental Neuroscience Program, Program on Neurogenetics, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2016.02.016DOI Listing
June 2016

Impact of the X Chromosome and sex on regulatory variation.

Genome Res 2016 06 21;26(6):768-77. Epub 2016 Apr 21.

Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA; Department of Computer Science, Stanford University, Stanford, California 94305, USA;

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http://dx.doi.org/10.1101/gr.197897.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889977PMC
June 2016

Comparative Analysis of Iron Homeostasis in Sub-Saharan African Children with Sickle Cell Disease and Their Unaffected Siblings.

Front Pediatr 2016 23;4. Epub 2016 Feb 23.

Centre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose, Faculté des Sciences de la Santé, University of Abomey-Calavi , Cotonou , Benin.

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http://dx.doi.org/10.3389/fped.2016.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762986PMC
March 2016

Aortic Dilatation Associated With a De Novo Mutation in the SOX18 Gene: Expanding the Clinical Spectrum of Hypotrichosis-Lymphedema-Telangiectasia Syndrome.

Can J Cardiol 2016 Jan 13;32(1):135.e1-7. Epub 2015 Apr 13.

Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.04.004DOI Listing
January 2016

Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis.

Neurobiol Aging 2016 Jan 28;37:209.e17-209.e21. Epub 2015 Sep 28.

Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.09.013DOI Listing
January 2016

ARMC5 mutations in a large French-Canadian family with cortisol-secreting β-adrenergic/vasopressin responsive bilateral macronodular adrenal hyperplasia.

Eur J Endocrinol 2016 Jan;174(1):85-96

Division of EndocrinologyDepartment of MedicineDivision of Medical GeneticsDepartment of Medicine, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, CanadaDepartment of PathologyCHUM, Montréal, Quebec, CanadaDepartment of PediatricsCentre de Recherche CHU Sainte-Justine, Université de Montréal, Montréal, Quebec, CanadaUnidade de SuprarrenalDisciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1530/EJE-15-0642DOI Listing
January 2016

Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion.

Clin J Am Soc Nephrol 2016 Jan 18;11(1):62-9. Epub 2015 Dec 18.

Nephrology Division, Sacré-Coeur Hospital, Montreal, Quebec, Canada;

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http://dx.doi.org/10.2215/CJN.04770415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702232PMC
January 2016

Recombination affects accumulation of damaging and disease-associated mutations in human populations.

Nat Genet 2015 Apr 16;47(4):400-4. Epub 2015 Feb 16.

1] Sainte-Justine University Hospital Research Centre, Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada. [2] CARTaGENE Project, Sainte-Justine University Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/ng.3216DOI Listing
April 2015

Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals.

J Hypertens 2015 Apr;33(4):727-35; discussion 735

aCentre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec bSimon Fraser University British Columbia, Bumbay, British Columbia cCHU Ste-Justine, Université de Montréal, Montréal dMédecine génétique, Université Laval, Ste-Foy, Québec eCentre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics, McGill University fEcogene-21 Clinical Research Center and Department of Medicine, Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1097/HJH.0000000000000475DOI Listing
April 2015

Prevalence, awareness, and management of CKD and cardiovascular risk factors in publicly funded health care.

Clin J Am Soc Nephrol 2014 Apr 23;9(4):713-9. Epub 2014 Jan 23.

Division of Nephrology, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada, †Medical and Population Genomics Laboratory, University of Montréal, Montréal, Quebec, Canada.

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http://dx.doi.org/10.2215/CJN.06550613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974355PMC
April 2014

High-resolution genomic analysis of human mitochondrial RNA sequence variation.

Science 2014 Apr;344(6182):413-5

CHU Sainte-Justine Research Centre, Department of Pediatrics, Faculty of Medicine, Université de Montreal, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.

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http://dx.doi.org/10.1126/science.1251110DOI Listing
April 2014

Genomic architecture of sickle cell disease in West African children.

Front Genet 2014 14;5:26. Epub 2014 Feb 14.

Department of Pediatrics, Faculty of Medicine, Sainte-Justine Research Center, University of Montreal Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fgene.2014.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924578PMC
March 2014

Cohort profile of the CARTaGENE study: Quebec's population-based biobank for public health and personalized genomics.

Int J Epidemiol 2013 Oct 15;42(5):1285-99. Epub 2012 Oct 15.

Department of Pediatrics, Faculty of Medicine, Université de Montreal, Montreal, Canada, Centre de Recherche du Centre Hospitalier Universitaire (CHU) Sainte-Justine, CARTaGENE, Canada, Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Canada, Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Canada and Centre de Recherche du Centre Hospitalier Universitaire du Québec (CHUQ), Université Laval, Québec, Canada.

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http://dx.doi.org/10.1093/ije/dys160DOI Listing
October 2013

Selective constraint, background selection, and mutation accumulation variability within and between human populations.

BMC Genomics 2013 Jul 23;14:495. Epub 2013 Jul 23.

Sainte Justine Research Centre, Department of Pediatrics, University of Montreal, Montreal, Canada.

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http://dx.doi.org/10.1186/1471-2164-14-495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727949PMC
July 2013

Exploiting gene expression variation to capture gene-environment interactions for disease.

Front Genet 2012 31;3:228. Epub 2013 May 31.

Sainte-Justine Research Center, University of Montreal Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fgene.2012.00228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668192PMC
June 2013

Hypervariable antigen genes in malaria have ancient roots.

BMC Evol Biol 2013 May 31;13:110. Epub 2013 May 31.

National Institute of Allergy of Infectious Disease, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1186/1471-2148-13-110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680017PMC
May 2013

Evidence for additive and interaction effects of host genotype and infection in malaria.

Proc Natl Acad Sci U S A 2012 Oct 4;109(42):16786-93. Epub 2012 Sep 4.

Mother and Child University Hospital Center (CHU) Sainte-Justine, Université de Montréal, Montréal, QC, Canada H3T 1C5.

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http://dx.doi.org/10.1073/pnas.1204945109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479498PMC
October 2012

Next-generation sequencing approaches for genetic mapping of complex diseases.

J Neuroimmunol 2012 Jul 27;248(1-2):10-22. Epub 2012 Jan 27.

Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S016557281100369
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http://dx.doi.org/10.1016/j.jneuroim.2011.12.017DOI Listing
July 2012

High recombination rates and hotspots in a Plasmodium falciparum genetic cross.

Genome Biol 2011 4;12(4):R33. Epub 2011 Apr 4.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/gb-2011-12-4-r33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218859PMC
February 2012

Age-dependent recombination rates in human pedigrees.

PLoS Genet 2011 Sep 1;7(9):e1002251. Epub 2011 Sep 1.

Department of Biochemistry, Faculty of Medicine, University of Montreal, Montreal, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1002251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164683PMC
September 2011

Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome.

Mol Biol Evol 2010 Sep 28;27(9):2198-209. Epub 2010 Apr 28.

Department of Organismic and Evolutionary Biology, Harvard University, Boston, MA, USA.

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http://dx.doi.org/10.1093/molbev/msq108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922621PMC
September 2010

Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents.

BMC Evol Biol 2008 Jul 30;8:223. Epub 2008 Jul 30.

Laboratoire GEMI, UMR 2724 CNRS-IRD, 911 avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1186/1471-2148-8-223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529309PMC
July 2008

Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome.

Nat Genet 2007 Jan 10;39(1):126-30. Epub 2006 Dec 10.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ng1924DOI Listing
January 2007

Recombination hotspots and population structure in Plasmodium falciparum.

PLoS Biol 2005 Oct 13;3(10):e335. Epub 2005 Sep 13.

Laboratory of Malaria and Vector Research, National Institutes of Health, Rockville, Maryland, USA.

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http://dx.doi.org/10.1371/journal.pbio.0030335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201364PMC
October 2005

Darwinian selection on a selfing locus.

Science 2004 Dec;306(5704):2081-4

Department of Genetics, North Carolina State University, Box 7614, Raleigh, NC 27695, USA.

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http://dx.doi.org/10.1126/science.1103776DOI Listing
December 2004

Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus.

PLoS Biol 2004 Jun 15;2(6):e142. Epub 2004 Jun 15.

Section of Evolution and Ecology, University of California, Davis, USA.

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https://dx.plos.org/10.1371/journal.pbio.0020142
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http://dx.doi.org/10.1371/journal.pbio.0020142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC423131PMC
June 2004

Low linkage disequilibrium indicative of recombination in foot-and-mouth disease virus gene sequence alignments.

J Gen Virol 2004 May;85(Pt 5):1095-100

Department of Zoology, University of Guelph, Guelph, Ontario, Canada N1G 2W1.

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http://dx.doi.org/10.1099/vir.0.19588-0DOI Listing
May 2004

Diversity and linkage of genes in the self-incompatibility gene family in Arabidopsis lyrata.

Genetics 2003 Aug;164(4):1519-35

Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462643PMC
August 2003

The evolutionary genomics of pathogen recombination.

Authors:
Philip Awadalla

Nat Rev Genet 2003 Jan;4(1):50-60

Section of Evolution and Ecology, University of California at Davis, California 95616, USA.

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http://www.nature.com/articles/nrg964
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http://dx.doi.org/10.1038/nrg964DOI Listing
January 2003

A coalescent-based method for detecting and estimating recombination from gene sequences.

Genetics 2002 Mar;160(3):1231-41

Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462015PMC
March 2002