Peter van Galen

Peter van Galen

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Peter van Galen

Peter van Galen

Publications by authors named "Peter van Galen"

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21Publications

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Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

Cell 2019 03 28;176(6):1265-1281.e24. Epub 2019 Feb 28.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Ludwig Center at Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193009
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http://dx.doi.org/10.1016/j.cell.2019.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515904PMC
March 2019

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.

Cell Rep 2018 10;25(5):1109-1117.e5

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183159
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http://dx.doi.org/10.1016/j.celrep.2018.10.021DOI Listing
October 2018

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer Cell 2018 01 14;33(1):29-43.e7. Epub 2017 Dec 14.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760343PMC
January 2018

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.

Cell Stem Cell 2017 02 15;20(2):233-246.e7. Epub 2016 Dec 15.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291795PMC
February 2017

A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes.

Mol Cell 2016 Jan 10;61(1):170-80. Epub 2015 Dec 10.

Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707994PMC
January 2016

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.

Blood 2015 Oct 28;126(16):1930-9. Epub 2015 Aug 28.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA;

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http://dx.doi.org/10.1182/blood-2015-06-649087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608240PMC
October 2015

Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells.

Exp Hematol 2015 Sep 2;43(9):756-9. Epub 2015 Jul 2.

Stem Cell Transplantation Program, Division of Hematology and Oncology, Boston Children's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.exphem.2015.05.007DOI Listing
September 2015

Isolation and identification of 4-α-rhamnosyloxy benzyl glucosinolate in Noccaea caerulescens showing intraspecific variation.

Phytochemistry 2015 Feb 4;110:166-71. Epub 2014 Dec 4.

Molecular Interaction Ecology, Institute of Water and Wetland Research (IWWR), Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany; Friedrich Schiller University Jena, Institute of Ecology, Dornburger-Str. 159, 07743 Jena, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00319422140049
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http://dx.doi.org/10.1016/j.phytochem.2014.11.016DOI Listing
February 2015

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

Nature 2014 Jun 28;510(7504):268-72. Epub 2014 Apr 28.

1] Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nature13228DOI Listing
June 2014

Self-renewal as a therapeutic target in human colorectal cancer.

Nat Med 2014 Jan 1;20(1):29-36. Epub 2013 Dec 1.

1] Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [3] Department of Surgery, Toronto General Hospital, Toronto, Ontario, Canada. [4].

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http://dx.doi.org/10.1038/nm.3418DOI Listing
January 2014

Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion.

Cell Stem Cell 2014 Jan;14(1):94-106

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2013.11.021DOI Listing
January 2014

Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.

Antimicrob Agents Chemother 2013 Oct 22;57(10):4794-800. Epub 2013 Jul 22.

Department of Dermatology and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/AAC.00603-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811400PMC
October 2013

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer.

Science 2013 Feb 13;339(6119):543-8. Epub 2012 Dec 13.

Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1126/science.1227670DOI Listing
February 2013

Attenuation of miR-126 activity expands HSC in vivo without exhaustion.

Cell Stem Cell 2012 Dec 8;11(6):799-811. Epub 2012 Nov 8.

Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.stem.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517970PMC
December 2012

Stem cell gene expression programs influence clinical outcome in human leukemia.

Nat Med 2011 Aug 28;17(9):1086-93. Epub 2011 Aug 28.

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nm.2415
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http://dx.doi.org/10.1038/nm.2415DOI Listing
August 2011