Publications by authors named "Peter W Lewis"

40Publications

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.

Proc Natl Acad Sci U S A 2020 11 16;117(44):27354-27364. Epub 2020 Oct 16.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706;

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November 2020

H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.

Mol Cell 2020 11 12;80(4):726-735.e7. Epub 2020 Oct 12.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA. Electronic address:

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November 2020

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.

Nat Commun 2019 05 13;10(1):2146. Epub 2019 May 13.

Department of Biomolecular Chemistry, School of Medicine and Public Health and Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI, 53715, USA.

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May 2019

Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase.

Proc Natl Acad Sci U S A 2019 04 9;116(17):8295-8300. Epub 2019 Apr 9.

Department of Chemistry, Princeton University, Princeton, NJ 08544;

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April 2019

Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation.

Mol Cell 2019 04 20;74(1):185-195.e4. Epub 2019 Feb 20.

Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison WI 53706, USA. Electronic address:

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April 2019

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.

Breast Cancer Res Treat 2019 May 2;175(1):39-50. Epub 2019 Feb 2.

Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

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May 2019

Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers.

Epigenetics 2018 23;13(7):683-692. Epub 2018 Aug 23.

a Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.

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March 2019

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.

Nat Commun 2017 10 30;8(1):1193. Epub 2017 Oct 30.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53706, USA.

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October 2017

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.

Proc Natl Acad Sci U S A 2016 May 16;113(22):6182-7. Epub 2016 May 16.

Wisconsin Institute of Discovery, University of Wisconsin, Madison, WI 53715; Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715;

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May 2016

Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.

Angew Chem Int Ed Engl 2015 May 14;54(22):6457-61. Epub 2015 Apr 14.

Department of Chemistry, Princeton University, Princeton, NJ 08544 (USA).

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May 2015

ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.

Proc Natl Acad Sci U S A 2015 Jun 23;112(22):6820-7. Epub 2014 Dec 23.

Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065;

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June 2015