Petr Kuzmic

Petr Kuzmic

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Petr Kuzmic

Petr Kuzmic

Publications by authors named "Petr Kuzmic"

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Sabellastarte magnifica Carboxypeptidase Inhibitor: The first Kunitz inhibitor simultaneously interacting with carboxypeptidases and serine proteases.

Biochimie 2018 Jul 3;150:37-47. Epub 2018 May 3.

Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373 - Bloco E, sala 10, Rio de Janeiro, RJ, 21941-902, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2018.04.024DOI Listing
July 2018

The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.

J Biol Chem 2017 08 19;292(31):12981-12993. Epub 2017 Jun 19.

From the Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115 and

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http://dx.doi.org/10.1074/jbc.M117.778886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546037PMC
August 2017

Analysis of a dual domain phosphoglycosyl transferase reveals a ping-pong mechanism with a covalent enzyme intermediate.

Proc Natl Acad Sci U S A 2017 07 19;114(27):7019-7024. Epub 2017 Jun 19.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1703397114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502628PMC
July 2017

An algebraic model to determine substrate kinetic parameters by global nonlinear fit of progress curves.

Anal Biochem 2017 Feb 4;518:16-24. Epub 2016 Nov 4.

BioKin Ltd., Watertown, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.11.001DOI Listing
February 2017

Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics.

Biochemistry 2016 09 2;55(37):5279-88. Epub 2016 Sep 2.

Department of Biology, Brandeis University , Waltham, Massachusetts 02454, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524190PMC
September 2016

An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations.

Anal Biochem 2015 Sep 27;484:82-90. Epub 2014 Nov 27.

Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, Pfizer, San Diego, CA 92121, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00032697140054
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http://dx.doi.org/10.1016/j.ab.2014.11.014DOI Listing
September 2015

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance.

Proc Natl Acad Sci U S A 2014 Jan 17;111(1):173-8. Epub 2013 Dec 17.

Oncology Research Unit, Worldwide Medicinal Chemistry, and Pharmacokinetics and Drug Metabolism, Pfizer Worldwide Research and Development, La Jolla, Pfizer Inc., San Diego, CA 92121.

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http://dx.doi.org/10.1073/pnas.1313733111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890870PMC
January 2014

Nonlinear regression models for determination of nicotinamide adenine dinucleotide content in human embryonic stem cells.

Stem Cell Rev Rep 2013 Dec;9(6):786-93

Department of Biology, Faculty of Medicine, Masaryk University, Building A3, Kamenice 735/5, 625 00, Brno-Bohunice, Czech Republic.

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http://dx.doi.org/10.1007/s12015-013-9454-3DOI Listing
December 2013

Homotropic cooperativity from the activation pathway of the allosteric ligand-responsive regulatory trp RNA-binding attenuation protein.

Biochemistry 2013 Dec 22;52(49):8855-65. Epub 2013 Nov 22.

Department of Chemistry and Biochemistry, and Biophysics Program, The Ohio State University , 484 West 12th Avenue, Columbus, Ohio 43210, United States.

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http://pubs.acs.org/doi/10.1021/bi401364v
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http://dx.doi.org/10.1021/bi401364vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946311PMC
December 2013

Optimal design for the dose-response screening of tight-binding enzyme inhibitors.

Authors:
Petr Kuzmič

Anal Biochem 2011 Dec 25;419(2):117-22. Epub 2011 Jul 25.

BioKin Ltd., Watertown, MA 02472, USA.

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http://dx.doi.org/10.1016/j.ab.2011.06.013DOI Listing
December 2011

A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin.

Proc Natl Acad Sci U S A 2011 Apr 11;108(17):6927-32. Epub 2011 Apr 11.

School of Life Sciences, Warwick University, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1018845108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084117PMC
April 2011

A generalized numerical approach to steady-state enzyme kinetics: applications to protein kinase inhibition.

Authors:
Petr Kuzmic

Biochim Biophys Acta 2010 Mar 28;1804(3):635-41. Epub 2009 Aug 28.

BioKin Ltd., 15 Main Street Suite 232, Watertown, MA 02472, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15709639090018
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http://dx.doi.org/10.1016/j.bbapap.2009.07.028DOI Listing
March 2010

DynaFit--a software package for enzymology.

Authors:
Petr Kuzmič

Methods Enzymol 2009 ;467:247-280

BioKin Ltd., Watertown, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(09)67010-5DOI Listing
January 2010

Analysis of residuals from enzyme kinetic and protein folding experiments in the presence of correlated experimental noise.

Anal Biochem 2009 Dec 12;395(1):1-7. Epub 2009 Jun 12.

BioKin Ltd., Watertown, MA 02472, USA.

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http://dx.doi.org/10.1016/j.ab.2009.05.051DOI Listing
December 2009

Application of the Van Slyke-Cullen irreversible mechanism in the analysis of enzymatic progress curves.

Authors:
Petr Kuzmic

Anal Biochem 2009 Nov 21;394(2):287-9. Epub 2009 Jul 21.

BioKin Ltd., 15 Main Street Suite 232, Watertown, MA 02472, USA.

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http://dx.doi.org/10.1016/j.ab.2009.06.040DOI Listing
November 2009

Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases.

Biochem J 2009 Aug 13;422(2):383-92. Epub 2009 Aug 13.

Discovery Research, Dyax Corp., 300 Technology Square, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1042/BJ20090010DOI Listing
August 2009

Complexation between methyl viologen (paraquat) bis(hexafluorophosphate) and dibenzo[24]crown-8 revisited.

Chemistry 2009 ;15(1):106-16

Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

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http://dx.doi.org/10.1002/chem.200801827DOI Listing
February 2009

A steady state mathematical model for stepwise "slow-binding" reversible enzyme inhibition.

Authors:
Petr Kuzmic

Anal Biochem 2008 Sep 28;380(1):5-12. Epub 2007 Nov 28.

BioKin Ltd, 15 Main Street, Suite 232, Watertown, MA 02472, USA.

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http://dx.doi.org/10.1016/j.ab.2007.11.027DOI Listing
September 2008

CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds.

J Biol Chem 2008 Feb 4;283(6):3487-96. Epub 2007 Dec 4.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.1074/jbc.M707630200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933162PMC
February 2008

Global analysis of protein-protein interactions reveals multiple CYP2E1-reductase complexes.

Biochemistry 2007 Sep 9;46(35):10192-201. Epub 2007 Aug 9.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.1021/bi7003476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592557PMC
September 2007

Structural and mechanistic changes along an engineered path from metallo to nonmetallo 3-deoxy-D-manno-octulosonate 8-phosphate synthases.

Biochemistry 2007 Apr 24;46(15):4532-44. Epub 2007 Mar 24.

Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi6024879
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http://dx.doi.org/10.1021/bi6024879DOI Listing
April 2007

Self-assembled small-molecule microarrays for protease screening and profiling.

Chembiochem 2006 Nov;7(11):1790-7

Protease Biochemistry, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://doi.wiley.com/10.1002/cbic.200600242
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http://dx.doi.org/10.1002/cbic.200600242DOI Listing
November 2006

A generalized numerical approach to rapid-equilibrium enzyme kinetics: application to 17beta-HSD.

Authors:
Petr Kuzmic

Mol Cell Endocrinol 2006 Mar 20;248(1-2):172-81. Epub 2005 Dec 20.

BioKin Ltd., 1652 South Grand Avenue, Suite 337, Pullman, WA 99163, USA.

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http://dx.doi.org/10.1016/j.mce.2005.10.012DOI Listing
March 2006

Practical robust fit of enzyme inhibition data.

Methods Enzymol 2004 ;383:366-81

Biokin Ltd., Pullman, Washington 99163, USA.

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http://dx.doi.org/10.1016/S0076-6879(04)83015-5DOI Listing
May 2004

Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: I. Two distinct activities for individual ATP sites in the gamma complex.

J Biol Chem 2004 Feb 10;279(6):4376-85. Epub 2003 Nov 10.

Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610-0245, USA.

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http://dx.doi.org/10.1074/jbc.M310429200DOI Listing
February 2004

Kinetic determination of tight-binding impurities in enzyme inhibitors.

Anal Biochem 2003 Aug;319(2):272-9

BioKin, Ltd., Pullman, WA 99163, USA.

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http://dx.doi.org/10.1016/s0003-2697(03)00248-3DOI Listing
August 2003

A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression.

Hum Genet 2002 Oct 13;111(4-5):339-49. Epub 2002 Aug 13.

Department of Genome Research, DNA Research Institute, Bioneer Corporation, Cheongwon-Kun, Chungbuk 363-813, Republic of Korea.

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http://dx.doi.org/10.1007/s00439-002-0771-xDOI Listing
October 2002

Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa. Hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo.

J Biol Chem 2002 Feb 7;277(8):6223-9. Epub 2001 Dec 7.

Yale Child Health Research Center, Division of Infectious Diseases, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8081, USA.

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http://dx.doi.org/10.1074/jbc.M109908200DOI Listing
February 2002