Petra Schneider

Petra Schneider

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Petra Schneider

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Evolutionary sex allocation theory explains sex ratios in natural Plasmodium falciparum infections.

Int J Parasitol 2019 Jul 31;49(8):601-604. Epub 2019 May 31.

Institute of Evolutionary Biology & Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, United Kingdom.

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http://dx.doi.org/10.1016/j.ijpara.2019.04.001DOI Listing
July 2019

Adaptive plasticity in the gametocyte conversion rate of malaria parasites.

PLoS Pathog 2018 11 14;14(11):e1007371. Epub 2018 Nov 14.

Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.plos.org/10.1371/journal.ppat.1007371
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http://dx.doi.org/10.1371/journal.ppat.1007371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261640PMC
November 2018

Adaptive periodicity in the infectivity of malaria gametocytes to mosquitoes.

Proc Biol Sci 2018 10 3;285(1888). Epub 2018 Oct 3.

Institute of Evolutionary Biology and Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK.

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http://rspb.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rspb.2018.1876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191691PMC
October 2018

Polypharmacological Drug-target Inference for Chemogenomics.

Mol Inform 2018 09 24;37(9-10):e1800050. Epub 2018 May 24.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, CH-8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/minf.201800050DOI Listing
September 2018

Premature Rejection of Plasticity in Conversion.

Trends Parasitol 2018 08 23;34(8):633-634. Epub 2018 Jun 23.

Institute of Evolutionary Biology & Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2018.06.004DOI Listing
August 2018

Native Electrospray Ionization Mass Spectrometry Reveals Multiple Facets of Aptamer-Ligand Interactions: From Mechanism to Binding Constants.

J Am Chem Soc 2018 06 1;140(24):7486-7497. Epub 2018 Jun 1.

Department of Chemistry and Applied Bioscience , ETH Zürich , CH-8093 Zürich , Switzerland.

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http://dx.doi.org/10.1021/jacs.7b13044DOI Listing
June 2018

Generative Recurrent Networks for De Novo Drug Design.

Mol Inform 2018 01 2;37(1-2). Epub 2017 Nov 2.

Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

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http://doi.wiley.com/10.1002/minf.201700111
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http://dx.doi.org/10.1002/minf.201700111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836943PMC
January 2018

A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds.

Angew Chem Int Ed Engl 2017 09 7;56(38):11520-11524. Epub 2017 Aug 7.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/anie.201706376DOI Listing
September 2017

Peptide-Membrane Interaction between Targeting and Lysis.

ACS Chem Biol 2017 09 8;12(9):2254-2259. Epub 2017 Aug 8.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH) , Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1021/acschembio.7b00504DOI Listing
September 2017

Exploring the Structural Space of the Galectin-1-Ligand Interaction.

Chembiochem 2017 08 22;18(15):1477-1481. Epub 2017 Jun 22.

Institute of Organic Chemistry, Julius Maximilians-Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.

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http://dx.doi.org/10.1002/cbic.201700251DOI Listing
August 2017

Phenotypic plasticity in reproductive effort: malaria parasites respond to resource availability.

Proc Biol Sci 2017 Aug;284(1860)

Institutes of Evolutionary Biology, and Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3FL, UK.

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http://dx.doi.org/10.1098/rspb.2017.1229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563815PMC
August 2017

Privileged Structures Revisited.

Angew Chem Int Ed Engl 2017 06 30;56(27):7971-7974. Epub 2017 May 30.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/anie.201702816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502582PMC
June 2017

Macromolecular target prediction by self-organizing feature maps.

Expert Opin Drug Discov 2017 Mar 27;12(3):271-277. Epub 2016 Dec 27.

a Department of Chemistry and Applied Biosciences , Swiss Federal Institute of Technology (ETH) , Zurich , Switzerland.

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http://dx.doi.org/10.1080/17460441.2017.1274727DOI Listing
March 2017

Active learning for computational chemogenomics.

Future Med Chem 2017 03 6;9(4):381-402. Epub 2017 Mar 6.

Kyoto University Graduate School of Medicine, Center for Medical Education, Life Science Informatics Research Unit, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.4155/fmc-2016-0197DOI Listing
March 2017

Scoring of de novo Designed Chemical Entities by Macromolecular Target Prediction.

Mol Inform 2017 01 19;36(1-2). Epub 2016 Sep 19.

Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 4, CH-, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/minf.201600110DOI Listing
January 2017

Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening.

Mol Inform 2017 01 21;36(1-2). Epub 2016 Sep 21.

Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/minf.201600091DOI Listing
January 2017

Hybrid Network Model for "Deep Learning" of Chemical Data: Application to Antimicrobial Peptides.

Mol Inform 2017 01 10;36(1-2). Epub 2016 Mar 10.

Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 4, CH-8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/minf.201600011DOI Listing
January 2017

Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide.

Angew Chem Int Ed Engl 2016 09 8;55(40):12408-11. Epub 2016 Sep 8.

Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093, Zürich, Switzerland.

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http://dx.doi.org/10.1002/anie.201605707DOI Listing
September 2016

From Complex Natural Products to Simple Synthetic Mimetics by Computational De Novo Design.

Angew Chem Int Ed Engl 2016 06 25;55(23):6789-92. Epub 2016 Apr 25.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/anie.201601941DOI Listing
June 2016

Counting on natural products for drug design.

Nat Chem 2016 06 25;8(6):531-41. Epub 2016 Apr 25.

Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.1038/nchem.2479DOI Listing
June 2016

De Novo Design at the Edge of Chaos.

J Med Chem 2016 05 16;59(9):4077-86. Epub 2016 Feb 16.

Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) , Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01849DOI Listing
May 2016

Designing Multi-target Compound Libraries with Gaussian Process Models.

Mol Inform 2016 05 2;35(5):192-8. Epub 2016 Mar 2.

Swiss Federal Institute of Technology (ETH) Zurich, Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.1002/minf.201501012DOI Listing
May 2016

Quantification of female and male Plasmodium falciparum gametocytes by reverse transcriptase quantitative PCR.

Mol Biochem Parasitol 2015 Jan-Feb;199(1-2):29-33. Epub 2015 Mar 28.

College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Alkhoud 123, Sultanate of Oman. Electronic address:

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http://dx.doi.org/10.1016/j.molbiopara.2015.03.006DOI Listing
January 2016

De Novo Fragment Design for Drug Discovery and Chemical Biology.

Angew Chem Int Ed Engl 2015 Dec 21;54(50):15079-83. Epub 2015 Oct 21.

Swiss Federal Institute of Technology (ETH Zürich), Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).

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http://dx.doi.org/10.1002/anie.201508055DOI Listing
December 2015

Revealing the Macromolecular Targets of Fragment-Like Natural Products.

Angew Chem Int Ed Engl 2015 Sep 17;54(36):10516-20. Epub 2015 Jul 17.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, 8093 Zurich (Switzerland).

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http://dx.doi.org/10.1002/anie.201504241DOI Listing
September 2015

Multidimensional Design of Anticancer Peptides.

Angew Chem Int Ed Engl 2015 Aug 26;54(35):10370-4. Epub 2015 Jun 26.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, 8093 Zurich (Switzerland).

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http://dx.doi.org/10.1002/anie.201504018DOI Listing
August 2015

Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor.

J Struct Biol 2015 Jun 16;190(3):261-70. Epub 2015 May 16.

Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2015.05.001DOI Listing
June 2015

Chemography of natural product space.

Planta Med 2015 Apr 26;81(6):429-35. Epub 2015 Feb 26.

Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1055/s-0034-1396322DOI Listing
April 2015

Impact of soyasaponin I on TLR2 and TLR4 induced inflammation in the MUTZ-3-cell model.

Food Funct 2015 Mar;6(3):1001-10

Department of Food Technology, University of Applied Sciences, Leipziger Str. 123, Fulda, Germany.

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http://dx.doi.org/10.1039/c4fo01065eDOI Listing
March 2015

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.

Nat Chem 2015 Mar 26;7(3):241-9. Epub 2015 Jan 26.

Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nchem.2158DOI Listing
March 2015

Revealing the macromolecular targets of complex natural products.

Nat Chem 2014 Dec 2;6(12):1072-8. Epub 2014 Nov 2.

Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.

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https://www.researchgate.net/profile/Tiago_Rodrigues5/public
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http://dx.doi.org/10.1038/nchem.2095DOI Listing
December 2014

Piloting the membranolytic activities of peptides with a self-organizing map.

Chembiochem 2014 Oct 9;15(15):2225-31. Epub 2014 Sep 9.

Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).

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http://dx.doi.org/10.1002/cbic.201402231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311381PMC
October 2014

Coping with polypharmacology by computational medicinal chemistry.

Chimia (Aarau) 2014 Sep;68(9):648-53

Eidgenössische Technische Hochschule, Department of Chemistry and Applied Biosciences Computer-Assisted Drug Design, Vladimir-Prelog-Weg 4, CH-8093 Zürich, Switzerland.

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http://dx.doi.org/10.2533/chimia.2014.648DOI Listing
September 2014

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.

Angew Chem Int Ed Engl 2014 Jul 4;53(27):7079-84. Epub 2014 Jun 4.

Departement Chemie und Angewandte Biowissenschaften, ETH Zürich, Vladimir-Prelog-Weg 3-4, 8093 Zürich (Switzerland).

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http://dx.doi.org/10.1002/anie.201311162DOI Listing
July 2014

Accessing new chemical entities through microfluidic systems.

Angew Chem Int Ed Engl 2014 Jun 6;53(23):5750-8. Epub 2014 May 6.

Eidgenössische Technische Hochschule (ETH) Zürich, Departement für Chemie und Angewandte Biowissenschaften, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).

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http://dx.doi.org/10.1002/anie.201400988DOI Listing
June 2014

Multi-objective molecular de novo design by adaptive fragment prioritization.

Angew Chem Int Ed Engl 2014 Apr 12;53(16):4244-8. Epub 2014 Mar 12.

Eidgenössische Technische Hochschule (ETH), Departement Chemie und Angewandte Biowissenschaften, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).

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http://dx.doi.org/10.1002/anie.201310864DOI Listing
April 2014

Targeting dynamic pockets of HIV-1 protease by structure-based computational screening for allosteric inhibitors.

J Chem Inf Model 2014 Mar 14;54(3):987-91. Epub 2014 Feb 14.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH) , Vladimir-Prelog-Weg 4 , 8093 Zürich, Switzerland.

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http://dx.doi.org/10.1021/ci400712hDOI Listing
March 2014

Combinatorial chemistry by ant colony optimization.

Future Med Chem 2014 Mar;6(3):267-80

ETH Zürich, Department of Chemistry & Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog Weg 4, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.4155/fmc.13.203DOI Listing
March 2014

Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus.

Proc Natl Acad Sci U S A 2014 Mar 3;111(11):4067-72. Epub 2014 Mar 3.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1073/pnas.1320001111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964060PMC
March 2014

Information use and plasticity in the reproductive decisions of malaria parasites.

Malar J 2014 Mar 26;13:115. Epub 2014 Mar 26.

Institute of Evolutionary Biology, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1186/1475-2875-13-115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986881PMC
March 2014

Combining on-chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPCR ligands.

Angew Chem Int Ed Engl 2014 Jan 26;53(2):582-5. Epub 2013 Nov 26.

Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland).

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http://dx.doi.org/10.1002/anie.201307786DOI Listing
January 2014

Common non-epigenetic drugs as epigenetic modulators.

Trends Mol Med 2013 Dec 18;19(12):742-53. Epub 2013 Sep 18.

Institute of Clinical Pharmacology, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany; Fraunhofer Institute of Molecular Biology and Applied Ecology - Project Group Translational Medicine and Pharmacology (IME-TMP), Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2013.08.006DOI Listing
December 2013

Analysis of flow cytometry data by matrix relevance learning vector quantization.

PLoS One 2013 18;8(3):e59401. Epub 2013 Mar 18.

Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059401PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601077PMC
September 2013

Incorporating privileged information through metric learning.

IEEE Trans Neural Netw Learn Syst 2013 Jul;24(7):1086-98

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http://dx.doi.org/10.1109/TNNLS.2013.2251470DOI Listing
July 2013

Drugs by numbers: reaction-driven de novo design of potent and selective anticancer leads.

Angew Chem Int Ed Engl 2013 Apr 20;52(17):4676-81. Epub 2012 Nov 20.

Universitätsfrauenklinik, Molekulare Onkologie und Gynäkologie, Eberhard Karls Universität, Calwerstrasse 7, 72076 Tübingen, Germany.

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http://doi.wiley.com/10.1002/anie.201206897
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http://dx.doi.org/10.1002/anie.201206897DOI Listing
April 2013

Chemically Advanced Template Search (CATS) for Scaffold-Hopping and Prospective Target Prediction for 'Orphan' Molecules.

Mol Inform 2013 Feb 7;32(2):133-138. Epub 2013 Feb 7.

ETH, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences Wolfgang-Pauli-Str. 10, CH-8093 Zurich, Switzerland fax: +41 44 633 13 79, tel: +41 44 633 74 38.

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http://dx.doi.org/10.1002/minf.201200141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743170PMC
February 2013

Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudi.

Proc Biol Sci 2012 Nov 26;279(1747):4677-85. Epub 2012 Sep 26.

Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK.

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http://dx.doi.org/10.1098/rspb.2012.1792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479731PMC
November 2012

Limited Rank Matrix Learning, discriminative dimension reduction and visualization.

Neural Netw 2012 Feb 17;26:159-73. Epub 2011 Oct 17.

University of Groningen, Johann Bernoulli Institute for Mathematics and Computer Science, The Netherlands.

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http://dx.doi.org/10.1016/j.neunet.2011.10.001DOI Listing
February 2012

Virtual screening for compounds that mimic protein-protein interface epitopes.

J Comput Chem 2012 Feb 8;33(5):573-9. Epub 2011 Dec 8.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Str. 10, CH-8093 Zurich, Switzerland.

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http://dx.doi.org/10.1002/jcc.22894DOI Listing
February 2012

Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions.

Angew Chem Int Ed Engl 2012 Jan 16;51(1):258-61. Epub 2011 Nov 16.

Eidgenössische Technische Hochschule (ETH) Zürich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.1002/anie.201105901DOI Listing
January 2012

From Virtual Screening to Bioactive Compounds by Visualizing and Clustering of Chemical Space.

Mol Inform 2012 Jan 30;31(1):21-6. Epub 2011 Nov 30.

ETH, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Str. 10, CH-8093 Zurich, Switzerland.

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http://dx.doi.org/10.1002/minf.201100147DOI Listing
January 2012

Neighborhood-preserving visualization of adaptive structure-activity landscapes: application to drug discovery.

Angew Chem Int Ed Engl 2011 Dec 7;50(49):11633-6. Epub 2011 Oct 7.

Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1002/anie.201105156DOI Listing
December 2011

Causes of variation in malaria infection dynamics: insights from theory and data.

Am Nat 2011 Dec 26;178(6):E174-E188. Epub 2011 Oct 26.

Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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http://dx.doi.org/10.1086/662670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937740PMC
December 2011

Efficient Kernelized prototype based classification.

Int J Neural Syst 2011 Dec;21(6):443-57

Department of Techn., Univ. of Bielefeld, Universitätsstrasse 21-23, 33615 Bielefeld, Germany.

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http://dx.doi.org/10.1142/S012906571100295XDOI Listing
December 2011

Fitness costs of disrupting circadian rhythms in malaria parasites.

Proc Biol Sci 2011 Aug 5;278(1717):2429-36. Epub 2011 Jan 5.

Institute of Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK.

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http://dx.doi.org/10.1098/rspb.2010.2457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125626PMC
August 2011

Reaction-driven de novo design, synthesis and testing of potential type II kinase inhibitors.

Future Med Chem 2011 Mar;3(4):415-24

Swiss Federal Institute of Technology, Department of Chemistry & Applied Biosciences, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.4155/fmc.11.8DOI Listing
March 2011

Competition and the evolution of reproductive restraint in malaria parasites.

Am Nat 2011 Mar;177(3):358-67

Institute of Evolutionary Biology, University of Edinburgh, School of Biological Sciences, United Kingdom.

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http://dx.doi.org/10.1086/658175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939351PMC
March 2011

Stress, drugs and the evolution of reproductive restraint in malaria parasites.

Proc Biol Sci 2010 Oct 19;277(1697):3123-9. Epub 2010 May 19.

Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1098/rspb.2010.0564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982055PMC
October 2010

Exploring the chemical space of gamma-secretase modulators.

Trends Pharmacol Sci 2010 Sep 28;31(9):402-10. Epub 2010 Jun 28.

ETH Zurich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.tips.2010.05.007DOI Listing
September 2010

Regularization in matrix relevance learning.

IEEE Trans Neural Netw 2010 May 15;21(5):831-40. Epub 2010 Mar 15.

Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1109/TNN.2010.2042729DOI Listing
May 2010

Target Profile Prediction: Cross-Activation of Peroxisome Proliferator-Activated Receptor (PPAR) and Farnesoid X Receptor (FXR).

Mol Inform 2010 Apr 19;29(4):287-92. Epub 2010 Feb 19.

Chair for Chem- and Bioinformatics, Goethe-University, LIFF, Siesmayerstr. 70, 60323 Frankfurt a.M., Germany.

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http://dx.doi.org/10.1002/minf.200900009DOI Listing
April 2010

Adaptive relevance matrices in learning vector quantization.

Neural Comput 2009 Dec;21(12):3532-61

Institute of Mathematics and Computing Science, University of Groningen, 9700 AK Groningen, The Netherlands.

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http://dx.doi.org/10.1162/neco.2009.11-08-908DOI Listing
December 2009

Distance phenomena in high-dimensional chemical descriptor spaces: consequences for similarity-based approaches.

J Comput Chem 2009 Nov;30(14):2285-96

Johann Wolfgang Goethe-University, Siesmayerstrasse 70, 60323 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/jcc.21218DOI Listing
November 2009

Distance learning in discriminative vector quantization.

Neural Comput 2009 Oct;21(10):2942-69

Institute of Mathematics and Computing Science, University of Groningen, 9700 AK Groningen, The Netherlands.

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http://dx.doi.org/10.1162/neco.2009.10-08-892DOI Listing
October 2009

Self-organizing molecular fingerprints: a ligand-based view on drug-like chemical space and off-target prediction.

Future Med Chem 2009 Apr;1(1):213-8

Johann Wolfgang Goethe-University, Siesmayerstr. 70, D-60323 Frankfurt am Main, Germany.

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http://dx.doi.org/10.4155/fmc.09.11DOI Listing
April 2009

Voyages to the (un)known: adaptive design of bioactive compounds.

Trends Biotechnol 2009 Jan 10;27(1):18-26. Epub 2008 Nov 10.

Johann Wolfgang Goethe-University, Institute of Organic Chemistry and Chemical Biology, LiFF, Siesmayerstr. 70, D-60323 Frankfurt am Main., Germany.

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http://dx.doi.org/10.1016/j.tibtech.2008.09.005DOI Listing
January 2009

From molecular shape to potent bioactive agents II: fragment-based de novo design.

ChemMedChem 2009 Jan;4(1):45-8

Goethe-University, Institute of Organic Chemistry and Chemical Biology, CMP/LiFF/ZAFES, Siesmayerstr. 70, 60323 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/cmdc.200800314DOI Listing
January 2009

Does the drug sensitivity of malaria parasites depend on their virulence?

Malar J 2008 Dec 16;7:257. Epub 2008 Dec 16.

Institutes of Evolution, Immunology and Infection Research, University of Edinburgh, EH9 3JT, UK.

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http://link.springer.com/content/pdf/10.1186/1475-2875-7-257
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http://www.malariajournal.com/content/7/1/257
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http://dx.doi.org/10.1186/1475-2875-7-257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636820PMC
December 2008

Gametocytes: insights gained during a decade of molecular monitoring.

Trends Parasitol 2008 Nov 16;24(11):525-30. Epub 2008 Sep 16.

Biochemistry Department, Faculty of Medicine, Sultan Qaboos University, Alkhod, PO Box 35, Muscat, Code 123, Oman, UK.

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http://dx.doi.org/10.1016/j.pt.2008.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764380PMC
November 2008

Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase.

ChemMedChem 2008 Oct;3(10):1535-8

Institute of Organic Chemistry and Chemical Biology, ZAFES/CMP, Johann Wolfgang Goethe-University, Siesmayerstr. 70, 60323 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/cmdc.200800153DOI Listing
October 2008

Application of molecular methods for monitoring transmission stages of malaria parasites.

Biomed Mater 2008 Sep 15;3(3):034007. Epub 2008 Aug 15.

Biochemistry Department, Faculty of Medicine, Sultan Qaboos University, Alkhod, PO Box 35, Muscat, Oman School of Biological Sciences, University of Edinburgh, UK.

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http://dx.doi.org/10.1088/1748-6041/3/3/034007DOI Listing
September 2008

Scaffold hopping by "fuzzy" pharmacophores and its application to RNA targets.

Chembiochem 2007 Nov;8(16):1932-6

Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Siesmayerstrasse 70, 60323 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/cbic.200700195DOI Listing
November 2007

Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.

J Med Chem 2007 May 27;50(11):2640-6. Epub 2007 Apr 27.

Institut für Organische Chemie und Chemische Biologie/ZAFES, Johann Wolfgang Goethe-Universität, Siesmayerstrasse 70, D-60323 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1021/jm060655wDOI Listing
May 2007

Age-dependent distribution of Plasmodium falciparum gametocytes quantified by Pfs25 real-time QT-NASBA in a cross-sectional study in Burkina Faso.

Am J Trop Med Hyg 2007 Apr;76(4):626-30

Department of Medical Microbiology, University Medical Centre Nijmegen, Nijmegen, The Netherlands.

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April 2007

Submicroscopic Plasmodium falciparum gametocyte densities frequently result in mosquito infection.

Am J Trop Med Hyg 2007 Mar;76(3):470-4

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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March 2007

Virtual screening for PPAR modulators using a probabilistic neural network.

ChemMedChem 2006 Dec;1(12):1346-50

Johann Wolfgang Goethe University, Institute of Organic Chemistry and Chemical Biology/ZAFES, Siesmayerstrasse 70, 60323 Frankfurt/Main, Germany.

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http://dx.doi.org/10.1002/cmdc.200600166DOI Listing
December 2006

(Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate.

Int J Parasitol 2006 Apr 24;36(4):403-8. Epub 2006 Jan 24.

Radboud University Nijmegen Medical Centre, Medical Microbiology 268, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ijpara.2006.01.002DOI Listing
April 2006

Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum.

J Infect Dis 2006 Apr 15;193(8):1151-9. Epub 2006 Mar 15.

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1086/503051DOI Listing
April 2006

Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors.

J Med Chem 2005 Nov;48(22):6997-7004

Institut für Organische Chemie und Chemische Biologie and Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität, Marie-Curie-Strasse 9, D-60439 Frankfurt, Germany.

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http://dx.doi.org/10.1021/jm050619hDOI Listing
November 2005

New allosteric modulators of metabotropic glutamate receptor 5 (mGluR5) found by ligand-based virtual screening.

Chembiochem 2005 Apr;6(4):620-5

Johann Wolfgang Goethe-Universität, Institut für Organische Chemie und Chemische Biologie, Marie-Curie-Strasse 11, 60439 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/cbic.200400332DOI Listing
April 2005

Experimental separation of Rashba and Dresselhaus spin splittings in semiconductor quantum wells.

Phys Rev Lett 2004 Jun 23;92(25 Pt 1):256601. Epub 2004 Jun 23.

Fakultät Physik, University of Regensburg, 93040 Regensburg, Germany.

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http://dx.doi.org/10.1103/PhysRevLett.92.256601DOI Listing
June 2004

Comparison of correlation vector methods for ligand-based similarity searching.

J Comput Aided Mol Des 2003 Oct;17(10):687-98

Johann Wolfgang Goethe-Universität, Institut für Organische Chemie und Chemische Biologie, Marie-Curie-Str. 11, D-60439 Frankfurt, Germany.

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October 2003