Dr Peteris Alberts, PhD

Dr Peteris Alberts

Dr Peteris Alberts, PhD

Dr Peteris Alberts

PhD

Introduction

Publications

52Publications

666Reads

2Profile Views

245PubMed Central Citations

A Case of Stage IV Chromophobe Renal Cell Carcinoma Treated with the Oncolytic ECHO-7 Virus, Rigvir®.

Am J Case Rep 2019 Jan 12;20:48-52. Epub 2019 Jan 12.

International Virotherapy Center, Research and Development, Riga, Latvia.

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http://dx.doi.org/10.12659/AJCR.912115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340265PMC
January 2019
8 Reads

The advent of oncolytic virotherapy in oncology: The Rigvir® story.

Eur J Pharmacol 2018 Oct 1;837:117-126. Epub 2018 Sep 1.

International Virotherapy Center, Teātra iela 9-9, Riga LV-1050, Latvia.

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http://dx.doi.org/10.1016/j.ejphar.2018.08.042DOI Listing
October 2018
165 Reads
2.532 Impact Factor

Effect of the oncolytic ECHO-7 virus Rigvir® on the viability of cell lines of human origin .

J Cancer 2018 28;9(6):1033-1049. Epub 2018 Feb 28.

International Virotherapy Center, Riga, Latvia.

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http://dx.doi.org/10.7150/jca.23242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868171PMC
February 2018
5 Reads
2.640 Impact Factor

Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in melanoma patients after surgical excision of the tumour in a retrospective study.

Melanoma Res 2015 Oct;25(5):421-6

aOutpatient Department, Riga Eastern Clinical University Hospital bInstitute of Microbiology and Virology cDepartment of Public Health and Epidemiology, Riga Stradiņš University dLatvian Virotherapy Center, Riga, Latvia eDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1097/CMR.0000000000000180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560272PMC
October 2015
117 Reads
11 Citations
2.282 Impact Factor

Single ascending oral dose pharmacokinetics and pharmacodynamics study of EV-077: the specific inhibitor of prostanoid- and isoprostane-induced cellular activation.

Eur J Clin Pharmacol 2013 Mar 20;69(3):459-65. Epub 2012 Jul 20.

AR Pharma Projects, Marlow, SL7 3PG, UK.

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http://dx.doi.org/10.1007/s00228-012-1348-9DOI Listing
March 2013
3 Reads
1 Citation
2.970 Impact Factor

Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases.

Future Cardiol 2009 Sep;5(5):479-93

KellSa s.a.s., Str. Campo e Zampe 12, I-13900 Biella, BI, Italy.

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http://dx.doi.org/10.2217/fca.09.33DOI Listing
September 2009
20 Reads
5 Citations

Characterization of energy expenditure in rodents by indirect calorimetry.

Curr Protoc Neurosci 2006 Aug;Chapter 9:Unit9.23D

McArthur and Associates GmbH, Basel, Switzerland.

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http://dx.doi.org/10.1002/0471142301.ns0923ds36DOI Listing
August 2006
5 Reads
7 Citations

Temperature dependence of O2 consumption; opposite effects of leptin and etomoxir on respiratory quotient in mice.

Obesity (Silver Spring) 2006 Apr;14(4):673-82

ECVAM, EC-Joint Research Centre, Ispra, Italy.

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http://dx.doi.org/10.1038/oby.2006.76DOI Listing
April 2006
7 Reads
8 Citations
3.734 Impact Factor

Regulation of 11beta-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans.

Diabetes Metab Res Rev 2005 Jul-Aug;21(4):359-66

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1002/dmrr.525DOI Listing
October 2005
10 Reads
4 Citations

Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice.

Diabetologia 2002 Nov 18;45(11):1528-32. Epub 2002 Sep 18.

Pharmacology 2, Department of Biology, Research, Biovitrum, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00125-002-0959-6DOI Listing
November 2002
4 Reads
41 Citations
6.671 Impact Factor

Characterization of a new muscarinic receptor antagonist PNU-171990 in guinea pig, cat and human smooth muscle.

Eur J Pharmacol 2002 Sep;451(2):171-5

Department of Biology, Biovitrum, UF5-1, SE-751 37, Uppsala, Sweden.

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http://dx.doi.org/10.1016/s0014-2999(02)02227-6DOI Listing
September 2002
7 Reads
2.532 Impact Factor

Effect of muscarinic antagonists on micturition pressure measured by cystometry in normal, conscious rats.

Urology 2002 Jun;59(6):963-8

Department of Pharmacology, Biovitrum, Uppsala, Sweden.

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http://dx.doi.org/10.1016/s0090-4295(02)01535-2DOI Listing
June 2002
5 Reads
3 Citations
2.190 Impact Factor

In vitro alpha-adrenoceptor autoradiography of the urethra and urinary bladder of the female pig, cat, guinea-pig and rat.

Scand J Urol Nephrol 2000 Aug;34(4):233-8

Department of Pharmacology, Pharmacia and Upjohn, Uppsala, Sweden.

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http://dx.doi.org/10.1080/003655900750041951DOI Listing
August 2000
3 Reads
1 Citation
1.062 Impact Factor

Selectivity of oxymetazoline for urethral pressure vs blood pressure in the anaesthetized female rabbit.

Scand J Urol Nephrol 2000 Jun;34(3):151-6

Department of Pharmacology, Pharmacia and Upjohn, Uppsala, Sweden.

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http://dx.doi.org/10.1080/003655900750016508DOI Listing
June 2000
5 Reads
1.062 Impact Factor

Characterisation of the functional alpha-adrenoceptor subtype in the isolated female pig urethra.

Eur J Pharmacol 1999 Apr;371(1):31-8

Department of Pharmacology, Pharmacia and Upjohn, Uppsala, Sweden.

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http://dx.doi.org/10.1016/s0014-2999(99)00182-xDOI Listing
April 1999
5 Reads
2.532 Impact Factor

The effect of phenylpropanolamine on the urethral pressure and heart rate is retained after repeated short-term administration in the unanaesthetized, conscious dog.

Scand J Urol Nephrol 1998 May;32(3):171-6

Department of Pharmacology, Pharmacia and Upjohn, Uppsala, Sweden.

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http://dx.doi.org/10.1080/003655998750015520DOI Listing
May 1998
4 Reads
1 Citation
1.062 Impact Factor

Presynaptic alpha 2A-adrenoceptors regulate the 3H-noradrenaline secretion in the guinea-pig urethra.

Authors:
P Alberts

Pharmacol Toxicol 1995 Aug;77(2):95-101

Department of Pharmacology, Pharmacia Pharmaceuticals, Uppsala, Sweden.

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http://dx.doi.org/10.1111/j.1600-0773.1995.tb00996.xDOI Listing
August 1995
3 Reads

Classification of the presynaptic muscarinic receptor subtype that regulates 3H-acetylcholine secretion in the guinea pig urinary bladder in vitro.

Authors:
P Alberts

J Pharmacol Exp Ther 1995 Jul;274(1):458-68

Department of Pharmacology, Pharmacia Pharmaceuticals, Uppsala, Sweden.

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July 1995
6 Reads
8 Citations
3.972 Impact Factor

Subtype classification of presynaptic alpha 2-adrenoceptors.

Authors:
P Alberts

Gen Pharmacol 1993 Jan;24(1):1-8

Department of Receptor Pharmacology, Kabi Pharmacia Therapeutics, Stockholm, Sweden.

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http://dx.doi.org/10.1016/0306-3623(93)90003-gDOI Listing
January 1993
3 Reads

Subtype classification of the presynaptic alpha-adrenoceptors which regulate [3H]-noradrenaline secretion in guinea-pig isolated urethra.

Authors:
P Alberts

Br J Pharmacol 1992 Jan;105(1):142-6

Department of Receptor Pharmacology, Urology & Gynaecology, Kabi Pharmacia Therapeutics, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908620PMC
http://dx.doi.org/10.1111/j.1476-5381.1992.tb14225.xDOI Listing
January 1992
3 Reads
2 Citations
4.842 Impact Factor

A new H-oxime restores rat diaphragm contractility after esterase inhibition in vitro.

Authors:
P Alberts

Eur J Pharmacol 1990 Aug;184(1):191-4

Division of Experimental Medicine, Swedish Defence Research Establishment, Umeå.

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http://dx.doi.org/10.1016/0014-2999(90)90682-vDOI Listing
August 1990
3 Reads
1 Citation
2.532 Impact Factor

Effects of N6,2'-O-dibutyryladenosine 3',5'-cyclic monophosphate, adenosine, and of oxotremorine and 3-isobutyl-1-methylxanthine on the electrically evoked [3H]acetylcholine secretion in the guinea-pig ileum myenteric plexus.

Authors:
P Alberts

Acta Physiol Scand 1989 Dec;137(4):489-96

Division of Experimental Medicine, Swedish Defence Research Establishment, Umeå.

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http://dx.doi.org/10.1111/j.1748-1716.1989.tb08785.xDOI Listing
December 1989
16 Reads
2 Citations

Effects of alaproclate, potassium channel blockers, and lidocaine on the release of 3H-acetylcholine from the guinea-pig ileum myenteric plexus.

Authors:
P Alberts S O Ogren

Pharmacol Toxicol 1989 Jul;65(1):25-32

Division of Experimental Medicine, Swedish Defence Research Establishment, Umeå.

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http://dx.doi.org/10.1111/j.1600-0773.1989.tb01121.xDOI Listing
July 1989
4 Reads
2 Citations

Interaction of forskolin with the effect of atropine on [3H]acetylcholine secretion in guinea-pig ileum myenteric plexus.

Authors:
P Alberts V R Ogren

J Physiol 1988 Jan;395:441-53

Division of Experimental Medicine, National Defence Research Institute, Umeå, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192003PMC
http://dx.doi.org/10.1113/jphysiol.1988.sp016928DOI Listing
January 1988
4 Reads
3 Citations
5.040 Impact Factor

Sarin and soman depress [3H]acetylcholine secretion in guinea-pig ileum myenteric plexus.

Authors:
P Alberts V R Ogren

Acta Physiol Scand 1985 Oct;125(2):347-8

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http://dx.doi.org/10.1111/j.1748-1716.1985.tb07727.xDOI Listing
October 1985
4 Reads
1 Citation

Role of adenosine 3',5'-cyclic monophosphate in adrenoceptor-mediated control of 3H-noradrenaline secretion in guinea-pig ileum myenteric nerve terminals.

Naunyn Schmiedebergs Arch Pharmacol 1985 Aug;330(2):114-20

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http://dx.doi.org/10.1007/bf00499903DOI Listing
August 1985
3 Reads
5 Citations
2.471 Impact Factor

Cadmium inhibition of [3H]acetylcholine secretion in guinea-pig ileum myenteric plexus.

Acta Physiol Scand 1985 Jun;124(2):313-6

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http://dx.doi.org/10.1111/j.1748-1716.1985.tb07666.xDOI Listing
June 1985
4 Reads
1 Citation

Mechanisms of facilitation and muscarinic or alpha-adrenergic inhibition of acetylcholine and noradrenaline secretion from peripheral nerves.

Authors:
P Alberts

Acta Physiol Scand Suppl 1982 ;506:1-39

Department of Physiology I, Karolinska Institutet, Stockholm, Sweden.

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January 1983
4 Reads
1 Citation

Acetylarsenocholine: a cholinergic agonist.

J Neurochem 1982 Sep;39(3):871-3

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http://dx.doi.org/10.1111/j.1471-4159.1982.tb07973.xDOI Listing
September 1982
4 Reads
4.281 Impact Factor

Role of calcium in muscarinic autoinhibition of 3H-acetylcholine secretion in guinea-pig ileum myenteric plexus.

Acta Physiol Scand 1982 Aug;115(4):487-91

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http://dx.doi.org/10.1111/j.1748-1716.1982.tb07108.xDOI Listing
August 1982
16 Reads
2 Citations

Site(s) and ionic basis of alpha-autoinhibition and facilitation of "3H'noradrenaline secretion in guinea-pig vas deferens.

J Physiol 1981 Mar;312:297-334

J. Physiol. (Lond.)

1. Mechanisms controlling the secretion of [(3)H]noradrenaline from the noradrenergic nerves of guinea-pig isolated vas deferens, prelabelled by incubation with [(3)H]noradrenaline, were studied using (a) different modes of (extramural or transmural) electrical nerve stimulation (a total of 300 shocks of varying strength, and a duration of 2 msec) at 1-30 Hz, or (b) depolarizing concentrations of K(+) (60-110 mm).2. The fractional rise in efflux of (3)H-labelled material (Deltat) was used to measure the secretion of [(3)H]noradrenaline.3. The dependence of [(3)H]noradrenaline secretion on the external Ca(2+) concentration (1-8 mm) was essentially hyperbolic. Double reciprocal plot analysis (1/Deltat vs. 1/Ca(2+)) of the data yields that blockade of alpha-autoinhibition (phentolamine 1 mum) does not increase the maximal secretory velocity, but does enhance the apparent affinity of the secretory mechanism for external Ca(2+). Exogenous noradrenaline has (qualitatively) opposite effects. The interaction between alpha-autoinhibition and external Ca(2+) thus shows a ;competitive' pattern, indicating that restriction of the utilization of external Ca(2+) is a major mechanism in alpha-autoinhibition of noradrenaline secretion, in this system.4. Phenoxybenzamine (10 mum) and phentolamine (1 mum) increased the secretion of [(3)H]noradrenaline evoked by depolarization with K(+) much less than that caused by electrical nerve stimulation (frequencies up to 10 Hz). Exogenous noradrenaline (1-5 mum) depressed the secretion evoked by both modes of stimulation. The results indicate that alpha-autoinhibition of [(3)H]noradrenaline secretion is mainly operative when the secretory stimulus requires conduction of nerve impulses between varicosities.5. The frequency dependence of [(3)H]noradrenaline secretion was hyperbolic, both in the presence and in the absence of alpha-autoinhibition; at each frequency the secretion (Deltat per shock) increased with the Ca(2+) concentration in the medium (0.6-8 mm). Double reciprocal plot analysis (1/Deltat vs. 1/frequency) of the data yields that the pattern of interaction between external Ca(2+) and facilitation depends on the presence or absence of alpha-autoinhibition (phentolamine 1 mum); in the former case it is ;non-competitive', in the latter ;competitive'. Similar analysis of the effect of facilitation by increasing the length of stimulus trains (from 5 to 300 pulses) at a constant frequency (5 Hz), on the Ca(2+) dependence of Deltat (1/Deltat vs. 1/Ca(2+)) in the absence of alpha-autoinhibition also yields that facilitation promotes utilization of external Ca(2+). These results apparently imply that a rise in external Ca(2+), in the presence of alpha-autoinhibition, augments the secretory response to electrical nerve stimulation mainly by promoting recruitment of active units (varicosities?), without markedly altering their ;affinity' for facilitation. In the absence of autoinhibition (when all units are already recruited?), the results seem to imply that facilitation promotes depolarization-secretion coupling in each, by more efficient utilization of external Ca(2+).6. The pattern of interaction between alpha-autoinhibition and facilitation depends on the Ca(2+)concentration in the medium. At or below the physiological level of Ca(2+) in extracellular fluid (1.2 mm) it is ;non-competitive', indicating that alpha-autoinhibition and facilitation act, at least in part, at separate targets under these conditions. At high (5.4 mm) external Ca(2+) the pattern becomes almost purely ;competitive', indicating that facilitation can, under suitable conditions, overcome all manifestations of alpha-autoinhibition.7. The secretion evoked by electrical nerve stimulation (Deltat per shock, at 1 or 10 Hz) increased with the strength of applied shocks, both when applied extra- or transmurally, in the presence or absence of alpha-autoinhibition. In the former case the rise in (Deltat per shock) vs. (current strength) was hyperbolic, in the latter it followed a biphasic pattern. Double reciprocal plot analysis (1/Deltat vs. 1/current) of the data yields a ;non-competitive' pattern of interaction between facilitation or alpha-autoinhibition, and exogenous current, when stimulation was extramural. When it was transmural the pattern is ;competitive'. The results seem to imply that hyperpolarization, or depolarization, of nerve terminals are major mechanisms whereby alpha-autoinhibition and facilitation, respectively, exert their effects on the secretory response to electrical nerve stimulation.8. Neither activation of Na(+), K(+)-ATPase, nor promotion of G(Cl) appear to be critically involved in alpha-autoinhibition. Experiments with known blockers of G(K) (tetraethylammonium, 4-aminopyridine and Rb(+)) did not give support to the notion that promotion of K(+) efflux is a mechanism whereby prejunctional alpha-adrenoceptors cause (hyperpolarization of nerve terminals and) autoinhibition of secretion. If alpha-autoinhibition does involve K(+) channels in the nerve terminal membrane, then these must be different from the (voltage-sensitive) K(+) channels blocked by the above mentioned inhibitors of K(+) efflux.9. The results are discussed in the context of a model that assumes that local control of noradrenaline secretion from noradrenergic nerves may be exerted both by control of invasion of terminals, and by control of depolarization-secretion coupling in each invaded varicosity. Under suitable conditions facilitation and alpha-autoinhibition may interact at both levels. It proposed that utilization of external Ca(2+) plays a pivotal role for both, and that restriction of invasion of nerve terminal varicosities is the main effect of alpha-autoinhibition, while promotion of depolarization-secretion coupling is the main effect of facilitation, at physiological concentrations of Ca(2+) in the medium. For the nerve the role of this dual control system is proposed to be to ensure ;rotational' activation of varicosities, and for the effector cell of noradrenergic junctions, to increase the signal/noise ratio.

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March 1981
5 Reads

The influence of 8-Br 3', 5'-cyclic nucleotide analogs and of inhibitors of 3', 5'-cyclic nucleotide phosphodiesterase, on noradrenaline secretion and neuromuscular transmission in guinea-pig vas deferens.

Naunyn Schmiedebergs Arch Pharmacol 1979 Aug;308(2):99-105

Naunyn Schmiedebergs Arch. Pharmacol.

The effects of 3', 5'-cyclic nucleotide phosphodiesterase (PDE) inhibitors and of 8-Br 3', 5'-cyclic nucleotide analogs on nerve-muscle transmission were studied in the guinea-pig vas deferens preincubated with 3H-noradrenaline. 8-Br cyclic AMP and the PDE inhibitors 3-isobutyl-1-methylxanthine (IBMX) and 3-propionyl-4-hydrazinopyrazolopyridine (SQ 20006) enhanced the secretion of 3H-NA evoked by transmural nerve stimulation. 8-Br cyclic GMP was without effect in this respect. The muscle contraction evoked by transmural nerve stimulation, high potassium or by application of exogenous noradrenaline was depressed by IBMX and SQ 2006. The contraction evoked by transmural nerve stimulation was enhanced by 8-Br cyclic AMP and depressed by 8-Br cyclic GMP. These findings suggest differential involvement of 3', 5'-adenosine- and guanosine-cyclic nucleotides in excitation-secretion-coupling in the noradrenergic sympathetic nerves, and in excitation-contraction-coupling in the smooth muscle, of guinea-pig vas deferens.

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August 1979
5 Reads

Muscarinic acetylcholine receptor from rat brain. Partial purification and characterization.

Authors:
P Alberts T Bartfai

J Biol Chem 1976 Mar;251(6):1543-7

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March 1976
5 Reads
3 Citations
4.573 Impact Factor

Top co-authors

Andra Tilgase
Andra Tilgase

International Virotherapy Center

6
Agnija Rasa
Agnija Rasa

International Virotherapy Center

5
Evija Olmane
Evija Olmane

Pauls Stradi?š Clinical University Hospital

4
Jurijs Nazarovs
Jurijs Nazarovs

Institute of Pathology

3