Philip A Marsden

Philip A Marsden

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Philip A Marsden

Philip A Marsden

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Epigenetic Determinants of Flow-Mediated Vascular Endothelial Gene Expression.

Hypertension 2019 Sep 29;74(3):467-476. Epub 2019 Jul 29.

From the Department of Laboratory Medicine and Pathobiology (K.H.K., P.A.M.), University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.13342DOI Listing
September 2019

LncRNAs and epigenetic regulation of vascular endothelium: genome positioning system and regulators of chromatin modifiers.

Curr Opin Pharmacol 2019 Apr 21;45:72-80. Epub 2019 May 21.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2019.04.012DOI Listing
April 2019

Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers.

J Vis Exp 2018 10 21(140). Epub 2018 Oct 21.

Institute of Medical Science, University of Toronto; Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital; Department of Laboratory Medicine and Pathobiology, University of Toronto; Department of Medicine, University of Toronto;

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https://www.jove.com/video/58478/gene-expression-analysis-en
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http://dx.doi.org/10.3791/58478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235583PMC
October 2018

Robust effects of genetic background on responses to subarachnoid hemorrhage in mice.

J Cereb Blood Flow Metab 2016 11 26;36(11):1942-1954. Epub 2015 Oct 26.

Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada

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http://dx.doi.org/10.1177/0271678X15612489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094306PMC
November 2016

Epigenetic determinants of cardiovascular gene expression: vascular endothelium.

Epigenomics 2016 07 6;8(7):959-79. Epub 2016 Jul 6.

Department of Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2217/epi-2016-0012DOI Listing
July 2016

Epigenetics in the Vascular Endothelium: Looking From a Different Perspective in the Epigenomics Era.

Arterioscler Thromb Vasc Biol 2015 Nov 24;35(11):2297-306. Epub 2015 Sep 24.

From the Department of Medical Biophysics (M.S.Y., P.A.M.) and Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital (M.S.Y., P.A.M.), University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.115.305043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618795PMC
November 2015

Posttranscriptional adaptations of the vascular endothelium to hypoxia.

Curr Opin Hematol 2015 May;22(3):243-51

aDepartment of Biochemistry and Molecular Biology bSylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida, USA cKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's, Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MOH.0000000000000139DOI Listing
May 2015

Nitric oxide and hypoxia signaling.

Vitam Horm 2014 ;96:161-92

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-800254-4.00007-6DOI Listing
April 2015

CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney.

Endocrinology 2015 Mar 30;156(3):1121-32. Epub 2014 Dec 30.

Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital (F.S.S., L.H.C., S.L.A., K.T., S.N.B., T.A.A., K.A.C., P.A.M., A.A.), Toronto, Canada M5B 1T8; EM Research Services (K.E.W.), Newcastle University, Newcastle upon Tyne, United Kingdom NE2 4HH; Ottawa Hospital Research Institute (M.M.S.), University of Ottawa, Ottawa, Canada K1Y 4E9; and Department of Pathology (I.W.G.), University of Manitoba, Winnipeg, Canada R3A 1R9.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2014-1650DOI Listing
March 2015

Effect of disturbed blood flow on endothelial cell gene expression: a role for changes in RNA processing.

Arterioscler Thromb Vasc Biol 2014 Sep;34(9):1806-8

From the Toronto General Research Institute, University Health Network, and the Department of Laboratory Medicine and Pathobiology, University of Toronto (M.I.C.), and St Michael's Hospital, Division of Nephrology, Department of Medicine, University of Toronto (P.A.M.), Toronto, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.114.304099DOI Listing
September 2014

Competition and collaboration between RNA-binding proteins and microRNAs.

Wiley Interdiscip Rev RNA 2014 Jan-Feb;5(1):69-86. Epub 2013 Oct 7.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/wrna.1197DOI Listing
July 2014

Differential HIF and NOS responses to acute anemia: defining organ-specific hemoglobin thresholds for tissue hypoxia.

Am J Physiol Regul Integr Comp Physiol 2014 Jul 23;307(1):R13-25. Epub 2014 Apr 23.

Department of Anesthesia, St. Michael's Hospital, University of Toronto, Ontario, Canada; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada;

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http://ajpregu.physiology.org/content/ajpregu/307/1/R13.full
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http://ajpregu.physiology.org/cgi/doi/10.1152/ajpregu.00411.
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http://dx.doi.org/10.1152/ajpregu.00411.2013DOI Listing
July 2014

Epigenetics of Cardiovascular Disease - A New "Beat" in Coronary Artery Disease.

Med Epigenet 2014 Apr;2(1):37-52

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada ; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada ; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1159/000360766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232955PMC
April 2014

Angiogenesis in glioblastoma.

N Engl J Med 2013 Oct;369(16):1561-3

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http://dx.doi.org/10.1056/NEJMcibr1309402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378489PMC
October 2013

Dysregulation of angiopoietin 1 and 2 in Escherichia coli O157:H7 infection and the hemolytic-uremic syndrome.

J Infect Dis 2013 Sep 24;208(6):929-33. Epub 2013 Jun 24.

Department of Medicine, Sandra A. Rotman, Laboratory for Global Health, Mount Sinai Hospital-University Health Network, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/infdis/jit268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749007PMC
September 2013

Epigenetics and cardiovascular disease.

Can J Cardiol 2013 Jan;29(1):46-57

Keenan Research Centre and Li Ka Shing Knowledge Institute, St Michael's Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2012.10.023DOI Listing
January 2013

MicroRNA-145 targeted therapy reduces atherosclerosis.

Circulation 2012 Sep;126(11 Suppl 1):S81-90

Division of Cardiac Surgery, Li Ka Shing Knowledge Institute at St. Michael's Hospital, Toronto, Ontario, Canada.

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http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.1
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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.084186DOI Listing
September 2012

Shiga toxin-associated hemolytic uremic syndrome: advances in pathogenesis and therapeutics.

Curr Opin Nephrol Hypertens 2012 Jul;21(4):433-40

Department of Laboratory Medicine and Pathobiology, University of Toronto, and Keenan Research Centre, Li KaShing Knowledge Institute, Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MNH.0b013e328354a62eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303627PMC
July 2012

Nitric oxide signaling in hypoxia.

J Mol Med (Berl) 2012 Mar 18;90(3):217-31. Epub 2012 Feb 18.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00109-012-0880-5DOI Listing
March 2012

The vascular endothelium: a wonderful network: introduction.

Authors:
Philip A Marsden

Semin Nephrol 2012 Mar;32(2):143-4

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http://dx.doi.org/10.1016/j.semnephrol.2012.03.001DOI Listing
March 2012

Gene regulation in the vascular endothelium: why epigenetics is important for the kidney.

Semin Nephrol 2012 Mar;32(2):176-84

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.semnephrol.2012.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303628PMC
March 2012

Bone marrow cell therapies for endothelial repair and their relevance to kidney disease.

Semin Nephrol 2012 Mar;32(2):215-23

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.semnephrol.2012.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303629PMC
March 2012

Pulse oximetry.

N Engl J Med 2011 07;365(2):184-5; author reply 185

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http://dx.doi.org/10.1056/NEJMc1105847DOI Listing
July 2011

Epigenetics in cardiovascular disease.

Curr Opin Cardiol 2011 May;26(3):209-15

Department of Medical Biophysics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/HCO.0b013e328345986eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303626PMC
May 2011

Epigenetics of the vascular endothelium.

J Appl Physiol (1985) 2010 Sep 22;109(3):916-26. Epub 2010 Apr 22.

Department of Medical Biophysics, Rm 7358, Medical Sciences Bldg., University of Toronto, and Department of Medicine, St. Michael's Hospital, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1152/japplphysiol.00131.2010DOI Listing
September 2010

Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle.

Can J Anaesth 2010 Aug 29;57(8):779-91. Epub 2010 May 29.

Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, ON, Canada.

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http://link.springer.com/10.1007/s12630-010-9329-x
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http://dx.doi.org/10.1007/s12630-010-9329-xDOI Listing
August 2010

Enhanced translation of heme oxygenase-2 preserves human endothelial cell viability during hypoxia.

J Biol Chem 2010 Mar 29;285(13):9452-61. Epub 2010 Jan 29.

Terrence Donnelly Laboratories, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada.

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http://dx.doi.org/10.1074/jbc.M109.077230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843195PMC
March 2010

Treatment of anemia in chronic kidney disease--strategies based on evidence.

Authors:
Philip A Marsden

N Engl J Med 2009 Nov 30;361(21):2089-90. Epub 2009 Oct 30.

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http://dx.doi.org/10.1056/NEJMe0909664DOI Listing
November 2009

Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma.

Am J Physiol Lung Cell Mol Physiol 2009 Jun 13;296(6):L911-20. Epub 2009 Mar 13.

Institutes of Medical Sciences, Dalla Lana School of Public Health, Faculty of Medicine, Ontario, Canada .

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http://dx.doi.org/10.1152/ajplung.00025.2009DOI Listing
June 2009

Role of a distal enhancer in the transcriptional responsiveness of the human CD200 gene to interferon-gamma and tumor necrosis factor-alpha.

Mol Immunol 2009 Jun 21;46(10):1951-63. Epub 2009 Apr 21.

Transplant Research Division, The Toronto Hospital, Department of Surgery and Immunology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.molimm.2009.03.015DOI Listing
June 2009

Regulation of endocytosis via the oxygen-sensing pathway.

Nat Med 2009 Mar 1;15(3):319-24. Epub 2009 Mar 1.

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nm.1922DOI Listing
March 2009

Verotoxin biology: molecular events in vascular endothelial injury.

Kidney Int Suppl 2009 Feb(112):S17-9

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ki.2008.612DOI Listing
February 2009

Dicer cuts the kidney.

J Am Soc Nephrol 2008 Nov 15;19(11):2043-6. Epub 2008 Oct 15.

Medical Sciences Building, Room 7358, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1681/ASN.2008090986DOI Listing
November 2008

Activated protein C and diabetic nephropathy.

N Engl J Med 2008 Apr;358(15):1628-30

Keenan Research Centre of the Li Ka Shing Knowledge Institute and the Division of Endocrinology, St. Michael's Hospital, Toronto.

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http://dx.doi.org/10.1056/NEJMcibr0801042DOI Listing
April 2008

Epigenetic regulation of vascular endothelial gene expression.

Circ Res 2008 Apr;102(8):873-87

Institute of Medical Sciences, St. Michael's Hospital and University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.171025DOI Listing
April 2008

Low-molecular-weight S-nitrosothiols and blood vessel injury.

Authors:
Philip A Marsden

J Clin Invest 2007 Sep;117(9):2377-80

Renal Division and Department of Medicine, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI33136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952645PMC
September 2007

Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase.

J Biol Chem 2007 May 2;282(21):15652-66. Epub 2007 Apr 2.

Department of Medical Biophysics, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M608318200DOI Listing
May 2007

Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats.

Am J Physiol Regul Integr Comp Physiol 2007 Jan 14;292(1):R403-14. Epub 2006 Sep 14.

Department of Anesthesia, Cara Phelan Trauma Research Centre, University of Toronto, St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1W8, Canada.

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http://dx.doi.org/10.1152/ajpregu.00403.2006DOI Listing
January 2007

Induction of matrix metalloproteinase-2 enhances systemic arterial contraction after hypoxia.

Am J Physiol Heart Circ Physiol 2007 Jan 15;292(1):H684-93. Epub 2006 Sep 15.

Dept. of Critical Care, Rm. 4-015, St. Michael's Hospital, 30 Bond St., Toronto, ON, Canada.

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http://www.physiology.org/doi/10.1152/ajpheart.00538.2006
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http://dx.doi.org/10.1152/ajpheart.00538.2006DOI Listing
January 2007

Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice.

Nat Med 2006 Sep 13;12(9):1081-7. Epub 2006 Aug 13.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1038/nm1460DOI Listing
September 2006

RNA interference as potential therapy--not so fast.

Authors:
Philip A Marsden

N Engl J Med 2006 Aug;355(9):953-4

Division of Nephrology, St. Michael's Hospital and the University of Toronto, Toronto.

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http://dx.doi.org/10.1056/NEJMcibr063864DOI Listing
August 2006

c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes.

J Biol Chem 2006 Jun 19;281(24):16443-52. Epub 2006 Apr 19.

Divisions of Vascular Surgery and Cardiac Surgery, Toronto General Hospital Research Institute of the University Health Network, University of Toronto, Toronto, Ontario M5G-2C4, Canada.

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http://dx.doi.org/10.1074/jbc.M602815200DOI Listing
June 2006

RNA transfection is a versatile tool to investigate endothelin-1 posttranscriptional regulation.

Exp Biol Med (Maywood) 2006 Jun;231(6):704-8

Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, University of Toronto, Medical Sciences Building, Room 7358, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

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June 2006

Cloning and characterization of the human CD200 promoter region.

Mol Immunol 2006 Feb 13;43(6):579-87. Epub 2005 Jun 13.

Transplant Research Division, The Toronto Hospital, Department of Surgery & Immunology, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.molimm.2005.04.014DOI Listing
February 2006

Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.

J Exp Med 2005 Dec;202(11):1587-97

Division of Respirology, Department of Medicine, and the McLaughlin Center for Molecular Medicine, University of Toronto and Toronto General Hospital Research Institute of the University Health Network, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1084/jem.20051108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213338PMC
December 2005

Extensive variation in the 5'-UTR of Dicer mRNAs influences translational efficiency.

Biochem Biophys Res Commun 2005 Sep;335(3):643-50

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.bbrc.2005.07.138DOI Listing
September 2005

Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells.

J Immunol 2005 Sep;175(6):3846-61

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.4049/jimmunol.175.6.3846DOI Listing
September 2005

Nitric oxide-eluting polyurethanes--vascular grafts of the future?

N Engl J Med 2005 Aug;353(7):730-1

Division of Cardiac Surgery, St. Michael's Hospital and the University of Toronto, Toronto.

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http://dx.doi.org/10.1056/NEJMcibr052030DOI Listing
August 2005

The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.

J Biol Chem 2005 Jul 3;280(26):24824-38. Epub 2005 May 3.

Department of Medical Biophysics, St. Michael's Hospital and University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.jbc.org/content/early/2005/05/03/jbc.M502115200.f
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http://www.jbc.org/cgi/doi/10.1074/jbc.M502115200
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http://dx.doi.org/10.1074/jbc.M502115200DOI Listing
July 2005

Glutathione depletion inhibits lipopolysaccharide-induced intercellular adhesion molecule 1 synthesis.

Free Radic Biol Med 2005 May;38(10):1333-43

Department of Surgery, University Health Network and University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.

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http://dx.doi.org/10.1016/j.freeradbiomed.2005.01.013DOI Listing
May 2005

Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript.

J Biol Chem 2004 Sep 2;279(36):37982-96. Epub 2004 Jul 2.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M400271200
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http://dx.doi.org/10.1074/jbc.M400271200DOI Listing
September 2004

The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation.

J Biol Chem 2004 Aug 4;279(33):35087-100. Epub 2004 Jun 4.

Renal Division and Department of Medicine, St. Michael's Hospital and University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M405063200DOI Listing
August 2004

CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules.

J Immunol 2004 Jun;172(12):7744-9

Transplant Research Division, Toronto Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.4049/jimmunol.172.12.7744DOI Listing
June 2004

Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel.

Arterioscler Thromb Vasc Biol 2004 Mar 1;24(3):405-12. Epub 2003 Dec 1.

Renal Division and Department of Medicine, St. Michael's Hospital and University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/01.ATV.0000109171.50229.33DOI Listing
March 2004

Role of the 3'-untranslated region of human endothelin-1 in vascular endothelial cells. Contribution to transcript lability and the cellular heat shock response.

J Biol Chem 2004 Mar 3;279(10):8655-67. Epub 2003 Dec 3.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada.

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http://dx.doi.org/10.1074/jbc.M312190200DOI Listing
March 2004

Abnormalities in villin gene expression and canalicular microvillus structure in progressive cholestatic liver disease of childhood.

Lancet 2003 Oct;362(9390):1112-9

Department of Multi-organ Transplantation Research, Toronto General Hospital, University Health Network, ON, Toronto, Canada.

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http://dx.doi.org/10.1016/S0140-6736(03)14467-4DOI Listing
October 2003

Predicting outcomes after renal transplantation--new tools and old tools.

Authors:
Philip A Marsden

N Engl J Med 2003 Jul;349(2):182-4

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http://dx.doi.org/10.1056/NEJMe030096DOI Listing
July 2003

Translational regulation of human neuronal nitric-oxide synthase by an alternatively spliced 5'-untranslated region leader exon.

J Biol Chem 2003 Jan 25;278(1):636-44. Epub 2002 Oct 25.

Renal Division and the Department of Medicine, St. Michael's Hospital and University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M209988200DOI Listing
January 2003

Perturbations in paracrine control of the circulation: role of the endothelial-derived vasomediators, endothelin-1 and nitric oxide.

Microsc Res Tech 2003 Jan;60(1):46-58

Renal Division and Department of Medicine, St. Michael's Hospital and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/jemt.10242DOI Listing
January 2003

Increased body lead burden--cause or consequence of chronic renal insufficiency?

Authors:
Philip A Marsden

N Engl J Med 2003 Jan;348(4):345-7

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http://dx.doi.org/10.1056/NEJMe020164DOI Listing
January 2003

Familial risk of preeclampsia in Newfoundland: a population-based study.

J Am Soc Nephrol 2002 Jul;13(7):1901-6

Department of Obstetrics, Memorial University Health Sciences Center, St. John's, Newfoundland A1B 3V6, Canada.

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http://dx.doi.org/10.1097/01.asn.0000017224.24670.82DOI Listing
July 2002

Cigarette smoking--association with hepatic artery thrombosis.

Liver Transpl 2002 Jul;8(7):588-90

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http://dx.doi.org/10.1053/jlts.2002.34151DOI Listing
July 2002

Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity.

J Immunol 2002 May;168(10):5170-7

Multi Organ Transplant Program, Toronto General Hospital and University of Toronto, 621 University Avenue 10th Floor, Room 116, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.4049/jimmunol.168.10.5170DOI Listing
May 2002

Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide.

J Immunol 2002 May;168(10):5252-9

Department of Surgery, University Health Network, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.168.10.5252DOI Listing
May 2002

An alternative promoter of the human neuronal nitric oxide synthase gene is expressed specifically in Leydig cells.

Am J Pathol 2002 Jan;160(1):369-80

Renal Division and Department of Medicine, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867129PMC
http://dx.doi.org/10.1016/S0002-9440(10)64380-5DOI Listing
January 2002