SimpleXMLElement Object ( [PubmedArticle] => Array ( [0] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => PubMed-not-MEDLINE [Owner] => NLM ) [PMID] => 33597816 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 19 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic-eCollection ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1179-5735 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Print ) [Volume] => 13 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 ) ) [Title] => Journal of central nervous system disease [ISOAbbreviation] => J Cent Nerv Syst Dis ) [ArticleTitle] => A Sum Score to Define Therapy-Refractory Myasthenia Gravis: A German Consensus. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1179573521989151 ) [ELocationID] => 10.1177/1179573521989151 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => In 2017, eculizumab has been approved for treatment-refractory generalised myasthenia gravis (TRgMG). The German Myasthenia Foundation has published a consensus statement on the use of eculizumab, with a recent update. However, a treatment-refractory state is still ill-defined and the term warrants further clarification. We aimed at developing a sum score to operationalise the definition of a TRgMG status, which is easy- to-handle in clinical decision making. [1] => We established a structured consensus process according to the Delphi consensus methodology, with 12 members of the medical advisory board of the German Myasthenia Foundation. Accordingly, 4 consensus rounds were accomplished. Additionally, a literature survey covering the years 2004-2020 was done and relevant information offered to the consensus group. Consensus criteria were predefined. In the consensus process the relative importance of scoring items were to be consented, with a sum score of 20 and above indicating a TRgMG status. [2] => The sum score considers the categories disease severity, inefficiency of antecedent therapies, cessation of therapies due to side effects, and long term stay on the intensive care unit. Categories were specified by a total of 13 scoring items. Eventually, the Delphi process developed an unanimous scoring consensus. [3] => We suggest a sum score to define treatment refractory state in generalised myasthenia gravis. Beyond clarifying the indication of eculizumab, this easy-to-handle score facilitates clinical decision making and offers new inclusion criteria for clinical studies that explore new therapeutic perspectives in myasthenia gravis treatment. ) [CopyrightInformation] => © The Author(s) 2021. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Schroeter [ForeName] => Michael [Initials] => M [Identifier] => https://orcid.org/0000-0001-8441-4793 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, University Cologne and University Hospital, Cologne, Germany. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Berger [ForeName] => Benjamin [Initials] => B [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Clinic of Neurology and Neurophysiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Blaes [ForeName] => Franz [Initials] => F [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, Gummersbach Hospital, Gummersbach, Germany. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hagenacker [ForeName] => Tim [Initials] => T [Identifier] => https://orcid.org/0000-0002-3631-3450 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, University Hospital Essen, Essen, Germany. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Jander [ForeName] => Sebastian [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, Heinrich-Heine-University, Medical Faculty, Düsseldorf, Germany. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kaiser [ForeName] => Julia [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, LVR-Klinik, Bonn, Nordrhein-Westfalen, Germany. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kalischewski [ForeName] => Petra [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Neurological outpatient clinic Drs. Kalischewski & Spiegel-Meixensberger, Leipzig, Germany. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Lee [ForeName] => De-Hyung [Initials] => DH [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, University of Regensburg, Regensburg, Bayern, Germany. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ruck [ForeName] => Tobias [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Münster, Münster, Nordrhein-Westfalen, Germany. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Schara [ForeName] => Ulrike [Initials] => U [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Pediatric Neurology, University Clinic Essen, University of Duisburg-Essen, UK. ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Urban [ForeName] => Peter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, Asklepios Klinik Barmbek, Hamburg, Germany. ) ) [11] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Meisel [ForeName] => Andreas [Initials] => A [Identifier] => https://orcid.org/0000-0001-7233-5342 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Experimental Neurology, Integrated Myasthenia gravis Center, Neurocure Clinical Research Center, Center for Stroke Research Berlin Charité - Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 01 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => J Cent Nerv Syst Dis [NlmUniqueID] => 101595026 [ISSNLinking] => 1179-5735 ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Neuroimmunology [1] => myopathy [2] => peripheral nervous system ) ) [CoiStatement] => Declaration of conflicting interests:The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: MS..: Personal honoraria from Alexion, Biogen, Gilead, Roche, Sanofi. Institutional support: Alexion, Bayer, Biogen, CSL Behring, Grifols, Merck, Sanofi, Teva. B.B.: Received travel grants and/or training expenses from Bayer Vital GmbH, Ipsen Pharma GmbH, Novartis, Biogen GmbH and Genzyme, as well as lecture fees from Ipsen Pharma GmbH, Alexion Pharma GmbH, Merck, Sanofi Genzyme and Roche. T.H.: Received honoraria from Alexion, Biogen, Sanofi-Aventis, Roche, Novartis, CSL Behring. Institutional support: Sanofi-Aventis, Biogen, Roche and Avexis. S.J.: Reports personal honoraria from Alexion, Biogen, Bayer Vital GmbH, Bristol-Myers Squibb, Pfizer, Daiichi Sankyo, and institutional support from Sanofi Genzyme, Alnylam Germany, Santhera, Novartis, CSL Behring, UCB Pharma, Shire. D.H.L.: Received personal honoria from Alexion, Biogen, Bayer Vital GmbH, Novartis, Sanofi Genzyme, Merck, Roche. P.K.: Personal honoraria from Alexion, Biogen, Novatris, Sanofi Genzyme, Merck, Teva, Roche. T.R.: Reports grants from German Ministry of Education, Science, Research and Technology, grants and personal fees from Sanofi-Genzyme and Alexion; personal fees from Biogen, Roche and Teva; personal fees and nonfinancial support from Merck Serono, outside the submitted work. F.B.: Received honoraria from Alexion, Grifols, Sanofi Genzyme. Travel grant from Bayer Vital GmbH. U.S.: Received honoraris for advisory board participation and counselling from Flexion. P.U.: Personal honoraria from Alexion, Grifols, Zambon, Desitin, Abbvie. A.M.: Reports personal honoraria from Alexion, Argnx, Novartis, Bayer, Grifols, Bristol-Myers Squibb, Pfizer, UCB Pharma, Hormosan and Morphosys as well as institutional support from Alexion and Octapharma. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 10 [Day] => 18 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 12 [Day] => 22 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 18 [Hour] => 6 [Minute] => 10 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 19 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 19 [Hour] => 6 [Minute] => 1 ) ) ) [PublicationStatus] => epublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33597816 [1] => 10.1177/1179573521989151 [2] => 10.1177_1179573521989151 [3] => PMC7863150 ) ) [ReferenceList] => SimpleXMLElement Object ( [Reference] => Array ( [0] => SimpleXMLElement Object ( [Citation] => Ther Adv Neurol Disord. 2019 Mar 01;12:1756286419832242 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30854027 ) ) [1] => SimpleXMLElement Object ( [Citation] => JAMA Neurol. 2020 Aug 1;77(8):974-981 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 32364568 ) ) [2] => SimpleXMLElement Object ( [Citation] => Ther Adv Neurol Disord. 2018 Jan 18;11:1756285617749134 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29403543 ) ) [3] => SimpleXMLElement Object ( [Citation] => Muscle Nerve. 2017 Aug;56(2):328-330 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 28010051 ) ) [4] => SimpleXMLElement Object ( [Citation] => Ann N Y Acad Sci. 2008;1132:76-83 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 18567856 ) ) [5] => SimpleXMLElement Object ( [Citation] => Muscle Nerve. 2018 Feb 27;: [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 29486521 ) ) [6] => SimpleXMLElement Object ( [Citation] => J Neurol. 2019 Mar;266(3):699-706 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 30649616 ) ) [7] => SimpleXMLElement Object ( [Citation] => J Clin Neuromuscul Dis. 2019 Jun;20(4):173-181 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 31135620 ) ) [8] => SimpleXMLElement Object ( [Citation] => Muscle Nerve. 2013 Jul;48(1):76-84 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23512355 ) ) [9] => SimpleXMLElement Object ( [Citation] => Ann N Y Acad Sci. 2003 Sep;998:432-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 14592911 ) ) ) ) ) ) [1] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 33291299 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 29 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 29 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1999-4915 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 12 [Issue] => 12 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 06 ) ) [Title] => Viruses [ISOAbbreviation] => Viruses ) [ArticleTitle] => Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix. [ELocationID] => Array ( [0] => E1401 [1] => 10.3390/v12121401 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of 21 April 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here, we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kemenesi [ForeName] => Gábor [Initials] => G [Identifier] => 0000-0001-9775-3065 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => National Laboratory of Virology, Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary. ) [1] => SimpleXMLElement Object ( [Affiliation] => Institute of Biology, Faculty of Sciences, University of Pécs, 7624 Pécs, Hungary. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zeghbib [ForeName] => Safia [Initials] => S [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 158-164 ) [ELocationID] => 10.1002/ana.25942 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Even though genetic predisposition has proven to be an important element in Parkinson's disease (PD) etiology, monozygotic (MZ) twins with PD displayed a concordance rate of only about 20% despite their shared identical genetic background. [1] => We recruited 5 pairs of MZ twins discordant for idiopathic PD and established skin fibroblast cultures to investigate mitochondrial phenotypes in these cellular models against the background of a presumably identical genome. To test for genetic differences, we performed whole genome sequencing, deep mitochondrial DNA (mtDNA) sequencing, and tested for mitochondrial deletions by multiplex real-time polymerase chain reaction (PCR) in the fibroblast cultures. Further, the fibroblast cultures were tested for mitochondrial integrity by immunocytochemistry, immunoblotting, flow cytometry, and real-time PCR to quantify gene expression. [2] => Genome sequencing did not identify any genetic difference. We found decreased mitochondrial functionality with reduced cellular adenosine triphosphate (ATP) levels, altered mitochondrial morphology, elevated protein levels of superoxide dismutase 2 (SOD2), and increased levels of peroxisome proliferator-activated receptor-gamma coactivator-α (PPARGC1A) messenger RNA (mRNA) in skin fibroblast cultures from the affected compared to the unaffected twins. Further, there was a tendency for a higher number of somatic mtDNA variants among the affected twins. [3] => We demonstrate disease-related differences in mitochondrial integrity in the genetically identical twins. Of note, the clinical expression matches functional alterations of the mitochondria. ANN NEUROL 2021;89:158-164. ) [CopyrightInformation] => © 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Dulovic-Mahlow [ForeName] => Marija [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => König [ForeName] => Inke R [Initials] => IR [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Trinh [ForeName] => Joanne [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Diaw [ForeName] => Sokhna Haissatou [Initials] => SH [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Urban [ForeName] => Peter P [Initials] => PP [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, Asklepios Klinik Barmbek, Hamburg, Germany. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Knappe [ForeName] => Evelyn [Initials] => E [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kuhnke 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SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kupnicka [ForeName] => Patrycja [Initials] => P [Identifier] => 0000-0002-0756-6483 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Szczecin, Poland. ) ) ) [11] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Balck [ForeName] => Alexander [Initials] => A [Identifier] => 0000-0003-3967-0282 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. ) ) [12] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Delcambre [ForeName] => Sylvie [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Molecular 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Neurogenetics. 2000;2:227-230. ) ) ) ) ) [5] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Data-Review [Owner] => NLM ) [PMID] => 32966777 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 15 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1095-6840 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 299 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Dec [Day] => 01 ) ) [Title] => General and comparative endocrinology [ISOAbbreviation] => Gen Comp Endocrinol ) [ArticleTitle] => Identification, presence, and possible multifunctional regulatory role of invertebrate gonadotropin-releasing hormone/corazonin molecule in the great pond snail (Lymnaea stagnalis). [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 113621 ) [ELocationID] => Array ( [0] => S0016-6480(20)30374-9 [1] => 10.1016/j.ygcen.2020.113621 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => In the last years, our interpretation of the origin and function of the gonadotropin-releasing hormone (GnRH) neuropeptide superfamily has changed substantially. A main driver for these conceptual changes came from increased investigations into functions and evolutionary lineage of previously identified molluscan GnRH molecules. Emerging evidence suggests not only reproductive, but also diverse biological effects of these molecules and proposes they should most likely be called corazonin (CRZ). Clearly, a more global understanding requires further exploration of species-specific functions and structure of invGnRH/CRZ peptides. Towards this goal, we have identified the full-length cDNA of invGnRH/CRZ peptide in an invertebrate model species, the great pond snail Lymnaea stagnalis, termed ly-GnRH/CRZ, and characterized the transcript and peptide distribution in the central nervous system (CNS) and peripheral organs. Our results are consistent with previous data that molluscan GnRHs are more related to CRZs and serve diverse functions. Hence, our findings support the notion that peptides originally termed molluscan GnRH are multifunctional modulators and that nomenclature change should be taken into consideration. [CopyrightInformation] => Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Fodor [ForeName] => István [Initials] => I [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Adaptive Neuroethology Research Group, Department of Experimental Zoology, Balaton Limnological Institute, Centre for Ecological Research, 8237 Tihany, Hungary. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zrinyi [ForeName] => Zita [Initials] => Z [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Adaptive Neuroethology Research Group, Department of Experimental Zoology, Balaton Limnological Institute, Centre for Ecological Research, 8237 Tihany, Hungary. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Horváth [ForeName] => Réka [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Adaptive Neuroethology Research Group, Department of Experimental Zoology, Balaton Limnological Institute, Centre for Ecological Research, 8237 Tihany, Hungary. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Urbán [ForeName] => Péter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Microbial Biotechnology Research Group, Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary; Genomics and Bioinformatics Core Facilities, Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Herczeg [ForeName] => Róbert [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Genomics and Bioinformatics Core Facilities, Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Büki [ForeName] => Gergely [Initials] => G [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Medical Genetics, Medical School, University of Pécs, 7624 Pécs, Hungary. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Koene [ForeName] => Joris M [Initials] => JM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Ecological Science, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tsai [ForeName] => Pei-San [Initials] => PS [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, CO 80309-0354, United States. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Pirger [ForeName] => Zsolt [Initials] => Z [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Adaptive Neuroethology Research Group, Department of Experimental Zoology, Balaton Limnological Institute, Centre for Ecological Research, 8237 Tihany, Hungary. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 401 ) [ELocationID] => 10.1007/s13205-020-02387-y [Abstract] => SimpleXMLElement Object ( [AbstractText] => In the present study, a total of 35 isolates collected from two different geographical locations viz., Germany and Hungary were tested for their methicillin-resistant phenotype which revealed a high incidence of methicillin-resistant . The quantitative test for biofilm production revealed that 73.3% of isolates were biofilm producers. The isolates were further characterized using a set of biochemical and genotypic methods such as amplification and analysis of species-specific sequence and gene. The 33 positive isolates were then characterized by the amplification of and toxin genes. Further, based on the biofilm-forming phenotype, 15 isolates were selected and characterized through PCR-RFLP of gene, polymorphism of gene and amplification of biofilm-associated genes. The dendrogram prepared from the results of both biochemical and genotypic analyses of the 15 isolates showed that except for the isolates SA G5 and SA H29, the rest of the isolates grouped themselves according to their locations. Thus, the two isolates were selected for further characterization through whole-genome sequencing. Comparative genome analysis revealed that SA G5 and SA H29 have 97.20% ANI values with 2344 gene clusters (core-genome) of which 16 genes were related to antibiotic resistance genes and 57 genes encode virulence factors. The highest numbers of singleton genes were found in SA H29 that encodes proteins for virulence, resistance, mobile elements, and lanthionine biosynthesis. The high-resolution phylogenetic trees generated based on shared proteins and SNPs revealed a clear difference between the two strains and can be useful in distinguishing closely related genomes. The present study demonstrated that the whole-genome sequence analysis technique is required to get a better insight into the MRSA strains which would be helpful in improving diagnostic investigations in real-time to improve patient care. [CopyrightInformation] => © The Author(s) 2020. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Naorem [ForeName] => Romen Singh [Initials] => RS [Identifier] => 0000-0001-9430-4643 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of General and Environmental Microbiology, Institute of Biology, University of Pécs, Pécs, 7624 Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Urban [ForeName] => Peter [Initials] => P [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of General and Environmental Microbiology, Institute of Biology, University of Pécs, Pécs, 7624 Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) [1] => SimpleXMLElement Object ( [Affiliation] => Microbial Biotechnology Research Group, Szentágothai Research Centre, Pécs, 7624 Hungary. ) ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Goswami [ForeName] => Gunajit [Initials] => G [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Life Sciences, Dibrugarh University, Dibrugarh, 786004 Assam India. 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[2] => Differentially methylated pathways likely involved in primary tumor development included those of neuronal differentiation, myelination, metabolic processes, synapse organization and endothelial cell proliferation, while pathways differentially active during glioblastoma recurrence involved those associated with cell processes and differentiation, immune response, Wnt regulation and catecholamine secretion and transport. [3] => DNA CpG methylation analyses in sequential clinical specimens revealed hypomethylation in certain pathways such as neuronal tissue development and angiogenesis likely involved in early tumor development and growth, while suggested altered regulation in catecholamine secretion and transport, Wnt expression and immune response contributing to glioblastoma recurrence. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 110949 ) [ELocationID] => Array ( [0] => S0303-7207(20)30249-5 [1] => 10.1016/j.mce.2020.110949 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Many studies on the control of reproduction in mollusks have focused on hormones (and proteins associated with the production and signaling of those hormones) which were originally discovered in humans, in the belief that if they are also present in mollusks, they must have the same role. However, although human sex steroids can be found in mollusks, they are so readily absorbed that their presence is not necessarily evidence of endogenous synthesis. A homolog of the vertebrate nuclear estrogen receptor has been found in mollusks, but it does not bind to estrogens or indeed to any steroid at all. Antibodies against human aromatase show positive immunostaining in mollusks, yet the aromatase gene has not been found in the genome of any invertebrates (let alone mollusks). This review will deal with these and other examples of contradictory evidence for a role of human hormones in invertebrate reproduction. [CopyrightInformation] => Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Fodor [ForeName] => István [Initials] => I [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => NAP Adaptive Neuroethology, Department of Experimental Zoology, Balaton Limnological Institute, Centre for Ecological Research, 8237, Tihany, Hungary. Electronic address: fodor.istvan@okologia.mta.hu. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Urbán [ForeName] => Péter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Genomics and Bioinformatics Core Facilities, Szentágothai Research Centre, University of Pécs, 7624, Pécs, Hungary. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Scott [ForeName] => Alexander P [Initials] => AP [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for Environment, Fisheries and Aquaculture Research (Cefas), Barrack Road, Weymouth, DT4 8UB, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Pirger [ForeName] => Zsolt [Initials] => Z [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => NAP Adaptive Neuroethology, Department of Experimental Zoology, Balaton Limnological Institute, Centre for Ecological Research, 8237, Tihany, Hungary. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Review [2] => Research Support, Non-U.S. Gov't ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 07 [Day] => 18 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Ireland [MedlineTA] => Mol Cell Endocrinol [NlmUniqueID] => 7500844 [ISSNLinking] => 0303-7207 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Estrogen receptor [1] => Mollusk [2] => Neuroendocrine [3] => Progesterone receptor [4] => Sex steroids [5] => Steroid pathway evolution ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 05 [Day] => 18 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 07 [Day] => 09 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 07 [Day] => 13 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 7 [Day] => 21 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 7 [Day] => 21 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 7 [Day] => 21 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32687858 [1] => S0303-7207(20)30249-5 [2] => 10.1016/j.mce.2020.110949 ) ) ) ) [9] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Process [Owner] => NLM ) [PMID] => 32449011 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 09 [Day] => 10 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1439-1104 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 20 [Issue] => 3 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 05 [Day] => 24 ) ) [Title] => Invertebrate neuroscience : IN [ISOAbbreviation] => Invert Neurosci ) [ArticleTitle] => Aging and disease-relevant gene products in the neuronal transcriptome of the great pond snail (Lymnaea stagnalis): a potential model of aging, age-related memory loss, and neurodegenerative diseases. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 9 ) [ELocationID] => 10.1007/s10158-020-00242-6 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Modelling of human aging, age-related memory loss, and neurodegenerative diseases has developed into a progressive area in invertebrate neuroscience. Gold standard molluscan neuroscience models such as the sea hare (Aplysia californica) and the great pond snail (Lymnaea stagnalis) have proven to be attractive alternatives for studying these processes. Until now, A. californica has been the workhorse due to the enormous set of publicly available transcriptome and genome data. However, with growing sequence data, L. stagnalis has started to catch up with A. californica in this respect. To contribute to this and inspire researchers to use molluscan species for modelling normal biological aging and/or neurodegenerative diseases, we sequenced the whole transcriptome of the central nervous system of L. stagnalis and screened for the evolutionary conserved homolog sequences involved in aging and neurodegenerative/other diseases. Several relevant molecules were identified, including for example gelsolin, presenilin, huntingtin, Parkinson disease protein 7/Protein deglycase DJ-1, and amyloid precursor protein, thus providing a stable genetic background for L. stagnalis in this field. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1-7 ) [ELocationID] => 10.1007/s11357-020-00195-z [Abstract] => SimpleXMLElement Object ( [AbstractText] => The global impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is significant in terms of public health effects and its long-term socio-economic implications. Among all social groups, the elderly is by far the most affected age group regarding morbidity and mortality. In multiple countries spanning several continents, there are an increasing number of reports referencing the novel coronavirus disease-2019 (COVID-19) spread among nursing homes. These areas are now recognized as potent hotspots regarding the pandemic, which one considers with special regard. Herein, we present currently available data of fatal COVID-19 cases throughout Hungary, along with the analysis of the co-morbidity network. We also report on viral genomic data originating from a nursing home resident. The genomic data was used for viral haplotype network analysis. We emphasize the urgent need for public health authorities to focus on nursing homes and residential service units worldwide, especially in the care of the elderly and infirmed. Our results further emphasize the recent statement released by the World Health Organization (WHO) regarding the vulnerability among seniors and especially the high risk of COVID-19 emergence throughout nursing and social homes. [CopyrightInformation] => © The Author(s) 2020. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kemenesi [ForeName] => Gábor [Initials] => G [Identifier] => https://orcid.org/0000-0001-9775-3065 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => 1Virological Research Group, University of Pécs, Szentágothai Research Center, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) [1] => SimpleXMLElement Object ( [Affiliation] => 2Faculty of Sciences, Department of Genetics and Molecular Biology, University of Pécs, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) [2] => SimpleXMLElement Object ( [Affiliation] => 3University of Pécs, National Coronavirus Research Center, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kornya [ForeName] => László [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Central Hospital of Southern Pest - National Institute of Hematology and Infectious Diseases, Budapest, Hungary. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tóth [ForeName] => Gábor Endre [Initials] => GE [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => 1Virological Research Group, University of Pécs, Szentágothai Research Center, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) [1] => SimpleXMLElement Object ( [Affiliation] => 2Faculty of Sciences, Department of Genetics and Molecular Biology, University of Pécs, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) [2] => SimpleXMLElement Object ( [Affiliation] => 3University of Pécs, National Coronavirus Research Center, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kurucz [ForeName] => Kornélia [Initials] => K [Identifier] => https://orcid.org/0000-0001-6190-1265 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => 3University of Pécs, National Coronavirus Research Center, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) [1] => SimpleXMLElement Object ( [Affiliation] => 5Faculty of Sciences, Department of Ecology, University of Pécs, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zeghbib [ForeName] => Safia [Initials] => S [Identifier] => https://orcid.org/0000-0001-9603-7489 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => 1Virological Research Group, University of Pécs, Szentágothai Research Center, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) [1] => SimpleXMLElement Object ( [Affiliation] => 2Faculty of Sciences, Department of Genetics and Molecular Biology, University of Pécs, Pecs, Hungary. [Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) [2] => SimpleXMLElement Object ( [Affiliation] => 3University of Pécs, National Coronavirus Research Center, Pecs, Hungary. 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[Identifier] => Array ( [0] => grid.9679.1 [1] => 0000 0001 0663 9479 ) ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 05 [Day] => 18 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Switzerland [MedlineTA] => Geroscience [NlmUniqueID] => 101686284 [ISSNLinking] => 2509-2723 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Coronavirus [1] => Genome sequencing [2] => Hotspot [3] => Outbreak [4] => nCoV2019 ) ) [CoiStatement] => Conflicts of interestThe authors declare that they have no conflict of interest. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 04 [Day] => 23 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 04 [Day] => 23 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 5 [Day] => 20 [Hour] => 6 [Minute] => 0 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 5 [Day] => 20 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 5 [Day] => 20 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32426693 [1] => 10.1007/s11357-020-00195-z [2] => 195 [3] => PMC7232926 ) ) [ReferenceList] => SimpleXMLElement Object ( [Reference] => Array ( [0] => SimpleXMLElement Object ( [Citation] => Mol Biol Evol. 1999 Jan;16(1):37-48 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 10331250 ) ) [1] => SimpleXMLElement Object ( [Citation] => Bioinformatics. 2014 Aug 1;30(15):2114-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24695404 ) ) [2] => SimpleXMLElement Object ( [Citation] => Lancet. 2020 Mar 28;395(10229):1015-1018 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 32197103 ) ) [3] => SimpleXMLElement Object ( [Citation] => Clin Infect Dis. 2010 Oct 15;51(8):931-6 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20822459 ) ) [4] => SimpleXMLElement Object ( [Citation] => Int J Infect Dis. 2020 May;94:91-95 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 32173574 ) ) [5] => SimpleXMLElement Object ( [Citation] => J Clin Nurs. 2020 Aug;29(15-16):2758-2759 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 32281165 ) ) [6] => SimpleXMLElement Object ( [Citation] => Nat Med. 2020 Apr;26(4):506-510 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 32284616 ) ) ) ) ) ) [12] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [IndexingMethod] => Curated [Owner] => NLM ) [PMID] => 32396943 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 09 [Day] => 28 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 09 [Day] => 28 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1439-3522 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 88 [Issue] => 9 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Sep ) ) [Title] => Fortschritte der Neurologie-Psychiatrie [ISOAbbreviation] => Fortschr Neurol Psychiatr ) [ArticleTitle] => [Structure and efferences of the substantia nigra pars compacta in Parkinson's disease]. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 591-599 ) [ELocationID] => 10.1055/a-1149-9280 [Abstract] => SimpleXMLElement Object ( [AbstractText] => There is consensus that the neuropathological characteristic of Parkinson's disease (PD) is the neuronal cell loss of the substantia nigra pars compacta (SNc) in connection with a Lewy pathology. The transsynaptic spread of Lewy pathology is considered essential in PD pathogenesis. Therefore, the knowledge of pre-existing neuroanatomical connections of the SNc is essential. We describe recent animal experiments on the afferent and efferent projections of the SNc and discuss the evidence for and against the sequential transsynaptic spread of Lewy pathology in the pathogenesis of PD. [CopyrightInformation] => © Georg Thieme Verlag KG Stuttgart · New York. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y [EqualContrib] => N ) [LastName] => Urban [ForeName] => Peter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Abteilung für Neurologie, Asklepios Klinik Barmbek. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y [EqualContrib] => N ) [LastName] => Falkenburger [ForeName] => Bjorn [Initials] => B [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Klinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Dresden. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y [EqualContrib] => N ) [LastName] => Jost [ForeName] => Wolfgang H [Initials] => WH [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Parkinson-Klinik Ortenau, Wolfach. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y [EqualContrib] => N ) [LastName] => Ransmayr [ForeName] => Gerhard [Initials] => G [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Klinik für Neurologie 2, Kepler Universitätsklinikum, Linz/Austria. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y [EqualContrib] => N ) [LastName] => Riederer [ForeName] => Peter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie, Universitätsklinikum Würzburg. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y [EqualContrib] => N ) [LastName] => Winkler [ForeName] => Christian [Initials] => C [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Krankenhaus Lindenbrunn, Coppenbrügge. ) ) ) ) [Language] => ger [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Review ) ) [VernacularTitle] => Struktur und Efferenzen der Substantia nigra pars compacta beim idiopathischen Parkinson-Syndrom. [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 05 [Day] => 12 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Germany [MedlineTA] => Fortschr Neurol Psychiatr [NlmUniqueID] => 8103137 [ISSNLinking] => 0720-4299 ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Animals ) [1] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [2] => SimpleXMLElement Object ( [DescriptorName] => Parkinson Disease [QualifierName] => pathology ) [3] => SimpleXMLElement Object ( [DescriptorName] => Pars Compacta [QualifierName] => pathology ) ) ) [OtherAbstract] => SimpleXMLElement Object ( [@attributes] => Array ( [Type] => Publisher [Language] => ger ) [AbstractText] => Es besteht Konsens, dass das neuropathologische Merkmal des idiopathischen Parkinson-Syndroms (IPS) der neuronale Zellverlust der Substantia nigra pars compacta (SNc) in Verbindung mit einer Lewy-Pathologie ist. Die transsynaptische Ausbreitung der Lewy-Pathologie wird als wesentlich in der Parkinson-Pathogenese angesehen. Daher ist die Kenntnis präexistenter neuroanatomischer Verbindungen der SNc wesentlich. Wir beschreiben hier neuere tierexperimentelle Befunde zu den afferenten und efferenten Projektionen der SNc und diskutieren die Evidenz für und gegen die sequentielle transsynaptische Ausbreitung der Lewy-Pathologie in der Pathogenese des IPS. ) [CoiStatement] => Der Workshop fand im Rahmen des jährlichen ‚Experten Meeting Parkinson‘ statt, das finanziell von den Firmen Bial, Desitin und Zambon unterstützt wurde (siehe Editorial). Darüberhinaus bestehen keine das Manuskript betreffende Interessenkonflikte. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 5 [Day] => 13 [Hour] => 6 [Minute] => 0 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 9 [Day] => 29 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 5 [Day] => 13 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32396943 [1] => 10.1055/a-1149-9280 ) ) ) ) [13] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 32335793 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 27 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 27 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1572-994X [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 56 [Issue] => 4 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Aug ) ) [Title] => Virus genes [ISOAbbreviation] => Virus Genes ) [ArticleTitle] => Crimean-Congo hemorrhagic fever virus infection triggers the upregulation of the Wnt signaling pathway inhibitor genes. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 508-514 ) [ELocationID] => 10.1007/s11262-020-01759-z [Abstract] => SimpleXMLElement Object ( [AbstractText] => Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic agent. Thus far, vaccines and specific antiviral therapies are not available against the threat of infection. Our knowledge regarding its pathogenesis is indeed limited, and thus, developing effective antiviral therapies is hampered. Several studies have demonstrated that the CCHFV infection has an impact on numerous signal transduction pathways. In parallel, the Wnt signaling pathway components are responsible for different important biological processes including cell fate determination, cell migration and cell polarity. Moreover, its implication among several virus infections has been proven, yet little is known in reference to which components of the Wnt pathway are being activated/inhibited as a response to the infection. Our aim was to elicit the influence of the CCHFV infection on adenocarcinomic human alveolar basal epithelial cells in vitro regarding the Wnt signaling pathway-related genes. Gene-expression changes of 92 Wnt-associated genes were examined 48 h post-infection. Furthermore, β-catenin levels were compared in the infected and uninfected cells. Significant changes were observed in the case of 13 genes. The majority of the upregulated genes are associated with the inhibition of the Wnt/β-catenin signaling. Additionally, infected cells expressed less β-catenin. Our findings suggest that CCHFV blocks the Wnt/β-catenin pathway. Our study corroborates the link between CCHFV infection and the Wnt signaling pathways. In addition, it broadens our knowledge in the CCHFV pathomechanism. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Papp [ForeName] => Henrietta [Initials] => H [Identifier] => https://orcid.org/0000-0003-3887-5657 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Virological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary. ) [1] => SimpleXMLElement Object ( [Affiliation] => Faculty of Sciences, Institute of Biology, University of Pécs, Pécs, Hungary. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zeghbib [ForeName] => Safia [Initials] => S [Identifier] => https://orcid.org/0000-0001-9603-7489 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Virological Research 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Centre, University of Pécs, Pécs, Hungary. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary. ) ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Madai [ForeName] => Mónika [Initials] => M [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Virological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary. ) [1] => SimpleXMLElement Object ( [Affiliation] => Faculty of Sciences, Institute of Biology, University of Pécs, Pécs, Hungary. ) ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kemenesi [ForeName] => Gábor [Initials] => G [Identifier] => https://orcid.org/0000-0001-9775-3065 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Virological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary. ) [1] => SimpleXMLElement Object ( [Affiliation] => Faculty of Sciences, Institute of Biology, University of Pécs, Pécs, Hungary. ) ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Urbán [ForeName] => Péter [Initials] => P [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Faculty of Sciences, Institute of Biology, University of Pécs, Pécs, Hungary. ) [1] => SimpleXMLElement Object ( [Affiliation] => Bioinformatics Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary. ) ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kvell [ForeName] => Krisztián [Initials] => K [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Wnt Signaling Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary. ) ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Jakab [ForeName] => Ferenc [Initials] => F [Identifier] => https://orcid.org/0000-0002-3913-0430 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Virological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary. jakab.ferenc@pte.hu. ) [1] => SimpleXMLElement Object ( [Affiliation] => Faculty of Sciences, Institute of Biology, University of Pécs, Pécs, Hungary. jakab.ferenc@pte.hu. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 04 [Day] => 25 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Virus Genes [NlmUniqueID] => 8803967 [ISSNLinking] => 0920-8569 ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Animals ) [1] => SimpleXMLElement Object ( [DescriptorName] => Cell Line, Tumor ) [2] => SimpleXMLElement Object ( [DescriptorName] => Gene Expression Regulation, Viral [QualifierName] => genetics ) [3] => SimpleXMLElement Object ( [DescriptorName] => Hemorrhagic Fever Virus, Crimean-Congo [QualifierName] => Array ( [0] => genetics [1] => pathogenicity ) ) [4] => SimpleXMLElement Object ( [DescriptorName] => Hemorrhagic Fever, Crimean [QualifierName] => Array ( [0] => genetics [1] => virology ) ) [5] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [6] => SimpleXMLElement Object ( [DescriptorName] => Virus Replication [QualifierName] => genetics ) [7] => SimpleXMLElement Object ( [DescriptorName] => Wnt Signaling Pathway [QualifierName] => genetics ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => A549 [1] => Gene expression [2] => Hemorrhagic fever virus [3] => Highly pathogenic [4] => Immunofluorescence [5] => Wnt/ß-catenin signaling pathway ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2019 [Month] => 12 [Day] => 12 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 04 [Day] => 16 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 4 [Day] => 27 [Hour] => 6 [Minute] => 0 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 1 [Day] => 28 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 4 [Day] => 27 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32335793 [1] => 10.1007/s11262-020-01759-z [2] => 10.1007/s11262-020-01759-z ) ) ) ) [14] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 32331300 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 25 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1422-0067 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 21 [Issue] => 8 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Apr [Day] => 22 ) ) [Title] => International journal of molecular sciences [ISOAbbreviation] => Int J Mol Sci ) [ArticleTitle] => Hemokinin-1 Gene Expression Is Upregulated in Trigeminal Ganglia in an Inflammatory Orofacial Pain Model: Potential Role in Peripheral Sensitization. [ELocationID] => Array ( [0] => E2938 [1] => 10.3390/ijms21082938 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => A large percentage of primary sensory neurons in the trigeminal ganglia (TG) contain neuropeptides such as tachykinins or calcitonin gene-related peptide. Neuropeptides released from the central terminals of primary afferents sensitize the secondary nociceptive neurons in the trigeminal nucleus caudalis (TNC), but also activate glial cells contributing to neuroinflammation and consequent sensitization in chronic orofacial pain and migraine. In the present study, we investigated the newest member of the tachykinin family, hemokinin-1 (HK-1) encoded by the gene in the trigeminal system. HK-1 had been shown to participate in inflammation and hyperalgesia in various models, but its role has not been investigated in orofacial pain or headache. In the complete Freund's adjuvant (CFA)-induced inflammatory orofacial pain model, we showed that expression increased in the TG in response to inflammation. Duration-dependent upregulation was associated with the extent of the facial allodynia. was detected in both TG neurons and satellite glial cells (SGC) by the ultrasensitive RNAscope in situ hybridization. We also compared gene expression changes of selected neuronal and glial sensitization and neuroinflammation markers between wild-type and -deficient () mice. Expression of the SGC/astrocyte marker in the TG and TNC was significantly lower in intact and saline/CFA-treated mice. The procedural stress-related increase of the SGC/astrocyte marker was also strongly attenuated in mice. Analysis of TG samples with a mouse neuroinflammation panel of 770 genes revealed that regulation of microglia and cytotoxic cell-related genes were significantly different in saline-treated mice compared to their wild-types. It is concluded that HK-1 may participate in neuron-glia interactions both under physiological and inflammatory conditions and mediate pain in the trigeminal system. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Aczél [ForeName] => Timea [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kecskés [ForeName] => Angéla [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => jrm00065 ) [ELocationID] => 10.2340/16501977-2665 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Clinical parameters for prediction of post-stroke spasticity are well established. This report introduces 2 brain magnetic resonance imaging (MRI) parameters (infarct volume and topographic distribution) as post-stroke spasticity predictors. [1] => Topographic and volumetric data from brain MRI for 98 patients with ischaemic stroke with spasticity, prevalent within the first 5 days after stroke and 6 months after stroke, were retrospectively correlated using Chris Rorden's MRIcron software. [2] => Lesions within the supply territory of the middle cerebral artery involving the pyramidal tract were more frequently associated with spasticity than without spasticity (30.8% vs 5.1%). Middle cerebral artery lesions not affecting the pyramidal tract were found more often in patients without spasticity (49.2% vs 10.3%). Spasticity showed a significantly higher association with middle cerebral artery+pyramidal tract/internal capsule lesions than did "no spasticity" (97.5% vs 18.7%, p < 0.01), and lesion volumes were significantly larger in patients with spasticity than in those without spasticity (p < 0.01). [3] => Large stroke volumes might predict post-stroke spasticity if the lesion is > 3 cm3 in size and if the lesion is located within the middle cerebral artery territory with involvement of the pyramidal tract and/or internal capsule. Lesion size ≤ 2 cm3 outside the middle cerebral artery territory is associated with lower risk of post-stroke spasticity. ) ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ri [ForeName] => Songjin [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Neurology, Charite Universitiy of Medicine, , 12203 Berlin, Germany. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kivi [ForeName] => Anatol [Initials] => A ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Urban [ForeName] => Peter P [Initials] => PP ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wolf [ForeName] => Thomas [Initials] => T ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wissel [ForeName] => Jörg [Initials] => J ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 05 [Day] => 31 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Sweden [MedlineTA] => J Rehabil Med [NlmUniqueID] => 101088169 [ISSNLinking] => 1650-1977 ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Adolescent ) [1] => SimpleXMLElement Object ( [DescriptorName] => Adult ) [2] => SimpleXMLElement Object ( [DescriptorName] => Aged ) [3] => SimpleXMLElement Object ( [DescriptorName] => Aged, 80 and over ) [4] => SimpleXMLElement Object ( [DescriptorName] => Brain [QualifierName] => pathology ) [5] => SimpleXMLElement Object ( [DescriptorName] => Cohort Studies ) [6] => SimpleXMLElement Object ( [DescriptorName] => Female ) [7] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [8] => SimpleXMLElement Object ( [DescriptorName] => Magnetic Resonance Imaging [QualifierName] => methods ) [9] => SimpleXMLElement Object ( [DescriptorName] => Male ) [10] => SimpleXMLElement Object ( [DescriptorName] => Middle Aged ) [11] => SimpleXMLElement Object ( [DescriptorName] => Muscle Spasticity [QualifierName] => Array ( [0] => etiology [1] => pathology ) ) [12] => SimpleXMLElement Object ( [DescriptorName] => Retrospective Studies ) [13] => SimpleXMLElement Object ( [DescriptorName] => Stroke [QualifierName] => complications ) [14] => SimpleXMLElement Object ( [DescriptorName] => Young Adult ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => magnetic resonance imaging [1] => prediction [2] => spasticity [3] => stroke ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => aheadofprint ) [Year] => 2020 [Month] => 03 [Day] => 12 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 3 [Day] => 18 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 3 [Day] => 18 [Hour] => 6 [Minute] => 0 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 7 [Day] => 31 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => epublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32179931 [1] => 10.2340/16501977-2665 ) ) ) ) [17] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [IndexingMethod] => Automated [Owner] => NLM ) [PMID] => 32028945 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 21 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 21 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1471-2318 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 20 [Issue] => 1 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 02 [Day] => 06 ) ) [Title] => BMC geriatrics [ISOAbbreviation] => BMC Geriatr ) [ArticleTitle] => Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 45 ) [ELocationID] => 10.1186/s12877-020-1445-z [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits, (ii) to investigate the interaction between both motor and cognitive deficits and (iii) to assess health status as well as treatment outcome of 1000 geriatric inpatients in hospitals of Kiel (Germany), Brescia (Italy), Porto (Portugal), Curitiba (Brazil) and Bochum (Germany). [1] => This is a prospective, explorative observational multi-center study. In addition to the comprehensive geriatric assessment, quantitative measures of reduced mobility and motor and cognitive deficits are performed before and after a two week's inpatient stay. Components of the assessment are mobile technology-based assessments of gait, balance and transfer performance, neuropsychological tests, frailty, sarcopenia, autonomic dysfunction and sensation, and questionnaires to assess behavioral deficits, activities of daily living, quality of life, fear of falling and dysphagia. Structural MRI and an unsupervised 24/7 home assessment of mobility are performed in a subgroup of participants. The study will also investigate the minimal clinically relevant change of the investigated parameters. 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Virostatic drugs are optional in severe cases (intense pain or suspicion of herpes zoster sine herpete) and mandatory in cases of varicella-zoster virus (VZV) infection. Corneal protection with dexpanthenol ophthalmic ointment, artificial tears, and a nocturnal moisture- retaining eye shield has been found useful in practice. In cases of incomplete recovery with residual facial weakness, both static and microsurgical dynamic methods can be used to restore facial nerve function. [3] => Because 25-40% of cases of facial nerve palsy are not idiopathic, differential diagnosis is very important; key diagnostic methods include a clinical neurological examin- ation, otoscopy, and a lumbar puncture for cerebrospinal fluid examination. 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[Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 2045-2322 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 9 [Issue] => 1 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 10 [Day] => 31 ) ) [Title] => Scientific reports [ISOAbbreviation] => Sci Rep ) [ArticleTitle] => Genetic characterization of a novel picornavirus in Algerian bats: co-evolution analysis of bat-related picornaviruses. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 15706 ) [ELocationID] => 10.1038/s41598-019-52209-2 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Bats are reservoirs of numerous zoonotic viruses. The Picornaviridae family comprises important pathogens which may infect both humans and animals. In this study, a bat-related picornavirus was detected from Algerian Minioptreus schreibersii bats for the first time in the country. Molecular analyses revealed the new virus originates to the Mischivirus genus. In the operational use of the acquired sequence and all available data regarding bat picornaviruses, we performed a co-evolutionary analysis of mischiviruses and their hosts, to authentically reveal evolutionary patterns within this genus. Based on this analysis, we enlarged the dataset, and examined the co-evolutionary history of all bat-related picornaviruses including their hosts, to effectively compile all possible species jumping events during their evolution. Furthermore, we explored the phylogeny association with geographical location, host-genus and host-species in both data sets. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zeghbib [ForeName] => Safia [Initials] => S [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Virological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Hungary. ) [1] => SimpleXMLElement Object ( [Affiliation] => Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Herczeg [ForeName] => Róbert [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Bioinformatics Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kemenesi [ForeName] => Gábor [Initials] => G [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Virological Research Group, BSL