Publications by authors named "Peter T Nelson"

100Publications

Embedding Brain Tissue for Routine Histopathology: A Processing Step Worthy of Consideration in the Digital Pathology Era.

Appl Immunohistochem Mol Morphol 2020 Nov/Dec;28(10):791-793

Department of Pathology and Laboratory Medicine, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY.

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http://dx.doi.org/10.1097/PAI.0000000000000832DOI Listing
August 2020

Brain structure changes over time in normal and mildly impaired aged persons.

AIMS Neurosci 2020 20;7(2):120-135. Epub 2020 May 20.

Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky, USA.

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http://dx.doi.org/10.3934/Neuroscience.2020009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321765PMC
May 2020

The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs.

Mol Neurobiol 2020 Jul 25;57(7):2996-3013. Epub 2020 May 25.

Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, 40536, USA.

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http://dx.doi.org/10.1007/s12035-020-01937-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320068PMC
July 2020

The MUC6/AP2A2 Locus and Its Relevance to Alzheimer's Disease: A Review.

J Neuropathol Exp Neurol 2020 06;79(6):568-584

Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1093/jnen/nlaa024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241941PMC
June 2020

Correction: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease.

Transl Psychiatry 2020 Mar 2;10(1):81. Epub 2020 Mar 2.

Department of Psychiatry, Laboratory of Molecular Neurogenetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

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http://dx.doi.org/10.1038/s41398-020-0757-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052148PMC
March 2020

Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease.

Transl Psychiatry 2020 02 3;10(1):47. Epub 2020 Feb 3.

Department of Psychiatry, Laboratory of Molecular Neurogenetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

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http://dx.doi.org/10.1038/s41398-020-0709-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026402PMC
February 2020

Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations.

J Neuropathol Exp Neurol 2020 03;79(3):305-313

Sanders-Brown Center on Aging, Division of Neuropathology, Department of Pathology, University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1093/jnen/nlz126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036651PMC
March 2020

Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.

J Neuropathol Exp Neurol 2020 01;79(1):3-21

Sanders-Brown Center on Aging (YK, DWF, ADB, SCA, W-XW, AW, LJB, BGN, QH, ELA, SA, IP, DAP, DMN, DWW, GAJ, LJVE, PTN); Department of Biostatistics (YK, DWF); Spinal Cord & Brain Injury Research Center (ADB); Department of Neuroscience (ADB, DWW, LJVE); Department of Epidemiology (ELA); Department of Neurology (DWW, GAJ); Department of Physiology (BCS, SE); and Department of Pathology (W-XW, JHN, PTN), University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1093/jnen/nlz116DOI Listing
January 2020

Methodology for Subcellular Fractionation and MicroRNA Examination of Mitochondria, Mitochondria Associated ER Membrane (MAM), ER, and Cytosol from Human Brain.

Methods Mol Biol 2020 ;2063:139-154

Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1007/978-1-0716-0138-9_11DOI Listing
January 2020

Reply: Limbic-predominant age-related TDP-43 encephalopathy (LATE).

Brain 2019 08;142(8):e43

University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1093/brain/awz186DOI Listing
August 2019

Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy.

Lab Invest 2019 07 11;99(7):993-1007. Epub 2019 Feb 11.

University of Kentucky College of Medicine, Lexington, KY, USA.

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http://dx.doi.org/10.1038/s41374-019-0196-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609463PMC
July 2019

TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.

Neurobiol Dis 2019 05 23;125:67-76. Epub 2019 Jan 23.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Biostatistics, University of Kentucky, Lexington, KY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183070
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http://dx.doi.org/10.1016/j.nbd.2019.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696921PMC
May 2019

Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice.

J Diabetes Res 2018 29;2018:1251345. Epub 2018 Oct 29.

Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA.

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https://www.hindawi.com/journals/jdr/2018/1251345/
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http://dx.doi.org/10.1155/2018/1251345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231393PMC
April 2019

Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs.

Neurobiol Aging 2019 02 23;74:135-146. Epub 2018 Oct 23.

Department of Biostatistics, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331247PMC
February 2019

Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study.

Neurology 2018 11 12;91(19):e1788-e1798. Epub 2018 Oct 12.

From the College of Medicine (T.T.), The Pennsylvania State University, State College; Departments of Neurology (S.A.S., C.H.K., M.M.C.), Neurobiology and Behavior (C.H.K.), and Epidemiology (M.M.C.), University of California, Irvine; and Department of Pathology, University of Kentucky Sanders-Brown Center on Aging (P.T.N.), University of Kentucky, Lexington.

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http://dx.doi.org/10.1212/WNL.0000000000006455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251605PMC
November 2018

The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses.

J Neuropathol Exp Neurol 2018 08;77(8):717-726

Sanders-Brown Center on Aging, Division of Neuropathology, Department of Pathology, University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1093/jnen/nly049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044344PMC
August 2018

The human MAPT locus generates circular RNAs.

Biochim Biophys Acta Mol Basis Dis 2018 09 3;1864(9 Pt B):2753-2760. Epub 2018 May 3.

University of Kentucky, Lexington, KY 40503, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434521PMC
September 2018

APOE DNA methylation is altered in Lewy body dementia.

Alzheimers Dement 2018 07 12;14(7):889-894. Epub 2018 Mar 12.

Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050144PMC
July 2018

BIN1 localization is distinct from Tau tangles in Alzheimer's disease.

Matters (Zur) 2017 Jan 12;2017. Epub 2017 Jan 12.

Department of Neurobiology, The University of Chicago; Sanders-Brown Center on Aging and Department of Physiology, University of Kentucky (US); Department of Pathology, The University of Chicago; Departments of Neurobiology, Neurology, and Pathology, The University of Chicago.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823513PMC
http://dx.doi.org/10.19185/matters.201611000018DOI Listing
January 2017

Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons.

J Neuropathol Exp Neurol 2018 Jan;77(1):21-39

Department of Molecular and Cellular Biochemistry; Department of Biostatistics; Sanders-Brown Center on Aging; Department of Pathology, University of Kentucky, Lexington, Kentucky; and Research and Development, Lexington VA Medical Center, Lexington, Kentucky.

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http://dx.doi.org/10.1093/jnen/nlx097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251632PMC
January 2018

The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.

J Neuropathol Exp Neurol 2018 Jan;77(1):2-20

Division of Neuropathology; Sanders-Brown Center on Aging; Department of Pathology; Department of Epidemiology; Department of Physiology; Department of Statistics; Department of Neurology; Department of Neuroscience; Department of Molecular and Cellular Biochemistry; Department of Biostatistics, University of Kentucky, Lexington, Kentucky; and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.

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http://dx.doi.org/10.1093/jnen/nlx099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901077PMC
January 2018

MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls.

Brain Res 2018 Jan 13;1678:374-383. Epub 2017 Nov 13.

Department of Statistics, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752138PMC
January 2018

Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults.

Neurobiol Aging 2018 02 4;62:64-71. Epub 2017 Nov 4.

Division of Neuropathology, Department of Pathology, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743774PMC
February 2018

Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.

Ann Neurol 2017 Aug 29;82(2):208-222. Epub 2017 Jul 29.

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY.

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http://dx.doi.org/10.1002/ana.24992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568970PMC
August 2017

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

J Neuropathol Exp Neurol 2017 Jul;76(7):605-619

Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlx041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251511PMC
July 2017

Hippocampal Sclerosis in Older Patients: Practical Examples and Guidance With a Focus on Cerebral Age-Related TDP-43 With Sclerosis.

Arch Pathol Lab Med 2017 Aug 3;141(8):1113-1126. Epub 2017 May 3.

From the Departments of Pathology and Genomic Medicine (Drs Cykowski, Powell, Rivera, and Takei), Internal Medicine (Dr Jackson), and Neurology (Dr Roman), Houston Methodist Hospital, Houston, Texas; the Department of Neurology, University of Texas Health Science Center at Houston (Dr Schulz); the Department of Pathology, Division of Neuropathology (Dr Nelson) and Sanders-Brown Center on Aging (Drs Jicha and Nelson), University of Kentucky, Lexington.

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http://dx.doi.org/10.5858/arpa.2016-0469-SADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922266PMC
August 2017

GABA receptor attenuation of GABA currents in neurons of the mammalian central nervous system.

Physiol Rep 2017 Mar;5(6)

Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York.

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http://dx.doi.org/10.14814/phy2.13129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371550PMC
March 2017

Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi.

Brain Pathol 2018 03 24;28(2):264-273. Epub 2017 Mar 24.

Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY.

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http://dx.doi.org/10.1111/bpa.12505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591757PMC
March 2018

CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

Exp Gerontol 2017 04 9;90:83-89. Epub 2017 Feb 9.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Pathology, College of Medicine, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1016/j.exger.2017.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389672PMC
April 2017

Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2.

Neurobiol Aging 2017 05 9;53:193.e17-193.e25. Epub 2017 Jan 9.

Department of Biostatistics, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385271PMC
May 2017

Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.

Neurobiol Aging 2017 04 5;52:98-105. Epub 2017 Jan 5.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359029PMC
April 2017

Widespread tau seeding activity at early Braak stages.

Acta Neuropathol 2017 01 22;133(1):91-100. Epub 2016 Nov 22.

Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., NL10.120, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1007/s00401-016-1644-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833300PMC
January 2017

miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).

Mol Neurodegener 2016 07 26;11(1):55. Epub 2016 Jul 26.

Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1186/s13024-016-0121-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960690PMC
July 2016

Cerebrovascular pathology and Alzheimer's disease.

Authors:
Peter T Nelson

Lancet Neurol 2016 08 14;15(9):895-896. Epub 2016 Jun 14.

University of Kentucky, Lexington, KY 40536-0230, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(16)30038-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327818PMC
August 2016

Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function.

Biochim Biophys Acta 2016 09 20;1862(9):1521-32. Epub 2016 May 20.

Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, USA; Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026189PMC
September 2016

"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).

J Neuropathol Exp Neurol 2016 06 21;75(6):482-98. Epub 2016 May 21.

From the Department of Pathology, Division of Neuropathology (PTN, JHN), Department of Neurology (GAJ, FAS, CDS), Department of Statistics (DWF, RJK), Department of Anatomy and Neurobiology (PTN, JHN, LJVE, ETI), Department of Epidemiology (ELA), and Sanders-Brown Center on Aging (PTN, ELA, OMA-J, GAJ, FAS, CDS, DWF, WXW, RJK, LJVE, ETI), University of Kentucky, Lexington, Kentucky; Department of Pathology & Laboratory Medicine and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, Pennsylvannia (JQT); Department of Epidemiology, University of Washington, Seattle, Washington (WAK); and Department of Pathology, Houston Methodist Hospital, Houston, Texas (MDC).

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https://academic.oup.com/jnen/article-lookup/doi/10.1093/jne
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http://dx.doi.org/10.1093/jnen/nlw033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366658PMC
June 2016

Non-random distribution of methyl-CpG sites and non-CpG methylation in the human rDNA promoter identified by next generation bisulfite sequencing.

Gene 2016 Jul 20;585(1):35-43. Epub 2016 Mar 20.

Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY 40292, United States; Department of Neurological Surgery, University of Louisville, Louisville, KY 40292, United States; Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY 40292, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2016.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934664PMC
July 2016

Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe.

J Alzheimers Dis 2016 ;52(1):373-83

University of Kentucky, Sanders-Brown Center on Aging and Pathology Department, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.3233/JAD-160077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978172PMC
January 2017

Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons.

J Neuropathol Exp Neurol 2016 May 12;75(5):397-407. Epub 2016 Mar 12.

From the Department of Pathology and Genomic Medicine (MDC, HT, SZP) and Houston Methodist Neurological Institute (HT, SZP), Houston Methodist Hospital, Houston, Texas; and Sanders-Brown Center on Aging (LJVE, FAS, GAJ, PTN), Department of Anatomy & Neurobiology(LJVE), Department of Neurology(FAS, GAJ), and Division of Neuropathology, Department of Pathology (PTN), University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1093/jnen/nlw014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009476PMC
May 2016

Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology.

Alzheimers Dement 2016 08 23;12(8):882-9. Epub 2016 Jan 23.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Rush University Medical Center, Department of Neurological Sciences, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958598PMC
August 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

Brain pathologies in extreme old age.

Neurobiol Aging 2016 Jan 19;37:1-11. Epub 2015 Oct 19.

Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688098PMC
January 2016

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

Hum Mol Genet 2016 Jan 26;25(2):211-22. Epub 2015 Oct 26.

Department of Pharmacology and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 874 Union Avenue/Crowe 401, Memphis, TN 38163, USA,

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http://dx.doi.org/10.1093/hmg/ddv445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706110PMC
January 2016

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.

Alzheimers Dement 2016 Feb 29;12(2):164-169. Epub 2015 Aug 29.

Department of Neurology, Massachusetts General Hospital, Charleston, MA, USA; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Charleston, MA, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.07.492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562409PMC
February 2016

Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes.

Neurobiol Aging 2015 Oct 8;36(10):2702-8. Epub 2015 Jul 8.

National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562901PMC
October 2015

ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.

Ageing Res Rev 2015 Nov 28;24(Pt B):111-25. Epub 2015 Jul 28.

University of Kentucky, Sanders-Brown Center on Aging, Lexington, KY 40536, USA; Department of Biostatistics, Lexington, KY, 40536, USA.

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http://dx.doi.org/10.1016/j.arr.2015.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661124PMC
November 2015

Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature.

J Neuropathol Exp Neurol 2015 Jul;74(7):642-52

From Department of Pathology, Division of Neuropathology (JHN, PTN), Department of Neurology (GAJ, FAS, CDS), Department of Statistics (RJK), Department of Epidemiology (ELA), Sanders-Brown Center on Aging (GAJ, FAS, ELA, RJK, CDS, TD, SA, EL, AB, LVE, PTN), and Department of Anatomy and Neurobiology (ETI, LVE, PTN), University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1097/NEN.0000000000000204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539239PMC
July 2015

Cerebrospinal fluid vascular endothelial growth factor.

JAMA Neurol 2015 May;72(5):502-3

Sanders-Brown Center on Aging, Division of Neuropathology, Department of Pathology, University of Kentucky, Lexington.

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http://dx.doi.org/10.1001/jamaneurol.2015.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444778PMC
May 2015

Unlocking the mysteries of TDP-43.

Neurology 2015 Mar 4;84(9):870-1. Epub 2015 Feb 4.

From the Department of Neurology (K.A.J.), Mayo Clinic, Rochester, MN; and Department of Pathology (P.T.N.), University of Kentucky, Lexington.

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http://dx.doi.org/10.1212/WNL.0000000000001322DOI Listing
March 2015

Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury.

Exp Neurol 2015 Mar 3;265:84-93. Epub 2015 Jan 3.

Physical Medicine and Rehabilitation, University of Kentucky, Lexington, KY 40536, USA; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2014.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346439PMC
March 2015

Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology.

J Neuropathol Exp Neurol 2015 Jan;74(1):75-84

From the Departments of Pathology (PTN) and Biostatistics (DWF), Sanders-Brown Center on Aging (PTN, W-XW, BRW, DWF), and Division of Biomedical Informatics, College of Public Health (SRE), University of Kentucky, Lexington, Kentucky; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (ABP, OV, L-SW); National Alzheimer's Coordinating Center (SEM) and Department of Epidemiology (WAK), University of Washington, Seattle, Washington; and Department of Biostatistics and Epidemiology, Perelman School of Medicine (ACN).

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http://dx.doi.org/10.1097/NEN.0000000000000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270894PMC
January 2015

Quantitative neuropathological assessment to investigate cerebral multi-morbidity.

Alzheimers Res Ther 2014 28;6(9):85. Epub 2014 Nov 28.

Department of Pathology, Division of Neuropathology, University of Kentucky, 800 Limestone Street, Lexington, KY 40536-0230 USA.

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http://link.springer.com/content/pdf/10.1186%2Fs13195-014-00
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http://alzres.com/content/6/9/85
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http://dx.doi.org/10.1186/s13195-014-0085-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247208PMC
December 2014

Self-reported memory complaints: implications from a longitudinal cohort with autopsies.

Neurology 2014 Oct 24;83(15):1359-65. Epub 2014 Sep 24.

From the Sanders-Brown Center on Aging (R.J.K., E.L.A., G.E.C., G.A.J., P.T.N., C.D.S., L.J.V.E., L.W., F.A.S.), Alzheimer's Disease Center (R.J.K., E.L.A., G.E.C., D.W.F., G.A.J., P.T.N., C.D.S., L.J.V.E., F.A.S.), Departments of Biostatistics (R.J.K., D.W.F.), Statistics (R.J.K., L.W.), Epidemiology (E.L.A.), and Pathology (P.T.N.), Department of Anatomy and Neurobiology, College of Medicine (L.J.V.E.), and Department of Neurology, College of Medicine (G.A.J., C.D.S., F.A.S.), University of Kentucky, Lexington; and Baptist Neurology Center (G.E.C.), Lexington, KY.

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http://dx.doi.org/10.1212/WNL.0000000000000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189103PMC
October 2014

White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.

Neurobiol Aging 2014 Oct 2;35(10):2263-71. Epub 2014 May 2.

Department of Neurology, University of Kentucky, Lexington, KY, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087077PMC
October 2014

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.

Front Genet 2014 23;5:88. Epub 2014 Apr 23.

Sanders-Brown Center on Aging, University of Kentucky Lexington, KY, USA ; Department of Anatomy and Neurobiology, University of Kentucky Lexington, KY, USA.

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http://dx.doi.org/10.3389/fgene.2014.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005958PMC
June 2014

Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells.

Genomics Proteomics Bioinformatics 2014 Feb 28;12(1):19-30. Epub 2014 Jan 28.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA; Department of Pathology, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2013.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975925PMC
February 2014

Is synaptic loss a unique hallmark of Alzheimer's disease?

Biochem Pharmacol 2014 Apr 9;88(4):517-28. Epub 2014 Jan 9.

Sanders-Brown Center on Aging and Alzheimer's Disease Center, University of Kentucky Medical Center, University of Kentucky, Lexington, KY 40536, United States; Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY 40536, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2013.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230706PMC
April 2014

Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort.

Dement Geriatr Cogn Disord 2014 31;37(5-6):294-306. Epub 2013 Dec 31.

University of Kentucky Alzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Ky., USA.

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http://dx.doi.org/10.1159/000355478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057973PMC
February 2015