Philip A Barker

Philip A Barker

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Philip A Barker

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Developmental Axon Degeneration Requires TRPV1-Dependent Ca Influx.

Authors:
Aaron D Johnstone Andrés de Léon Nicolás Unsain Julien Gibon Philip A Barker

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 27.

Department of Biology, University of British Columbia Okanagan, Kelowna, British Columbia V1V 1V7, Canada.

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http://dx.doi.org/10.1523/ENEURO.0019-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399429PMC
May 2019

The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons.

Authors:
Rhalena A Thomas Julien Gibon Carol X Q Chen Sabrina Chierzi Vincent G Soubannier Stephanie Baulac Philippe Séguéla Keith Murai Philip A Barker

eNeuro 2018 Jul-Aug;5(4). Epub 2018 Sep 7.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0185-18.2018
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http://dx.doi.org/10.1523/ENEURO.0185-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140115PMC
March 2019

A novel method for quantifying axon degeneration.

Authors:
Aaron D Johnstone Robin M Hallett Andrés de Léon Bruno Carturan Julien Gibon Philip A Barker

PLoS One 2018 18;13(7):e0199570. Epub 2018 Jul 18.

Department of Biology, University of British Columbia Okanagan, Kelowna, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199570PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051587PMC
December 2018

Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat.

Authors:
Léa Décarie-Spain Sandeep Sharma Cécile Hryhorczuk Victor Issa-Garcia Philip A Barker Nathalie Arbour Thierry Alquier Stephanie Fulton

Mol Metab 2018 04 31;10:1-13. Epub 2018 Jan 31.

Centre de Recherche du CHUM, Université de Montréal, Quebec, Canada; Montreal Diabetes Research Centre, Université de Montréal, Quebec, Canada; Department of Nutrition, Université de Montréal, Quebec, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778173093
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http://dx.doi.org/10.1016/j.molmet.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985233PMC
April 2018

Author Correction: Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration.

Authors:
Nicolas Unsain Martin D Bordenave Gaby F Martinez Sami Jalil Catalina von Bilderling Federico M Barabas Luciano A Masullo Aaron D Johnstone Philip A Barker Mariano Bisbal Fernando D Stefani Alfredo O Cáceres

Sci Rep 2018 Apr 12;8(1):6002. Epub 2018 Apr 12.

Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), UNC, Friuli, 2434 - 5016, Córdoba, Argentina.

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http://dx.doi.org/10.1038/s41598-018-23781-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897346PMC
April 2018

Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration.

Authors:
Nicolas Unsain Martin D Bordenave Gaby F Martinez Sami Jalil Catalina von Bilderling Federico M Barabas Luciano A Masullo Aaron D Johnstone Philip A Barker Mariano Bisbal Fernando D Stefani Alfredo O Cáceres

Sci Rep 2018 02 14;8(1):3007. Epub 2018 Feb 14.

Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), UNC, Friuli, 2434 - 5016, Córdoba, Argentina.

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http://dx.doi.org/10.1038/s41598-018-21232-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812996PMC
February 2018

Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain.

Authors:
Julien Gibon Philip A Barker

Neuroscientist 2017 12 17;23(6):587-604. Epub 2017 Mar 17.

1 Department of Biology, University of British Columbia, Kelowna, BC, Canada.

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http://dx.doi.org/10.1177/1073858417697037DOI Listing
December 2017

Generation and characterization of mice bearing null alleles of nradd/Nrh2.

Authors:
Nicolas Unsain Genevieve Dorval Jae Hyung Sheen Philip A Barker

Genesis 2016 Dec 12;54(12):605-612. Epub 2016 Nov 12.

Vice Principal Research University of British Columbia, Okanagan Campus, 3247 University Way, Kelowna, British Columbia, V1V1V7, Canada.

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http://dx.doi.org/10.1002/dvg.22989DOI Listing
December 2016

Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile.

Authors:
Julien Gibon Min Su Kang Arturo Aliaga Behrang Sharif Pedro Rosa-Neto Philippe Séguéla Philip A Barker Alexey Kostikov

Bioorg Med Chem 2016 10 13;24(19):4759-4765. Epub 2016 Aug 13.

Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A2B4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.08.020DOI Listing
October 2016

The X-linked inhibitor of apoptosis regulates long-term depression and learning rate.

Authors:
Julien Gibon Nicolas Unsain Karine Gamache Rhalena A Thomas Andres De Leon Aaron Johnstone Karim Nader Philippe Séguéla Philip A Barker

FASEB J 2016 09 17;30(9):3083-90. Epub 2016 May 17.

Biology Unit, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada;

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http://dx.doi.org/10.1096/fj.201600384RDOI Listing
September 2016

Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes.

Authors:
Víctor Danelon Laura E Montroull Nicolás Unsain Philip A Barker Daniel H Mascó

Mol Cell Neurosci 2016 09 20;75:81-92. Epub 2016 Jul 20.

Laboratorio de Neurobiología, Instituto de Investigaciones Biológicas y Tecnológicas, IIByT-CONICET-FCEFyN, Universidad Nacional de Córdoba, Av. Vélez Sarsfield 1611, Córdoba, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2016.07.002DOI Listing
September 2016

HBpF-proBDNF: A New Tool for the Analysis of Pro-Brain Derived Neurotrophic Factor Receptor Signaling and Cell Biology.

Authors:
Perrine Gaub Andrès de Léon Julien Gibon Vincent Soubannier Geneviève Dorval Philippe Séguéla Philip A Barker

PLoS One 2016 7;11(3):e0150601. Epub 2016 Mar 7.

Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3A 2B4, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150601PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780767PMC
August 2016

Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1-LGI1 signaling.

Authors:
Rhalena A Thomas Amirthagowri Ambalavanan Guy A Rouleau Philip A Barker

Mol Genet Genomic Med 2016 Jul 11;4(4):447-56. Epub 2016 Mar 11.

Department of Neurology and NeurosurgeryMontreal Neurological InstituteMcGill University3801 UniversityMontrealQuebecH3A 2B4Canada; Department of BiologyUniversity of British ColumbiaKelownaBC. V1V 1V7Canada.

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http://dx.doi.org/10.1002/mgg3.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947863PMC
July 2016

Interpretation and application of carbon isotope ratios in freshwater diatom silica.

Authors:
Megan Webb Philip A Barker Peter M Wynn Oliver Heiri Maarten van Hardenbroek Frances Pick James M Russell Andy W Stott Melanie J Leng

J Quat Sci 2016 May 17;31(4):300-309. Epub 2016 Jun 17.

NERC Isotope Geosciences FacilitiesBritish Geological SurveyNottinghamUK; Centre for Environmental GeochemistrySchool of GeographyUniversity of NottinghamNottinghamUK.

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http://dx.doi.org/10.1002/jqs.2837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014241PMC
May 2016

North Atlantic forcing of moisture delivery to Europe throughout the Holocene.

Authors:
Andrew C Smith Peter M Wynn Philip A Barker Melanie J Leng Stephen R Noble Wlodek Tych

Sci Rep 2016 04 25;6:24745. Epub 2016 Apr 25.

Lancaster Environment Centre, Lancaster University, Lancaster, LA1 4YQ, UK.

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http://dx.doi.org/10.1038/srep24745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842961PMC
April 2016

Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex.

Authors:
Julien Gibon Philip A Barker Philippe Séguéla

Mol Brain 2016 Mar 1;9:23. Epub 2016 Mar 1.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Suite 778, Montreal, Quebec, H3A 2B4, Canada.

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http://dx.doi.org/10.1186/s13041-016-0203-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774087PMC
March 2016

An experiment to assess the effects of diatom dissolution on oxygen isotope ratios.

Authors:
Andrew C Smith Melanie J Leng George E A Swann Philip A Barker Anson W Mackay David B Ryves Hilary J Sloane Simon R N Chenery Mike Hems

Rapid Commun Mass Spectrom 2016 Jan;30(2):293-300

Department of Geology, University of Leicester, Leicester, LE1 7RH, UK.

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http://dx.doi.org/10.1002/rcm.7446DOI Listing
January 2016

Drip water electrical conductivity as an indicator of cave ventilation at the event scale.

Authors:
Andrew C Smith Peter M Wynn Philip A Barker Melanie J Leng

Sci Total Environ 2015 Nov 19;532:517-27. Epub 2015 Jun 19.

NERC Isotope Geosciences Facility, British Geological Survey, Nottingham NG12 5GG, United Kingdom; Centre for Environmental Geochemistry, University of Nottingham, Nottingham NG7 2RD, United Kingdom.

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http://dx.doi.org/10.1016/j.scitotenv.2015.06.037DOI Listing
November 2015

New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles.

Authors:
Nicolas Unsain Philip A Barker

Neuron 2015 Nov;88(3):461-74

Irving K. Barber School of Arts and Sciences, University of British Columbia, Kelowna, BC V1V 1V7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.08.029DOI Listing
November 2015

cIAP2 supports viability of mice lacking cIAP1 and XIAP.

Authors:
Kristen N Heard Mathieu J M Bertrand Philip A Barker

EMBO J 2015 Oct;34(19):2393-5

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.15252/embj.201592060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601659PMC
October 2015

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation.

Authors:
Jorge L Cueva Vargas Ingrid K Osswald Nicolas Unsain Mark R Aurousseau Philip A Barker Derek Bowie Adriana Di Polo

J Neurosci 2015 Sep;35(35):12088-102

Department of Neuroscience and University of Montreal Hospital Research Center (CRCHUM), University of Montreal, Montreal, Quebec H2X 0A9, Canada,

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http://dx.doi.org/10.1523/JNEUROSCI.1273-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605307PMC
September 2015

proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.

Authors:
Julien Gibon Shannon M Buckley Nicolas Unsain Vesa Kaartinen Philippe Séguéla Philip A Barker

J Neurosci 2015 Jul;35(26):9741-53

Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A2B4, and

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http://dx.doi.org/10.1523/JNEUROSCI.4655-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605143PMC
July 2015

p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade.

Authors:
Michele Zeinieh Amir Salehi Vijidha Rajkumar Philip A Barker

J Cell Sci 2015 Feb;128(3):447-59

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http://dx.doi.org/10.1242/jcs.152173DOI Listing
February 2015

High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.

Authors:
Katrina Y Choe Su Y Han Perrine Gaub Brent Shell Daniel L Voisin Blayne A Knapp Philip A Barker Colin H Brown J Thomas Cunningham Charles W Bourque

Neuron 2015 Feb 22;85(3):549-60. Epub 2015 Jan 22.

Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Montreal, QC H3G1A4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.12.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577058PMC
February 2015

LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation.

Authors:
Andrea M A Schreij Mathilde Chaineau Wenjing Ruan Susan Lin Philip A Barker Edward A Fon Peter S McPherson

EMBO Rep 2015 Jan 26;16(1):79-86. Epub 2014 Nov 26.

Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.15252/embr.201438714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304731PMC
January 2015

S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis.

Authors:
Alejandro Villarreal Rocío Seoane Agustina González Torres Gerardo Rosciszewski Maria Florencia Angelo Alicia Rossi Philip A Barker Alberto Javier Ramos

J Neurochem 2014 Oct 5;131(2):190-205. Epub 2014 Jul 5.

Laboratorio de Neuropatología Molecular, Instituto de Biología Celular y Neurociencia "Prof. E. De Robertis", Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

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http://doi.wiley.com/10.1111/jnc.12790
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http://dx.doi.org/10.1111/jnc.12790DOI Listing
October 2014

Neurotrophins in the regulation of cellular survival and death.

Authors:
Claire Ceni Nicolas Unsain Michele P Zeinieh Philip A Barker

Handb Exp Pharmacol 2014 ;220:193-221

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada, H3A 2B4.

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http://dx.doi.org/10.1007/978-3-642-45106-5_8DOI Listing
August 2014

Production and isolation of axons from sensory neurons for biochemical analysis using porous filters.

Authors:
Nicolas Unsain Kristen N Heard Julia M Higgins Philip A Barker

J Vis Exp 2014 Jul 8(89). Epub 2014 Jul 8.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University;

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http://dx.doi.org/10.3791/51795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212973PMC
July 2014

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.

Authors:
Peter A Forsyth Niveditha Krishna Samuel Lawn J Gerardo Valadez Xiaotao Qu David A Fenstermacher Michelle Fournier Lisa Potthast Prakash Chinnaiyan Geoffrey T Gibney Michele Zeinieh Philip A Barker Bruce D Carter Michael K Cooper Rajappa S Kenchappa

J Biol Chem 2014 Mar 11;289(12):8067-85. Epub 2014 Feb 11.

From the Department of Neuro-Oncology, Moffitt Cancer Center and Research Institute and.

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http://dx.doi.org/10.1074/jbc.M113.513762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961639PMC
March 2014

Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development.

Authors:
Wenjing Ruan Nicolas Unsain Julie Desbarats Edward A Fon Philip A Barker

PLoS One 2013 27;8(3):e60091. Epub 2013 Mar 27.

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060091PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609737PMC
September 2013

XIAP regulates caspase activity in degenerating axons.

Authors:
Nicolas Unsain Julia M Higgins Kristen N Parker Aaron D Johnstone Philip A Barker

Cell Rep 2013 Aug 15;4(4):751-63. Epub 2013 Aug 15.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.celrep.2013.07.015DOI Listing
August 2013

Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.

Authors:
Laurent Methot Robert Hermann Yeman Tang Rita Lo Hosam Al-Jehani Sumit Jhas Devon Svoboda Ruth S Slack Philip A Barker Stefano Stifani

Mol Cell Biol 2013 Jul 20;33(14):2797-808. Epub 2013 May 20.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1128/MCB.01610-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700133PMC
July 2013

ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.

Authors:
Ariel M Wilson Barbara Morquette Mohamed Abdouh Nicolás Unsain Philip A Barker Elena Feinstein Gilbert Bernier Adriana Di Polo

J Neurosci 2013 Jan;33(5):2205-16

Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, University of Montreal, Montreal, Quebec H3T 1J4, Canada.

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http://www.jneurosci.org/content/33/5/2205.full.pdf
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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2635-12.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.2635-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619125PMC
January 2013

An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.

Authors:
Niall S Kenneth J Michael Younger Elizabeth D Hughes Danielle Marcotte Philip A Barker Thomas L Saunders Colin S Duckett

Biochem J 2012 Apr;443(2):355-9

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1042/BJ20120249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327503PMC
April 2012

Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.

Authors:
Reddy P Kommaddi Rhalena Thomas Claire Ceni Kathleen Daigneault Philip A Barker

FASEB J 2011 Jun 16;25(6):2061-70. Epub 2011 Mar 16.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St., Montreal, QC, Canada, H3A 2B4.

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http://dx.doi.org/10.1096/fj.10-173740DOI Listing
June 2011

Developing a methodology for carbon isotope analysis of lacustrine diatoms.

Authors:
Elizabeth R Hurrell Philip A Barker Melanie J Leng Christopher H Vane Peter Wynn Chris P Kendrick Dirk Verschuren F Alayne Street-Perrott

Rapid Commun Mass Spectrom 2011 Jun;25(11):1567-74

Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK.

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http://dx.doi.org/10.1002/rcm.5020DOI Listing
June 2011

TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex.

Authors:
Zizhen Zhang Antonio Reboreda Angel Alonso Philip A Barker Philippe Séguéla

Hippocampus 2011 Apr;21(4):386-97

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4 Canada.

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http://dx.doi.org/10.1002/hipo.20755DOI Listing
April 2011

Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor.

Authors:
Reddy P Kommaddi Kathleen M Dickson Philip A Barker

J Neurochem 2011 Feb 13;116(3):396-405. Epub 2010 Dec 13.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2010.07120.xDOI Listing
February 2011

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling.

Authors:
Claire Ceni Reddy Peera Kommaddi Rhalena Thomas Emily Vereker Xiaoyang Liu Peter S McPherson Brigitte Ritter Philip A Barker

J Cell Sci 2010 Jul 8;123(Pt 13):2299-307. Epub 2010 Jun 8.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.062612
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http://dx.doi.org/10.1242/jcs.062612DOI Listing
July 2010

LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition.

Authors:
Rhalena Thomas Kristy Favell Jose Morante-Redolat Madeline Pool Christopher Kent Melissa Wright Kathleen Daignault Gino B Ferraro Samuel Montcalm Yves Durocher Alyson Fournier Jordi Perez-Tur Philip A Barker

J Neurosci 2010 May;30(19):6607-12

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montréal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.5147-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632578PMC
May 2010

De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.

Authors:
Julie Gauthier Nathalie Champagne Ronald G Lafrenière Lan Xiong Dan Spiegelman Edna Brustein Mathieu Lapointe Huashan Peng Mélanie Côté Anne Noreau Fadi F Hamdan Anjené M Addington Judith L Rapoport Lynn E Delisi Marie-Odile Krebs Ridha Joober Ferid Fathalli Fayçal Mouaffak Ali P Haghighi Christian Néri Marie-Pierre Dubé Mark E Samuels Claude Marineau Eric A Stone Philip Awadalla Philip A Barker Salvatore Carbonetto Pierre Drapeau Guy A Rouleau

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7863-8. Epub 2010 Apr 12.

Department of Medicine, Centre of Excellence in Neuromics of Université de Montréal, Centre Hospitalier de l'Université de Montréal Research Center, Université de Montréal, Montréal, QC H2L 2W5, Canada

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http://dx.doi.org/10.1073/pnas.0906232107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867875PMC
April 2010

ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway.

Authors:
Frédéric Lebrun-Julien Mathieu J Bertrand Olivier De Backer David Stellwagen Carlos R Morales Adriana Di Polo Philip A Barker

Proc Natl Acad Sci U S A 2010 Feb 3;107(8):3817-22. Epub 2010 Feb 3.

Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montreal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1073/pnas.0909276107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840442PMC
February 2010

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

Authors:
Mathieu J M Bertrand Karine Doiron Katherine Labbé Robert G Korneluk Philip A Barker Maya Saleh

Immunity 2009 Jun 21;30(6):789-801. Epub 2009 May 21.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.immuni.2009.04.011DOI Listing
June 2009

Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling.

Authors:
Marina Snapyan Morgane Lemasson Monika S Brill Mathieu Blais Mireille Massouh Jovica Ninkovic Claude Gravel François Berthod Magdalena Götz Philip A Barker André Parent Armen Saghatelyan

J Neurosci 2009 Apr;29(13):4172-88

The Cellular Neurobiology Unit, Centre de Recherche Université Laval Robert-Giffard, Québec, Québec, Canada G1J 2G3.

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http://dx.doi.org/10.1523/JNEUROSCI.4956-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665362PMC
April 2009

A p75(NTR) pivoting paradigm propels perspicacity.

Authors:
Philip A Barker

Neuron 2009 Apr;62(1):3-5

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.neuron.2009.04.005DOI Listing
April 2009

Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.

Authors:
Frédéric Lebrun-Julien Laure Duplan Vincent Pernet Ingrid Osswald Przemyslaw Sapieha Philippe Bourgeois Kathleen Dickson Derek Bowie Philip A Barker Adriana Di Polo

J Neurosci 2009 Apr;29(17):5536-45

Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montreal, Quebec H3T 1J4, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.0831-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665839PMC
April 2009

Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.

Authors:
Scott J Russo Matthew B Wilkinson Michelle S Mazei-Robison David M Dietz Ian Maze Vaishnav Krishnan William Renthal Ami Graham Shari G Birnbaum Thomas A Green Bruce Robison Alan Lesselyong Linda I Perrotti Carlos A Bolaños Arvind Kumar Michael S Clark John F Neumaier Rachael L Neve Asha L Bhakar Philip A Barker Eric J Nestler

J Neurosci 2009 Mar;29(11):3529-37

Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6173-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677656PMC
March 2009

Observations on the function of nuclear factor kappa B (NF-kappaB) in the survival of adult primary sensory neurons after nerve injury.

Authors:
Svetlana Gushchina Veronica Leinster Dongsheng Wu Avin Jasim Maria Demestre Luis Lopez de Heredia Gregory J Michael Philip A Barker Peter M Richardson Charalambos Magoulas

Mol Cell Neurosci 2009 Feb 8;40(2):207-16. Epub 2008 Nov 8.

Neuroscience Centre, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E12AT, UK.

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http://dx.doi.org/10.1016/j.mcn.2008.10.010DOI Listing
February 2009

Whither proBDNF?

Authors:
Philip A Barker

Nat Neurosci 2009 Feb;12(2):105-6

Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1038/nn0209-105DOI Listing
February 2009

Mutations in the calcium-related gene IL1RAPL1 are associated with autism.

Authors:
Amélie Piton Jacques L Michaud Huashan Peng Swaroop Aradhya Julie Gauthier Laurent Mottron Nathalie Champagne Ronald G Lafrenière Fadi F Hamdan Ridha Joober Eric Fombonne Claude Marineau Patrick Cossette Marie-Pierre Dubé Pejmun Haghighi Pierre Drapeau Philip A Barker Salvatore Carbonetto Guy A Rouleau

Hum Mol Genet 2008 Dec 18;17(24):3965-74. Epub 2008 Sep 18.

Centre for Excellence in Neuromics, CHUM Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada H2L 4M1.

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http://dx.doi.org/10.1093/hmg/ddn300DOI Listing
December 2008

Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.

Authors:
Johanna Pispa Marja Pummila Philip A Barker Irma Thesleff Marja L Mikkola

Hum Mol Genet 2008 Nov 9;17(21):3380-91. Epub 2008 Aug 9.

Developmental Biology Program, Institute of Biotechnology, 00014 University of Helsinki, PO Box 56, Finland.

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http://dx.doi.org/10.1093/hmg/ddn232DOI Listing
November 2008

Apoptotic sensitivity of murine IAP-deficient cells.

Authors:
Julie M Rumble Mathieu J M Bertrand Rebecca A Csomos Casey W Wright Lori Albert Tak W Mak Philip A Barker Colin S Duckett

Biochem J 2008 Oct;415(1):21-5

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1042/BJ20081188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676106PMC
October 2008

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.

Authors:
Mathieu J M Bertrand Snezana Milutinovic Kathleen M Dickson Wai Chi Ho Alain Boudreault Jon Durkin John W Gillard James B Jaquith Stephen J Morris Philip A Barker

Mol Cell 2008 Jun;30(6):689-700

Montreal Neurological Institute, McGill University, Montreal, Quebec H3A2B4, Canada.

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http://dx.doi.org/10.1016/j.molcel.2008.05.014DOI Listing
June 2008

Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation.

Authors:
Jacqueline Boutilier Claire Ceni Promila C Pagdala Alison Forgie Kenneth E Neet Philip A Barker

J Biol Chem 2008 May 25;283(19):12709-16. Epub 2008 Feb 25.

Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal H3A 2B4, Canada.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M710018200
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442317PMC
May 2008

Soluble adenylyl cyclase is not required for axon guidance to netrin-1.

Authors:
Simon W Moore Karen Lai Wing Sun Fang Xie Philip A Barker Marco Conti Timothy E Kennedy

J Neurosci 2008 Apr;28(15):3920-4

Centre for Neuronal Survival, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.1523/JNEUROSCI.0547-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670467PMC
April 2008

Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.

Authors:
Bhooma Srinivasan Zhaohui Wang Anne M Brun-Zinkernagel Robert J Collier Roy A Black Stuart J Frank Philip A Barker Rouel S Roque

Mol Cell Neurosci 2007 Dec 15;36(4):449-61. Epub 2007 Aug 15.

Department of Cell Biology and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1016/j.mcn.2007.08.005DOI Listing
December 2007

Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis.

Authors:
Kazushige Furuya Toshinori Ozaki Takayuki Hanamoto Mitsuchika Hosoda Syunji Hayashi Philip A Barker Kunio Takano Masahiko Matsumoto Akira Nakagawara

J Biol Chem 2007 Jun 23;282(25):18365-78. Epub 2007 Apr 23.

Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1074/jbc.M610522200DOI Listing
June 2007

Atmospheric science. The monsoon's past.

Authors:
Philip A Barker

Science 2007 Jun;316(5829):1295-6

Department of Geography, Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK.

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http://dx.doi.org/10.1126/science.1143451DOI Listing
June 2007

Something old, something new: BDNF-induced neuron survival requires TRPC channel function.

Authors:
Wayne S Sossin Philip A Barker

Nat Neurosci 2007 May;10(5):537-8

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http://dx.doi.org/10.1038/nn0507-537DOI Listing
May 2007

Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription.

Authors:
Alberto Ramos Wai Chi Ho Stephanie Forte Kathleen Dickson Jacqueline Boutilier Kristy Favell Philip A Barker

J Neurosci 2007 Feb;27(6):1498-506

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.1523/JNEUROSCI.4806-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673569PMC
February 2007

High affinity not in the vicinity?

Authors:
Philip A Barker

Neuron 2007 Jan;53(1):1-4

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.neuron.2006.12.018DOI Listing
January 2007

The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface.

Authors:
Maria Salomé Sirerol-Piquer Ana Ayerdi-Izquierdo José Manuel Morante-Redolat Vicente Herranz-Pérez Kristy Favell Philip A Barker Jordi Pérez-Tur

Hum Mol Genet 2006 Dec 26;15(23):3436-45. Epub 2006 Oct 26.

Unitat de Genètica Molecular, Departament de Genòmica i Proteòmica, Institut de Biomedicina de València-CSIC, Spain.

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http://dx.doi.org/10.1093/hmg/ddl421DOI Listing
December 2006

Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.

Authors:
Rajappa S Kenchappa Niccolò Zampieri Moses V Chao Philip A Barker Henry K Teng Barbara L Hempstead Bruce D Carter

Neuron 2006 Apr;50(2):219-32

Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1016/j.neuron.2006.03.011DOI Listing
April 2006

AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.

Authors:
Amir H Salehi Stephen J Morris Wai-Chi Ho Kathleen M Dickson Genevieve Doucet Snezana Milutinovic Jon Durkin John W Gillard Philip A Barker

Chem Biol 2006 Feb;13(2):213-23

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada.

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http://dx.doi.org/10.1016/j.chembiol.2005.11.012DOI Listing
February 2006

p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.

Authors:
Joe P S Makkerh Claire Ceni Daniel S Auld François Vaillancourt Genevieve Dorval Philip A Barker

EMBO Rep 2005 Oct;6(10):936-41

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1038/sj.embor.7400503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369184PMC
October 2005

Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.

Authors:
José M Lora Dong Mei Zhang Sha Mei Liao Timothy Burwell Anne Marie King Philip A Barker Latika Singh Marie Keaveney Jay Morgenstern José Carlos Gutiérrez-Ramos Anthony J Coyle Christopher C Fraser

J Biol Chem 2005 Oct 25;280(43):36510-7. Epub 2005 Aug 25.

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1074/jbc.M507977200DOI Listing
October 2005

Getting RIP'd Stunts Your Growth.

Authors:
Claire Ceni Philip A Barker

Neuron 2005 Jun;46(6):839-40

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada.

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http://dx.doi.org/10.1016/j.neuron.2005.06.002DOI Listing
June 2005

Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells.

Authors:
Wai Chi Ho Kathleen M Dickson Philip A Barker

Cancer Res 2005 May;65(10):4273-81

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3494DOI Listing
May 2005

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

Authors:
Esther B E Becker Jenny Howell Yuki Kodama Philip A Barker Azad Bonni

J Neurosci 2004 Oct;24(40):8762-70

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2953-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729963PMC
October 2004

TRAF6-dependent NF-kB transcriptional activity during mouse development.

Authors:
Kathleen M Dickson Asha L Bhakar Philip A Barker

Dev Dyn 2004 Sep;231(1):122-7

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/dvdy.20110DOI Listing
September 2004

p75NTR is positively promiscuous: novel partners and new insights.

Authors:
Philip A Barker

Neuron 2004 May;42(4):529-33

Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.neuron.2004.04.001DOI Listing
May 2004

Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension.

Authors:
Jean-François Bouchard Simon W Moore Nicolas X Tritsch Philippe P Roux Masoud Shekarabi Philip A Barker Timothy E Kennedy

J Neurosci 2004 Mar;24(12):3040-50

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4 Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.4934-03.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729852PMC
March 2004

The p75 neurotrophin receptor: multiple interactors and numerous functions.

Authors:
Jannifer J Gentry Philip A Barker Bruce D Carter

Prog Brain Res 2004 ;146:25-39

Center for Molecular Neuroscience, Department of Biochemistry, Vanderbilt University Medical School, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/S0079-6123(03)46002-0DOI Listing
February 2004

A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice.

Authors:
Christine E Paul Emily Vereker Kathleen M Dickson Philip A Barker

J Neurosci 2004 Feb;24(8):1917-23

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.1523/JNEUROSCI.5397-03.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730398PMC
February 2004

Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad.

Authors:
Asha L Bhakar Jenny L Howell Christine E Paul Amir H Salehi Esther B E Becker Farid Said Azad Bonni Philip A Barker

J Neurosci 2003 Dec;23(36):11373-81

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, H3A 2B4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740508PMC
December 2003

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

Authors:
Amir H Salehi Steven Xanthoudakis Philip A Barker

J Biol Chem 2002 Dec 9;277(50):48043-50. Epub 2002 Oct 9.

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1074/jbc.M205324200DOI Listing
December 2002

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

Authors:
Philippe P Roux Geneviève Dorval Mathieu Boudreau Alexandre Angers-Loustau Stephen J Morris Joe Makkerh Philip A Barker

J Biol Chem 2002 Dec 17;277(51):49473-80. Epub 2002 Oct 17.

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montréal, Québec H3A 2B4, Canada.

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http://dx.doi.org/10.1074/jbc.M203428200DOI Listing
December 2002

Constitutive nuclear factor-kappa B activity is required for central neuron survival.

Authors:
Asha L Bhakar Laura-Lee Tannis Christine Zeindler Maria Pia Russo Christian Jobin David S Park Sandra MacPherson Philip A Barker

J Neurosci 2002 Oct;22(19):8466-75

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757785PMC
October 2002

Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis.

Authors:
Stephen E Kendall Donna E Goldhawk Chris Kubu Philip A Barker Joseph M Verdi

Mech Dev 2002 Sep;117(1-2):187-200

The Laboratory of Neural Stem Cell Biology, The John P Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada N6A 5K8.

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http://dx.doi.org/10.1016/s0925-4773(02)00204-6DOI Listing
September 2002

Retrograde signaling by the neurotrophins follows a well-worn trk.

Authors:
Philip A Barker Natasha K Hussain Peter S McPherson

Trends Neurosci 2002 Aug;25(8):379-81

Centre for Neuronal Survival and Cell Biology of Excitable Tissues Group, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.1016/s0166-2236(02)02199-9DOI Listing
August 2002

Neurotrophin signaling through the p75 neurotrophin receptor.

Authors:
Philippe P Roux Philip A Barker

Prog Neurobiol 2002 Jun;67(3):203-33

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Que., Canada H3A 2B4.

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June 2002

The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease.

Authors:
Philip A Barker Amir Salehi

J Neurosci Res 2002 Mar;67(6):705-12

Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1002/jnr.10160
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March 2002