Petr Mlejnek

Petr Mlejnek

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Petr Mlejnek

Petr Mlejnek

Publications by authors named "Petr Mlejnek"

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53Publications

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Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis.

Biomolecules 2020 Jan 3;10(1). Epub 2020 Jan 3.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic.

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http://dx.doi.org/10.3390/biom10010077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022710PMC
January 2020

Estimation of ABCB1 concentration in plasma membrane.

J Cell Biochem 2019 Oct 18;120(10):18406-18414. Epub 2019 Jun 18.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.

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http://dx.doi.org/10.1002/jcb.29157DOI Listing
October 2019

The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance.

Biomolecules 2019 Oct 31;9(11). Epub 2019 Oct 31.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.3390/biom9110675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921012PMC
October 2019

Systems genetic analysis of brown adipose tissue function.

Physiol Genomics 2018 01 10;50(1):52-66. Epub 2017 Nov 10.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus , Aurora, Colorado.

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http://dx.doi.org/10.1152/physiolgenomics.00091.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866413PMC
January 2018

Apoptosis Induced by the Curcumin Analogue EF-24 Is Neither Mediated by Oxidative Stress-Related Mechanisms nor Affected by Expression of Main Drug Transporters ABCB1 and ABCG2 in Human Leukemia Cells.

Int J Mol Sci 2017 Oct 31;18(11). Epub 2017 Oct 31.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.3390/ijms18112289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713259PMC
October 2017

Reversal of ABCB1 mediated efflux by imatinib and nilotinib in cells expressing various transporter levels.

Chem Biol Interact 2017 Aug 13;273:171-179. Epub 2017 Jun 13.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.1016/j.cbi.2017.06.012DOI Listing
August 2017

Downregulation of Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

Hypertension 2017 06 10;69(6):1084-1091. Epub 2017 Apr 10.

From the Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic (F.L., O.Š., V.K., M.P.); Institute of Physiology (V.L., V.Z., P.M., J.Š., M.Š., M.P.) and Institute of Molecular Genetics (H.S.), Czech Academy of Sciences, Prague, Czech Republic; Institute for Experimental Medicine, Prague, Czech Republic (J.T., V.Š., L.K.); Department of Genetics, Cell Biology, and Development and Center for Genome Engineering, University of Minnesota, Minneapolis (C.G.S., D.F.V.); Max-Delbrück-Center for Molecular Medicine in the Hemholtz Society, Berlin, Germany (Z.I.); and Department of Molecular Medicine "Sapienza" University of Rome, Italy (M.M.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08798DOI Listing
June 2017

Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome.

Hypertension 2016 Feb 14;67(2):335-41. Epub 2015 Dec 14.

From the Department of Model Diseases, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic (M.P., V.Z., V.L., P.M., J.Š., M.Š.); Institute of Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic (V.K., J.K., J.Š.); Center of Experimental Medicine, Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (V.Š., J.T., L.K.); and Department of Laboratory Medicine, University of California, San Francisco (T.K., J.W., T.W.K.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06158DOI Listing
February 2016

Loss of mitochondrial transmembrane potential and glutathione depletion are not sufficient to account for induction of apoptosis by carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone in human leukemia K562 cells.

Chem Biol Interact 2015 Sep 23;239:100-10. Epub 2015 Jun 23.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic; Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.1016/j.cbi.2015.06.033DOI Listing
September 2015

Can the assessment of ABCB1 gene expression predict its function in vitro?

Eur J Haematol 2015 Aug 22;95(2):150-9. Epub 2015 Jan 22.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.

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http://dx.doi.org/10.1111/ejh.12470DOI Listing
August 2015

N-acetylcysteine prevents the geldanamycin cytotoxicity by forming geldanamycin-N-acetylcysteine adduct.

Chem Biol Interact 2014 Sep 3;220:248-54. Epub 2014 Jul 3.

Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77715, Czech Republic; Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77715, Czech Republic.

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http://dx.doi.org/10.1016/j.cbi.2014.06.025DOI Listing
September 2014

Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels of ABCB1 and ABCG2 in human leukemia cells.

Chem Biol Interact 2014 Aug 19;219:203-10. Epub 2014 Jun 19.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2014.06.009DOI Listing
August 2014

Cytokinin-induced cell death is associated with elevated expression of alternative oxidase in tobacco BY-2 cells.

Authors:
Petr Mlejnek

Protoplasma 2013 Oct 7;250(5):1195-202. Epub 2013 May 7.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc, Czech Republic,

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http://dx.doi.org/10.1007/s00709-013-0501-3DOI Listing
October 2013

Effects of synthetic A3 adenosine receptor agonists on cell proliferation and viability are receptor independent at micromolar concentrations.

J Physiol Biochem 2013 Sep 27;69(3):405-17. Epub 2012 Nov 27.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.

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http://link.springer.com/content/pdf/10.1007/s13105-012-0222
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http://link.springer.com/10.1007/s13105-012-0222-7
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http://dx.doi.org/10.1007/s13105-012-0222-7DOI Listing
September 2013

Tissue-specific peroxisome proliferator activated receptor gamma expression and metabolic effects of telmisartan.

Am J Hypertens 2013 Jun 20;26(6):829-35. Epub 2013 Feb 20.

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://dx.doi.org/10.1093/ajh/hpt019DOI Listing
June 2013

Can P-glycoprotein mediate resistance to nilotinib in human leukaemia cells?

Pharmacol Res 2013 Jan 26;67(1):79-83. Epub 2012 Oct 26.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.1016/j.phrs.2012.10.012DOI Listing
January 2013

P-glycoprotein mediates resistance to A3 adenosine receptor agonist 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-n-methyluronamide in human leukemia cells.

J Cell Physiol 2012 Feb;227(2):676-85

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.

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http://dx.doi.org/10.1002/jcp.22775DOI Listing
February 2012

Interactions of N-desmethyl imatinib, an active metabolite of imatinib, with P-glycoprotein in human leukemia cells.

Ann Hematol 2011 Jul 12;90(7):837-42. Epub 2011 Jan 12.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc, 77515, Czech Republic.

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http://dx.doi.org/10.1007/s00277-010-1142-7DOI Listing
July 2011

Assay for determination of daunorubicin in cancer cells with multidrug resistance phenotype.

J Chromatogr B Analyt Technol Biomed Life Sci 2011 Jul 11;879(21):1875-80. Epub 2011 May 11.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc 77515, Czech Republic.

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https://linkinghub.elsevier.com/retrieve/pii/S15700232110031
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http://dx.doi.org/10.1016/j.jchromb.2011.05.008DOI Listing
July 2011

A non-radioactive assay for precise determination of intracellular levels of imatinib and its main metabolite in Bcr-Abl positive cells.

Talanta 2011 Feb 19;83(5):1466-71. Epub 2010 Nov 19.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. mlejnek

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http://dx.doi.org/10.1016/j.talanta.2010.11.028DOI Listing
February 2011

Halogenation of N⁶-benzyladenosine decreases its cytotoxicity in human leukemia cells.

Toxicol In Vitro 2010 Dec 15;24(8):2079-83. Epub 2010 Jul 15.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

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https://linkinghub.elsevier.com/retrieve/pii/S08872333100017
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http://dx.doi.org/10.1016/j.tiv.2010.07.010DOI Listing
December 2010

Partial glutathione reductase deficiency as a cause of diverse clinical manifestations in a family with unstable hemoglobin (Hemoglobin Haná, β63(E7) His-Asn).

Blood Cells Mol Dis 2010 Oct 9;45(3):219-22. Epub 2010 Aug 9.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

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http://dx.doi.org/10.1016/j.bcmd.2010.07.003DOI Listing
October 2010

Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glycoprotein expression.

Toxicol In Vitro 2009 Dec 6;23(8):1482-90. Epub 2009 Sep 6.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.1016/j.tiv.2009.09.001DOI Listing
December 2009

Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) do not inhibit caspase-3 and caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli.

J Cell Biochem 2008 Dec;105(6):1501-6

Faculty of Medicine and Dentistry, Department of Biology, Palacky University Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.1002/jcb.21971DOI Listing
December 2008

The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells.

Toxicol In Vitro 2008 Aug 4;22(5):1356-60. Epub 2008 Mar 4.

Department of Biology, Faculty of Medicine, Palacky University, Hnevotinska 3, Olomouc 77515, Czech Republic.

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https://linkinghub.elsevier.com/retrieve/pii/S08872333080006
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http://dx.doi.org/10.1016/j.tiv.2008.02.017DOI Listing
August 2008

Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases.

J Cell Biochem 2008 Apr;103(5):1646-56

Department of Biology, Faculty of Medicine, Palacky University, Hnevotinska 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.1002/jcb.21550DOI Listing
April 2008

Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat.

Hypertension 2008 Jan 10;51(1):148-53. Epub 2007 Dec 10.

Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.100743DOI Listing
January 2008

Cyclosporin A potentiates the cytotoxic effects of methyl methanesulphonate in HL-60 and K562 cells.

Altern Lab Anim 2007 Mar;35(1):79-85

Department of Biology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic.

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http://dx.doi.org/10.1177/026119290703500117DOI Listing
March 2007

Apoptosis induced by N6-substituted derivatives of adenosine is related to intracellular accumulation of corresponding mononucleotides in HL-60 cells.

Toxicol In Vitro 2005 Oct 21;19(7):985-90. Epub 2005 Sep 21.

Department of Biology, Faculty of Medicine, Palacký University Olomouc, Hnevotínská 3, Olomouc, Czech Republic.

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http://dx.doi.org/10.1016/j.tiv.2005.06.023DOI Listing
October 2005

A new transgenic rat model of hepatic steatosis and the metabolic syndrome.

Hypertension 2005 May 4;45(5):1004-11. Epub 2005 Apr 4.

Department of Laboratory Medicine, University of California, San Francisco, USA.

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http://dx.doi.org/10.1161/01.HYP.0000161995.64192.2bDOI Listing
May 2005

Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat.

J Biol Chem 2003 Nov 27;278(46):45209-15. Epub 2003 Aug 27.

Institute of Physiology, Czech Academy of Sciences and the Center for Integrated Genomics, Prague 14220, Czech Republic.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M304869200
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http://dx.doi.org/10.1074/jbc.M304869200DOI Listing
November 2003

Activation of caspase-like proteases and induction of apoptosis by isopentenyladenosine in tobacco BY-2 cells.

Planta 2002 May 13;215(1):158-66. Epub 2002 Mar 13.

Department of Botany and Plant Physiology, Mendel University of Agriculture and Forestry Brno, Zemedelská 1, 613 00 Brno, Czech Republic.

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http://dx.doi.org/10.1007/s00425-002-0733-5DOI Listing
May 2002