Publications by authors named "Peter W Stacpoole"

94Publications

Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.

Drug Metab Dispos 2020 Nov 1;48(11):1217-1223. Epub 2020 Sep 1.

Departments of Medicinal Chemistry (E.J.S., M.G.S., L.R.-F., M.O.J.), Medicine (L.P.H., P.W.S.), and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida

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http://dx.doi.org/10.1124/dmd.120.000142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589944PMC
November 2020

Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.

Drug Metab Dispos 2020 Nov 1;48(11):1224-1230. Epub 2020 Sep 1.

Departments of Medicinal Chemistry (E.J.S., R.M., M.O.J.), Medicine (L.P.H., P.W.S.), and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida

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http://dx.doi.org/10.1124/dmd.120.000143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589945PMC
November 2020

Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.

Drug Metab Dispos 2020 Jul 1;48(7):563-569. Epub 2020 May 1.

Departments of Medicinal Chemistry (S.C.J., C.J.W., M.O.J.), Pharmacotherapy and Translational Research (T.Y.L.), Medicine (P.W.S.), Biochemistry and Molecular Biology (P.W.S.), and Molecular Genetics and Microbiology (L.A.G., R.R.), University of Florida, Gainesville, Florida

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http://dx.doi.org/10.1124/dmd.120.090639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289049PMC
July 2020

Mitochondrial diseases in North America: An analysis of the NAMDC Registry.

Neurol Genet 2020 Apr 2;6(2):e402. Epub 2020 Mar 2.

Department of Neurology (E.B., V.E., S.D., K.E., X.Q.R., M.H.), Columbia University Medical Center, New York; Department of Biostatistics (Y.L., V.C., J.K., J. Grier, R.B., J.L.P.T.), Mailman School of Public Health, Columbia University, New York; Radboudumc (R.S.), Nijmegen, The Netherlands; Department of Pediatrics (B.H.C.), Northeast Ohio Medical University and Akron Children's Hospital; Genetics Unit (A.K.), Massachusetts General Hospital, Boston; Department of Pediatrics (G.D.V.), State University of New York at Buffalo; Departments of Neurosciences and Pediatrics (R.H.), University of California at San Diego; Department of Pediatrics (J.L.K.V.H., A.L.), University of Colorado School of Medicine, Aurora; Department of Molecular and Human Genetics (F.S.), Baylor College of Medicine, Houston, TX; Texas Children's Hospital (F.S.), Houston; Joint BCM-CUHK Center of Medical Genetics (F.S.), Prince of Wales Hospital, ShaTin, New Territories, Hong Kong; Department of Neurology (S.P.), Cleveland Clinic, OH; Departments of Genetics and Genome Sciences and Pediatrics (J.K.B., S.D.D.), and Center for Human Genetics, University Hospitals Cleveland Medical Center, Case Western Reserve University, OH; Departments of Neurology and Clinical Genomics (R.H.G.), Mayo Clinic, Rochester, MN; Department of Neurology (R.P.S.), University of Washington, Seattle Children's Hospital; Department of Pediatrics (G.M.E.), Stanford University, Palo Alto, CA; Department of Medicine (P.W.S.), University of Florida at Gainesville; Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai (J. Ganesh), New York; Mitochondrial Medicine Frontier Program (Z.Z.-C., M.J.F., A.C.G.), Division of Human Genetics, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine; University of Pennsylvania Perelman School of Medicine (Z.Z.-C.), Philadelphia; Department of Neurology (M.T.), McMasters University, Toronto, Ontario, Canada; Department of Neurology (A.G.), Children's National Health Network, Washington, DC; Office of Dietary Supplements (K.C.), National Institutes of Health, Bethesda, MD; and Eunice Kennedy Shriver National Institute of Child Health and Human Development (D.K.), National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1212/NXG.0000000000000402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164977PMC
April 2020

Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes.

J Leukoc Biol 2020 03 2;107(3):467-484. Epub 2020 Jan 2.

Department of Internal Medicine/Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1002/JLB.3A1119-236RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044062PMC
March 2020

The changing landscape of clinical trials for mitochondrial diseases: 2011 to present.

Mitochondrion 2020 01 25;50:51-57. Epub 2019 Oct 25.

Departments of Medicine (Division of Endocrinology, Diabetes and Metabolism), College of Medicine, University of Florida, United States; Biochemistry and Molecular Biology, College of Medicine, University of Florida, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2019.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934893PMC
January 2020

Dichloroacetate-induced peripheral neuropathy.

Int Rev Neurobiol 2019 11;145:211-238. Epub 2019 Jun 11.

Department of Pathology, University of California San Diego, La Jolla, CA, United States.

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http://dx.doi.org/10.1016/bs.irn.2019.05.003DOI Listing
January 2020

Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.

Drug Metab Dispos 2018 08 31;46(8):1118-1128. Epub 2018 May 31.

Department of Medicinal Chemistry (G.Z., M.O.J., M.G.S., S.C.J.), Department of Pharmacotherapy and Translational Research (T.L.), Center for Pharmacogenomics (T.L.), and Departments of Medicine and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida; and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (P.S.).

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0818
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http://dx.doi.org/10.1124/dmd.118.081810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038028PMC
August 2018

Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.

Genet Test Mol Biomarkers 2018 Apr 19;22(4):266-269. Epub 2018 Mar 19.

4 Department of Pathology, College of Medicine, University of Florida , Gainesville, Florida.

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http://dx.doi.org/10.1089/gtmb.2017.0261DOI Listing
April 2018

Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.

Biochem Pharmacol 2018 06 5;152:236-243. Epub 2018 Apr 5.

Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960630PMC
June 2018

Development of a novel observer reported outcome tool as the primary efficacy outcome measure for a rare disease randomized controlled trial.

Mitochondrion 2018 09 10;42:59-63. Epub 2017 Nov 10.

Department of Psychiatry (Division of Addiction Research) and Biobehavioral Core, University of Florida, College of Medicine, Gainesville, FL 32610, United States.

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http://dx.doi.org/10.1016/j.mito.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587967PMC
September 2018

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.

J Natl Cancer Inst 2017 11;109(11)

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, and Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL.

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http://dx.doi.org/10.1093/jnci/djx071DOI Listing
November 2017

Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.

J Clin Pharmacol 2018 02 15;58(2):212-220. Epub 2017 Sep 15.

Center for Pharmacometrics & Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USA.

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http://dx.doi.org/10.1002/jcph.1009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967850PMC
February 2018

Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

Pharmacol Ther 2017 02 19;170:166-180. Epub 2016 Oct 19.

Department of Medicine, University of Florida, Gainesville, FL 32610-0226, United States; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, United States.

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http://dx.doi.org/10.1016/j.pharmthera.2016.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274567PMC
February 2017

Pharmacogenetic considerations with dichloroacetate dosing.

Pharmacogenomics 2016 05 4;17(7):743-53. Epub 2016 May 4.

Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610-0485, USA.

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http://dx.doi.org/10.2217/pgs-2015-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558523PMC
May 2016

GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.

Biochim Biophys Acta 2016 Jun 2;1860(6):1202-10. Epub 2016 Feb 2.

Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610-0485, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2016.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837035PMC
June 2016

Vitamin B6 nutritional status and cellular availability of pyridoxal 5'-phosphate govern the function of the transsulfuration pathway's canonical reactions and hydrogen sulfide production via side reactions.

Biochimie 2016 Jul 4;126:21-6. Epub 2016 Jan 4.

Division of Endocrinology and Metabolism, Departments of Biochemistry and Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1016/j.biochi.2015.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899128PMC
July 2016

Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.

Biochem Biophys Res Commun 2015 Apr 3;459(3):463-8. Epub 2015 Mar 3.

Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610-0485, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.02.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380591PMC
April 2015

The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.

Pharmacogenet Genomics 2015 May;25(5):239-45

aDepartment of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy bDepartment of Medicinal Chemistry, College of Pharmacy cDepartment of Medicine, College of Medicine dDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA eDepartment of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

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http://dx.doi.org/10.1097/FPC.0000000000000129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382440PMC
May 2015

Sleep disorders associated with primary mitochondrial diseases.

J Clin Sleep Med 2014 Nov 15;10(11):1233-9. Epub 2014 Nov 15.

Department of Medicine, University of Florida, College of Medicine, Gainesville, FL and Division of Endocrinology, Metabolism and Diabetes, and Department of Biochemistry and Molecular Biology, University of Florida, College of Medicine, Gainesville, FL.

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http://dx.doi.org/10.5664/jcsm.4212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224726PMC
November 2014

Dichloroacetate and cancer: new home for an orphan drug?

Biochim Biophys Acta 2014 Dec 23;1846(2):617-29. Epub 2014 Aug 23.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL, United States; Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.08.005DOI Listing
December 2014

Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.

Chem Biol Interact 2014 May 13;215:33-9. Epub 2014 Mar 13.

Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610-0485, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2014.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019600PMC
May 2014

Pharmacokinetics of oral dichloroacetate in dogs.

J Biochem Mol Toxicol 2013 Dec 13;27(12):522-5. Epub 2013 Sep 13.

Small Animal Clinical Sciences, University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1002/jbt.21518DOI Listing
December 2013

Long-term safety of dichloroacetate in congenital lactic acidosis.

Mol Genet Metab 2013 Jun 6;109(2):139-43. Epub 2013 Apr 6.

Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.ymgme.2013.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751427PMC
June 2013

The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients.

Mol Genet Metab 2012 Jul;106(3):385-94

Department of Medicine (Division of Endocrinology, Metabolism and Diabetes), College of Medicine, University of Florida, Gainesville, FL 32611, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003492PMC
http://dx.doi.org/10.1016/j.ymgme.2012.03.017DOI Listing
July 2012

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

Aging Cell 2012 Jun 4;11(3):371-7. Epub 2012 Apr 4.

Departments of Medicine (Division of Endocrinology and Metabolism) and Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32611, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2012.00805.xDOI Listing
June 2012

The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients.

Mol Genet Metab 2012 Jan 7;105(1):34-43. Epub 2011 Oct 7.

Departments of Medicine (Division of Endocrinology and Metabolism), College of Medicine, University of Florida, Gainesville, FL 32611, USA.

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http://dx.doi.org/10.1016/j.ymgme.2011.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754811PMC
January 2012

Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.

Drug Metab Dispos 2012 Feb 25;40(2):232-9. Epub 2011 Oct 25.

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610-0485, USA.

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http://dx.doi.org/10.1124/dmd.111.041533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263939PMC
February 2012

Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts.

Mol Genet Metab 2011 Nov 28;104(3):255-60. Epub 2011 Jul 28.

Department of Medicine (Division of Endocrinology and Metabolism), College of Medicine, University of Florida, Gainesville, FL 32611, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109671921100249
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http://dx.doi.org/10.1016/j.ymgme.2011.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205311PMC
November 2011

Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.

J Clin Pharmacol 2012 Jun 3;52(6):837-49. Epub 2011 Jun 3.

Department of Medicine, Division of Endocrinology and Metabolism, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1177/0091270011405664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786668PMC
June 2012

Why are there no proven therapies for genetic mitochondrial diseases?

Mitochondrion 2011 Sep 13;11(5):679-85. Epub 2011 May 13.

Department of Medicine, Division of Endocrinology and Metabolism, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.mito.2011.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155622PMC
September 2011

The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?

Environ Health Perspect 2011 Feb 4;119(2):155-8. Epub 2010 Oct 4.

Department of Medicine, Division of Endocrinology and Metabolism, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1289/ehp.1002554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040600PMC
February 2011

Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

J Pharmacol Exp Ther 2011 Jan 30;336(1):87-94. Epub 2010 Sep 30.

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610-0485, USA.

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http://dx.doi.org/10.1124/jpet.110.173195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014303PMC
January 2011

An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.

Mol Genet Metab 2010 Oct-Nov;101(2-3):183-91. Epub 2010 Jul 15.

Division of Endocrinology and Metabolism, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.ymgme.2010.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950252PMC
January 2011

Peripheral neuropathy in rats exposed to dichloroacetate.

J Neuropathol Exp Neurol 2009 Sep;68(9):985-93

Department of Pathology, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181b40217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741559PMC
September 2009

Production of 1-carbon units from glycine is extensive in healthy men and women.

J Nutr 2009 Apr 25;139(4):666-71. Epub 2009 Feb 25.

Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville, FL 32611-0370, USA.

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http://dx.doi.org/10.3945/jn.108.103580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666360PMC
April 2009

The heme precursor delta-aminolevulinate blocks peripheral myelin formation.

J Neurochem 2008 Sep 4;106(5):2068-79. Epub 2008 Jul 4.

Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610-0244, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05552.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574579PMC
September 2008

Role of dichloroacetate in the treatment of genetic mitochondrial diseases.

Adv Drug Deliv Rev 2008 Oct-Nov;60(13-14):1478-87. Epub 2008 Jul 4.

Department of Medicine, Division of Endocrinology and Metabolism, College of Medicine, University of Florida, Gainesville, FL 32610-0226, USA.

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http://dx.doi.org/10.1016/j.addr.2008.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746325PMC
December 2008

Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.

Pediatrics 2008 May 14;121(5):e1223-8. Epub 2008 Apr 14.

Department of Medicine, General Clinical Research Center, JHMHC, Gainesville, FL 32610-0226, USA.

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http://dx.doi.org/10.1542/peds.2007-2062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777225PMC
May 2008

A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate.

Mol Genet Metab 2008 Apr 21;93(4):381-7. Epub 2008 Feb 21.

Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida College of Medicine, Gainesville, FL, USA.

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http://dx.doi.org/10.1016/j.ymgme.2007.10.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583368PMC
April 2008

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

J Pharmacol Exp Ther 2008 Mar 20;324(3):1163-71. Epub 2007 Dec 20.

Departments of Medicine, University of Florida Colleges of Medicine and Pharmacy, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1124/jpet.107.134593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613565PMC
March 2008

Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine.

J Nutr 2007 Dec;137(12):2647-52

Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611-0370, USA.

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https://academic.oup.com/jn/article/137/12/2647/4670029
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833992PMC
http://dx.doi.org/10.1093/jn/137.12.2647DOI Listing
December 2007

Pyruvate dehydrogenase complex deficiency caused by ubiquitination and proteasome-mediated degradation of the E1 subunit.

J Biol Chem 2008 Jan 8;283(1):237-43. Epub 2007 Oct 8.

Department of Pediatrics, Division of Cellular and Molecular Therapy, Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1074/jbc.M704748200DOI Listing
January 2008

MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.

Anal Chem 2007 Nov 26;79(21):8170-5. Epub 2007 Sep 26.

Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA.

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http://dx.doi.org/10.1021/ac0713555DOI Listing
November 2007

Down-regulation of expression of rat pyruvate dehydrogenase E1alpha gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery.

Mitochondrion 2007 Jul 20;7(4):253-9. Epub 2007 Feb 20.

Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.mito.2007.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1973157PMC
July 2007

Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect.

J Neurochem 2007 Jan;100(2):429-36

Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610-024, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04248.xDOI Listing
January 2007

Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.

J Clin Pharmacol 2006 Dec;46(12):1449-59

General Clinical Research Center, University of Florida, 1600 Archer Road, Gainesville, Florida 32610, USA.

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http://doi.wiley.com/10.1177/0091270006292627
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http://dx.doi.org/10.1177/0091270006292627DOI Listing
December 2006

Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.

Mol Genet Metab 2006 Sep-Oct;89(1-2):97-105. Epub 2006 Jun 12.

Department of Medicine, Division of Endocrinology and Metabolism, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.ymgme.2006.04.015DOI Listing
October 2006

Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.

Mitochondrion 2006 Jun 3;6(3):126-35. Epub 2006 May 3.

Division of Endocrinology and Metabolism, Department of Medicine, University of Florida College of Medicine, P.O. Box 10226, Gainesville, FL 32610, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S156772490600056
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http://dx.doi.org/10.1016/j.mito.2006.04.001DOI Listing
June 2006

A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Jun 19;837(1-2):125-32. Epub 2006 May 19.

Division of Endocrinology and Metabolism, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.jchromb.2006.04.027DOI Listing
June 2006

Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.

Biochem Pharmacol 2006 May 3;71(11):1648-61. Epub 2006 Apr 3.

Laboratory of Cellular and Developmental Genetics, CREFSIP, Department of Medicine, University Laval, Que., Canada G1K 7P4.

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http://dx.doi.org/10.1016/j.bcp.2006.02.017DOI Listing
May 2006

Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women.

J Nutr 2006 Feb;136(2):373-8

Food Science andHuman Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611-0370, USA.

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https://academic.oup.com/jn/article/136/2/373/4664298
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http://dx.doi.org/10.1093/jn/136.2.373DOI Listing
February 2006

Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.

Drug Metab Dispos 2006 Jan 30;34(1):36-42. Epub 2005 Sep 30.

Division of Endocrinology and Metabolism, Department of Medicine, University of Florida, FL 32610, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.105.003996
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http://dx.doi.org/10.1124/dmd.105.003996DOI Listing
January 2006

Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.

Am J Clin Nutr 2005 Mar;81(3):648-55

Food Science & Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville 32611-0370, USA.

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https://academic.oup.com/ajcn/article/81/3/648/4649023
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http://dx.doi.org/10.1093/ajcn/81.3.648DOI Listing
March 2005

Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.

J Nutr 2005 Mar;135(3):389-96

Food Science & Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville, FL 32611, USA.

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http://dx.doi.org/10.1093/jn/135.3.389DOI Listing
March 2005

Liquid chromatography-tandem mass spectrometry method for the simultaneous determination of delta-ALA, tyrosine and creatinine in biological fluids.

Clin Chim Acta 2004 Dec;350(1-2):219-30

Department of Medicine (Division of Endocrinology and Metabolism), College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.cccn.2004.08.009DOI Listing
December 2004

Effects of exercise on emerging and traditional cardiovascular risk factors.

Prev Med 2004 Nov;39(5):894-902

Department of Epidemiology, Nutritional Sciences Program, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.ypmed.2004.03.012DOI Listing
November 2004

Unified gas chromatographic-mass spectrometric method for quantitating tyrosine metabolites in urine and plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2004 Sep;808(2):153-61

Division of Endocrinology and Metabolism, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.jchromb.2004.05.005DOI Listing
September 2004

Methylphenidate does not improve cognitive function in healthy sleep-deprived young adults.

J Investig Med 2004 Apr;52(3):192-201

University of Florida College of Medicine, Gainesville, FL 32610-1042, USA.

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http://dx.doi.org/10.1136/jim-52-03-34DOI Listing
April 2004

Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets.

J Clin Endocrinol Metab 2004 Apr;89(4):1641-5

Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1210/jc.2003-031796DOI Listing
April 2004

Simultaneous determination of trace levels of nine haloacetic acids in biological samples as their pentafluorobenzyl derivatives by gas chromatography/tandem mass spectrometry in electron capture negative ion chemical ionization mode.

Anal Chem 2003 Aug;75(16):4065-80

Department of Medicine, Division of Endocrinology and Metabolism, College of Medicine, University of Florida, Box 100226, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1021/ac034036wDOI Listing
August 2003

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

Biochem Pharmacol 2003 Nov;66(10):2029-38

Division of Endocrinology and Metabolism, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.bcp.2003.07.002DOI Listing
November 2003

Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.

Am J Physiol Endocrinol Metab 2004 Feb 14;286(2):E272-9. Epub 2003 Oct 14.

Food Science and Human Nutrition Department, Institute of Food and Agricultural Science, University of Florida, Gainesville, Florida 32611-0370, USA.

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http://dx.doi.org/10.1152/ajpendo.00351.2003DOI Listing
February 2004

A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management.

Clin Infect Dis 2003 Oct 5;37(7):890-7. Epub 2003 Sep 5.

Department of Cellular and Molecular Medicine Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom.

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http://dx.doi.org/10.1086/377536DOI Listing
October 2003

Efficacy of dichloroacetate as a lactate-lowering drug.

J Clin Pharmacol 2003 Jul;43(7):683-91

Department of Medicine (Division of Endocrinology and Metabolism), Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, USA.

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July 2003

The pyruvate dehydrogenase complex as a target for gene therapy.

Curr Gene Ther 2003 Jun;3(3):239-45

Department of Medicine, Division of Endocrinology and Metabolism, University of Florida, College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.2174/1566523034578320DOI Listing
June 2003

Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.

J Clin Pharmacol 2003 Apr;43(4):386-96

Department of Physiology, University of Science and Technology, School of Medical Sciences, Departments of Child Health and Medicine, Komfo-Anokye Teaching Hospital, Kumasi, Ghana.

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http://dx.doi.org/10.1177/0091270003251392DOI Listing
April 2003

Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults.

Diabetes Care 2003 Mar;26(3):557-62

Department of Medicine, University of Florida, Gainesville, Florida 32610-0226, USA.

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http://dx.doi.org/10.2337/diacare.26.3.557DOI Listing
March 2003

Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors.

Mol Ther 2002 Sep;6(3):394-9

Department of Pediatrics, The General Clinical Research Center, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1006/mthe.2002.0683DOI Listing
September 2002

Renal manifestations of congenital lactic acidosis.

Am J Kidney Dis 2002 Jan;39(1):12-23

Department of Pediatrics, Division of Nephrology, and the General Clinical Research Center, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1053/ajkd.2002.29872DOI Listing
January 2002