Peter Van Loo

Peter Van Loo

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Peter Van Loo

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Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

Cancer Cell 2019 Mar;35(3):441-456.e8

Research Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK; Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428691PMC
March 2019

Translating insights into tumor evolution to clinical practice: promises and challenges.

Genome Med 2019 03 29;11(1):20. Epub 2019 Mar 29.

The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-019-0632-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440005PMC
March 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Timing somatic events in the evolution of cancer.

Genome Biol 2018 07 24;19(1):95. Epub 2018 Jul 24.

The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.

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http://dx.doi.org/10.1186/s13059-018-1476-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057033PMC
July 2018

Association between crural vessel patency and successful transmetatarsal amputation: a single centre experience.

S Afr J Surg 2018 Jun;56(2):50-53

Department of General and Vascular Surgery, James Cook University Hospital, Middlesbrough, United Kingdom.

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June 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal.

Cell 2018 04 12;173(3):595-610.e11. Epub 2018 Apr 12.

Translational Cancer Therapeutics Laboratory, the Francis Crick Institute, London NW1 1AT, UK; Cancer Research UK Lung Cancer Centre of Excellence London, University College London Cancer Institute, London WC1E 6DD, UK; Department of Medical Oncology, University College London Hospitals, London NW1 2BU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938372PMC
April 2018

Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Authors:
Christopher Abbosh Nicolai J Birkbak Gareth A Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari John Le Quesne David A Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kirkizlar Thomas B K Watkins Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin Hiley Siow Ming Lee Martin D Forster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Martin Hayward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M Janes Ricky Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Joseph Anne Marie Quinn Phil A Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter Marianne Nicolson Hardy Remmen Keith Kerr Mahendran Chetty Lesley Gomersall Dean A Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash Jason F Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U Akarca John A Hartley Helen L Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltan Szallasi Roland F Schwarz Javier Herrero Aengus Stewart Sergio A Quezada Karl S Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J W L Aerts Allan Hackshaw Jacqui A Shaw Bernhard G Zimmermann Charles Swanton

Nature 2018 02 20;554(7691):264. Epub 2017 Dec 20.

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http://dx.doi.org/10.1038/nature25161DOI Listing
February 2018

Universal Patterns of Selection in Cancer and Somatic Tissues.

Cell 2017 Nov 19;171(5):1029-1041.e21. Epub 2017 Oct 19.

Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK; Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720395PMC
November 2017

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.

Cell 2017 Nov 26;171(6):1259-1271.e11. Epub 2017 Oct 26.

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720478PMC
November 2017

Principles of Reconstructing the Subclonal Architecture of Cancers.

Cold Spring Harb Perspect Med 2017 Aug 1;7(8). Epub 2017 Aug 1.

The Francis Crick Institute, London NW1 1AT, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a026625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538405PMC
August 2017

Tracking the Evolution of Non-Small-Cell Lung Cancer.

N Engl J Med 2017 06 26;376(22):2109-2121. Epub 2017 Apr 26.

From the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., G.A.W., N. McGranahan, N.J.B., S.V., S.S., D.H.J., R.R., S.-M.L., M.D.F., C.A., S.M.J., C.D., C.S.), London and Manchester, Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., J.A.H.), Bill Lyons Informatics Centre (J.H.), and Cancer Immunology Unit (S.A.Q.), UCL Cancer Institute, the Translational Cancer Therapeutics Laboratory (G.A.W., N. McGranahan, N.J.B., T.B.K.W., A.R., T.C., S. Turajlic, H.X., C.T.H., C.S.), Department of Bioinformatics and Biostatistics (R.M., M.S., S.H., M.E., A.S.), Advanced Sequencing Facility (N. Matthews), and Cancer Genomics Laboratory (S.D., P.V.L.), Francis Crick Institute, the Renal and Skin Units, Royal Marsden Hospital (S. Turajlic), the Departments of Medical Oncology (M.J.-H., S.-M.L., M.D.F., T.A., C.A., C.S.), Pathology (M.F., E.B., T.M.), Cardiothoracic Surgery (D.L., M.H., S. Kolvekar, N.P.), Respiratory Medicine (S.M.J., R.T.), and Radiology (A.A.), UCL Hospitals, Lungs for Living, UCL Respiratory, UCL (S.M.J.), the Department of Radiotherapy, North Middlesex University Hospital (G.A.), the Department of Respiratory Medicine, Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., H.B., Y.N., A.H.), London, Cancer Studies, University of Leicester (D.A.M., D.A.F., J.A.S., J.L.Q.), the Department of Thoracic Surgery, Glenfield Hospital (A.N., S.R.), and the Medical Research Center Toxicology Unit (J.L.Q.), Leicester, the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., Y.S.), the Departments of Cardiothoracic Surgery (R.S.) and Pathology (L.J., A.M.Q.) and the North West Lung Centre (P.A.C.), University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Manchester, the Departments of Thoracic Surgery (B.N.) and Cellular Pathology (G.L., S. Trotter), Birmingham Heartlands Hospital, Molecular Pathology Diagnostic Services, Queen Elizabeth Hospital (P.T., B.O.), and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Birmingham, the Departments of Medical Oncology (M.N.), Cardiothoracic Surgery (H.R.), Pathology (K.K.), Respiratory Medicine (M.C.), and Radiology (L.G.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen, the Department of Respiratory Medicine, Barnet and Chase Farm Hospitals, Barnet (S. Khan), the Department of Respiratory Medicine, Princess Alexandra Hospital, Harlow (P.R.), the Department of Clinical Oncology, St. Luke's Cancer Centre, Guildford (V.E.), the Departments of Pathology (B.I.), Respiratory Medicine (M.I.-S.), and Radiology (V.P.), Ashford and St. Peters' Hospitals, Surrey, the Department of Clinical Oncology, Velindre Hospital (J.F.L.), the Departments of Radiology (H.A.) and Respiratory Medicine (H.D.), University Hospital Llandough, the Departments of Pathology (R.A.) and Cardiothoracic Surgery (M.K.), University Hospital of Wales, and Cardiff University (R.A.), Cardiff, and Wellcome Trust Sanger Institute, Hinxton, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom; the Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby (Z.S.); the Computational Health Informatics Program, Boston Children's Hospital and Harvard Medical School, Boston (Z.S.); MTA-SE-NAP, Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary (Z.S.); Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin (R.F.S.); and the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.).

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http://dx.doi.org/10.1056/NEJMoa1616288DOI Listing
June 2017

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Authors:
Christopher Abbosh Nicolai J Birkbak Gareth A Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari John Le Quesne David A Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kirkizlar Thomas B K Watkins Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin Hiley Siow Ming Lee Martin D Forster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Martin Hayward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M Janes Ricky Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Joseph Anne Marie Quinn Phil A Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter Marianne Nicolson Hardy Remmen Keith Kerr Mahendran Chetty Lesley Gomersall Dean A Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash Jason F Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U Akarca John A Hartley Helen L Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltan Szallasi Roland F Schwarz Javier Herrero Aengus Stewart Sergio A Quezada Karl S Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J W L Aerts Allan Hackshaw Jacqui A Shaw Bernhard G Zimmermann Charles Swanton

Nature 2017 04;545(7655):446-451

Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.

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http://dx.doi.org/10.1038/nature22364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812436PMC
April 2017

Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution.

Br J Haematol 2017 03 7;176(5):825-829. Epub 2016 Apr 7.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1111/bjh.13999DOI Listing
March 2017

How Subclonal Modeling Is Changing the Metastatic Paradigm.

Clin Cancer Res 2017 Feb 18;23(3):630-635. Epub 2016 Nov 18.

Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0234DOI Listing
February 2017

ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data.

Curr Protoc Bioinformatics 2016 12 8;56:15.9.1-15.9.17. Epub 2016 Dec 8.

Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/cpbi.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097604PMC
December 2016

The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma.

Cancer Res 2016 09 3;76(17):5092-102. Epub 2016 Aug 3.

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Department for Environmental Health and Science, University College of Southeast Norway, Bø, Norway.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0658DOI Listing
September 2016

Genomic Characterization of Primary Invasive Lobular Breast Cancer.

J Clin Oncol 2016 06 29;34(16):1872-81. Epub 2016 Feb 29.

Christine Desmedt, Gabriele Zoppoli, Denis Larsimont, Debora Fumagalli, David Brown, Françoise Rothé, Delphine Vincent, Naima Kheddoumi, Ghizlane Rouas, Samira Majjaj, Sylvain Brohée, Roberto Salgado, Martine Piccart-Gebhart, and Christos Sotiriou, Institut Jules Bordet; Christine Galant, Cliniques Universitaires Saint Luc, Brussels; Peter Van Loo, University of Leuven; Thomas Van Brussel and Diether Lambrechts, VIB Vesalius Research Center, Leuven, Belgium; Gabriele Zoppoli, University of Genoa and Istituto di Ricerca a Carattere Clinico-Scientifico San Martino-National Cancer Institute, Genoa; Giancarlo Pruneri, Patrick Maisonneuve, and Giuseppe Viale, European Institute of Oncology; Marco Fornili and Elia Biganzoli, University of Milan, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Gunes Gundem and Peter J. Campbell, Wellcome Trust Sanger Institute, Cambridgeshire; Peter Van Loo, The Francis Crick Institute, London, United Kingdom; Ron Bose, Washington University School of Medicine, St Louis, MO; Otto Metzger, Dana-Farber Cancer Institute, Boston, MA; and François Bertucci, Institut Paoli-Calmettes, Marseille, France.

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http://dx.doi.org/10.1200/JCO.2015.64.0334DOI Listing
June 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1516192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979995PMC
June 2016

Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN.

PLoS One 2015 8;10(5):e0126371. Epub 2015 May 8.

Section of Genetics, Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine and Biosciences, Norwegian University of Life Sciences (NMBU),Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126371PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425491PMC
February 2016

Copy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors.

Endocr Relat Cancer 2015 Dec 23;22(6):953-67. Epub 2015 Sep 23.

Laboratory for Functional GenomicsFondation Jean Dausset - Centre d'Etude du Polymorphisme Humain (CEPH), Paris, FranceInstitute of BiomedicineAarhus University, Aarhus, DenmarkEndocrine and Metabolic Surgery DepartmentAP-HM La Conception, Marseille, FranceDepartment of EndocrinologyAP-HM La Timone, Marseille, FranceDepartment of GeneticsInstitute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, NorwayDivision of SurgeryTransplantation and Cancer Medicine, Department of Oncology, Oslo University Hospital, Oslo, NorwayThe K G Jebsen Center for Breast Cancer ResearchInstitute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayPathology DepartmentAP-HM La Timone, Marseille, FranceNuclear Endocrine Imaging and Treatment DepartmentAP-HM La Timone, Marseille, FranceCancer Research UKLondon Research Institute, London, UKDepartment of Human GeneticsUniversity of Leuven, Leuven, BelgiumGenotyping FacilitiesCentre National de Génotypage, CEA-Institut de Génomique, Evry, FranceDepartment of Clinical Molecular Biology (EpiGen)University of Oslo, Ahus, Lokerod, NorwayLaboratory of Molecular BiologyAP-HM La Conception and CRN2M, Aix-Marseille University, Marseille, FranceLaboratory for Epigenetics and EnvironmentCentre National de Génotypage, CEA-Institut de Génomique, Evry, France

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http://dx.doi.org/10.1530/ERC-15-0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621769PMC
December 2015

On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients.

Alzheimers Dement 2015 Nov 29;11(11):1265-76. Epub 2015 Apr 29.

VIB Center for the Biology of Disease, KU Leuven, Leuven, Belgium; Center for Human Genetics, KU Leuven, Leuven, Belgium; Department of Molecular Neuroscience, University College London (UCL) Institute of Neurology, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.02.007DOI Listing
November 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

J Pathol Clin Res 2015 Apr 16;1(2):113-23. Epub 2015 Mar 16.

UCL Cancer Institute, University College LondonHuntley StreetLondonUK; Sarah Cannon-University College London Advanced Diagnostics Molecular Profiling Research LaboratoriesUCL Cancer Institute, UCLLondonUK; Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustMiddlesexUK.

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http://dx.doi.org/10.1002/cjp2.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858131PMC
April 2015

SNES makes sense? Single-cell exome sequencing evolves.

Genome Biol 2015 Apr 29;16:86. Epub 2015 Apr 29.

The Francis Crick Institute, London, WC2A 3LY, UK.

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http://dx.doi.org/10.1186/s13059-015-0650-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414391PMC
April 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

Differential and limited expression of mutant alleles in multiple myeloma.

Blood 2014 Nov 18;124(20):3110-7. Epub 2014 Sep 18.

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Department of Hematology/Oncology, Boston Veterans Administration Healthcare System, West Roxbury, MA;

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http://dx.doi.org/10.1182/blood-2014-04-569327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231420PMC
November 2014

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.

Mol Oncol 2014 Mar 3;8(2):273-84. Epub 2013 Dec 3.

Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway; K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Clinical Molecular Biology (EpiGen), Medical Division, Akershus University Hospital, Lørenskog, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964809PMC
March 2014

Single cell analysis of cancer genomes.

Curr Opin Genet Dev 2014 Feb 26;24:82-91. Epub 2014 Feb 26.

Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium; Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2013.12.004DOI Listing
February 2014

Next-generation sequencing of disseminated tumor cells.

Front Oncol 2013 31;3:320. Epub 2013 Dec 31.

Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet , Oslo , Norway ; K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo , Oslo , Norway ; Department of Clinical Molecular Biology (EpiGen), Medical Division, Akershus University Hospital , Lørenskog , Norway.

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http://dx.doi.org/10.3389/fonc.2013.00320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876274PMC
January 2014

ABSOLUTE cancer genomics.

Nat Biotechnol 2012 Jul 10;30(7):620-1. Epub 2012 Jul 10.

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http://dx.doi.org/10.1038/nbt.2293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428863PMC
July 2012

Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of NF1 in neurofibromatosis type 1-associated glomus tumors.

Genes Chromosomes Cancer 2012 May 17;51(5):429-37. Epub 2012 Jan 17.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1002/gcc.21928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295917PMC
May 2012

Analyzing cancer samples with SNP arrays.

Methods Mol Biol 2012 ;802:57-72

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-61779-400-1_4DOI Listing
April 2012

Allele-specific copy number analysis of tumors.

Proc Natl Acad Sci U S A 2010 Sep 13;107(39):16910-5. Epub 2010 Sep 13.

Department of Genetics, Institute for Cancer Research, Clinic for Cancer and Surgery, Oslo University Hospital, Montebello, N-0310 Oslo, Norway.

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http://link.springer.com/content/pdf/10.1186%2Fgb-2013-14-3-
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947907PMC
September 2010

Comparative expressed sequence hybridization studies of t(11;18)(q21;q21)-positive and -negative gastric MALT lymphomas reveal both unique and overlapping gene programs.

Mod Pathol 2010 Mar 15;23(3):458-69. Epub 2010 Jan 15.

Section of Morphology and Molecular Pathology, Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/modpathol.2009.182DOI Listing
March 2010

Computational methods for the detection of cis-regulatory modules.

Brief Bioinform 2009 Sep 4;10(5):509-24. Epub 2009 Jun 4.

Department of Human Genetics, VIB and University of Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/bib/bbp025DOI Listing
September 2009

Evidence for co-evolution between human microRNAs and Alu-repeats.

PLoS One 2009 11;4(2):e4456. Epub 2009 Feb 11.

Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637760PMC
April 2009

Polysomy 17 in breast cancer: clinicopathologic significance and impact on HER-2 testing.

J Clin Oncol 2008 Oct 15;26(30):4869-74. Epub 2008 Sep 15.

Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1200/JCO.2007.13.4296DOI Listing
October 2008

ENDEAVOUR update: a web resource for gene prioritization in multiple species.

Nucleic Acids Res 2008 Jul 28;36(Web Server issue):W377-84. Epub 2008 May 28.

Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Belgium.

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http://dx.doi.org/10.1093/nar/gkn325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447805PMC
July 2008

Gene prioritization through genomic data fusion.

Nat Biotechnol 2006 May;24(5):537-44

Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Herestraat 49, bus 602, 3000 Leuven, Belgium.

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May 2006

TOUCAN 2: the all-inclusive open source workbench for regulatory sequence analysis.

Nucleic Acids Res 2005 Jul;33(Web Server issue):W393-6

Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology and K.U.Leuven Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160115PMC
July 2005

A genetic algorithm for the detection of new cis-regulatory modules in sets of coregulated genes.

Bioinformatics 2004 Aug 25;20(12):1974-6. Epub 2004 Mar 25.

Department of Electrical Engineering (ESAT-SCD), Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Heverlee (Leuven), Belgium.

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August 2004

Computational detection of cis -regulatory modules.

Bioinformatics 2003 Oct;19 Suppl 2:ii5-14

Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven, Belgium.

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October 2003