Philip A Barker

Philip A Barker

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Philip A Barker

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Developmental Axon Degeneration Requires TRPV1-Dependent Ca Influx.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 27.

Department of Biology, University of British Columbia Okanagan, Kelowna, British Columbia V1V 1V7, Canada.

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http://dx.doi.org/10.1523/ENEURO.0019-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399429PMC
May 2019

A novel method for quantifying axon degeneration.

PLoS One 2018 18;13(7):e0199570. Epub 2018 Jul 18.

Department of Biology, University of British Columbia Okanagan, Kelowna, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199570PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051587PMC
December 2018

Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat.

Mol Metab 2018 04 31;10:1-13. Epub 2018 Jan 31.

Centre de Recherche du CHUM, Université de Montréal, Quebec, Canada; Montreal Diabetes Research Centre, Université de Montréal, Quebec, Canada; Department of Nutrition, Université de Montréal, Quebec, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778173093
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http://dx.doi.org/10.1016/j.molmet.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985233PMC
April 2018

Author Correction: Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration.

Sci Rep 2018 Apr 12;8(1):6002. Epub 2018 Apr 12.

Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), UNC, Friuli, 2434 - 5016, Córdoba, Argentina.

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http://dx.doi.org/10.1038/s41598-018-23781-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897346PMC
April 2018

Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration.

Sci Rep 2018 02 14;8(1):3007. Epub 2018 Feb 14.

Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), UNC, Friuli, 2434 - 5016, Córdoba, Argentina.

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http://dx.doi.org/10.1038/s41598-018-21232-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812996PMC
February 2018

Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain.

Neuroscientist 2017 12 17;23(6):587-604. Epub 2017 Mar 17.

1 Department of Biology, University of British Columbia, Kelowna, BC, Canada.

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http://dx.doi.org/10.1177/1073858417697037DOI Listing
December 2017

Generation and characterization of mice bearing null alleles of nradd/Nrh2.

Genesis 2016 Dec 12;54(12):605-612. Epub 2016 Nov 12.

Vice Principal Research University of British Columbia, Okanagan Campus, 3247 University Way, Kelowna, British Columbia, V1V1V7, Canada.

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http://dx.doi.org/10.1002/dvg.22989DOI Listing
December 2016

Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile.

Bioorg Med Chem 2016 10 13;24(19):4759-4765. Epub 2016 Aug 13.

Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A2B4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.08.020DOI Listing
October 2016

The X-linked inhibitor of apoptosis regulates long-term depression and learning rate.

FASEB J 2016 09 17;30(9):3083-90. Epub 2016 May 17.

Biology Unit, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada;

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http://dx.doi.org/10.1096/fj.201600384RDOI Listing
September 2016

Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes.

Mol Cell Neurosci 2016 09 20;75:81-92. Epub 2016 Jul 20.

Laboratorio de Neurobiología, Instituto de Investigaciones Biológicas y Tecnológicas, IIByT-CONICET-FCEFyN, Universidad Nacional de Córdoba, Av. Vélez Sarsfield 1611, Córdoba, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2016.07.002DOI Listing
September 2016

HBpF-proBDNF: A New Tool for the Analysis of Pro-Brain Derived Neurotrophic Factor Receptor Signaling and Cell Biology.

PLoS One 2016 7;11(3):e0150601. Epub 2016 Mar 7.

Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3A 2B4, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150601PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780767PMC
August 2016

Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1-LGI1 signaling.

Mol Genet Genomic Med 2016 Jul 11;4(4):447-56. Epub 2016 Mar 11.

Department of Neurology and NeurosurgeryMontreal Neurological InstituteMcGill University3801 UniversityMontrealQuebecH3A 2B4Canada; Department of BiologyUniversity of British ColumbiaKelownaBC. V1V 1V7Canada.

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http://dx.doi.org/10.1002/mgg3.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947863PMC
July 2016

Interpretation and application of carbon isotope ratios in freshwater diatom silica.

J Quat Sci 2016 May 17;31(4):300-309. Epub 2016 Jun 17.

NERC Isotope Geosciences FacilitiesBritish Geological SurveyNottinghamUK; Centre for Environmental GeochemistrySchool of GeographyUniversity of NottinghamNottinghamUK.

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http://dx.doi.org/10.1002/jqs.2837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014241PMC
May 2016

North Atlantic forcing of moisture delivery to Europe throughout the Holocene.

Sci Rep 2016 04 25;6:24745. Epub 2016 Apr 25.

Lancaster Environment Centre, Lancaster University, Lancaster, LA1 4YQ, UK.

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http://dx.doi.org/10.1038/srep24745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842961PMC
April 2016

Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex.

Mol Brain 2016 Mar 1;9:23. Epub 2016 Mar 1.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Suite 778, Montreal, Quebec, H3A 2B4, Canada.

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http://dx.doi.org/10.1186/s13041-016-0203-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774087PMC
March 2016

An experiment to assess the effects of diatom dissolution on oxygen isotope ratios.

Rapid Commun Mass Spectrom 2016 Jan;30(2):293-300

Department of Geology, University of Leicester, Leicester, LE1 7RH, UK.

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http://dx.doi.org/10.1002/rcm.7446DOI Listing
January 2016

Drip water electrical conductivity as an indicator of cave ventilation at the event scale.

Sci Total Environ 2015 Nov 19;532:517-27. Epub 2015 Jun 19.

NERC Isotope Geosciences Facility, British Geological Survey, Nottingham NG12 5GG, United Kingdom; Centre for Environmental Geochemistry, University of Nottingham, Nottingham NG7 2RD, United Kingdom.

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http://dx.doi.org/10.1016/j.scitotenv.2015.06.037DOI Listing
November 2015

New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles.

Neuron 2015 Nov;88(3):461-74

Irving K. Barber School of Arts and Sciences, University of British Columbia, Kelowna, BC V1V 1V7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.08.029DOI Listing
November 2015

cIAP2 supports viability of mice lacking cIAP1 and XIAP.

EMBO J 2015 Oct;34(19):2393-5

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.15252/embj.201592060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601659PMC
October 2015

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation.

J Neurosci 2015 Sep;35(35):12088-102

Department of Neuroscience and University of Montreal Hospital Research Center (CRCHUM), University of Montreal, Montreal, Quebec H2X 0A9, Canada,

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http://dx.doi.org/10.1523/JNEUROSCI.1273-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605307PMC
September 2015

proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.

J Neurosci 2015 Jul;35(26):9741-53

Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A2B4, and

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http://dx.doi.org/10.1523/JNEUROSCI.4655-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605143PMC
July 2015

High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.

Neuron 2015 Feb 22;85(3):549-60. Epub 2015 Jan 22.

Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Montreal, QC H3G1A4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.12.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577058PMC
February 2015

LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation.

EMBO Rep 2015 Jan 26;16(1):79-86. Epub 2014 Nov 26.

Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.15252/embr.201438714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304731PMC
January 2015

S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis.

J Neurochem 2014 Oct 5;131(2):190-205. Epub 2014 Jul 5.

Laboratorio de Neuropatología Molecular, Instituto de Biología Celular y Neurociencia "Prof. E. De Robertis", Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

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http://doi.wiley.com/10.1111/jnc.12790
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http://dx.doi.org/10.1111/jnc.12790DOI Listing
October 2014

Neurotrophins in the regulation of cellular survival and death.

Handb Exp Pharmacol 2014 ;220:193-221

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada, H3A 2B4.

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http://dx.doi.org/10.1007/978-3-642-45106-5_8DOI Listing
August 2014

Production and isolation of axons from sensory neurons for biochemical analysis using porous filters.

J Vis Exp 2014 Jul 8(89). Epub 2014 Jul 8.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University;

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http://dx.doi.org/10.3791/51795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212973PMC
July 2014

XIAP regulates caspase activity in degenerating axons.

Cell Rep 2013 Aug 15;4(4):751-63. Epub 2013 Aug 15.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.celrep.2013.07.015DOI Listing
August 2013

Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.

FASEB J 2011 Jun 16;25(6):2061-70. Epub 2011 Mar 16.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St., Montreal, QC, Canada, H3A 2B4.

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http://dx.doi.org/10.1096/fj.10-173740DOI Listing
June 2011

Developing a methodology for carbon isotope analysis of lacustrine diatoms.

Rapid Commun Mass Spectrom 2011 Jun;25(11):1567-74

Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK.

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http://dx.doi.org/10.1002/rcm.5020DOI Listing
June 2011

TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex.

Hippocampus 2011 Apr;21(4):386-97

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4 Canada.

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http://dx.doi.org/10.1002/hipo.20755DOI Listing
April 2011

Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor.

J Neurochem 2011 Feb 13;116(3):396-405. Epub 2010 Dec 13.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2010.07120.xDOI Listing
February 2011

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling.

J Cell Sci 2010 Jul 8;123(Pt 13):2299-307. Epub 2010 Jun 8.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.062612
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http://dx.doi.org/10.1242/jcs.062612DOI Listing
July 2010

ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway.

Proc Natl Acad Sci U S A 2010 Feb 3;107(8):3817-22. Epub 2010 Feb 3.

Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montreal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1073/pnas.0909276107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840442PMC
February 2010

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

Immunity 2009 Jun 21;30(6):789-801. Epub 2009 May 21.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.immuni.2009.04.011DOI Listing
June 2009

A p75(NTR) pivoting paradigm propels perspicacity.

Authors:
Philip A Barker

Neuron 2009 Apr;62(1):3-5

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.neuron.2009.04.005DOI Listing
April 2009

Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.

J Neurosci 2009 Apr;29(17):5536-45

Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montreal, Quebec H3T 1J4, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.0831-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665839PMC
April 2009

Observations on the function of nuclear factor kappa B (NF-kappaB) in the survival of adult primary sensory neurons after nerve injury.

Mol Cell Neurosci 2009 Feb 8;40(2):207-16. Epub 2008 Nov 8.

Neuroscience Centre, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E12AT, UK.

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http://dx.doi.org/10.1016/j.mcn.2008.10.010DOI Listing
February 2009

Whither proBDNF?

Authors:
Philip A Barker

Nat Neurosci 2009 Feb;12(2):105-6

Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1038/nn0209-105DOI Listing
February 2009

Mutations in the calcium-related gene IL1RAPL1 are associated with autism.

Hum Mol Genet 2008 Dec 18;17(24):3965-74. Epub 2008 Sep 18.

Centre for Excellence in Neuromics, CHUM Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada H2L 4M1.

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http://dx.doi.org/10.1093/hmg/ddn300DOI Listing
December 2008

Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.

Hum Mol Genet 2008 Nov 9;17(21):3380-91. Epub 2008 Aug 9.

Developmental Biology Program, Institute of Biotechnology, 00014 University of Helsinki, PO Box 56, Finland.

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http://dx.doi.org/10.1093/hmg/ddn232DOI Listing
November 2008

Apoptotic sensitivity of murine IAP-deficient cells.

Biochem J 2008 Oct;415(1):21-5

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1042/BJ20081188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676106PMC
October 2008

Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation.

J Biol Chem 2008 May 25;283(19):12709-16. Epub 2008 Feb 25.

Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal H3A 2B4, Canada.

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http://www.jbc.org/content/283/19/12709.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M710018200
Publisher Site
http://dx.doi.org/10.1074/jbc.M710018200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442317PMC
May 2008

Soluble adenylyl cyclase is not required for axon guidance to netrin-1.

J Neurosci 2008 Apr;28(15):3920-4

Centre for Neuronal Survival, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.1523/JNEUROSCI.0547-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670467PMC
April 2008

Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.

Mol Cell Neurosci 2007 Dec 15;36(4):449-61. Epub 2007 Aug 15.

Department of Cell Biology and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1016/j.mcn.2007.08.005DOI Listing
December 2007

Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis.

J Biol Chem 2007 Jun 23;282(25):18365-78. Epub 2007 Apr 23.

Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

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http://dx.doi.org/10.1074/jbc.M610522200DOI Listing
June 2007

Atmospheric science. The monsoon's past.

Authors:
Philip A Barker

Science 2007 Jun;316(5829):1295-6

Department of Geography, Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK.

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http://dx.doi.org/10.1126/science.1143451DOI Listing
June 2007

High affinity not in the vicinity?

Authors:
Philip A Barker

Neuron 2007 Jan;53(1):1-4

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.neuron.2006.12.018DOI Listing
January 2007

The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface.

Hum Mol Genet 2006 Dec 26;15(23):3436-45. Epub 2006 Oct 26.

Unitat de Genètica Molecular, Departament de Genòmica i Proteòmica, Institut de Biomedicina de València-CSIC, Spain.

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http://dx.doi.org/10.1093/hmg/ddl421DOI Listing
December 2006

Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.

Neuron 2006 Apr;50(2):219-32

Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1016/j.neuron.2006.03.011DOI Listing
April 2006

p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.

EMBO Rep 2005 Oct;6(10):936-41

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1038/sj.embor.7400503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369184PMC
October 2005

Getting RIP'd Stunts Your Growth.

Neuron 2005 Jun;46(6):839-40

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada.

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http://dx.doi.org/10.1016/j.neuron.2005.06.002DOI Listing
June 2005

Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells.

Cancer Res 2005 May;65(10):4273-81

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3494DOI Listing
May 2005

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

J Neurosci 2004 Oct;24(40):8762-70

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2953-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729963PMC
October 2004

TRAF6-dependent NF-kB transcriptional activity during mouse development.

Dev Dyn 2004 Sep;231(1):122-7

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/dvdy.20110DOI Listing
September 2004

p75NTR is positively promiscuous: novel partners and new insights.

Authors:
Philip A Barker

Neuron 2004 May;42(4):529-33

Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.neuron.2004.04.001DOI Listing
May 2004

The p75 neurotrophin receptor: multiple interactors and numerous functions.

Prog Brain Res 2004 ;146:25-39

Center for Molecular Neuroscience, Department of Biochemistry, Vanderbilt University Medical School, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/S0079-6123(03)46002-0DOI Listing
February 2004

A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice.

J Neurosci 2004 Feb;24(8):1917-23

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.1523/JNEUROSCI.5397-03.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730398PMC
February 2004

Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad.

J Neurosci 2003 Dec;23(36):11373-81

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, H3A 2B4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740508PMC
December 2003

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

J Biol Chem 2002 Dec 9;277(50):48043-50. Epub 2002 Oct 9.

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1074/jbc.M205324200DOI Listing
December 2002

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

J Biol Chem 2002 Dec 17;277(51):49473-80. Epub 2002 Oct 17.

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montréal, Québec H3A 2B4, Canada.

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http://dx.doi.org/10.1074/jbc.M203428200DOI Listing
December 2002

Constitutive nuclear factor-kappa B activity is required for central neuron survival.

J Neurosci 2002 Oct;22(19):8466-75

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757785PMC
October 2002

Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis.

Mech Dev 2002 Sep;117(1-2):187-200

The Laboratory of Neural Stem Cell Biology, The John P Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada N6A 5K8.

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http://dx.doi.org/10.1016/s0925-4773(02)00204-6DOI Listing
September 2002

Retrograde signaling by the neurotrophins follows a well-worn trk.

Trends Neurosci 2002 Aug;25(8):379-81

Centre for Neuronal Survival and Cell Biology of Excitable Tissues Group, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.1016/s0166-2236(02)02199-9DOI Listing
August 2002

Neurotrophin signaling through the p75 neurotrophin receptor.

Prog Neurobiol 2002 Jun;67(3):203-33

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Que., Canada H3A 2B4.

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June 2002

The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease.

J Neurosci Res 2002 Mar;67(6):705-12

Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1002/jnr.10160
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http://dx.doi.org/10.1002/jnr.10160DOI Listing
March 2002