Peter Valent

Peter Valent

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Peter Valent

Peter Valent

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Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms.

Semin Cancer Biol 2019 Aug 10. Epub 2019 Aug 10.

Institute of Anatomy and Experimental Morphology, University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.semcancer.2019.07.025DOI Listing
August 2019

Immunotherapy-Based Targeting and Elimination of Leukemic Stem Cells in AML and CML.

Int J Mol Sci 2019 Aug 29;20(17). Epub 2019 Aug 29.

Department of Internal Medicine V (Hematology & Oncology), Medical University of Innsbruck, 1090 Innsbruck, Austria.

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http://dx.doi.org/10.3390/ijms20174233DOI Listing
August 2019

Effects of ibrutinib on proliferation and histamine release in canine neoplastic mast cells.

Vet Comp Oncol 2019 Jul 8. Epub 2019 Jul 8.

Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/vco.12520DOI Listing
July 2019

Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches.

Int J Mol Sci 2019 Jun 18;20(12). Epub 2019 Jun 18.

Division of Allergy and Clinical Immunology, University of Salerno, 84131 Salerno, Italy.

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http://dx.doi.org/10.3390/ijms20122976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627900PMC
June 2019

A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens.

Allergy 2019 Jun 22. Epub 2019 Jun 22.

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/all.13956DOI Listing
June 2019

The Mastocytosis Society Survey on Mast Cell Disorders: Part 2-Patient Clinical Experiences and Beyond.

J Allergy Clin Immunol Pract 2019 Apr 8;7(4):1157-1165.e6. Epub 2018 Aug 8.

Department of Internal Medicine, Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Mich. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2018.07.032DOI Listing
April 2019

Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia.

Leuk Lymphoma 2019 Apr 2;60(4):1098-1101. Epub 2018 Oct 2.

a Department of Microbiology and Immunology and Fels Institute for Cancer Research and Molecular Biology Lewis Katz School of Medicine , Temple University , Philadelphia , PA , USA.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2018.1
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http://dx.doi.org/10.1080/10428194.2018.1520988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445778PMC
April 2019

Doctor, I Think I Am Suffering from MCAS: Differential Diagnosis and Separating Facts from Fiction.

J Allergy Clin Immunol Pract 2019 Apr;7(4):1109-1114

Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Mich.

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http://dx.doi.org/10.1016/j.jaip.2018.11.045DOI Listing
April 2019

A kinase profile-adapted drug combination elicits synergistic cooperative effects on leukemic cells carrying BCR-ABL1 in Ph+ CML.

Leuk Res 2019 Mar 28;78:36-44. Epub 2018 Dec 28.

Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2018.12.013DOI Listing
March 2019

Additional prognostic impact of the percentage of erythroid cells in the bone marrow of patients with myelodysplastic syndromes.

Leuk Res 2019 02 28;77:8-13. Epub 2018 Dec 28.

University of Rochester Medical Center, Department of Pathology, Hematopathology Unit and James P. Wilmot Cancer Institute, Rochester, NY, USA.

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http://dx.doi.org/10.1016/j.leukres.2018.12.012DOI Listing
February 2019

ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications.

Authors:
Peter Valent

Pathobiology 2019 1;86(1):30-38. Epub 2018 Jun 1.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna,

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https://www.karger.com/Article/FullText/489042
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http://dx.doi.org/10.1159/000489042DOI Listing
January 2019

Therapeutic Vulnerabilities in -Mutant AML Unmasked by Palbociclib.

Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.

Institute of Pharmacology and Toxicology, University of Veterinary Medicine, 1210 Vienna, Austria.

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http://dx.doi.org/10.3390/ijms19123987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321303PMC
December 2018

The underestimated role of basophils in Ph chronic myeloid leukaemia.

Eur J Clin Invest 2018 Oct 6;48(10):e13000. Epub 2018 Aug 6.

LBPA CNRS UMR8113, Ecole Normale Supérieure de Paris Saclay, Cachan, France.

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http://dx.doi.org/10.1111/eci.13000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175372PMC
October 2018

Major response of PNH to an AML chemotherapy protocol.

Ann Hematol 2018 Aug 22;97(8):1487-1488. Epub 2018 Mar 22.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00277-018-3307-8DOI Listing
August 2018

Phenotyping and Target Expression Profiling of CD34/CD38 and CD34/CD38 Stem- and Progenitor cells in Acute Lymphoblastic Leukemia.

Neoplasia 2018 06 15;20(6):632-642. Epub 2018 May 15.

Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994777PMC
June 2018

The JAK2 blocker TG101209 is a potent inhibitor of clonogenic progenitor cell growth in patients with chronic myeloid leukaemia.

Br J Haematol 2018 04 21;181(1):137-139. Epub 2017 Feb 21.

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

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http://doi.wiley.com/10.1111/bjh.14508
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http://dx.doi.org/10.1111/bjh.14508DOI Listing
April 2018

The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma.

Vet Comp Oncol 2018 Mar 11;16(1):55-68. Epub 2017 Apr 11.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/vco.12311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824979PMC
March 2018

Anemia at older age: etiologies, clinical implications, and management.

Blood 2018 02 15;131(5):505-514. Epub 2017 Nov 15.

Department of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology, Pneumology), Innsbruck Medical University, Innsbruck, Austria.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-07
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http://dx.doi.org/10.1182/blood-2017-07-746446DOI Listing
February 2018

BCR-ABL1 compound mutants display differential and dose-dependent responses to ponatinib.

Haematologica 2018 01 5;103(1):e10-e12. Epub 2017 Oct 5.

Children's Cancer Research Institute, and Department of Pediatrics, Medical University of Vienna, Austria

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http://dx.doi.org/10.3324/haematol.2017.176347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777206PMC
January 2018

Evaluation of cooperative antileukemic effects of nilotinib and vildagliptin in Ph chronic myeloid leukemia.

Exp Hematol 2018 01 12;57:50-59.e6. Epub 2017 Oct 12.

Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria; Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.exphem.2017.09.012DOI Listing
January 2018

Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.

Expert Opin Ther Targets 2018 01 24;22(1):45-57. Epub 2017 Nov 24.

a Institute of Animal Breeding and Genetics , University of Veterinary Medicine Vienna , Vienna , Austria.

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http://dx.doi.org/10.1080/14728222.2018.1406924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743003PMC
January 2018

Peripheral arterial disease outcomes and association with suPAR: A bridge to myeloid precursors or mast cells or both?

Atherosclerosis 2017 09 8;264:77-78. Epub 2017 Jul 8.

Medical University of Vienna, Department of Medicine II, Division of Angiology, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.07.007DOI Listing
September 2017

Risk factors and mechanisms contributing to TKI-induced vascular events in patients with CML.

Leuk Res 2017 08 12;59:47-54. Epub 2017 May 12.

Medical Clinic III for Oncology, Haematology, Immunology and Rheumatology, University Hospital Bonn (UKB), Germany.

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http://dx.doi.org/10.1016/j.leukres.2017.05.008DOI Listing
August 2017

Expression of CD25 on leukemic stem cells in BCR-ABL1 CML: Potential diagnostic value and functional implications.

Exp Hematol 2017 07 27;51:17-24. Epub 2017 Apr 27.

Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X173013
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http://dx.doi.org/10.1016/j.exphem.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044418PMC
July 2017

Evaluation of efficacy of alemtuzumab in 5 patients with aplastic anemia and/or myelodysplastic neoplasm.

Wien Klin Wochenschr 2017 Jun 14;129(11-12):404-410. Epub 2016 Oct 14.

Department of Internal Medicine I, Division of Hematology & Hemostaseology, AKH, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00508-016-1091-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486731PMC
June 2017

Quantification of human diamine oxidase.

Clin Biochem 2017 May 29;50(7-8):444-451. Epub 2016 Dec 29.

Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S00099120163030
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http://dx.doi.org/10.1016/j.clinbiochem.2016.12.011DOI Listing
May 2017

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts.

Blood 2017 03 28;129(11):1420-1427. Epub 2016 Dec 28.

Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2016-09-731893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356454PMC
March 2017

Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia.

J Clin Oncol 2017 Jan 7;35(2):175-184. Epub 2016 Nov 7.

Sieghart Sopper, Günther Gastl, Matthias Baldauf, Zlatko Trajanoski, and Dominik Wolf, Medical University Innsbruck; Sieghart Sopper and Dominik Wolf, Tyrolean Cancer Research Institute; Matthias Baldauf, Oncotyrol, Innsbruck; Peter Valent, Medical University of Vienna, Vienna, Austria; Satu Mustjoki and Kimmo Porkka, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Deborah White and Timothy Hughes, South Australian Health and Medical Research Institute and University of Adelaide School of Medicine, Adelaide, South Australia, Australia; Andreas Burchert, Universitätsklinikum Gießen und Marburg and Philipps Universität Marburg, Marburg; Andreas Hochhaus, Thomas Ernst, and Thomas Schenk, Universitätsklinikum Jena, Jena; Dominik Wolf, University Hospital of Bonn, Bonn, Germany; Bjørn T. Gjertsen, University of Bergen, Bergen, Norway; Frank Giles, Northwestern University, Chicago, IL; and Jeroen J.W.M. Janssen and Gert J. Ossenkoppele, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2016.67.0893DOI Listing
January 2017

Karyotype plus NPM1 mutation status defines a group of elderly patients with AML (≥60 years) who benefit from intensive post-induction consolidation therapy.

Am J Hematol 2016 12 8;91(12):1239-1245. Epub 2016 Nov 8.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/ajh.24560DOI Listing
December 2016

Is ruxolitinib a potentially useful drug in hematological malignancies with RAS pathway hyperactivation?

Haematologica 2016 12;101(12):e492

Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria.

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http://dx.doi.org/10.3324/haematol.2016.156448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479601PMC
December 2016

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice.

Haematologica 2016 10;101(10):1133-1143

Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Austria.

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http://dx.doi.org/10.3324/haematol.2016.146563DOI Listing
October 2016

Mechanisms, safety and efficacy of a B cell epitope-based vaccine for immunotherapy of grass pollen allergy.

EBioMedicine 2016 Sep 20;11:43-57. Epub 2016 Aug 20.

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049999PMC
September 2016

Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis.

N Engl J Med 2016 Jun;374(26):2530-41

From the Hematology Division, Stanford University School of Medicine-Stanford Cancer Institute, Stanford, CA (J.G.); Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (H.C.K.-N.); Department of Pathology, University of New Mexico, Albuquerque (T.I.G.); Mastocytosis Center, Brigham and Women's Hospital, Boston (C.A.); Institute of Pathology, Ludwig-Maximilians-University Munich, Munich (K.S., H.-P.H.), Department of Dermatology and Venereology, University of Cologne, Cologne, and University of Luebeck, Luebeck (K.H.), and Department of Hematology and Oncology, University Hospital Mannheim of the University of Heidelberg, Mannheim (A.R.) - all in Germany; University of Paris Descartes, Institut Imagine INSERM Unité 1163 and Centre National de la Recherche Scientifique ERL8654, Centre de Reference des Mastocytoses, Paris (O.H.); Division of Hematology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus (F.T.A.); Division of Hematology/Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia (E.H.); Myeloproliferative Neoplasms Program, Memorial Sloan Kettering Cancer Center, New York (M.J.M.); Novartis Pharmaceuticals, East Hanover, NJ (D.W.S., E.J.S.); Novartis Pharma, Basel, Switzerland (M.V., A.H.L.); and the Department of Internal Medicine I, Division of Hematology and Hemostaseology, and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna (P.V.).

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http://dx.doi.org/10.1056/NEJMoa1513098DOI Listing
June 2016

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?

Int J Mol Sci 2016 Jun 27;17(7). Epub 2016 Jun 27.

3rd Medical Department with Hematology and Medical Oncology, Hemostaseology, Rheumatology and Infectious Diseases, Laboratory for Immunological and Molecular Cancer Research, Oncologic Center, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.

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http://dx.doi.org/10.3390/ijms17071009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964385PMC
June 2016